For cancer patient who has bilateral serous borderline tumor, microscopic tumor deposits in omentum and peritoneal fluid has atypical cells, does chemo be helpful or hormonal therapy? As the tumors are er and pgr positive
Borderline tumors do not respond to conventional chemotherapy, so the side-effects outweigh any potential benefit. I'm not sure about hormonal therapy; it isn't used commonly in our institution, but might have value. check with your gynecologic-oncologist
Thanks for this suggestion. I have discussed invasion in mucinous tumors in some of my videos, such as this one-- th-cam.com/video/oAwe2ZYsTNE/w-d-xo.html, but the specific topic you suggest is probably worth considering as a stand alone topic. I will keep my eyes open for the right case to introduce the discussion.
In a case like this one, would it be worthwhile to mention the microinvasion, since there is no change to the prognosis or to the necessity of any complementary surgery? In a 71 old woman, the surgeon and the patient surely will want to perform that surgery, won't they? Thank you for the case!!
You raise a good point. The value in making this diagnosis is primarily to facilitate further study and follow-up. there isn't a large dataset of these type cases, so the apparent good prognosis is not based on as robust an experience as we might like. Also, in terms of scientific study in the future, such cases may offer key insights into the biology of the transformation that will benefit patients with more severe disease, or potentially help prevent more severe disease. In truth, our diagnostic abilities and the therapeutic capabilities or therapeutic needs do not always go in lock-step synchronization.
Borderline tumors with microinvasion appear mostly as lower grade tumors with small areas of invading tumor that is higher grade usually. Microinvasive carcinoma is a tumor that appears to be entirely carcinoma with limited depth of invasion
For cancer patient who has bilateral serous borderline tumor, microscopic tumor deposits in omentum and peritoneal fluid has atypical cells, does chemo be helpful or hormonal therapy? As the tumors are er and pgr positive
Borderline tumors do not respond to conventional chemotherapy, so the side-effects outweigh any potential benefit. I'm not sure about hormonal therapy; it isn't used commonly in our institution, but might have value. check with your gynecologic-oncologist
Would you please discuss on Mucinous borderline tumor with microinvasion?
Thanks for this suggestion. I have discussed invasion in mucinous tumors in some of my videos, such as this one-- th-cam.com/video/oAwe2ZYsTNE/w-d-xo.html, but the specific topic you suggest is probably worth considering as a stand alone topic. I will keep my eyes open for the right case to introduce the discussion.
In a case like this one, would it be worthwhile to mention the microinvasion, since there is no change to the prognosis or to the necessity of any complementary surgery? In a 71 old woman, the surgeon and the patient surely will want to perform that surgery, won't they? Thank you for the case!!
You raise a good point. The value in making this diagnosis is primarily to facilitate further study and follow-up. there isn't a large dataset of these type cases, so the apparent good prognosis is not based on as robust an experience as we might like. Also, in terms of scientific study in the future, such cases may offer key insights into the biology of the transformation that will benefit patients with more severe disease, or potentially help prevent more severe disease. In truth, our diagnostic abilities and the therapeutic capabilities or therapeutic needs do not always go in lock-step synchronization.
What is the difference between micro invasion and micro invasive carcinoma
Borderline tumors with microinvasion appear mostly as lower grade tumors with small areas of invading tumor that is higher grade usually. Microinvasive carcinoma is a tumor that appears to be entirely carcinoma with limited depth of invasion
Thank you ❤
Most welcome