From now..when ever I 'll get bored of book-reading I will come to this channel. We medical students need more videos like this and the songs.. whenever you end with human physiology I would like you to go towards plant physiology which is also imp. for many pre -medical students...❤😍thanks alot
@Wanderlust my first year, first semester, Anat and physio 😂 Edit for context: it was all online because of 2020s chaos so all of the professors combined to teach the sections like one class online. So I had 3 lecture instructors and 1 lab and it was an absolute nightmare smh. Good news, I made it 😂
Super helpful! I have a rare genetic mutation that causes a malformation of sodium and potassium voltage gated ion channels and it is very helpful for me to learn more about how these systems (are supposed to) work.
you answered the 2 questions that none of my teachers from highschool AP to university was never able to teach me. and you did it in 5 minutes. 1. how do action potentials cause depolarization to move down the axon..what it actually looks like...na spreading out 2. what it actually means when they say "resting potential is maintained by na/k pump"
This video is so helpful I always watch TH-cam videos before going to lecture so that I'm not sitting there all confused and your video was so helpful you explained everything so concisely and in a way that's so easily understood thank you!
Thankyou so much for making this video so perfectly. I had seen many video ..but they loose some important points.. which makes me confuse. But i learnt very well from this one.
hi this was so useful to watch thank u!! i just have a q abt the relative proportions of charges in the short bit after hyperpolarisation? u said the Na/K pump will bring it back to resting mem potential. if the Na/K pump is transporting net 1 positive ion out, so the inside goes from negative to even more negative, why isnt it hyperpolarising further away from resting mem potential?
Using the term overshoots at the 3:14 mark is very misleading as the "overshoot" of an action potential is typically reserved for the peak of the action potential. During this phase, the membrane potential is >0 mV rather than the negative value the red arrow suggests in the illustration of an action potential.
just wondering- you said na channels close at +30, but don't they first inactivate... and don't actually close until we reach hyperpolarization.. which gives the absolute and relative refractory periods?
Hi Jakari, Not sure I understand your first question, but there are definitely sodium channel blocking drugs - e.g. lidocaine - the local anesthetic. Voltage-gated sodium channels are closed at rest, but there are leaky sodium and potassium channels that are open at rest. Hope that helps!
@@NeuralAcademy Sorry for the misunderstanding. I believed that there was a structure connected to the membrane that hangs down and begins to block the voltage-gated sodium channels as the action potential begins to repolarize.
@@jakarigainer91 You're probably referring to the *inactivation* gate, which this video has ignored, and called just a 'second gate'. It's sometimes referred to as a 'ball and chain' gate. And you're right as to when it operates. And when the voltage gate is closed, that inactivation gate is *not* also closed, as shown in the video, it's *open* . It only begins to close sometime after the voltage gate has opened, with the time delay determined mostly by the *length* of the tether that attaches to the blocking inactivating 'ball'.
this video and so many others disregard the fact of sodium inactivation that begins and the peak of the action potential and ends after hyperpolarization
From now..when ever I 'll get bored of book-reading I will come to this channel. We medical students need more videos like this and the songs.. whenever you end with human physiology I would like you to go towards plant physiology which is also imp. for many pre -medical students...❤😍thanks alot
You are teaching me more than all 4 of my Anatomy professors combined
Of course he is teaching more than the anatomy professors, this is physiology
@@firefoxyt6600 😂😂😂😂
@Wanderlust my first year, first semester, Anat and physio 😂
Edit for context: it was all online because of 2020s chaos so all of the professors combined to teach the sections like one class online. So I had 3 lecture instructors and 1 lab and it was an absolute nightmare smh. Good news, I made it 😂
Hope you guys will become popular soon, the videos are such high quality!
Aww, thank you so so much! :-D We're excited because the channel is growing so quickly! Comments and likes and subscribes and shares really help!
Super helpful! I have a rare genetic mutation that causes a malformation of sodium and potassium voltage gated ion channels and it is very helpful for me to learn more about how these systems (are supposed to) work.
Thank you so much. Going to watch this on repeat probably until I get it all.
this was amazing. makes everything very understandable. 100% recommended the video to anybody.
Animation have always helped me understand the material better. Thank you!
I've never understood this since my premed years, never thought I can get it at all. Thanks to you guys I finally get it now. Huge thanks.
By far the best explained video about action potential!
Amazing illustrations. 👌👌👌👌👌
you answered the 2 questions that none of my teachers from highschool AP to university was never able to teach me. and you did it in 5 minutes.
1. how do action potentials cause depolarization to move down the axon..what it actually looks like...na spreading out
2. what it actually means when they say "resting potential is maintained by na/k pump"
so well organized. explained physiology beautifully
the best video out there on the action potential....thank you so much for helping me learn this.
Your teaching way is amazing! Thank you buddy!
I love this channel. You've been helping me a lot making sure I'm writing correct answers for my study guide for school.
Lovely animation ♥️♥️♥️ thanks
..
.
This channel is soooo underrated 🥺
Loved it ..brief and to the point
This video is so helpful I always watch TH-cam videos before going to lecture so that I'm not sitting there all confused and your video was so helpful you explained everything so concisely and in a way that's so easily understood thank you!
U deserve way more subscribers!!!
Thanku for making it easier 😊
amazing amazing video. Helped me understand the topic so much better. thanks again!
I just luv ur explanation
Excellent , one of the best explanations I’ve seen
Awsome video!!!! Im stunned im studying medicine and not even my orofessor could explain like that perfect speed
After 3 videos, 5 chapters, 2 books and 1 hour crying FINALLY I understand
I love the way you explain :,) and the songs are touchwood😄😍😁😀thanx😁 hope u will go more higher and higher :,)
Just loved the explanation! Thank you.
Such a great video, thank you!!
Ur saving lives! Thank you
Top quality guys well done x
I really understood the concept. Thank you. It was done very well. I hope you complete other videos.
Really an awesome vdo!!!! Applauses!!
Perfect explanation!
Thankyou so much for making this video so perfectly. I had seen many video ..but they loose some important points.. which makes me confuse. But i learnt very well from this one.
Understood very easily thanks
Excellent video and explanation! I understood everything very easily, thank you.
Super helpful
Thank you
hi this was so useful to watch thank u!! i just have a q abt the relative proportions of charges in the short bit after hyperpolarisation? u said the Na/K pump will bring it back to resting mem potential. if the Na/K pump is transporting net 1 positive ion out, so the inside goes from negative to even more negative, why isnt it hyperpolarising further away from resting mem potential?
Using the term overshoots at the 3:14 mark is very misleading as the "overshoot" of an action potential is typically reserved for the peak of the action potential. During this phase, the membrane potential is >0 mV rather than the negative value the red arrow suggests in the illustration of an action potential.
OMG this was so helpful!! THANK YOU
we all understand now thanks to you
Oh god thank you. Understood this very easily!
Thank you so much
nicely explained
Wonderful
Hello...how does hypocalcemia lead to muscle spasms? How does calcium in hypocalcemia cause increased depolarization? Thank you for this video.
it was amazing ..THANKYOU
Good job 🥰🥰🥰
So helpful!!!!!
You deserve many likes
just wondering- you said na channels close at +30, but don't they first inactivate... and don't actually close until we reach hyperpolarization.. which gives the absolute and relative refractory periods?
Thank you so much, it was really helpful!
How Could Na and K Pump maintain back hyperpolarization from -90 to -70 ???
I’m a grad student and this is saving my ass rn
thank you so much--very helpful!! :)
Thank you
Interessante! Il passaggio di elettricità dei neuroni, sembra simile ad una corrente alternata
Loved it
its was fantastic
Hermoso todo.
Is there anything that has to do with blockades on the voltage-gated sodium channels and inactivation?
Also, are the sodium channels closed at rest?
Hi Jakari, Not sure I understand your first question, but there are definitely sodium channel blocking drugs - e.g. lidocaine - the local anesthetic. Voltage-gated sodium channels are closed at rest, but there are leaky sodium and potassium channels that are open at rest. Hope that helps!
@@NeuralAcademy Sorry for the misunderstanding. I believed that there was a structure connected to the membrane that hangs down and begins to block the voltage-gated sodium channels as the action potential begins to repolarize.
No problem! The voltage gated sodium channels close quickly at the peak of the action potential.
@@jakarigainer91 You're probably referring to the *inactivation* gate, which this video has ignored, and called just a 'second gate'. It's sometimes referred to as a 'ball and chain' gate. And you're right as to when it operates. And when the voltage gate is closed, that inactivation gate is *not* also closed, as shown in the video, it's *open* . It only begins to close sometime after the voltage gate has opened, with the time delay determined mostly by the *length* of the tether that attaches to the blocking inactivating 'ball'.
this video and so many others disregard the fact of sodium inactivation that begins and the peak of the action potential and ends after hyperpolarization
great
🙏🙏🙏
Perfect
If you'd like, I can help with the voice narration free of charge!
way better than john green. takes him way too long to get to the point and goes off track a lot
all of these happen when i flex my arm
all of these happen when you blink
4:44
60th n