It seems that "cure" means no symptoms for 5 yrs. I had DLBCL in 1998 -Chop X6 { Rchop not available yet} and spleen removed; with remission until 2010 - R chop X6 with remission until 2017 - R chop again with remission until 2020 - taking R chop now {01/2021} just wondering what next. I'm 84 yrs old, already beat the odds, for my age I'm still in good health.
@@mudassakhan I sure hope the best outcome for your father: I have found that the first treatment with me is the worst, I think it is the chemo that is killing the cancer cells and that makes one feel so bad.Tell him to hang in there and hopefully it will get better and he can beat this.
@@tooneboone3869 see an herbalist. Make sure doc knows so there are no interference. We only had to not get vitamin C drops but everything else was okay.
A patient diagnosed with Peripheral T cell NHL in the year 2014. Location of the infected lymph node was Right Gorin, which enlarged to lower abdomen. Peripheral T cell NHL digonosed after excision biopsy. She got 7 Cycle CHOP and Radiotherapy. In September 2020 a PET-CT Scan done after she notice sever itching problem. PET scan showed an 70x51x70mm sized Anterior Mediastinal Mass with SUV max 11. Thoracic surgeon refused to operate the mass. A core biopsy and histochemestry done few days ago. Which shows an Intermediate grade Diffuse large B cell Lymphoma. CD20, BCL6 & MUM1 are positive. BCL2, CD3, CD5 & CD10 Negative. Bone marrow aspiration suggesting "Reactive marrow with myeloid hyperplasia and excess of lymphocytes". Before all these diagnosis the patient only faced itching problem. First symptom noticed on the beginning of August 2020. Last 24-26th October the patient suddenly faced swallowing face. An echocardiogram of the heart on 27th October showing small amount of fluid buildup around her heart. LDH lifted to 366. Her oncologists immediately suggest chemotherapy. The new chemo protocol is R-GCEOP. 1st Cycle started on 27th October and splited into 3 days. Rithuximab, Cyclophosphamide, Gemcitabine, Etopside, Vincristine, prednisone given. After 1st cycle chemo, face swallowing and itching removed significantly. Do you think the new protocol of chemotherapy is good for the patient? And is it possible to a patient treated previously with T cell Lymphoma will affected newly by DLBCL? Is chemotherapy alone is good option to remove the DLBCL? If remove with chemo further Stem cell transplantation is necessary? Her current age 32 years.
Thanks for presentation on large B-Cell Lymphoma. It wasn't clear from your video as to where the mutations in the B-Cells were occurring: was this in the bone marrow or in the lymph nodes? And secondly, what were the cause or causes of these mutations? Is this cancer preventable? And if so, how? Thanks so much, Rick
Would like to know what kind of follow-up is recommended post chemo and radiation. Mine involves no scanning, just LDH lab and self checking my nodes. Thank you. As an afterthought, I would much prefer periodic scans at least in the first few years, but I understand that this is not common practice .
Yes indeed thank you for this informative lecture BUT: Please note that listening to new words makes it difficult to understand. The "auto-generated closed captions" (or subtitles) actually confuses many of the more rarely used words. Not only does CAR-T becomes carty (guessable, after all) but what is teza medicine? what is "how dreams are expressed"? I guessed it, should be "how genes are expressed", but when you, the very good lecturer, are a bit unprecise in your pronunciations as we all are sometimes then this goes awry not only for the auto-generation algorithm but also for the human ear.
Hi, thanks for the information. I was diagnosed with Stage3, DLBCL in 2016. I underwent RCHOP plus immunotherapy. I was in remission for 3.5 years. Lately, I found a lump on the right neck (mandibular) . Prior to that I had throats infection and coughing with greenish sputum. After it was cleared I felt the lump. I am scheduled to see my oncologist next week. What would be the test best to determine if it is a relapse? Should there be another biopsy done to confirm relapse or CTscan etc will do. I am 59 this year. You mentioned that it is highly treatable. I hope to know more about the side effects of the treatment that your mentioned.
Her explanations are perfect. Putting everything in layman’s term. Very much appreciate your information.
Dr. Amengual is my favorite doctor. She works hard at the frontline of her field and truly cares about her patients.
It seems that "cure" means no symptoms for 5 yrs. I had DLBCL in 1998 -Chop X6 { Rchop not available yet} and spleen removed; with remission until 2010 - R chop X6 with remission until 2017 - R chop again with remission until 2020 - taking R chop now {01/2021} just wondering what next. I'm 84 yrs old, already beat the odds, for my age I'm still in good health.
Oh really
my father 70 year old first r-chop just done last week am so worried about my father he is so weak and eats nothing
@@mudassakhan I sure hope the best outcome for your father: I have found that the first treatment with me is the worst, I think it is the chemo that is killing the cancer cells and that makes one feel so bad.Tell him to hang in there and hopefully it will get better and he can beat this.
@@tooneboone3869 see an herbalist. Make sure doc knows so there are no interference. We only had to not get vitamin C drops but everything else was okay.
@@mudassakhan Hi Mudassar Hows your father doing now ?
My son age of 24 had this deases
This is very well done by Dr Amengual.
A patient diagnosed with Peripheral T cell NHL in the year 2014. Location of the infected lymph node was Right Gorin, which enlarged to lower abdomen. Peripheral T cell NHL digonosed after excision biopsy. She got 7 Cycle CHOP and Radiotherapy. In September 2020 a PET-CT Scan done after she notice sever itching problem. PET scan showed an 70x51x70mm sized Anterior Mediastinal Mass with SUV max 11. Thoracic surgeon refused to operate the mass. A core biopsy and histochemestry done few days ago. Which shows an Intermediate grade Diffuse large B cell Lymphoma. CD20, BCL6 & MUM1 are positive. BCL2, CD3, CD5 & CD10 Negative. Bone marrow aspiration suggesting "Reactive marrow with myeloid hyperplasia and excess of lymphocytes". Before all these diagnosis the patient only faced itching problem. First symptom noticed on the beginning of August 2020. Last 24-26th October the patient suddenly faced swallowing face. An echocardiogram of the heart on 27th October showing small amount of fluid buildup around her heart. LDH lifted to 366. Her oncologists immediately suggest chemotherapy. The new chemo protocol is R-GCEOP. 1st Cycle started on 27th October and splited into 3 days. Rithuximab, Cyclophosphamide, Gemcitabine, Etopside, Vincristine, prednisone given. After 1st cycle chemo, face swallowing and itching removed significantly. Do you think the new protocol of chemotherapy is good for the patient? And is it possible to a patient treated previously with T cell Lymphoma will affected newly by DLBCL? Is chemotherapy alone is good option to remove the DLBCL? If remove with chemo further Stem cell transplantation is necessary? Her current age 32 years.
Very informative
thank you
Thanks for presentation on large B-Cell Lymphoma. It wasn't clear from your video as to where the mutations in the B-Cells were occurring: was this in the bone marrow or in the lymph nodes? And secondly, what were the cause or causes of these mutations? Is this cancer preventable? And if so, how? Thanks so much, Rick
CNS metastasis prophylaxis with methotrexate injected into spinal column?
what do you think of car-t for first treatment
It’s super expensive so they hold off as long as possible
Where does Waldenstroms come from into the picture
I diagnosis DlBCL and my first chemo R Chop is totally fail and my toumer spread what to do next plz guide me something
Would like to know what kind of follow-up is recommended post chemo and radiation. Mine involves no scanning, just LDH lab and self checking my nodes. Thank you.
As an afterthought, I would much prefer periodic scans at least in the first few years, but I understand that this is not common practice .
Double Hit Lymphoma? Cure rate?
Comfortable? with treatment!
Yes indeed thank you for this informative lecture BUT: Please note that listening to new words makes it difficult to understand. The "auto-generated closed captions" (or subtitles) actually confuses many of the more rarely used words. Not only does CAR-T becomes carty (guessable, after all) but what is teza medicine? what is "how dreams are expressed"? I guessed it, should be "how genes are expressed", but when you, the very good lecturer, are a bit unprecise in your pronunciations as we all are sometimes then this goes awry not only for the auto-generation algorithm but also for the human ear.
She speaks too fast anyway. The need a better narrator .
She’s beautiful.
Hi, thanks for the information. I was diagnosed with Stage3, DLBCL in 2016. I underwent RCHOP plus immunotherapy. I was in remission for 3.5 years. Lately, I found a lump on the right neck (mandibular) . Prior to that I had throats infection and coughing with greenish sputum. After it was cleared I felt the lump. I am scheduled to see my oncologist next week. What would be the test best to determine if it is a relapse? Should there be another biopsy done to confirm relapse or CTscan etc will do. I am 59 this year. You mentioned that it is highly treatable. I hope to know more about the side effects of the treatment that your mentioned.
Thanks for your comments, Rhoda. What was the protocol you were on 3.5 years ago? And what were the side effects? God speed in a safe recovery. Rick
Any update on ur current prognosis
Any updates? My mother is also in the same condition
thank you.