CRISPR: Can we control it? | Jennifer Doudna, Richard Dawkins, Steven Pinker, & more | Big Think
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- CRISPR: Can we control it?
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CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a revolutionary technology that gives scientists the ability to alter DNA. On the one hand, this tool could mean the elimination of certain diseases. On the other, there are concerns (both ethical and practical) about its misuse and the yet-unknown consequences of such experimentation.
"The technique could be misused in horrible ways," says counter-terrorism expert Richard A. Clarke. Clarke lists biological weapons as one of the potential threats, "Threats for which we don't have any known antidote." CRISPR co-inventor, biochemist Jennifer Doudna, echos the concern, recounting a nightmare involving the technology, eugenics, and a meeting with Adolf Hitler.
Should humanity even have access to this type of tool? Do the positives outweigh the potential dangers? How could something like this ever be regulated, and should it be? These questions and more are considered by Doudna, Clarke, evolutionary biologist Richard Dawkins, psychologist Steven Pinker, and physician Siddhartha Mukherjee.
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TRANSCRIPT:
0:41 Jennifer Doudna defines CRISPR
3:47 CRISPR’s risks
4:52 Artificial selection vs. artificial mutation
6:25 Why Steven Pinker believes humanity will play it safe
9:20 Lessons from history
10:58 How CRISPR can help
11:22 Jennifer Doudna’s chimeric-Hitler dream
- Our ability to manipulate genes can be very powerful. It has been very powerful.
- This is going to revolutionize human life.
- Would the consequences be bad? And they might be.
- Every time you monkey with the genome you are taking a chance that something will go wrong.
- The technique could be misused in horrible ways.
- When I started this research project, I've kind of had this initial feeling of what have I done.
JENNIFER DOUDNA: CRISPR gene-editing technology is a tool that scientists can use to change the letters of DNA in cells in precise ways. So I like to use the analogy of a word processor on a computer. So we have a document, you can think about the DNA in a cell, like the text of a document that has the instructions to tell the cell how to grow and divide and become a brain cell or a liver cell, or develop into an entire organism. And just like in a document, the CRISPR technology gives scientists a way to go in and edit the letters of DNA. Just like we might cut and paste text in our document or replace whole sentences, even whole paragraphs or chapters. We can now do that using the CRISPR technology in the DNA of cells. CRISPR is an acronym that actually represents a sequence of DNA letters in the genomes of cells. It's found in bacteria and it was interesting to scientists originally because it's a bacterial immune system, a way that bacteria can fight viral infection. For scientists this is sort of really a gift that allows research to proceed very quickly in terms of understanding the genetics of cells and organisms but also provides a very practical way to solve problems. In clinical medicine, the opportunity to make changes to blood cells that would cure diseases like sickle cell anemia, a disease where we've understood the genetic cause for a long time. But until now there hasn't been a way to actually think about treating patients. And now with this technology, it's possible in principle to remove stem cells that give rise to blood cells in a person's body, make edits to those cells that would correct the mutation causing a sickle cell disease and then replace those cells to essentially give a patient a new set of cells that don't have the defect. It's one thing to talk about being able to remove mutations from the human population that cause genetic disease. And I think for many people that would be a desirable thing to do. On the other hand, I think it's a very different discussion to think about using a technology like this to create enhanced human beings. People that are taller or have a certain eye color or other kinds of physical or intellectual traits that might be considered desirable. And it sort of immediately brings up sort of the the whole area of eugenics and sort of access to technology. Who gets access, who pays for it, who decides, who decides whether or not to do such a thing, should companies be allowed to offer this as a service to parents who want to do this and if so, should they be regulated in some way? There's a lot of very interesting and challenging questions, I think that go along with that.
RICHARD CLARKE: The technique could be misused in horrible ways. It could be...
To read the full transcript, please visit bigthink.com/videos/crispr-ca...
Does the positive potential of CRISPR outweigh the danger?
Absolutely it does
We can get rid of cancer born illnesses and anything negative in our genetics, so I'd say yes! Good luck!
Doesn't really matter at this point what any of us think about it, it's going to be used now regardless of that.
@@bruhsoundeffect2882 anything anyone comes up with will be used by friends and coworkers until they die or pass on the knowledge, that's all science is. Look at bill gates trying to put maasive amounts of co2 in the air to dim the sun, worst case scenario is it creates mini ice ages everywhere but does it matter? No, life finds a way and just like what happened before we respawn and try try again like if it was a video game. The only difference is our starting gear, I like the technology of today and the advancements we are doing however I dont like the idiots gaining power and testing theories without first thinking of the consequences and without testing it small scale first. Elon musk is trying to take us to mars so I gotta say this, if Bill gates really wants to try the great co2 experiment, first let us civilize mars so on the offhand I'm right and we go into an ice age, we dont lose all our shit and have some technology to come back from... Otherwise we are shitting where we eating and that's what will kill us in the end regardless of the intentions.
100%
I'm sure I'm not the first one to notice that Jennifer's last name works out to Do - U - DNA
Lol
That's crazy
@@yungifez I bet you'll never forget that for the rest of your life ;)
She’s also a man...
she gotta be lab grown with that surname init
ya i know it 5 years ago
I am begging for CRISPR to save my daughter with Huntington's disease
Is getting closer...check all the studies Tel Avid University in Israel is doing...CRISPR is a game changer...I been following for the pass 2 years...the Pfizer and Moderna are here thanks to CRISPR...but, they're have major concerns because China and Russia are already using CRISPR for their soldiers...but, pray to God for this treatment is for everyone not only the rich and powerful....God bless you and you beautiful angel...she's going to be okay.
While I wish your daughter well with her battle with Huntington’s disease, unfortunately it is years, if not decades away from being used for a practical purpose like that. Crispr is still in its early stage, and much more research and development will be needed before we can cure these types of diseases. And when it gets to the point when we can cure these diseases, there will be a long line of rich and important people who will unfortunately be first in line.
@@Bejman13 we're already seeing success in some gene therapies now with blindness, hemophilia, and even leukemia. It's hard to say when a sudden breakthrough will happen, but it will come much faster if people stop fearing all change.
I admit that I don't know much about CRISPR, but like the OP, I wish that this technology was around much sooner to save my daughter. The syndrome my daughter has went undetected during my pregnancy, and I had amniocentesis done to make sure that I was going to have a neurotypical baby. I did everything right. It wasn't until she was in the NICU for a month that they found out that she has Charge syndrome. All her senses are impaired, she's clinically deaf-blind. I had depression for a year and though I love her to death, I'm still fearful for her future, especially if CRISPR becomes popular and will lead to less funding for special needs individuals down the line. I predict that this will be the standard to proofreading your fetus's genes while they're in the womb, and with the special needs population declining, they're going to be discriminated at a much higher rate. I empathize with the OP. Though this technology is wonderful, I can't help but think of GATTACA with discrimination against your genetic code.
Matthew 28:19,20: 10:22
JESUS HEALS!! 👑
Repent, believe and be baptized in the name of the Father, son, and holy ghost. 💕 Time will be no more soon.
My only problem with this is that scientists really do not understand how much they know and how much they don't know about DNA in terms of data and instructions.
Something tells me we're about to find out.
@@klumpytheklown3798
I never really thought about or realized much about genetic engineering until I read the book "Altered Genes, Twisted Truth" about how corrupt the industry is and how much the rules are bent to allow them to experiment with their products on people. Part of that book Drucker the author talks about there being no regulation of GMO foods, and how some years ago scientists discover a whole new system in DNA they didn't understand, thought they have been doing their primitive GMO shotgunning for decades. We are their guinea pigs.
But they will do it no matter what, like the hydrogen bomb. They said before they blew it up , it could ignite the whole atmosphere
Well what do you expect, kinda like reverse engineering an app by looking at it's bytecode
@@nedisawegoyogya
It is nothing like Bytecodes. We invented computers and apps and byte codes, there is no meaning in them other than what we gave them, and they can be deciphered totally. That is not true with DNA at all. They really do not know what they are doing with DNA. Read Altered Genes, Twisted Truth by Steven Druker and find out how nice it is to know what you are talking about.
“And the light of a candle shall shine no more at all in thee; and the voice of the bridegroom and of the bride shall be heard no more at all in thee: for thy merchants were the great men of the earth; for by thy sorceries were all nations deceived.”
- Revelation 18:23 (KJV)
Waiting for this to cure my son who suffer duchenne muscular dystrophy. Each day counts.
Praying for your son
@@freethinker2976 fake
@@himanshu89721 uhm. NO. A 30 YEAR old injury of mine has completely disappeared. In ONE session. So you speak of fake as if you know when you know nothing of the kind. Keep your lies to yourself esp when s/o can and IS making a difference. You, on the other hand, are causing doubt. Shame on you.
@@freethinker2976 c'mon man, don't do this.
Because of evaluations it might actually take a while until CRISPR treatment is common and safe..
Your son is a gift and you can give him the kind of love that only a parent can give. Even and especially when healing might not be in sight. I'm convinced that acts of this love have a permanence beyond what we may yet be able to perceive.
I hope your prayers get answered and don't give up
The final comment from Jennifer Doudna was the best and more sobering warning for those that may be apply the technology for evil. Thank you Jennifer
If anyone is more interested in the history of crispr and its applications, as well as Dounda’s life, I recommend reading the code breaker.
no i sick of hearing all basic expo shiz i ready to start resurecting shizzle, I waiting for you to start growing me my new gf
@@treemanzoneskullyajan711 u rite
They are playing in Satan’s playground. There are consequences for this evil activity. They will know when God starts talking directly to them about trying to recreate His Creation.
@@mimilong3817 k
Brilliant book! I started investing in CRISPR companies after reading it.
The dangers of CRISPR are strongly overvalued in my opinion. We need so much more knowledge on genomics to even begin to give people 'enhanced capabilities'. It could be used for bad ends, but the same is true for all current methods of genetic modification like Zinc fingers and TALENs. CRISPR is just a faster and more reliable means to an end
Finally someone knows what they are talking about. Tired of these complete retards in the comment section spewing nonsense. First intellectual i see here
@@kiwiclips1321 only small thinkers here... i am the only big think....................
At last some one said this, they are giving us way too much credits. Most of us can't even a run a flow cytometry right with out having a few hitches. 😂😂
Oh! This video reminded me, I was going to re-watch the movie "Gattaca" 😉
ME TOOOOOOOOOOOO
No your not you'll forget
I saw it the first time the other night. 90s cheese factor off the charts. Found it hard to watch. Do people really think its a classic?
@@JelqtronZero you are most probably right! xD
@@Jack458111 I don't know, if it is a classic. I watched it many years ago, and want to re-watch, because I barely remember it ;)
I wanna take a moment and thank Big Think for creating this amazing content and raising awareness to this incredible technology.
Incredibly evil. Playing God trying to improve on His Creation. They are all atheists.
They are playing in Satan’s playground. There are consequences for this evil activity. They will know when God starts talking directly to them about trying to recreate His Creation.
This is more than 20 years to late.
They are trying to say sorry for the pandemic and giving Han Hitler the final race solution.
No shit
listening to this, while reading the book The Code Breaker which details the journey of Jennifer Doudna makes me think of the movie Blade Runner. What I realized is that, Tyrell really could have fixed Roy and his group of replicants who forced their way back to Earth. It makes me think of the discussion Roy had with Tyrell in his penthouse and the famous lines from Roy (Rutger Hauer) , how interesting that movie relevance became.
Thanks for the information
Language imprinting itself on biology. The ultimate power move.
Cure muscular dystrophy. That would be an awesome genetic advancement. And a very crispy thank you to the science community. 🕊️❤️🌹
Why stop with MD? There is a very long list of diseases that plague humankind which need eradication and I feel like it's our responsibility to prevent these diseases from inflicting any more suffering on our descendents as it has our ancestors.
no no they are using this to bring down the number to 500.000.000,not for curing anyone.
The inventors might but the rulers wont.
They are playing in Satan’s playground. There are consequences for this evil activity. They will know when God starts talking directly to them about trying to recreate His Creation.
Thank you for this information
I was born a "lame" child and still feel like a "lame" adult at times. However, the more I learn, by reading and listening, I have become more confident with my own "lack of intelligence". Books are great ways to make "genetic modifications" in your own mind if you try.
Alan Watts said it best, "We have the technology to change gens, but I told them, make sure you keep some "regular" people so they can make their own choices." (paraphrased)
Wrt the Alan Watts quote, he just says to ensure they produce a variety of types.... not really "regular"
The last person that wanted to control humanity's hair color and eye color... The same spirit is at work.
Whenever technology this powerful comes forward, it is militarized.
It’s unfortunate but it’s true.
It was militarized before it was made public.
@@Ivan.A.Trulyuski that was my first thought
No. Most technology comes from the military. Believe me. If WW3 started tomorrow. Technology and science would advance ten fold.
I agree, the more powerful the technology, the worst. Like the internet, you know how powerful that is? We should have banished it before it even started. Same with antibiotics, vaccines and sewage systems. (sarcasm)
Quite impressive talks !!! ...
Why doesn't anyone ever suggest improving dental health genetically?
Sign me up for growing new teeth every 20 years please!
imagine your calcium needs tripling, osteoporosis at 30, and still not having good teeth. Teeth are *expensive* to make, and even moreso to make well.
@@kirknay Exactly. I know a very small number of people who have perfect teeth. No dentist is involved, it must be genetic. If there is anything that can be done genetically to make everyone have perfect dental health for life I think more people would want that than for everyone to be tall, blonde and blue eyed.
@@julieisthatart nope, more than likely they just have good diets and take really good care of them.
Most of our dental problems today are due to the food we eat now, not any genetic defects. Even wisdom teeth growing wrong are because we don't put strain on our jaws as kids like our ancestors did with nuts and raw grains.
Strange that Dawkins ignored that American slaves were bred for centuries using artificial selection (which was of course horrendous).
Also the multiple instances of forced sterilization... Strange that Dawkins finds this "easy way" preferable to giving individuals the choice themselves.
For a second there, I thought Dawkins was going to mention Khan, but then I remembered that he doesn't watch movies or television.
Who's Khan?
@@LuisAldamiz star trek villain who is a genetically modified human
@@HansPeter-pj4uf - Ah. I only know Dr. Spock and Klingon language and sometimes I confuse both. It was not really a hit over here back in the 20th century. On the other hand "Battleship Galactica" was and also "V" but Star Trek is barely remembered.
Watched all of it
So, at the very beginning of the video Jennifer Doudna explains how we and all the bio mass that composed of us is, just code in a sequence no more no less... just text in a word processor... I love it! humbling to all those who think they are right about anything that matters... even me, even myself... this very comment is just the consequence of that code and how it interacts to other codes of the same nature and the environment... just a gear in a deterministic machine we call the world, the universe and existence...
What a fantastic video
Fantastically Evil.
Richard DAwkins said (about 5 min in) that we have never used artificial selection on humans. Of course we have, it happens all the time. One example is slavery---on the slave ships, the weak died, the physically strong survived, and then the physically strong were challenged yet again by forcing them into physically demanding work which left only the strongest alive.
The world history of slavery including the Atlantic slave trade was terrible but it wasn’t artificial selection. E.g. the American slaves were free to pair with other slaves. They weren’t paired up so the stronger ones produced more offspring.
I think you are talking about natural selection.
@@gazlives Um, pretty sure you're wrong about that. Slave owners were smarter than you think.
"You've had CRISPR gene changes?" "Yes, I have gained 10 IQ points! Of course I now have deer antlers that growing out of my shoulders, but that's ok..."
lmaoooooooooooooooo u right
The assertion that increasing IQ might be risky was absurd. It seems equally likely, if not more likely, that increasing IQ would unintentionally cure diseases.
i dont think they will give anyone an IQ points. no they wont
Lmao !
For you formed my inward parts;
you knitted me together in my mother's womb.
I praise you, for I am fearfully and wonderfully made.
Wonderful are your works;
my soul knows it very well.
My frame was not hidden from you,
when I was being made in secret,
intricately woven in the depths of the earth.
Psalm 139:13-15
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I hope that Will give us a bigger life span and a better quality life. Health is a very expensive thing
This technique has been used on patients with sickle-cell disease in a study. The study was stopped because some patients developed cancer after treatment (leukemia) and preliminary trials didn't proof to be effective.
@@danbo967 Oh, didn't work first try. We should probably give up then.
@@DAndyLord No, you should think about the human sacrifice it takes to follow this route.
@@danbo967 Human sacrifice is required for medical advancements. So long as there is informed consent, it's a really important part of medical research.
If not for the sacrifice of the people testing our vaccines we'd never have vaccinated anyone.
@@DAndyLord sure that’s why I said it’s something to think to about.
I have been interested in DNA and CRISPR since I did a Coursera course in Astrobiology mainly due to having scoliosis (Curvature of the Spine) and often have thought that genetic manipulation would be a lot safer than having the damaged part of a spine cut out and replaced with a metal rod. If that actually works by introducing hundreds of new cells into the body, how many people not just people suffering scoliosis but other spinal injuries would benefit from CRISPR.
Like every action (karma), it can be used to benefit or to harm. There is nothing absolute about CRISPR, but there are choices and their consequences to be considered to enable staying on the path of benefit/compassionate positive action, versus straying to the path of power for ego aggrandization/evil.
Why Prof. Virginijus Siksnys 🇱🇹 is not mentioned. He was in the forefront of the discoveries about this technology.
Genetic changes are usually filtered by the environment.
That filtering can be a painful process!
Can anyone who understands the subject answer me this question i had for years: I understand how CRISPR can "edit" the DNA of one cell but how can it spread to all the cells in the body? Say you want to edit a certain gene in an adult human, how can the CRISPR go to all the millions of cells in the body and edit that gene?
That only happens when you edit the genes of am embryo, which then divides and grows into a full person.
So one of the ways that is almost possible is if you use a virus to carry the DNA insert and CRISPR protein /sgRNA. Vira are quite small though and can only carry very limited sizes of DNA inserts. The cool think about vira is that they can self replicate though and bind to specific cells given the correct receptors :). Hope that answers your question.
@@DamKaKaDaNi If I understood you correctly, So "the virus" will affect the whole body and edit all the cells, nails, hair all of it?
@@TheCreeeg This was previously my understanding of the technology. But I heard few experts talking about editing adult genes.
@@user-hh2is9kg9j yes I believe it can be used in adults, but thr crispr is "aimed" at a specific cell type, like red blood cells only. Or something like that. (I'm no expert, but I have learned a lot from the book The Codebreaker about the lady Doudna)
Creating humans to do menial tasks is a moot point… we’re already heading down robotics and AI routes for that. So that doesn’t worry me at all… it’s more worrying to think there’s an option to weaponise this kind of technology.
“ Current trials are underway in five treatment areas: blood disorders, cancers, eye disease, chronic infections, and protein-folding disorders. All current CRISPR clinical trials are intended to edit specific cells or tissues without affecting sperm or eggs, meaning no DNA changes can be passed onto future generations.” Source: Innovative Genomics Institute. Explanation on their website.
Brave New World anyone?
i think the more interesting and maybe even practical question is designing life forms and DNA sequences from the ground up. although something like that seems very far off
Imagine a hybrid machine human man-made serial killer. I guess cops feel threatened now. They’ll be replaced. So much for defending “authority.”
It's already been done. If you look for it you'll find it.
@@juanfernandez1696 i should have been more specific and said intelligent life forms
@@mahlina1220 imagine sub humans
Would have been interesting if big think also had Dr John Sanford to give his thoughts on this.
Personally I would side with the "no way" camp. History has shown us repeatedly how evil mankind is. If there is a way to use this for power, we will do it. We like to praise and glorify intelligence, to often at the expense of wisdom. This technology could become to powerful for our own good. I'm sure AI will be our demise anyway, long before we have this fully developed.
Well it is out there. We might as well make the best out of it!! And "bad countries" wont ban it and will use it anyhow. So they should might as well push it in ethical countries to not stay behind and allowing more power to "bad countries" It is a wonderful discovery
They are playing in Satan’s playground. There are consequences for this evil activity. They will know when God starts talking directly to them about trying to recreate His Creation.
@@pamelathompson6783 :
You will find out the truth one of these days. Just like I did. I was a previous non religious person…that was, until I literally, saw he light.
Does the ant look up to the heavens at night and understand the workings of the universe? Does it even understand what the moon is? Humans are that way too until they are saved. Only Jesus Saves.
It is not true to say, with all the respect of Dawkins, that it is the same to modify or selectively separate traits, and then combine certain strains, as to make a direct modification of some block chains that we can´t have ( not now) for certain what kind of consecuences are we going to have modify not knowing what are the complex relations to that part with others. Until it is not understand it as a complex system, it could be a very great mess what is about to happen.
What's wrong with frequency healing.
Look what's going on with THE GMO CROPS ARE YOU KIDDING ME??!!!
They are playing in Satan’s playground. There are consequences for this evil activity. They will know when God starts talking directly to them about trying to recreate His Creation.
Bioshock. Rapture. A videogame i still think about even with the many years passed. An underwater utopia turned dystopia because of madness following the people's excessive "splicing" (similarities to editing self with use of needles). There IS a balance. Tipping the scales will bite you in the a$$.
Good reference!
They are playing in Satan’s playground. There are consequences for this evil activity. They will know when God starts talking directly to them about trying to recreate His Creation.
@ 4:25 hmmmmm sounds a lot like the book "Brave new world".
small think spotted......
Thank u all very much
I have never seen anything made by humans that was our perfect it’s always flawed
And things created by “god” are perfect? Like humans?
@@bojackbutterscotchhorseman3091 how the fuck do you guys find any way to bring god to everything for no fckn reason?!!
@@dedopest3305 because in everything is god and only a mind that is in denial doesn’t know that to its own peril
@@bojackbutterscotchhorseman3091 As perfect as he wanted it to be but then we questioned him and now we sit with the results
@@vivianoosthuizen8990 oh shit, and here is a believer with the gobbledygook.
What have they done ? ... they have done “GATTACA” for real
we only need 1 myostatin gene but we have 2. there is allready a crispr technique where you can turn genes on and off without risking to damage the genom. obvious stuff like myostatin increases qol dramatically.
Staying on the top of the food chain wasnt an easy task for humanity for thousands of years. Challenging the nature is in human’s dna. Thats what makes us most unique and gave us the ability to adapt.
The Pandora’s Box has being opened...it’s really a Double-edged sword...
it really isnt
They're curing the blind and people with sickle saloma....check the documentary on Netflix.
@@dilan1970 The documentary “Unnature Selection” is still available on Netflix, please check it.
@@potemkin8606 We are angels and also we are devils. The painful from Faust. Yes, there is no doubt that the creatures on earth are editable and codable. Reflectly thinking just asking ourselves “ who coded us” rather than always subjectively view the world and see we are human being have the ability to code this or that...This issue is Not technic and engineering itself, a quite old question, the possible potential problem is “human nature”, ourselves...
12:50 not gonna lie, her dream made me think of Kramer in that Seinfeld episode: "It's a pig-man!!" Lol
I thought the same thing!
This is so exciting, and utterly terrifying at the same time!
For those that don't know, eugenics was an American practice written into law long before Hitler copied the idea.
Project paperclip
To Dr Dawkins I’d say that although it’s harder to alter human evolution via genome editing than via forced artificial selection, in time we will slide down the slope to where it’s culturally acceptable. To Pinker I’d say very true that we know not yet what we do but as soon as one trait is presumed to be worked out at the multi gene level then all bets are off and there’s no stopping the rich from using it.
Man After Man gives a potentially horrific but realistic possible outcome of such technology.
They are playing in Satan’s playground. There are consequences for this evil activity. They will know when God starts talking directly to them about trying to recreate His Creation.
@@mimilong3817 we need to stop agriculture and farming livestock
@@NMPWN :
Well if you take a look at Mars , there is no agriculture there. God created this earth, humans, plants and animals..the plants and animals were created for our food (not all animals, not all plants are for our consumption). For human beings to think that they know better that God Most High, is to take us the way of Mars. I don’t care what these “scientists” say their altruistic goal is, it’s not a good thing for humanity. They’ve been lying to us throughout modern history.
OH DEAR
What an amazing woman!
Think about the fear we had of self driving vehicles and the possibilities
People are afraid of change
I didn’t have any. Take a leap of faith.
@@mactastic144 very ironic statement
"People are afraid of change" That's not necessarily a bad thing; way too much people in the modern world equate(d) 'progress' with 'change' - and look where we're, right now...
This technique has been used on patients with sickle-cell disease in a study. The study was stopped because some patients developed cancer after treatment (leukemia) and preliminary trials didn't proof to be effective.
It’s not that people are afraid of change. You have to understand the costs FAR exceed the benefits.
But follow the money. New technology = more money. Not necessarily improving lives. But, the human ego never ceases to fail, right?
'And I had this stone cold fear, thinking "what have I done". *laughs*'
hold me I'm scared
They always think how to militarized everything... :)
7:00 I don't belive that for a second.
Interesting and worthwhile video.
Did Dawkins say we've never done genetic changes the "easy way" as if forced sterilization and forced breeding hasn't happened? And he thinks that's *better* than allowing individuals to choose. Absolutely crazy perspective.
I think that he meant easy from a scientific standpoint.
It's easy to have unintended consequences. Traits are decided by multiple genes in most cases
But it's not easy to know if the unintended consequences are good or bad. I expect most would be good.
@@Qstandsforred Why? I don't think you have any data to support that assertion.
@@maxidaho Never said I did. It's just my (somewhat informed) guess. That said, I'm sure I could make a fairly compelling argument. In any case, the burden of proof is on the one making the assertion, which I am not.
When it comes to bioweapons, uncontrollable micro organisms is understandable. But what about larger creatures. We use dogs in our military and they are an extremely important part of it. We have bred dogs for better results. So if you grow a genetically superior dog in a lab, does that make it a bioweapon when we have done it naturally for so long? I cannot find any information explaining if lab grown animals that can have a larger degree of control falls under the same umbrella as uncontrollable microorganisms. Any thoughts?
4:14 Yes! Augments and Superheroes now!
Read "The Promethean Right"
Interesting book.
It will be ignored accordingly.
Idiocracy is now.
@@toserveman9317 But YOU will read it right?
@@FR-yr2lo
Reading? No one said there would be reading!
@@FR-yr2lo
That's you, huh?
I wish-listed it.
Good luck
To cure is to accept what is.
Thermodynamics taught me - there's a specific and predetermined direction of natural phenomenons to occur. It's almost (since, I can't claim to know everything) always smart to not go against it.
It's futile to wish for the sun to rise from the west.
How is this not blowing up?!? This video was fantastic! very interesting bringing up hitler with gene editing.
Damn 80 year old dawkins
Which is why Computational Biochemistry is used with A.I. and Machine Learning to anticipate any potential problems than humans making asinine assumptions about what may go wrong. Many models of the human body have already been mapped, so the chance for failure is extremely low.
Right. When I think of bottlenecks to advancement of such medical technologies, it would always come to me as inability to test because it's hard to get subjects. Now as we're flourishing in computational models, can we expect this to be new standard of testing ground? Like where are we in that at present?
Tree of knowledge is NOT
the tree of life !!
I wrote my epq about the dangers of genome modification, specifically CRISPR, and istg I had to spend ages finding quotes from these guys. Where was this video when I was writing it haha
They are playing in Satan’s playground. There are consequences for this evil activity. They will know when God starts talking directly to them about trying to recreate His Creation.
@@mimilong3817 I respect your opinion as a religious person, but I think this video is more focussed on the risks of the science itself, and less to do with what people think their god thinks.
@@tobylittlejohn8827 :
Scientists think they ARE gods. But it doesn’t matter that they don’t believe believe in God for Him to exist and be in control.
@@mimilong3817 I don't mind engaging in a debate about the science, but I'm not going to argue about religion. You believe what you believe, I believe what I want.
Who's to say we havent started working on humans yet? All we know are the lies they feed us.
I vaguely recall a story about the Chinese and gene editing. That may be cognitive bias though.
They have been for 20 years
Any technology can be used for good or for bad. How CRISPR is regulated should depend upon its risks, the degree of benefit (genetic disease vs. cosmetic) and the costs of not using it (e.g. lifetime of disability).
This is a great achievement. But negative impacts weighs more than positives.
E=mc^2....such a great finding, can be used for the welfare of society. But lost millions of lives....just an example.
This guy said we've never cloned humans , yah right these people need to quit playing God !
God does not intervene
4:08
Like "A brave new world"
Super capabilities for the rich.
Well I've just been told I must get my RNA edited, or I can't work anymore.
Our intelligence has long washed out our wisdom
Nature goes on forever for everyone and everything to return as everyone and everything an infinite number of times through evolutionary processes.
We are just doing time playing on the wheel
What could go right too.
Jeez, Doudna’s dream was terrifying
The dream of Hitler with the pig nose missed one critical component, collectivism. As long as we are trained and accustomed to think for ourselves, we can take good advice from Steven Pinker.
I thought hard about this and had misgivings, but then I saw the money rolling into my bank account(s)...and my misgivings were stilled (glassy smile).
Hilarious, and true. This is how our future looks like on Earth (if we have any): CRISPRs to counteract radioactive mutated fetuses, on top of georngineered skies, and GMO freedom fries. How marvelous. Just Genius. 💩
We are angels and also we are devils. The painful from Faust. Yes, there is no doubt that the creatures on earth are editable and codable. Reflectly thinking just asking ourselves “ who coded us” rather than always subjectively view the world and see we are human being have the ability to code this or that...This issue is Not technic and engineering itself, a quite old question, the possible potential problem is “human nature”, ourselves...
this potential is very well known since 5-8 years. Even more: In US little labours experiment-kits have been sold that would have to be registered and applied for as a genome experiment in Germany. (level 2 out if 5) You can now create new viruses in every garage...
Yes. We will destroy ourselves.
They are playing in Satan’s playground. There are consequences for this evil activity. They will know when God starts talking directly to them about trying to recreate His Creation.
Genetic enhancement is a wonderful idea and the likes of me not only want it but need it. Humanity must embrace genetic and technological enhancement
As long as it is proven to be very safe and egalitarian
@@guthrie_the_wizard why egalitarian?
I could have sworn the first guy was Jeff Goldblum from Jurassic park 😂 🦕 (if ur not as old as a 🦕 he's also in The Avengers)
😂😂😂 I STILL have my VHS of JP. That movie fits so perfectly in this conversation, 😂🤦♀️we're doomed.
@@ShinyNix86 haha 😂 nostalgia
Hello
🤔
?? Please
We are gods, but for the wisdom.
They are playing in Satan’s playground. There are consequences for this evil activity. They will know when God starts talking directly to them about trying to recreate His Creation.
If I were to have an offspring, I would prefer that they would have all of my strength and none of my weaknesses. I believe that would apply for all parents.
It would not. what you call weaknesses are what make you, “you”. And you don’t know what strengths lie behind them.
@@drichards4426
If I was being foolish enough to wont a carbon copy of me, that might be applicable. That would border on negligence and would be terribly egotistical.
The more choices and options the next generation have the better.
@@willofone2120 your natural born child would no be a carbon clone of you. There is a lot of assumption bias in these talks. We’re not discussing the hundreds of people who would likely die from any miscalculation with any of this stuff.
@@willofone2120 literally everything from fast food to being in the wrong environment can give you cancer. You don’t think editing your genetic sequences with little data wouldn’t have side effects ??
@@drichards4426 there a lot of points that are not broken up so here are the responses.
me: i am in support of genetic editing to improve the lives of the Next Generation.
you: Strengths and weaknesses are what make you you.
me: that would only mater if I was making another me, but I would not.
you see where the subject of my comment went off the rails right?
"I'm not so much sure its an ethical problem as a more practical problem-," said the village atheist. Just to counterbalance the statement needed the combined ethical wisdom of Clarke, Pinker, CRISPER scientist herself and the others.
The better question is... what could go right!
I frankly think repairing hereditary genetic diseases and outright change the genome are two entirely different things. I think it's narrowminded of people to fear the first because of the latter.
We already have a negative impact on the genome because we removed natural selection with modern medicine and it would only make sense that we used modern medicine to correct for that as well.
Besides, the ability to identify genetic disorders at the fetal stage is getting better as well and people are just going to compensate with abortions anyway.
you've got a point when you mention how we're fighting natural selection- I agree we should clean up the mess we leave using new medicine
You make a good point but how can you be confident that this "clean up" wont cause a bigger unintended mess? I think about Bret Weinstein talking about tailamers and how if you shorten the tailamers in the Gene's of mice you diminish the rates of cancer, sounds cool until you also discover it lessens the lifespan of the cells and can lead to earlier non-cancer, age related death.
@@Gabekelley It wasn't my intention to give the impression that we should go all out and experiment and just hope for the best. But we should definitely use what we will learn to be safe to fix genetic disorders. How we will learn that is going to be the hard way like with every treatment and that is slow and steady. I think the real danger and cause for concern is that it might be rushed.
Step 1 towards Xenomorph's and Neomorph's Done.