Thrombotic Thrombocytopenic Purpura (TTP)

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  • เผยแพร่เมื่อ 12 ม.ค. 2025

ความคิดเห็น • 181

  • @medic-9
    @medic-9 ปีที่แล้ว +8

    Love the Gordon Ramsay monologue at the end 🤣

  • @dayo.s2512
    @dayo.s2512 4 ปีที่แล้ว +9

    Wow loved how you explain everything in details and you repeat the important things more than 1 time.

  • @Sammy.a1287
    @Sammy.a1287 3 ปีที่แล้ว +9

    Coombs test is negative because although the IgG antibodies are present, they are not against RBC's or platelets, they are against the enzyme which breaks down vWF.

  • @siddharthtrivedi320
    @siddharthtrivedi320 3 ปีที่แล้ว +11

    You made medicine super fun whilst givin proper info. Thanks . Subbed!

  • @cjodyssey
    @cjodyssey 4 ปีที่แล้ว +45

    9:59 "i dont care nerd" will now be my response when the attending trys to pimp me

  • @jameslazib4989
    @jameslazib4989 3 ปีที่แล้ว +23

    love the energy you're bringing hahah

  • @princevegeta5968
    @princevegeta5968 3 ปีที่แล้ว +11

    The unique and funny way of explaining stuff and the way tough topics are broken down into easy and digestible bits are a boon to have, before exams.
    Keep up God's work good sir!! Left you a like❤

  • @msdreirae6401
    @msdreirae6401 ปีที่แล้ว +2

    OMG I love this so much! thank you. i just started working in hematology after working for years in onco and ITU. I was having a hard time making patterns and organizing my studies. this extremely helps! thank you!!!!!

  • @PedramV
    @PedramV 3 ปีที่แล้ว +19

    I was diagnosed with TTP a couple of weeks ago. Still in the hospital, but PEX got things in order (the last one was three days ago). This video was extremely helpful and helped me understand what's happening to me. Thank you!
    Btw, they suspect I might actually be one of those extremely rare cases of inherited TTP. Gotta start buying lottery tickets 😂

    • @PedramV
      @PedramV 3 ปีที่แล้ว +11

      Update: ADAMTS13 Inhibitor test came back positive so at least I was getting the right treatment. And it has been working. ADAMTS13 activity is in the normal range (0.41) and platelet count has stabilized in the lower end of the normal range. So far so good!

    • @salamsthoughts5842
      @salamsthoughts5842 2 ปีที่แล้ว +1

      What are ur symptoms?

    • @PedramV
      @PedramV 2 ปีที่แล้ว +2

      @@salamsthoughts5842 couple of bruises on the legs, a bit of confusion, and petechiae (both legs). I was feeling unwell for a few days before all of these symptoms appeared.

    • @PedramV
      @PedramV 2 ปีที่แล้ว +4

      @@salamsthoughts5842 everything has been normal after the treatment. Platelets normalized around 160 (even though they dropped to 130 for a couple of weeks) and ADAMTS13 activity has been between 0.48 and 0.79 (doing the test every month).

    • @sefagoktepe7090
      @sefagoktepe7090 2 ปีที่แล้ว +1

      @@PedramV get well bro❤

  • @ifrahakbar2878
    @ifrahakbar2878 4 ปีที่แล้ว +11

    the gordon ramsay bit: excellent!!

  • @cheffinitupwithmrpossibili5623
    @cheffinitupwithmrpossibili5623 ปีที่แล้ว +1

    currently an img studying for my step 1 and this video gave me a much clearer understanding of TTP!

  • @shreyaray5500
    @shreyaray5500 3 ปีที่แล้ว +2

    Ahh this was so much fun. Where was this channel all my life!,

  • @timiahgallishaw1405
    @timiahgallishaw1405 3 ปีที่แล้ว +7

    I currently have ttp but I’m fighting I will get through this !!

  • @mbimbi6157
    @mbimbi6157 3 ปีที่แล้ว +4

    The Rolls-Royce of medicine indeed. 🩸

  • @shahabuddin6149
    @shahabuddin6149 3 ปีที่แล้ว +1

    Wow really you're all material is very conceptual,thanks sir keep it up,be happy and healthy forever

  • @amarbhagat5798
    @amarbhagat5798 2 ปีที่แล้ว +2

    Data - information- knowledge- wisdom great bro💥💥💥💯💯❤️

  • @nightstar8504
    @nightstar8504 4 ปีที่แล้ว +8

    Hello, doctor
    I have one question. In TTP , vWf is overly active,platelets are adhered to form a thrombosis and the number of circulated free platelets decrease. In Bernard Soulier disease vWf is normal but receptor is inactive. It doesn't adhere to form thrombosis. So,they should be circulated freely through the bloodstream .But why ,platelet number decrease instead of increasing ?

    • @McMedLife
      @McMedLife ปีที่แล้ว +2

      Great question! From my understanding, lack of GP1b also leads to the platelets being abnormally shaped in Bernard-Soulier syndrome (i.e. "Giant platelet cells") and, as you mentioned, since they are freely circulating in the bloodstream due to lack the ability for adhesion, they are also subject to shearing forces, leading to further shape irregularities. This, combined with their increased freely circulating quantity leads to detection by the immune system and hence the their destruction and clearance by the immune system.

  • @sydalg95
    @sydalg95 ปีที่แล้ว

    9:56 😂 I had this aquired ttp as a kid about 20 yr ago just wanted to understand it a bit better for some reason this morning. It went dormant without treatment if i am recalling correctly? The doctors back then thought it was lukemia for a short period before figuring out it was TTP. Scary stuff thanks for the laugh!

  • @nninnne1432
    @nninnne1432 4 หลายเดือนก่อน

    I love you man u literally saving my life .

  • @s.u.k.k.u8765
    @s.u.k.k.u8765 3 ปีที่แล้ว +4

    I thought i will watch the pathology of TTP only and skip the rest video…but crap i got Stuck 😂😂😂
    Your videos are extremely helpful n fun to watch. 🙂

  • @pinkrose9594
    @pinkrose9594 3 ปีที่แล้ว +3

    Mo Salah of medicine 🔝🔝

  • @mohamedelhadi4477
    @mohamedelhadi4477 4 ปีที่แล้ว +3

    my new fav channel ;)

  • @aakankshapatel2192
    @aakankshapatel2192 4 ปีที่แล้ว +2

    Genius Simplifying Work ✅✅✅✅

  • @codrut913
    @codrut913 4 ปีที่แล้ว +9

    This guy is funny and very good !!!

  • @drbonfire
    @drbonfire 4 ปีที่แล้ว +17

    "you need to know what the flip you are talking about" hahaha fortunately that is the reason I am here good sir

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  4 ปีที่แล้ว

      Thank you so much for watching 😊

    • @drbonfire
      @drbonfire 4 ปีที่แล้ว +2

      @@MedicosisPerfectionalis Thank you for making the video! We have our heme/onc/cardio/renal/pulm exam coming up (yes, our deans did that 🤪) and I am about to be the biggest fan of the heme/onc playlist!!

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  4 ปีที่แล้ว +1

      Good luck 🍀 to you, dear :)

  • @nimrafaraz2549
    @nimrafaraz2549 ปีที่แล้ว +1

    Wow, I wish to be amazing like this medicosis guy superb🎉

  • @driffat100
    @driffat100 10 หลายเดือนก่อน

    Very well explain which helps to memorise clear concepts for exam preparation ❤keep it up bro💯👍🙏

  • @colormekubrick2757
    @colormekubrick2757 3 ปีที่แล้ว +3

    Hello, I just got out of the hospital after a bought with TTP. Luckily I caught it in time before it took me. I’m 44 years old. My blood counts are normal. I had about 6 sessions of plasmapheresis. Its now my second night back at home after discharge, and at night I tend to shake a little bit when lying down. Is this just my body slowly accommodating to the plasmapheresis process? I’m also on prednisone. Thank you so much.

  • @hello-un8gh
    @hello-un8gh ปีที่แล้ว

    Great video! Unlike many professors you explain in a clear and simple way!
    In this regard, I was told that in TTP, unlike DIC, there is no hemorrhagic risk and the purpura is due to blood extravasation following endothelial damage due to ischemia caused by the formation of microthrombi.
    But i was wondering...Isn't poropra a result of thrombocytopenia? Furthermore, shouldn't thrombocytopenia (

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  ปีที่แล้ว

      Great question!
      There might be a hemorrhagic risk, but it really depends on how low the platelet count. A person with a platelet count of 4,000 is a completely different story than a patient with a platelet count of 48,000. Also, we have to take the coagulation factors into consideration. Platelets usually protect us from superficial bleeding, whereas the coagulation factors protect us from deep tissue bleeding (e.g. internal bleeding).
      Hope that helps!

  • @hammerradiology1470
    @hammerradiology1470 3 ปีที่แล้ว

    Just yesterday I saw a case of TTP from a dog bite. It escalated to sepsis and internal bleeding...the lab results and images all indicate an aquired TTP. Really interesting.

  • @stanleyigbinosa1952
    @stanleyigbinosa1952 9 หลายเดือนก่อน

    This is medicosis, the Rolls Royce of medicine 😂❤

  • @marzena888888
    @marzena888888 3 ปีที่แล้ว +1

    Where do the neurologic symptoms and fever come from? I have watched the video carefully and loved it, but I don't really get the reasons for these additional symptoms

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  3 ปีที่แล้ว +3

      It’s a systemic pathophysiological process that can affect anything. Statistically, some symptoms are more common than others, but I don’t know why.

    • @bitterguard5233
      @bitterguard5233 3 ปีที่แล้ว

      Neurological symptoms due to microembolic occlusion probably

  • @1rrrrrrrrrrr544f
    @1rrrrrrrrrrr544f 2 หลายเดือนก่อน

    Keep it up ❤❤
    But why is the quality so bad 😢

  • @AliKhan-sr1cm
    @AliKhan-sr1cm 3 ปีที่แล้ว

    Keep up the great work

  • @Tumi_2000
    @Tumi_2000 3 ปีที่แล้ว +1

    OMG I was so going "its 76 to 100" on the MCV😂😂

  • @ABC-fv7ow
    @ABC-fv7ow 4 ปีที่แล้ว +2

    Nicely explained.Since TTP is intravascular hemolysis,then why splenomegaly in it?Pls answer

    • @SixthKiller
      @SixthKiller 4 ปีที่แล้ว

      To increase the plt count. This is no longer applicable.

    • @DucTapeDino
      @DucTapeDino 4 ปีที่แล้ว

      Im pretty sure its because you are getting Schistocytes from the platelet microthrombi that is being formed in TTP. Its shearing the rbcs as they come along and so now that they are effected/damaged, the spleen filters them out which causes the spleen to overwork leading to work induced hyperplasia. i.e. splenomegaly.

    • @DucTapeDino
      @DucTapeDino 4 ปีที่แล้ว

      Or it could be what SixthKiller is saying and just extramedullary hematopoesis occurring due to the loss of platelets but i dont rlly believe that since there is no hepatomegaly.

  • @sarayaraddad23
    @sarayaraddad23 2 ปีที่แล้ว

    Amazing video 🙏🏻

  • @andreacanepa2560
    @andreacanepa2560 3 ปีที่แล้ว

    Loved it, thanks!

  • @dranamika3
    @dranamika3 4 ปีที่แล้ว

    Fantastic man!

  • @roshnyjacob5493
    @roshnyjacob5493 4 ปีที่แล้ว +1

    amazing videos. Do you talk on histopathology topics?

  • @DinaAwd
    @DinaAwd 3 ปีที่แล้ว +1

    Loved it thank u so much 💖

  • @kennedychisenga4001
    @kennedychisenga4001 3 ปีที่แล้ว

    Glad I've come to know you

  • @زهراءسعدمحمدصالح
    @زهراءسعدمحمدصالح 3 ปีที่แล้ว

    You are amazing thank you so much ☘️🙏🏻

  • @Kamalesh_77
    @Kamalesh_77 5 หลายเดือนก่อน

    5:25
    Ribozyme is not a protien I guess

  • @fidelia5937
    @fidelia5937 2 ปีที่แล้ว +12

    I have 2 boys and now my baby girl husband and I are carriers..... But no matter what science says nothing is impossible for God Doctors are always surprise how my boy body react prayers are so powerful never stop believing God is amazing and always can do miracle's TTP🔗chain breakers Philippians 4:13🙏❤ thank you Dr beautiful explained

  • @kpot9357
    @kpot9357 4 ปีที่แล้ว

    thank u, helpful video
    BTW in university, we were taught that schistocytes could never be an artifacts

  • @Moosemoose1
    @Moosemoose1 3 ปีที่แล้ว

    I have a question: if the inhibitor of the ADAMST13 gene is IgG, why isn't TTP considered an immune disorder?

    • @ahmedrashwan7250
      @ahmedrashwan7250 3 ปีที่แล้ว

      It is actually considered immune disorder and ttt is prednisone for that cause

    • @Moosemoose1
      @Moosemoose1 3 ปีที่แล้ว

      @@ahmedrashwan7250 ah, then what would differentiate it from ITP in that case?

    • @ahmedrashwan7250
      @ahmedrashwan7250 3 ปีที่แล้ว

      @@Moosemoose1 I asked myself the same question and the answer is that ITP is a no platelet thing but TTP is crazy platelets the forms thrombosis every where causeing micro angiopathic hemolysis of r.b.cs and stuff like that

  • @sathakamara1324
    @sathakamara1324 2 ปีที่แล้ว

    What's with the purple cat at the end?

  • @nagatsatti8426
    @nagatsatti8426 4 ปีที่แล้ว

    Wonderful and excellent thank you doctor

  • @motomoto898
    @motomoto898 4 ปีที่แล้ว

    Excellent. Thank you.

  • @AliHamza-bz2oo
    @AliHamza-bz2oo ปีที่แล้ว

    Why fever occurs in ttp plz explain

  • @ShilpaSharma-tf4of
    @ShilpaSharma-tf4of 2 หลายเดือนก่อน

    Brahmi Chyawanprash for planet Ayurveda It supports almost all systems of the body. It is a purely natural product and does not contain binders, preservatives, additives, yeast, and fillers in it.

  • @marciadorsey3974
    @marciadorsey3974 3 ปีที่แล้ว +1

    he cracks me up

  • @dimana1004
    @dimana1004 2 หลายเดือนก่อน

    The FFP joke is elite 😂😂😂😂😂😂omg

  • @aytakchichak7456
    @aytakchichak7456 4 ปีที่แล้ว

    marvellous...thank you

  • @ياسمينالشام-ف3ل7ر
    @ياسمينالشام-ف3ل7ر 4 ปีที่แล้ว +1

    amazing!
    thank you.. I loved it .. but if you could please speak much more slowly.. I'm getting lost sometimes 🥺

    • @heatherrotz3388
      @heatherrotz3388 4 ปีที่แล้ว +3

      change the playback speed to 0.75!

    • @DucTapeDino
      @DucTapeDino 4 ปีที่แล้ว

      Awkward Im over here wishing 3x speed was as option 😂😂😂.

  • @psychewadud
    @psychewadud ปีที่แล้ว

    Why there is hemolysis i could not get it. Plz help

    • @123456789suarez
      @123456789suarez ปีที่แล้ว

      Due to the deposition of microthrombi in the small vessels, the lumen becomes narrower. RBCs try to squeeze through the narrowed lumen....and it goes boom

  • @drsamkitshah6177
    @drsamkitshah6177 4 ปีที่แล้ว +1

    Excellent!!!!!!

  • @al-qira8596
    @al-qira8596 4 ปีที่แล้ว

    Amazing Keep up journey

  • @bellenaval784
    @bellenaval784 3 ปีที่แล้ว

    hi do you have document for these?

  • @FatimaBaloch-n6z
    @FatimaBaloch-n6z ปีที่แล้ว

    Amazing 😍😍

  • @mekdadhassan4282
    @mekdadhassan4282 3 ปีที่แล้ว +1

    Amazing vedio 🌹

  • @afridi3dart17
    @afridi3dart17 3 ปีที่แล้ว +2

    Hhhh as you educating others as well as you bringing smile 🙂🙂😁 also the way you are teaching wooooww and you also making question from yourself and answering too

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  3 ปีที่แล้ว +1

      Thank you 😊

    • @afridi3dart17
      @afridi3dart17 3 ปีที่แล้ว

      @@MedicosisPerfectionalis i was my assignment and watching many videos but at least I found it at your channel and hence completed my assignment 🙂🙂☺️ love you

  • @chrisa.8032
    @chrisa.8032 หลายเดือนก่อน

    Medicosis - The Rolls-Royce of Medicine

  • @stellarose4854
    @stellarose4854 3 ปีที่แล้ว

    My brother is in hospital with this he is only 12 please give me hope

    • @sydalg95
      @sydalg95 ปีที่แล้ว

      I'm 29 I had it when I was younger than your brother

    • @sydalg95
      @sydalg95 ปีที่แล้ว

      It rarely even crosses my mind this many years later

  • @rahmahl5762
    @rahmahl5762 3 ปีที่แล้ว

    I don’t get the answer ☹️☹️

    • @rahmahl5762
      @rahmahl5762 3 ปีที่แล้ว

      AKI + Thrombocytopenia? 😕

    • @rahmahl5762
      @rahmahl5762 3 ปีที่แล้ว

      Yuppp I’ve already watched the next video
      It’s MAHA + thrombocytopenia 🤭

  • @mahdi6832
    @mahdi6832 2 หลายเดือนก่อน

    nice information

  • @srinivasaraosirasapalli5104
    @srinivasaraosirasapalli5104 2 ปีที่แล้ว +1

    Excellent

  • @HarteTed
    @HarteTed 3 หลายเดือนก่อน

    178 O'Keefe Prairie

  • @roop502
    @roop502 4 ปีที่แล้ว

    Wonderful!!!!!

  • @mhuraic
    @mhuraic 4 ปีที่แล้ว

    Why is there a fever in TTP?

    • @billybarker3064
      @billybarker3064 4 ปีที่แล้ว

      I have TTP. 7 episodes. Not a single fever.

    • @sofacitysounds947
      @sofacitysounds947 4 ปีที่แล้ว

      Never had a fever either.
      1 episode...super severe though

    • @SixthKiller
      @SixthKiller 4 ปีที่แล้ว

      I am with ttp and I had a massive sweating all the time. Today was my second plasmapheresis.

  • @msbzamalek
    @msbzamalek ปีที่แล้ว +1

    Great 👍

  • @brewedmeditation2886
    @brewedmeditation2886 11 หลายเดือนก่อน

    Upshaw Schulman syndrome. Very difficult name for Bengali

  • @mandisangema2568
    @mandisangema2568 3 ปีที่แล้ว +1

    LOL! The Rolls Royce of Medicine

  • @abdou.b3259
    @abdou.b3259 7 หลายเดือนก่อน

    There is no fever

  • @LeeMinhoNepal
    @LeeMinhoNepal 4 ปีที่แล้ว

    I want to know how you make such videos. Writing and making pictures too. always explained best.

  • @eltonfredy8558
    @eltonfredy8558 4 ปีที่แล้ว +3

    I'm waiting for your explanation about DIC 😁😁

  • @kingstonfreeman9309
    @kingstonfreeman9309 2 ปีที่แล้ว

    it was very scary this is sierous

  • @doc1780
    @doc1780 4 ปีที่แล้ว

    Fever and no bloody diarrhea !

  • @deepakg4623
    @deepakg4623 2 ปีที่แล้ว

    My baby 5 manth old TTP

  • @GretchenTurbyfill-f5w
    @GretchenTurbyfill-f5w 3 หลายเดือนก่อน

    Vandervort Summit

  • @udithaudumulla1139
    @udithaudumulla1139 4 ปีที่แล้ว

    So funny ..thank you ❤️

  • @shamisomushayi1486
    @shamisomushayi1486 3 ปีที่แล้ว +1

    Rolce Roy's medicine

  • @VogtDaphne
    @VogtDaphne 3 หลายเดือนก่อน

    2563 Krystel Mount

  • @SassoonCheryl-y6p
    @SassoonCheryl-y6p 3 หลายเดือนก่อน

    Ernestina Groves

  • @mohammedimam2412
    @mohammedimam2412 4 ปีที่แล้ว

    Can u make an Arabic translate for your videos?

  • @Yottifferent
    @Yottifferent 3 ปีที่แล้ว

    Here bc J Dilla died from this

  • @sonysanaka6056
    @sonysanaka6056 2 ปีที่แล้ว

    Hello telugu lo explain chIagalaru

  • @grmnsmith145
    @grmnsmith145 2 ปีที่แล้ว

    My mom died from this

  • @toufytaylorsversion8700
    @toufytaylorsversion8700 4 ปีที่แล้ว +1

    you are so fast slow down a bit

  • @douglasthescottishtwin3989
    @douglasthescottishtwin3989 2 ปีที่แล้ว

    Tehrik-i-Taliban Pakistan is TTP

  • @abdirahmangulled8128
    @abdirahmangulled8128 2 ปีที่แล้ว

    You're goated 😂

  • @ЮлияШеина-с4д
    @ЮлияШеина-с4д 4 ปีที่แล้ว

    AKI & MAHA?🙈

  • @IvethFonsecaop-x5z
    @IvethFonsecaop-x5z 4 หลายเดือนก่อน

    Perez Patricia Lee Sandra Lee Barbara

  • @drvivekpratap
    @drvivekpratap ปีที่แล้ว

    Gr8

  • @jamalimurtaza6527
    @jamalimurtaza6527 4 ปีที่แล้ว

  • @WalkerVirgil-i6q
    @WalkerVirgil-i6q 3 หลายเดือนก่อน

    Young Patricia Harris Frank Lewis Matthew

  • @denniswebster3519
    @denniswebster3519 3 หลายเดือนก่อน

    Young Susan Robinson George Perez Kenneth

  • @ebisinecarlmaristobi8842
    @ebisinecarlmaristobi8842 ปีที่แล้ว

    Hello, your teaching is really nice but you talk really fast it would be nice to tone down your pace. Thank you

  • @PhoenixRising-21
    @PhoenixRising-21 ปีที่แล้ว

    Slow down with explanation