Worth noting why the study was retracted, according to an FTC settlement agreement, because "the company who made the extract paid a researcher in India to conduct this study, and the authors allegedly falsified the data (weight measurements, treatment arm, trial length). When the original author couldn't get the study published, the company hired two more researchers to write the study results for publication." Not just some methodology or data issues, but absolute outright fraud of the worst kind. Sadly a lot of the skepticism and anti-science noise we see now is because of this outrageous sorts of deceit. It accounts for, presumably / hopefully, a small percentage of papers, but it has an outsized influence on people's perception of science.
Interest. When I zoomed into the study it lists a chemistry company, an University in PA, USA, and the India providence person. This makes more sense knowing the research being compromised. Unfortunately, rhe product is considered a supplement that does not have strict regulations and they are allowed to make claims without product research. Buyer Beware.
@@DennisForbes Our brains are wired to weigh the tiny negatives as much more important than the consistent positives. When you stub your toe, your brain doesn’t say “99.9999% of everything is still fine!” From a survival standpoint the exceptional makes a difference. I think this carries over into how much we change our attitude from tiny negative inputs.
for body building advice, dr. Mike is great and his humor is, at least to me, addictive :)))) for health, science and also for your humour, I'm coming here.
I take all docs with a pinch of salt. Berg, Lustig, Gundry and a few in the controversial field of Covid-19. In the field of health and nutrition, I've never heard Dr Nic say something I knew or suspected to be false.
I can't listen to Dr. Gundry; his voice makes me sleepy. He's out there to sell his products. Dr. Berg-well, he's a chiropractor and supports Scientology, but I still listen to him. I'd never heard of Dr. Nic until now. I respect Dr. John Campbell and Physionic just to mention a few.
Campbell is a fraud who went down a rabbit hole during Covid and has completely lost the plot. He seems like a kindly old man whose heart was in the right place but he is woefully over his skis when interpreting data. Am I correct that he was a nurse practitioner or paramedic (no disrespect to those professions), however he comments with a veneer of expertise that’s outside of the scope of his training and that leads to stunning and dangerous misinterpretations.
I had never heard of chlorogenic acid until recently when it was mentioned in Dr Zemel's research on the interaction of Leucine and Resveratrol, which are worth a read. They tested different polyphenols in a followup paper which is where the chlorogenic acid came in. Then switched to some pharmaceuticals for Phase 2 humans trials. Looks promising.
According to MedlinePlus, roasted coffee _still_ contains chlorogenic acid. In any case, I read that chlorogenic acid has not been approved as a prescription drug or food additive recognized as a safe ingredient for foods or beverages. There is not enough evidence to determine whether it is safe or effective for human health in high doses.
I think I’m not alone in saying I’d buy an hour long team effort from you and Dr Mike! Choose the subjects, we don’t care. The intersection of high intelligence and razor wit in very different forms would be wildly entertaining.
@@m.j.5681 he does seem to me like a pretty smart individual. I'm genuinely curious as to what cues you use to affirm he isn't one. Could you give some ?
Very fun and entertaining 😂. Thank you. I wonder what Mike would say about you making of this video? Haha. I'm not at all "Brooklin" but but I can guess. 😅
Dr Mike is great although when you get into some of the nitty gritty nutrition and exercise stuff it becomes apparent that’s he’s more specialized in applications for.. “untested” individuals
Not certain about drinking "beans" as there has never been any real RCT's (lock and key, metabolic ward), but "flicking the bean" so to speak has proven to increase NEAT, non-exercise activity thermogenesis which could increase total energy used in a day. Living here in Colombia, still don't know why they call it a coffee "bean" when it is truly a coffee cherry (fruit) seed / pit.
In coffee bean extracts, I always heard that the EGCG (is that the compound mentioned in the video? idk) content was what you were looking for, because it supposedly had a thermogenic effect that aided in burning more fat. And then the black coffee mentioned at the end, I always heard that attributed to a level of hunger suppression from the caffeine.
14:45 CGA is not completely converted by roasting. Black Coffee contains residual CGA. Since CGA increases insulin sensitivity, it may improve glucose utilization for energy.
This is great, Dr Mike is yeah very smart can I have seen him on some shows where they had to xXx practically every word he was saying 😅😅 so enjoy your show learning so much thank you so much have a great day 😊😊
@@babybalrog common, you wouldn't be measuring your weight with a gaping chest wound... The Senzu bean would just fill the gap with similar cells you had previously. It'd also make you feel full, so technically it'd be similar to Ozempic, so you eat less and lose weight 😜
coffee is not roasted to 475 degrees! At an internal temp of 455 degrees, it's totally burnt and will burst into flame. If the roaster pulls it out of the oven and the beans are 455, they will taste awful, well... burnt! Medium roasts end up with internal temps of 425 to 435. Darker roasts from 442 to 448 (which are dark enough for most people to taste a burnt taste, as in Charbucks). One thing he is right about though is that the darker the coffee is roasted, the less of the beneficial compounds like chlorogenic acid remain in the bean. Green coffee will have more of coffee's beneficial compounds than even lightly roasted coffee.
@Physionic It's been a while, but I don't think the.results.were really strong. Especially, compared to green tea. Having said thst, we also looked.at the skin of the coffee bean, which has interesring phytosterols. I was actually discussing this with the CEO of a coffee.company yesterday. Because, there is so much waste after roasting.
@Physionic The question we were examining was whether coffee roasting turns specific phytosterols into toxic substances. This was actually done in the lab. I can send you a paper on this topic, if you're.interedted. For the chlorogenic acid experiment, I checked.but could not find the lab material.
So the explanation is that the sugar is burned more in the liver which prevents the sugar from entering the blood stream which prevents the sugar from turning to fat? If so, what would cause the liver to increase its metabolic rate? Would the intense increase in metabolic rate also lead to free radical production that could exceed the antioxidant capacity of the liver and accelerate liver aging?
The first dead giveaway should be the freaking headline!!! "Miracle Bean" 🤦♂️ This is supposed to be science?? Let's start by pointing out that coffee "beans" are freaking seeds and NOT BEANS in any fashion other than popular lingo of the lay public. They come out of a fruit, a red berry that is also high in very beneficial polyphenols. To clarify for Nic and Mike and the watchers of this channel; chlorogenic acid is the primary polyphenol found in the seeds of the coffee plant, among others (like basically all plant tissues it contains flavanoids, terpenes, polyphenols, and the like that protect it's cells UV degredation and possibly from things like insect predation). While it is degraded quite a bit by high heat, brewed coffee does retain a fair amount. So much so that, along with the polyphenols in beer, it turns out that coffee and beer contribute the highest amount of polyphenols found in the average American diet. SAD (pun most definitely intended 😉)! The saddest part of all is that for how amazing the effect of these types of molecules are, they will never get funding for proper "human randomized controlled trials" (in the voice of Layne Norton 😉" because the NIH is in too loving a relationship with industry. They both LOVE money and not so much cheap, actionable information to keep the American public from going to the doctor and buying all their "wares" (e.g. pharmaceutical drugs, fancy surgeries, et cetera)🤑. Possible mechanisms for weight loss effects from some of these molecules are, but not limited to, AMPK activation, beiging of white adipose tissue along with increased brown fat metabolism, increasing UCP's (uncoupling proteins), slowing and preventing some amount of sugars during digestion, feeding and modulating the microbiome, blocking TMAO conversion from TMA in the gut...... There's so much to be researched and unpacked, but alas, if it can't be patented or at least trademarked, nothing really ever gets done 😢😖😡. Greed is a hell of a drug 😁
Dr. Nic wins again. I am not sure if I missed it, but was this study retracted after Dr. OZ used it for his promotional information, or after? If it was retracted after, it would be nice to see if Dr. OZ also retracted his promotion of this product.
Hi Nicolas, in this Video No subtiteles where available. Although my Englisch is quite good I used to activate subtitles from time to time to read while I am Hearing to get rare words better. Also the automatic Translation Tool from TH-cam often makes a good Job in translating these words. Will you be able to activate subtitles in the Future. Greetings from Leipzig in Germany Tobias
@Physionic your Welcome Most of your other Videos have subtitles . Anyway i was able to follow the Video and your pronounciation is very clear in General so it is easier to follow. Nevertheless your content or the vocab in the Videos are kind of advanced for a non native speaker. Of course it is because of the content and the topic of this nice channel
If you watch a video as soon as it goes public, sometimes not all features are available. I didn't realize that myself until I uploaded some of my own videos. Even the resolutions are restricted. There's a processing time of hours, sometimes a day or so for longer videos. A video will first unlock only at low resolution and no subtitles and then as the processing completed other resolutions and subtitles unlock over time. As a creator there may be a way around this by uploading and then delaying making them public, but I don't upload enough to know from experience. I just know new videos don't always have everything unlocked, resolution limitations and subtitles being the most obvious (to me). I'm not sure if there's other things restricted until fully processed. On the user side you need both the TH-cam processing to finish and then a browser cache refresh. (Usually automatic with a browser reload but not always)
As much as I like Dr.Mike, sometimes the satire jokes gets in the way of learning. Specially if you speak another language than English; satire, sarcasm, slang and cultural specifics, doesn't translate well. We need more channel like this; a straight YES, NO, MAYBE and NOT ENOUGH EVIDENCE.
I notice in this and a previous video the specific mention of "black" coffee ... wondering if you are implying that coffee with milk might, for whatever reason ???, impact the health benefits of polyphenols contained in coffee beans.
So the study supposedly showed that they lost 15% of their body weight in fat, but 10% overall, so they must have been lifting heavy weights and eating a high percentage of protein to increase lean body weight that much. There is probably no way they could have done that in 22 weeks. That should have been a red flag for Oz but he doesn’t seem to have a red flag meter.
Was the study retracted before or after that Dr. Oz episode? Do we know the reason for the retraction? Not that I'm a Dr. Oz fan -- far from it. Also, I've never watched Dr. Mike. Now, I can see myself watching him when I need a jolt of Bronx humor.
Doctors are not scientists and doctor organizations act as a union not a scientific organization. Doctors do have some science training and a little bit of statistics. They sometimes get additional training and do scientific research such as Peter Attia when he went to the NIH and NIC. Attia's training and experience is apparent when he analyzes studies. Hopefully Dr Oz recommended the bean before the study was the retracted. He should have mentioned the small number of participants, need for replication and potential weaknesses in the the study. In his defense the type of study is generally one the strongest -double blind, placebo controlled. But as I understand it he did push magic elixirs on various shows.
it's a catch-22-situation(!). but what He says about magic is plain wrong-I hang out with Fairies and Unicorns on a regular basis, We meet up for a cup of purple coffee in a neighbouring Universe and We're All underweight now. regards.
Thanks for the feedback - I was hesitant to release this, actually. It was worth it if you got a chuckle out of it (and hopefully learned a thing or two!)
If this is your first introduction to Dr Mike, his channel is a great science-based source of weight/strength training information...with a batch of laughs (he is a real potty-mouth and plays with social no-nos, but knows his stuff when it comes to training, nutrition, and weight loss or gain)
Learn to read more than a headline. Wikipedia lists everyone by their names not their title. His education is listed in the article (md = medical doctor) Your reading comprehension sucks if you managed to find Wikipedia and failed to notice the information you asked is answered there.
Does anyone know, why such a solid video does NOT have captions? I have to abandon it now, so if they will become available at any time, can anyone notice me, please?
I can’t wait 15 min to finish the video when my comment can be so early. But knowing the punchline is going to be a doozy I am going to put it on 1.5 speed. So far I have to say Dr. Mike is pretty funny.
Nic, please, pretty please do one on "the unified theory of sleep: eukaryotes endosymbiotic relationship with mitochondria and rem the push back response for awakening" It's a life or death quest for me as I have little sws and the connection here to my problem seems to be my best fit to my experience here with other metabolic effects too. Perhaps cyanide (i work hplc), perhaps thc, perhaps my own northern uncoupled mitochondria, who knows. You if anyone. 🙏
Looks like everyone is a doctor now on the social media or claim to be. I know Nic and Mike are real doctors, and so is Oz while in my opinion he shouldn't be one. So now we arrived at having commentary on commentary on TV quack doctor. Alright. Weird times. However giving a sort of a " peer review " of popular influencers with huge audiences and their claims is a big positive ,so thanks for that Nic. Edited comment to address misinterpretations and expand on originally provided information that was brought to my attention by certain members of the audience.
Well the “TV quack” had a huge audience and influence (and has a real MD degree) so ya, it makes sense for someone knowledgeable to parse his claims. No need to be snarky about other people’s degrees. A PhD has a doctorate.
@MelloCello55 I have no problem with people being actual doctors either MD or PhD. I call Oz a quack because he pushes unproven stuff to his enormous audience and that does harm.
@@MelloCello55 For whatever reason my comment didn't get through. I have nothing against people being actual doctors. I am against pushing unproven products by a TV doctor to his audience. That does harm.
@@MelloCello55 They do. It adds weight to their words. Sometimes they have no title sometimes they have doctor of Chiropractic title which honestly makes them as much of a doctor as sport glasses make you an athlete.
About the metabolism. He was saying that they are 2400 kcal and burned 2000 kcal bmi which is an increase in weight of 400 kcal. Critical thinking is your friend.
Also worth nothing that green tea extract can cause liver failure. People just need to eat less and get off their asses more (not necessarily "move more" or "do exercise") and get up off that sofa, chair, or bed and live a little.
Zero Side Effects, could be because they started with 50 volunteers, dosed them before the study started, and eliminated those who had adverse reactions.
Great video! ZumRX, which is a green coffee bean extract, is use in weight loss and pre workout products. Not for weight loss but for its slower delivery of caffeine for a prolonged energy hit. It’s supposed to deliver not more than 55% of the total caffeine at 1 hour and not less than 80% at 6 hours. Because of its polyphenol content it’s suppose to have nitric oxide inducing benefits and help with lipid metabolism. But there are a number of other extracts and foods that have a good amount of polyphenols in them. Keep up the great content.
“But Nic there is a major oversight you over looked” I say in the comments “What’s that? Something I missed?” Replies Nic “You missed the part about Dr Israel being HUGE! After not agreeing with him, though he was basically right, he’ll eat you for breakfast ” (Contents removed by TH-cam censor team) Yells Nic
Dr. Oz should have talked about dr.Pepper the miracle soda, so that there would have been 4 Dr's in this title. I am sure Dr. Oz would love to get Dr.Pepper money and totally prepared to sacrifice his first born, so this is not far fetched.
I I stopped watching "Doctor Mike" a couple years ago, when he (back then an adamant CICO proponent, dont know what he tells now), claimed that he's not only shure its only calories, he knows it for a fact. because "we have read the studies. ALL OF THEM"
@mbarley That's a... 'compliance beforehand' stance - for passive cowards... I sincerely doubt it's a strategy Dr. Nic or Dr. Mike would consider (obviously)😊 Just my 2cents...but I do know you were kidding😆
@barbarafairbanks4578 I was kidding but as I am nit an American I can act 'brave' without implications. Let's hope our bravery won't be tested as shameless people the likes of dr Oz assume positions of power
![The Easiest Way to Lose Body Fat [Study 242]](http://i.ytimg.com/vi/GcaQiFhTd2A/mqdefault.jpg)
![The Easiest Way to Lose Body Fat [Study 242]](/img/tr.png)
Worth noting why the study was retracted, according to an FTC settlement agreement, because "the company who made the extract paid a researcher in India to conduct this study, and the authors allegedly falsified the data (weight measurements, treatment arm, trial length). When the original author couldn't get the study published, the company hired two more researchers to write the study results for publication."
Not just some methodology or data issues, but absolute outright fraud of the worst kind.
Sadly a lot of the skepticism and anti-science noise we see now is because of this outrageous sorts of deceit. It accounts for, presumably / hopefully, a small percentage of papers, but it has an outsized influence on people's perception of science.
Thank you for sharing, Dennis - this puts things in perspective...
Interest. When I zoomed into the study it lists a chemistry company, an University in PA, USA, and the India providence person. This makes more sense knowing the research being compromised. Unfortunately, rhe product is considered a supplement that does not have strict regulations and they are allowed to make claims without product research. Buyer Beware.
Surprised Pikachu face
Grifters gonna grift.
@@DennisForbes Our brains are wired to weigh the tiny negatives as much more important than the consistent positives. When you stub your toe, your brain doesn’t say “99.9999% of everything is still fine!” From a survival standpoint the exceptional makes a difference. I think this carries over into how much we change our attitude from tiny negative inputs.
I love Dr. Mike who is very smart and is not afraid to call out a shyster. Dr. Oz is a shyster.
@@cindykurneck He didn’t strike me as being smart with his comment about chlorogenic acid. He doesn’t seem to know how to google.
@@sassenspeyghel4155 So you don’t have Google either? Or didn’t listen to Dr. Nic talk about it? Ha.
@@sassenspeyghel4155 We have different definitions of a joke. In my world, they are funny.
Not disagreeing. He actually was a very respected heart surgeon. Like many he was drawn in by the lure of HWood and fame.
@ The reply of people who call inane remarks a joke. “Don’t be so sensitive.” Thats your next one I’m sure.
for body building advice, dr. Mike is great and his humor is, at least to me, addictive :)))) for health, science and also for your humour, I'm coming here.
I have reservations about Mike’s transhumanist opinions. He’s completely on board with the prospect of cybernetics and drugs that cause immortality.
To your point, it's an "opinion" ... I have lots em too
I agree.Scientist my self. Other fields...and no humour /cause I'm German need to get it elsewhere.
@@jwintheproimmortality is impossible......you mean indefinite lifespan potential
@DWbo-r7vyou know what I meant.
If a doctor told me something he wanted me to use was MAGICAL, I would excuse myself, and RUN away from his office, never to return.
I remember Dr. Oz coming out every week on the Oprah show with a different item to help lose weight.
You would've thought that all his viewers would be super thin after all these years.... Oh, wait. It was just their wallets... 😢
@7:11
The table shows a side effect (possible) - blood pressure went up for the average participant, by 3.9% SP - that is significant to be sure.
Nice catch :)
And now Oz is going to be in charge of my healthcare. What could go wrong?
It's a spokesman's Job from what I understand. And besides even a monkey with a hammer would be better than what we have now.
Yeah that was not a good call.
No, you’re in charge of your healthcare..
Well...IS there any room for U.S. health care to downgrade any further than it already is?🫨
I don't think so.😒
gives a new meaning to "taking care" of you.
I take all docs with a pinch of salt. Berg, Lustig, Gundry and a few in the controversial field of Covid-19. In the field of health and nutrition, I've never heard Dr Nic say something I knew or suspected to be false.
I can't listen to Dr. Gundry; his voice makes me sleepy. He's out there to sell his products. Dr. Berg-well, he's a chiropractor and supports Scientology, but I still listen to him. I'd never heard of Dr. Nic until now. I respect Dr. John Campbell and Physionic just to mention a few.
Campbell is a fraud who went down a rabbit hole during Covid and has completely lost the plot. He seems like a kindly old man whose heart was in the right place but he is woefully over his skis when interpreting data. Am I correct that he was a nurse practitioner or paramedic (no disrespect to those professions), however he comments with a veneer of expertise that’s outside of the scope of his training and that leads to stunning and dangerous misinterpretations.
Berg is no doctor…he is a chiropractor who gives lots of money to Scientology. The guy is a fake.
@@Franky2A3there's zero evidence he was ever a scientologist. A kid just made that up in a youtube video. It's just heresay
I had never heard of chlorogenic acid until recently when it was mentioned in Dr Zemel's research on the interaction of Leucine and Resveratrol, which are worth a read. They tested different polyphenols in a followup paper which is where the chlorogenic acid came in. Then switched to some pharmaceuticals for Phase 2 humans trials. Looks promising.
I like Dr Mike with all his strong language as well. This is probably because I am from England where everyone is so rigid and image conscious
Dr. Nic best doctor. Just wanted to say that. Now let me watch the video.
Ha, thanks :)
According to MedlinePlus, roasted coffee _still_ contains chlorogenic acid. In any case, I read that chlorogenic acid has not been approved as a prescription drug or food additive recognized as a safe ingredient for foods or beverages. There is not enough evidence to determine whether it is safe or effective for human health in high doses.
Caffeine.
@@mballer it’s not caffeine if that’s what u mean. It’s a polyphenol.
If you eat a diet rich in fruits and vegetable you get a decent amount of chlorogenic acid.
"Are you a crackpot? Yes? Would you like a position in the Whitehouse?".
I think I’m not alone in saying I’d buy an hour long team effort from you and Dr Mike! Choose the subjects, we don’t care. The intersection of high intelligence and razor wit in very different forms would be wildly entertaining.
Haha, he has me beat, but I would definitely have fun.
Israetel "high intelligence" LMAO - no.
@@m.j.5681 Oh man. Sorry to hear your ass is now gone. That was some hard laughing
@@m.j.5681 he does seem to me like a pretty smart individual. I'm genuinely curious as to what cues you use to affirm he isn't one. Could you give some ?
"The Dr. Mike on Dr. Oz's miracle bean re-examined by Dr. Nic situation is insane"
Mike is great for sure!
Dr. Mike is soooo professional
10:08 I think you meant the coffee roasting process. Subsequently we’d have to look at the brewing process as well.
I love you bringing in Dr. Mike!
Very fun and entertaining 😂. Thank you. I wonder what Mike would say about you making of this video? Haha. I'm not at all "Brooklin" but but I can guess. 😅
Dr Mike is great although when you get into some of the nitty gritty nutrition and exercise stuff it becomes apparent that’s he’s more specialized in applications for.. “untested” individuals
“Boil it down” 😂 Good pun Nic even if not intended.
Not certain about drinking "beans" as there has never been any real RCT's (lock and key, metabolic ward), but "flicking the bean" so to speak has proven to increase NEAT, non-exercise activity thermogenesis which could increase total energy used in a day. Living here in Colombia, still don't know why they call it a coffee "bean" when it is truly a coffee cherry (fruit) seed / pit.
In coffee bean extracts, I always heard that the EGCG (is that the compound mentioned in the video? idk) content was what you were looking for, because it supposedly had a thermogenic effect that aided in burning more fat. And then the black coffee mentioned at the end, I always heard that attributed to a level of hunger suppression from the caffeine.
Great video. Thanks.
14:45 CGA is not completely converted by roasting. Black Coffee contains residual CGA. Since CGA increases insulin sensitivity, it may improve glucose utilization for energy.
400 calories was the approximate daily deficit. 17 lbs x 3500 cals ÷ 22 weeks ÷ 7 days = 386 cals
drs nic, mike, & oz ... a triple threat
Ooou, good one!
"triple threat wins championships" that was funny, but I'm not sure most people will get it 😆
Dr., Dr., Dr.,...and Doctor ~ Spies Like Us.
This is great, Dr Mike is yeah very smart can I have seen him on some shows where they had to xXx practically every word he was saying 😅😅 so enjoy your show learning so much thank you so much have a great day 😊😊
damn I thought they finally discovered the Senzu bean
Duuuuuuuuude, that would be epic!
Healing the gaping wound in your chest would technically we weight gain, not loss
@@babybalrog common, you wouldn't be measuring your weight with a gaping chest wound... The Senzu bean would just fill the gap with similar cells you had previously. It'd also make you feel full, so technically it'd be similar to Ozempic, so you eat less and lose weight 😜
Great video
Retracted.
Burying that lead super deep.
Retracted for what?
I never trusted Dr Oz's eyebrows.
Most likely a type 1 error due to low population or wrong statistical analysis.
According to Dr. Greger it's chlorogenic acid that accounts for coffee's health benefits.
That is true, in my opinion.
But roasted beans lose any meaningful amount of chlorogenic acid.
coffee is not roasted to 475 degrees! At an internal temp of 455 degrees, it's totally burnt and will burst into flame. If the roaster pulls it out of the oven and the beans are 455, they will taste awful, well... burnt! Medium roasts end up with internal temps of 425 to 435. Darker roasts from 442 to 448 (which are dark enough for most people to taste a burnt taste, as in Charbucks). One thing he is right about though is that the darker the coffee is roasted, the less of the beneficial compounds like chlorogenic acid remain in the bean. Green coffee will have more of coffee's beneficial compounds than even lightly roasted coffee.
Dr Mike in the house. 💪🤘🏼👍
The tea has been served & it’s scalding hot!
Physionic / Dr. Mike collab when!? 🤯
Ha! If only. I’m way too small a channel to be on the radar.
@@Physionic well I think you have a great channel! Keep up the good work!
Dr. Mike 👍🏽
I actually did a lab where we administered chlorogenic acid to cancer cells to see if there would be a positive effect.
What happened?
@Physionic It's been a while, but I don't think the.results.were really strong. Especially, compared to green tea. Having said thst, we also looked.at the skin of the coffee bean, which has interesring phytosterols. I was actually discussing this with the CEO of a coffee.company yesterday. Because, there is so much waste after roasting.
@Physionic The question we were examining was whether coffee roasting turns specific phytosterols into toxic substances. This was actually done in the lab. I can send you a paper on this topic, if you're.interedted. For the chlorogenic acid experiment, I checked.but could not find the lab material.
@Physionic Also, on further reflection, I think the experiment was to see if chlorogenic acid could affect insulin levels in a cancer cell line.
Now do a review of the science behind the “Trim 7” claims
I believe he's already done that. (If it's the 'TRIM' - age-reversal study you are referring to -??)
@ “Trim 7” is a concoction of 7 components that supposedly drive body fat reduction. Same developers as the “Muscle 5” concoction.
This video was hilarious on all levels 😂😂😂
So the explanation is that the sugar is burned more in the liver which prevents the sugar from entering the blood stream which prevents the sugar from turning to fat? If so, what would cause the liver to increase its metabolic rate? Would the intense increase in metabolic rate also lead to free radical production that could exceed the antioxidant capacity of the liver and accelerate liver aging?
How old is that DR. Oz episode?
Why was the study retracted?
Some one posted the official reason in a post above.
Can you link the full video? I couldn’t find it on your channel, Thanks
Thank you for the reminder, I added it
The first dead giveaway should be the freaking headline!!! "Miracle Bean" 🤦♂️ This is supposed to be science?? Let's start by pointing out that coffee "beans" are freaking seeds and NOT BEANS in any fashion other than popular lingo of the lay public. They come out of a fruit, a red berry that is also high in very beneficial polyphenols. To clarify for Nic and Mike and the watchers of this channel; chlorogenic acid is the primary polyphenol found in the seeds of the coffee plant, among others (like basically all plant tissues it contains flavanoids, terpenes, polyphenols, and the like that protect it's cells UV degredation and possibly from things like insect predation). While it is degraded quite a bit by high heat, brewed coffee does retain a fair amount. So much so that, along with the polyphenols in beer, it turns out that coffee and beer contribute the highest amount of polyphenols found in the average American diet. SAD (pun most definitely intended 😉)! The saddest part of all is that for how amazing the effect of these types of molecules are, they will never get funding for proper "human randomized controlled trials" (in the voice of Layne Norton 😉" because the NIH is in too loving a relationship with industry. They both LOVE money and not so much cheap, actionable information to keep the American public from going to the doctor and buying all their "wares" (e.g. pharmaceutical drugs, fancy surgeries, et cetera)🤑. Possible mechanisms for weight loss effects from some of these molecules are, but not limited to, AMPK activation, beiging of white adipose tissue along with increased brown fat metabolism, increasing UCP's (uncoupling proteins), slowing and preventing some amount of sugars during digestion, feeding and modulating the microbiome, blocking TMAO conversion from TMA in the gut...... There's so much to be researched and unpacked, but alas, if it can't be patented or at least trademarked, nothing really ever gets done 😢😖😡. Greed is a hell of a drug 😁
Dr. Nic wins again. I am not sure if I missed it, but was this study retracted after Dr. OZ used it for his promotional information, or after? If it was retracted after, it would be nice to see if Dr. OZ also retracted his promotion of this product.
Hi Nicolas, in this Video No subtiteles where available. Although my Englisch is quite good I used to activate subtitles from time to time to read while I am Hearing to get rare words better. Also the automatic Translation Tool from TH-cam often makes a good Job in translating these words. Will you be able to activate subtitles in the Future. Greetings from Leipzig in Germany Tobias
Thanks - I'll see what I can do
@Physionic your Welcome Most of your other Videos have subtitles . Anyway i was able to follow the Video and your pronounciation is very clear in General so it is easier to follow. Nevertheless your content or the vocab in the Videos are kind of advanced for a non native speaker. Of course it is because of the content and the topic of this nice channel
Retry now, I was waiting myself and I have noticed that the text is finally available.
@@Physionic it seams to Work now. Maybe a TH-cam bug
If you watch a video as soon as it goes public, sometimes not all features are available.
I didn't realize that myself until I uploaded some of my own videos. Even the resolutions are restricted. There's a processing time of hours, sometimes a day or so for longer videos.
A video will first unlock only at low resolution and no subtitles and then as the processing completed other resolutions and subtitles unlock over time.
As a creator there may be a way around this by uploading and then delaying making them public, but I don't upload enough to know from experience.
I just know new videos don't always have everything unlocked, resolution limitations and subtitles being the most obvious (to me). I'm not sure if there's other things restricted until fully processed.
On the user side you need both the TH-cam processing to finish and then a browser cache refresh. (Usually automatic with a browser reload but not always)
As much as I like Dr.Mike, sometimes the satire jokes gets in the way of learning.
Specially if you speak another language than English; satire, sarcasm, slang and cultural specifics, doesn't translate well.
We need more channel like this; a straight YES, NO, MAYBE and NOT ENOUGH EVIDENCE.
I notice in this and a previous video the specific mention of "black" coffee ... wondering if you are implying that coffee with milk might, for whatever reason ???, impact the health benefits of polyphenols contained in coffee beans.
No, milk is likely fine, but the actual compounds that benefit are the coffee itself.
So the study supposedly showed that they lost 15% of their body weight in fat, but 10% overall, so they must have been lifting heavy weights and eating a high percentage of protein to increase lean body weight that much. There is probably no way they could have done that in 22 weeks. That should have been a red flag for Oz but he doesn’t seem to have a red flag meter.
He can't sense red flags, only green notes
Was the study retracted before or after that Dr. Oz episode? Do we know the reason for the retraction? Not that I'm a Dr. Oz fan -- far from it. Also, I've never watched Dr. Mike. Now, I can see myself watching him when I need a jolt of Bronx humor.
Doctors are not scientists and doctor organizations act as a union not a scientific organization.
Doctors do have some science training and a little bit of statistics.
They sometimes get additional training and do scientific research such as Peter Attia when he went to the NIH and NIC. Attia's training and experience is apparent when he analyzes studies.
Hopefully Dr Oz recommended the bean before the study was the retracted. He should have mentioned the small number of participants, need for replication and potential weaknesses in the the study. In his defense the type of study is generally one the strongest -double blind, placebo controlled.
But as I understand it he did push magic elixirs on various shows.
it's a catch-22-situation(!). but what He says about magic is plain wrong-I hang out with Fairies and Unicorns on a regular basis, We meet up for a cup of purple coffee in a neighbouring Universe and We're All underweight now. regards.
That was so funny - more of these pls!
Thanks for the feedback - I was hesitant to release this, actually. It was worth it if you got a chuckle out of it (and hopefully learned a thing or two!)
I was saving this as a reward to watch after my workout. 3:20 SAME and your face(s) make me laugh.
If this is your first introduction to Dr Mike, his channel is a great science-based source of weight/strength training information...with a batch of laughs (he is a real potty-mouth and plays with social no-nos, but knows his stuff when it comes to training, nutrition, and weight loss or gain)
In Wikipedia Dr.Oz is listed just as Mehmet Cengiz Öz. Does this mean the "Dr" is just for show?
Learn to read more than a headline.
Wikipedia lists everyone by their names not their title. His education is listed in the article (md = medical doctor)
Your reading comprehension sucks if you managed to find Wikipedia and failed to notice the information you asked is answered there.
White bean extract?
Does anyone know, why such a solid video does NOT have captions? I have to abandon it now, so if they will become available at any time, can anyone notice me, please?
Hey - I just checked on the back end and TH-cam is still processing the captions. Nothing I can do, but wait.
@@Physionic subs are there, video watched, now for the algoooooo!
3 doctors and one bean
I don't want results, I want problems always!
I can’t wait 15 min to finish the video when my comment can be so early. But knowing the punchline is going to be a doozy I am going to put it on 1.5 speed. So far I have to say Dr. Mike is pretty funny.
Nic, please, pretty please do one on "the unified theory of sleep: eukaryotes endosymbiotic relationship with mitochondria and rem the push back response for awakening"
It's a life or death quest for me as I have little sws and the connection here to my problem seems to be my best fit to my experience here with other metabolic effects too. Perhaps cyanide (i work hplc), perhaps thc, perhaps my own northern uncoupled mitochondria, who knows. You if anyone. 🙏
2:14 need to see the study for the magic claims re age 8
"Hello everybody"
"Hi Dr Nic"
You have to do a Simpsons meme
Can’t wait for Dr. Ducette to weigh in
Looks like everyone is a doctor now on the social media or claim to be. I know Nic and Mike are real doctors, and so is Oz while in my opinion he shouldn't be one. So now we arrived at having commentary on commentary on TV quack doctor. Alright. Weird times. However giving a sort of a " peer review " of popular influencers with huge audiences and their claims is a big positive ,so thanks for that Nic. Edited comment to address misinterpretations and expand on originally provided information that was brought to my attention by certain members of the audience.
Well the “TV quack” had a huge audience and influence (and has a real MD degree) so ya, it makes sense for someone knowledgeable to parse his claims. No need to be snarky about other people’s degrees. A PhD has a doctorate.
@MelloCello55 I have no problem with people being actual doctors either MD or PhD. I call Oz a quack because he pushes unproven stuff to his enormous audience and that does harm.
@@MelloCello55 For whatever reason my comment didn't get through. I have nothing against people being actual doctors. I am against pushing unproven products by a TV doctor to his audience. That does harm.
@@demonfedor3748 Right, but saying “everyone is a doctor now” implies that people without degrees that confer the title are using the title.
@@MelloCello55 They do. It adds weight to their words. Sometimes they have no title sometimes they have doctor of Chiropractic title which honestly makes them as much of a doctor as sport glasses make you an athlete.
Does Israeletz do clinical research studies?
He holds a PhD - that does mean that he did have to at one point.
I would guess, though, that he currently does not.
His "knowledge" is second hand at best.
Coffee is a coffee bean extract.
The “magic” is the humans will say/do anything or fame or fortune…imagine that!
I would like to hear your thoughts on krill oil and its potential to reduce Alzheimer’s, as discussed in Nick Norwitz's latest video. Thank you.
It is kinda wacky how some studies have such a small sample size, I get it due to budget and getting participants can be a challenge.
Coffee speeds up my digestion ie poo.😊
Whatever you say, Dr. Physionics
What a twist!
Hehe :)
About the metabolism. He was saying that they are 2400 kcal and burned 2000 kcal bmi which is an increase in weight of 400 kcal. Critical thinking is your friend.
Jesus you phrased it almost as poorly as Dr Oz. 400 cals was the approximate deficit... 17 lbs x 3500cals/lb ÷ 22 weeks ÷ 7 days/week = 386 cals/day
Participants in the study we around 170 pounds? I'M 170 pounds at 5'6". I'M overweight?
I unsubbed from Dr. Mike when he claimed that canola oil consumption is not harmful.
Makes a differece if it's GMO or not organic. Autor of "Seeds of Deception" was on CoastAM the other night he's censored off all other media.
That's called 'throwing the baby out with the bathwater'
...your loss, is basically what it amounts to.
Well, it isn't. But from this video, Dr. Mike doesn't look at original sources, which stops me from being interested in him.
Seems like your impressed with Israetel.
I'm not impressed with the juice monkey.
The average make would burn about 1600-1800 calories/day just breathing ...
This should start with if the results support drinking more coffee, so we know if we want to watch... 😅
That was a thing... the punchline was a kicker though.
The science white hats like Dr. Nic will be very busy in the coming years.
It's the holy grail stack
My youtube spheres are intersecting. 😁
Also worth nothing that green tea extract can cause liver failure. People just need to eat less and get off their asses more (not necessarily "move more" or "do exercise") and get up off that sofa, chair, or bed and live a little.
Zero Side Effects, could be because they started with 50 volunteers, dosed them before the study started, and eliminated those who had adverse reactions.
Certainly possible - that would need to be reported, which it wasn't, but who knows...
Great video! ZumRX, which is a green coffee bean extract, is use in weight loss and pre workout products. Not for weight loss but for its slower delivery of caffeine for a prolonged energy hit. It’s supposed to deliver not more than 55% of the total caffeine at 1 hour and not less than 80% at 6 hours. Because of its polyphenol content it’s suppose to have nitric oxide inducing benefits and help with lipid metabolism. But there are a number of other extracts and foods that have a good amount of polyphenols in them. Keep up the great content.
Yeah. Dokter Oz lost me when he claimed these people had a Basal Metabolism of 400 Calories per day. Did he mean to say 1,400? That's plausible.
coffee beans brown roasted NOT green
Doc, Doc, goose
I forgot I was watching nics video, you scared me there
Am I that ugly? 😂
@ more like I scroll too much.
“There are too many doctors up in here.” -Nelly
“But Nic there is a major oversight you over looked” I say in the comments
“What’s that? Something I missed?” Replies Nic
“You missed the part about Dr Israel being HUGE! After not agreeing with him, though he was basically right, he’ll eat you for breakfast ”
(Contents removed by TH-cam censor team) Yells Nic
RFK is having a "#>*°+~" start. Oops
better off w OZZY...! "no offence Ozzy"
this was hard to listen to..always appreciate info though
Dr. Oz should have talked about dr.Pepper the miracle soda, so that there would have been 4 Dr's in this title.
I am sure Dr. Oz would love to get Dr.Pepper money and totally prepared to sacrifice his first born, so this is not far fetched.
I I stopped watching "Doctor Mike" a couple years ago, when he (back then an adamant CICO proponent, dont know what he tells now), claimed that he's not only shure its only calories, he knows it for a fact. because "we have read the studies. ALL OF THEM"
As "Dr" Oz is going to hold a position in Trump's benevolent regime of truth and light, I would curb my criticism if I were you or Dr Mike...
@mbarley
That's a...
'compliance beforehand' stance - for passive cowards...
I sincerely doubt it's a strategy Dr. Nic or Dr. Mike would consider (obviously)😊
Just my 2cents...but I do know you were kidding😆
@barbarafairbanks4578 I was kidding but as I am nit an American I can act 'brave' without implications. Let's hope our bravery won't be tested as shameless people the likes of dr Oz assume positions of power