Homology-dependent double strand break repair

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  • เผยแพร่เมื่อ 7 ก.ย. 2024
  • In this animation, we explore how a transposon moves as a consequence of DNA cut-and-paste transposition.
    ukcatalogue.oup...

ความคิดเห็น • 55

  • @reeseymeimei
    @reeseymeimei 9 ปีที่แล้ว +794

    I will take my genetics exam and remember this man whispering about double strand break repairs.

  • @gingerrmoe
    @gingerrmoe 7 ปีที่แล้ว +410

    Snape, you gotta move away from the microphone when you breathe.

    • @Ethentent
      @Ethentent 7 ปีที่แล้ว +6

      I thought the same thing! But yeah, it sounds like he's trying to make an ASMR video xD

  • @uneloutredeuxloutres
    @uneloutredeuxloutres 6 ปีที่แล้ว +234

    Is this oxford press ASMR?

    • @leenasa2286
      @leenasa2286 5 ปีที่แล้ว

      Lise Rose MAURIN 😭😭😭😭

  • @daniellaschaening4470
    @daniellaschaening4470 6 ปีที่แล้ว +50

    Wow! I didn't know I could speak parseltongue, but I understood everything this guy just said!

  • @taylorbrady4213
    @taylorbrady4213 9 ปีที่แล้ว +151

    This guy should be a Bond villain.

    • @k.j.b.h5245
      @k.j.b.h5245 8 ปีที่แล้ว +1

      +Taylor Brady Jajaja i thought the same when first listened his voice.

  • @karstenlane6864
    @karstenlane6864 9 ปีที่แล้ว +39

    This was incredibly helpful. To see this animation done with DNA looking structures, as oppose to just lines, made a world of difference. Thank you millions :D

  • @misterphuzz
    @misterphuzz 7 ปีที่แล้ว +54

    I don't care about the voice. At least I can understand the words he speaks, unlike many other big-time science video producers. And the visuals were so helpful.

  • @omrisinder5602
    @omrisinder5602 8 ปีที่แล้ว +208

    whats going on with that man voice??
    does anyone else feel discomfort with that??

    • @Kjonesa
      @Kjonesa 7 ปีที่แล้ว +34

      literally only went to the comments section to see if anyone else noticed that, lol.

    • @skarpengland
      @skarpengland 5 ปีที่แล้ว +1

      his voice is awesome. Funny part of learning for oncology.

  • @adrianbulfon8430
    @adrianbulfon8430 10 ปีที่แล้ว +8

    One of the best videos Ive seen to date!

  • @roveradamus
    @roveradamus 9 ปีที่แล้ว +66

    Good video. But the narration made me uncomfortable. Please record the audio away from the microphone please!

  • @simonbaker9909
    @simonbaker9909 9 ปีที่แล้ว +9

    Valuable animation, but could use some more explanation, such as: 1) under what conditions is the homologous dsDNA conveniently located nearby, and how is the physical coordination/matching of regions initiated; 2) other references (wikipedia) mention two different paths to resolving the bubble, one involving cross-over, the other not -- is this true, or is this video more accurate information showing only the non-crossover way; 3) how does the bubble know when it has synthesized enough new DNA on the invading strand to match the other hanging end of the broken DNA?
    Why is the description of the video seemingly wrong ("Published on Aug 12, 2014
    In this animation, we explore how a transposon moves as a consequence of DNA cut-and-paste transposition. ")?

  • @dinosaursgorawrish
    @dinosaursgorawrish 8 ปีที่แล้ว +61

    its worse because when you turn up the volume you can hear his heavy gasp for air in between sentences

  • @anubhavdas2095
    @anubhavdas2095 5 ปีที่แล้ว +8

    Really nice video, I got goosebumps

  • @karenn.8810
    @karenn.8810 8 ปีที่แล้ว +13

    good animation and well explained ! this was very helpful

  • @moonju0116
    @moonju0116 9 ปีที่แล้ว +49

    Why is this guy whispering?

  • @sym2988
    @sym2988 6 ปีที่แล้ว +1

    even though you whispered through this whole thing this was a great visualization aid, thank you

  • @MrCharanthej
    @MrCharanthej 5 ปีที่แล้ว +1

    Great video.....Both videos on Homologous repair and Non homologous repair are nice...Thankyou.....

  • @ImperialGoldfish
    @ImperialGoldfish 6 ปีที่แล้ว +3

    Incredibly helpful explanation, thank you

  • @kufuffin47
    @kufuffin47 5 ปีที่แล้ว +1

    Amazingly helpful animation. Thank you!

  • @murg526
    @murg526 6 ปีที่แล้ว +3

    That voice will be haunting me

  • @Dornatum
    @Dornatum 8 ปีที่แล้ว +1

    I don't understand how the C region is entirely newly synthesized DNA. I thought the endonucleases only removed one strand of DNA from the site of damage. At 0:36, I still see a single strand of C. How is that removed later on?

  • @AMillionOs
    @AMillionOs 7 ปีที่แล้ว +5

    His voice makes you automatically think he knows what he's doing

  • @xx8113
    @xx8113 6 ปีที่แล้ว

    brilliant video---!love the animation!

  • @NH-px6vj
    @NH-px6vj 5 ปีที่แล้ว +3

    This boy seriously needs to learn how to use his voice effectively when presenting something to people. I can’t focus at all because his voice is like a noise. He’s gotta speak clearly

  • @turma85medicinaepm7
    @turma85medicinaepm7 6 ปีที่แล้ว

    very comprehensive, thank you.

  • @DeemahAd
    @DeemahAd 9 ปีที่แล้ว

    Did you mention that the nuclease digests 5' ends???

  • @oglow100
    @oglow100 9 ปีที่แล้ว +7

    Thuderf00t is that you?

  • @sebastianaguiarbrunemeier9192
    @sebastianaguiarbrunemeier9192 6 ปีที่แล้ว

    Well explained

  • @goldenyuusha
    @goldenyuusha 7 ปีที่แล้ว +2

    this was like asmr

  • @hazemelnahrawy2715
    @hazemelnahrawy2715 7 ปีที่แล้ว

    great

  • @peishitan2519
    @peishitan2519 9 ปีที่แล้ว +1

    Hmmmmmm Where did the homologous strand come from? Did it come from its sister chromatid?

  • @SrirachaPilsner
    @SrirachaPilsner 6 ปีที่แล้ว +1

    why is werner herzog explaining homologous repair to me rn

  • @bongwhanyeon9584
    @bongwhanyeon9584 8 ปีที่แล้ว +2

    It sounds like Jigsaw

  • @MrMetalHead1100
    @MrMetalHead1100 6 ปีที่แล้ว

    it looks like it created a repeat in the DNA

  • @maria11135
    @maria11135 8 ปีที่แล้ว +5

    With this voice. NO!!!

  • @zackfairthepuppy
    @zackfairthepuppy 7 ปีที่แล้ว +4

    Bio ASMR

  • @ldnt1698
    @ldnt1698 7 ปีที่แล้ว

    This is probably a really stupid question but the other name for this method of repair is Homologous Recombination, Right?

    • @ldnt1698
      @ldnt1698 7 ปีที่แล้ว

      and micro homology - mediated end joining is the other video, the Holliday junction resolution.

  • @Sannoon93
    @Sannoon93 6 ปีที่แล้ว

    am i color blind or the "pink" strand is actually purple hahaha men! just kidding :P very useful video narrated by the a guy who is extremely dehydrated yet congested and should narrate the villain in a movie or something!!

  • @omerfaruksimitcioglu3190
    @omerfaruksimitcioglu3190 9 ปีที่แล้ว

    içinden konuşuyo sanırım

  • @jschoong94
    @jschoong94 9 ปีที่แล้ว

    Narration can be improved.

  • @isabelshelton07
    @isabelshelton07 6 ปีที่แล้ว

    thanks for the video but creepy voice

  • @rakeshbam9883
    @rakeshbam9883 9 ปีที่แล้ว +7

    confusing as heck

  • @00the00virus00
    @00the00virus00 8 ปีที่แล้ว +3

    Horrible voiceover.