Great addition to the previous video on dementia. One thing I think a lot of medical professionals and health influencers alike are overlooking is the effect of poor oral health on cognitive decline and dementia risk. The mouth is the gateway to the rest of the body, and pathogenic bacteria that cause chronic inflammation in the gums and jawbones, particularly due to periodontal disease (which is disturbingly common), can spread to other parts of the body, including the brain, and cause chronic inflammation there as well, increasing the risk of neurodegenerative diseases like dementia. It seems to be more than just correlation (people with dementia struggling to keep up with oral health), as periodontal disease often predates the development of dementia, and some of the pathogenic bacteria heavily implicated in periodontal disease, like Porphyromonas Gingivalis, increase the risk of beta-amyloid plaques in the brain, which is heavily implicated in the development of neurodegenerative diseases. Poor oral health seems to have causative relation with a very large number of other common diseases as well. I'd say, good oral health is one of the often overlooked pillars of overall health and longevity. Oh, and pets help with fighting feelings of social isolation and loneliness. Dogs, for example, are no replacement for human contact, but I honestly never feel lonely with my trusty little pupper by my side, and there's research backing this up as well...
That's actually discussed in the extended version. It wasn't added to the 'probable' risk factors, because while it is on the radar, it doesn't have quite the level of evidence needed to graduate to that point yet - we'll see in the future... Good point!
I'm socially isolated on purpose. Family stresses me out and the stress will probably contribute to my possible eventual dementia. I do meet with my bff every other week. That's plenty enough for me.
@@nunyabeezwacks1408 Same, I do enjoy social interactions when its certain people at certain times, but there is a level of peace and happiness that can only be achieved when I am alone. I also never feel lonely. I think I am just built differently. I also wonder if the longevity studies on the benefits for married people differ between men and women. Love the username by the way!
@@TheCookiecupcakes There are some effects that are more pronounced in men, mainly the ones relating to health (the current theory is that married men visit the doctor more often due to pressure from their wives), but as far as I'm aware all the positive impacts observed are valid both for men and women, HOWEVER, as I mentioned in another comment, most of those studies compare "currently married people" vs "currently unmarried people", with the later including divorced and widowed people, but when you instead compare "currently married people" vs "people who NEVER married", then most of the differences are gone, so it seems that the negative outcomes in "currently unmarried people" are mostly driven by the negative emotional impacts of getting a divorce or your partner dying.
On the air pollution subject: A stupidly effective air cleaner can be built for about $50-100 using a box fan and taping one merv 13 or higher to the intake side or building a sort of cube out of four filters and the box fan with the fan facing upward. Using a device like that can decrease the pollutant concentration in your bedroom , for example, and therefore reduce your overall exposure to air pollution. You can also purchase hepa air cleaners that are more elegant but cost more.
"Being married" is too simplistic. The question should be: "Is the relationship with your spouse a relatively pleasant and fulfilling one? Or are you generally miserable around them, but lack the motivation, energy and discipline to change the situation for the better? If its the latter, I believe your dementia risk is not being mitigated by being married.
My two daughters have autism. When I was young about 4 years old I would stutter. I knew what I wanted to say but the words never entered my brain. The doctor told my mother to just let me speak slowly until I got out what I wanted to say. Then after growing up I never talked a lot while the other kids were talking a lot more. My dad said I was an introvert. I didn't know what to talk about and so I only really had one friend who was like me. I am still like that I can't remember the word I want until an hour later when it pops into my head. Far to late for a fluent conversation. But I know when I get short sleep for a few days in a row, maybe 5 hours for 4 or 5 days , my ability to speak gets a lot better and I sound like an orator. I have no idea why it happens. My older daughter is 4 and she is learning a lot of words now but only for the last 6 months and single words mostly. She seems to be getting better just the last few weeks. My second daughter just turned 3 and only says two words maybe. She is autistic also but not diagnosed yet, waiting for the appointment for the specialist which takes over a year. I am 68 now and have 4 daughter. 2 older daughters in their 20's. I think the autism is due to epigenetic changes in DNA and it could be a very natural response to some environmental factor. After all many autistic people can concentrate on one topic and this is how new inventions pop up. I used to pound on the piano as a kid and other kids did the same , playing random notes but my daughter turns on the piano and plays the notes one at a time up and down the piano and then different instruments and will play one note for about 5 minutes until it drives you crazy. I don't know if she is memorizing the sound of a single note? I just let her play all she can because she seems to like it. I try to teach her some basic songs and will see what happens.
Wow Marc - really generous of you. I almost wish you had joined the Insiders so I can offer more benefit to you, but I appreciate this nonetheless. Thank you.
Regarding marital status, there is also the fact that "unmarried people" cohorts usually include divorced and widowed people, and many of the associations between "unmarried status" and things like depression and lower life satisfaction go away when you compare "married vs never married" rather than "married vs currently unmarried". EDIT: I know Nick was joking, but that idea of "getting desperate and rushing to find someone to marry due to being scared by the statistics on the negative outcomes for unmarried people" could actually increase your chances of having said negative outcomes, given that doing so may end up leading you to get into a bad marriage and then divorce, which seems to be the group that is really driving the negative effects seen in unmarried cohorts.
3:06 bro(er- I mean, Doctor), this is one of the things that makes you so unique as an expert health advocate. You have a great sense of humor without escaping out of making legitimate analytical claims.
I know this guy and he had a mother that died with dementia, an older sister that died with dementia, and he did basically nothing about it and now he has dementia. And here's the thing, he is strongly social. Always around his friends though it was probably a group of 10 or so. He is a talker, but seldom learned new skills really beyond doing some house cleaning. He probably borders on obese and eats what he feels like eating. He hates vegetables. Everyone gets more isolated as they get older. I think it can be mentally stimulating if you are introduced to new ideas, but I have my doubts about people sitting together on a couch watching television. I can't believe that would stop anything. I would rather be out hiking, studying anything, learning an instrument, programming, and fixing things around the house, not just keeping it clean. I think it's mainly atrophy.
I think just going on TH-cam and bouncing your ideas off other people and arguing is helpful. I also just read that people who like to complain seem to live longer. Maybe it is because they don't take any shit and don't stew in their emotions and just let it all out.
If you have vision problems you can’t read. Reading is stimulating so that tallies. My mother in law has macular degeneration. She used to read a lot but that is now too difficult. She just got diagnosed with vascular dementia, which I guess has the same causes, so two factors together. Vision loss also makes you less confident to walk, let alone run or cycle.
This video gave me deep belly laughs, thank you kind sir. After dealing with Dementia on a nationwide scale the past four years, it made me realize that the brain is the most interesting thing in the world to me. We know less about brains, than we do about space, or the depths of the ocean.
You brought up air pollutants. There is another that most people aren't aware of which comes off of tires, asphalt and brakes. It's a very very fine black powder or soot that shows when it accumulates. Since I live in an urban environment with high traffic, I've witnessed it over time. It is so fine it doesn't come out of carpet with vacuuming; it must me cleaned out professionally.
Check out frying food, it spits up all kinds of tiny oil particles and other burnt stuff and you breath this in and it can go to your brain. So maybe it is better to eat out or not fry food at home, or get an extra heavy duty hood for your oven to blow this stuff outside. I also read that most of the fine plastic in the air, that is world wide now, does not come from your home plastic that you recycle but it comes from cars and roads, tires wearing down. This all goes into the air and spreads worldwide .
Exposure to nanoparticles during cooking causes changes to brain activity similar to that observed in early-stage Alzheimer’s disease, finds new research from Nazarbayev University School of Engineering and Digital Sciences (NU SEDS).x
People with high BP are told to decrease salt intake. Should they also restrict sugar? Fructose converts to uric acid, which decreases nitric oxide. Increased insulin retains salt. Both increase BP.
Superb as always from Nicolas Verhoeven. I suspect you've already thought of this Nic but wanted to leave it open to the audience, but I think the high blood pressure through a large chunk of life followed by a sudden phase of low blood pressure prior to dementia is indeed probably not causative in itself regarding dementia - but rather a predictable pattern. It may reflect the bulk of one's adult life working (and/or the bulk of one's adult life in a phase of work where one has a lot of agency or is doing very stimulating work), followed by retirement or moving to a final phase of less agency/being simply less stimulated. I don't have the stats, but there's considerable research showing an overall decline in health for retired people and there's a lot of advice on having a plan to have stimulating hobbies etc when that time comes. If one connects it to the research that you have excellent summarised in these 2 related videos, then this would correlate nicely with retirement/demotion/boredom in the tail end of on'e career with less stimulation of the your mind depending on one's job, less social interaction, less movement leading to lower cardiovascular health, less likely to bother get hearing aids (less frequent need for it with increased isolation), more likely to be depressed as you no longer have a job that may have defined who one is to a potentially unhealthy degree etc. Obviously I'm basing this on logic and probability built on the data you have analysed here and on other research showing patterns post-retirement, so I'm not sure it is correct of course. However, usually 'counter-intuitive' and dramatic physiological changes like this are not causative, but rather correlative. I'm a software guy, but I used to be a molecular biologist and initially worked in medical research and then biotech - once a scientist, always one I guess. Not that all scientists understand logic, or even how to be a good scientist for that matter. I'd like to commend you on being one of the very few communicators in this space that consistently delivers value. In fact I can't think of anyone I'd rank higher in the pursuit of your 2 stated goals of making medical research understandable, and empowerment of non science 'trained' individuals in who to deconstruct medical research (and by extension a lot of scientific research). I wish you continued success and thank you for the tremendous value you create and share.
That's an interesting hypothesis. It's true that retirement can hit some people extremely hard, which could play a major factor. I think there's a lot there that still needs to be figured out. I appreciate you speculating on the topic - makes for interesting reading!
@@Physionic Yes of course - far too many moving parts to figure out in a single long term study, but fun to speculate on. Ultimately it's probably wise to make decisions /plans based on a combination of data, logic, and probability. Sometimes awaiting the burden of ultimate proof is indeed a burden. The key is not go beyond that by communicating something probable (or seemingly probable based on X,Y, and Z) as if it were written in the stars and/or proven - which is what the majority of youtube bro-culture (you know, the ones that think data is made of cherries) indulges in (at least in my perhaps not modest enough opinion)
Similarly to vision loss, hearing loss is also a risk factor for cognitive impairment and dementia. I suppose isolation is, once again, the key - loss of senses isolates one from the world and from other people.
About the correlation between social isolation and dementia... maybe the arrow of causation is from the latter to the former. How could that be elucidated?
When The ratio of LDL to HDL is high (more LDL than HDL particles) in the blood there is a disruption of the performance of cardiovascular wall repair. A dietary intake high in fried food using seed oil has a high LDL dietary intake is very common in the American diet. A dietary intake high in Omega 3 will increase the level of HDL and improves the performance of cardiovascular inner wall repair.
As pointed out in the video, there have been studies showing an association between brain health and exercise. However, considering that cardiovascular health is also linked to brain health, this link could be explaining the mechanism behind the improved brain health from exercise. Exercise improves cardiovascular health which leads to improved brain health.
Here's an idea about the blood pressure drop prior to dementia onset - maybe it's related to a decline in sympathetic activity that precedes dementia? Not all hypertension is caused by obesity or salt intake, some people just have overactive sympathetic nervous systems. Maybe whatever causes dementia just causes less sympathetic activity in general (which would lower BP). Like maybe the proteins that cause dementia also inhibit response to things like adrenaline.
Seems like a worthwhile hypothesis, if you believe as I do that the body is supremely intelligent. High BP is in many cases an adaptive response to obstruction(s). Perhaps at some point the body realizes the futility/danger of prolonged increases of BP and finally gives up on brain health and seeks to lower BP to reduce damage beginning to occur from hbp elsewhere in the body.
Thank you so much for all your efforts in sharing such valuable information! I would love to hear your opinion on recent studies showing a link between anti depressant usage and dementia. 😊
Were there drugs used to reduce the blood pressure like beta blockers? If reduced blood pressure also means reduced blood circulation volume , i imagine reduced performance of kidney and liver function, leaving more toxins in circulation.
In regard to the higher LDL it maybe useful to to breakdown the percentage difference between healthy LDL to oxidized LDL as it pertains to the connection to Dementia
I wonder to what extent social isolation rather than being a risk factor for dementia is instead a leading indicator of undiagnosed dementia, i.e. if behavioural changes brought about by the early stages of dementia are leading to social isolation?
7:51 I have a hypothesis: the first few years when hypertension starts, endothelial damage in the arteries supplying the brain accrues leading to repair with cholesterol and other clotting molecules creating scar tissue, plaque, and calcifications which narrow the arteries leading to ischemia in the brain which starts the brain tissue degradation process that leads to dementia. At the early stages of dementia, before behavioral symptoms manifest but blood pressure had already been observed to be high, the subject in question is put on blood pressure lowering medication and is also encouraged to change their diet and other lifestyle aspects but the combo frequently over-corrects blood pressure making it even harder for blood and oxygen to be pumped through the already ischemic arteries in the neck and head. This combo of initial damage from the start of the hypertension topped off with the over-corrected blood pressure a few years later leads to a double whammy of blood and oxygen deprivation to brain tissue, accelerating the manifestation of dementia symptoms.
Diabetes isn't caused by carbs. People who have diabetes handle glucose badly. Prevent diabetes, by eating healthy (which includes healthy carbs like beans and whole grains), and you can handle carbs from fruit fine.
@@Physionicdo you think you could get through to people about something like carb quality? The difference between added sugar and beans or fruit, for instance.
@@Physionic Poland is still using coal for a lot of heating. There's a lot of infrastructure deficits and a lot of houses still use individual coal furnaces for getting their heat in the winter and hot water throughout the year. Whereas cities have central heating/thermal plants and gas for the most part.
The key is WHERE. Some rural areas use low quality coal as fuel sometimes moist woods or even waste like plastics with old fashion cold burning. That's very problematic especially in winters. Air pollution is mostly quantify as PM2.5 or PM10 particles in ppm units. Most cities limited their car traffic to prefer more eco form of public transporting. But I bet wooden smoke is less harmful than oil or diesel fumes with heavy metals residues or coal/plastic smoke.
I think it would’ve been more clarifying to separate the different forms of dementia. For example, the typical cardiovascular risk factors are hardly surprising as risk factors for vascular dementia
Regarding low blood pressure and less flow thru brain. I think that's a big factor in brain health. I am hardcore on inversion and hang upside down for 15 minutes per day. It's well know to improve mood and help with anxiety and depression. IMO I think it's a preventive maintenance thing you can do for the brain. Of course all the other factors like diet, exercise and social interactions need to be done too.
How about the number of times you've had covid? Or if you have long Covid? Or having an autoimmune disease (which increases inflammation levels)? These are pretty widespread, and should have some effect on dementia too.
To the question about why blood pressure suddenly goes down before a dementia diagnosis, I think I might have a hypothesis. Perhaps a person who did not take care of their health for most of their life is now experiencing health issues stemming from their bad lifestyle so they see a doctor. The doctor makes them get all kinds of checks done and sees that that person has all kinds of issues and one of them is high blood pressure so they give them blood pressure meds. Now that person is regularly getting check ups done because they have to and one of the things that get found later on is dementia. Blood pressure is not causative in this case but it is correlated. Basically what I'm saying is a lifestyle that causes high blood pressure might also cause elevated dementia risk and when one health issue gets discovered the others are soon to follow.
That's a great question! My gut instinct is that it does, especially if you talk to them like they're people, as many do. I could also see the answer being no, because maybe the preventative factor is that you need back and forth communication, specifically interpreting the language of another human and responding to it appropriately. Maybe the truth is in the middle, dogs mitigate the risk but not as much as humans 🤷🏽
About the blood pressure-dementia phenomenon, here's my guess: Chronic hypertension damages small blood vessels in the brain, leading to structural changes, impaired cerebral autoregulation, and reduced resilience to changes in blood pressure. A sudden drop in blood pressure after years of hypertension can cause cerebral hypoperfusion, particularly in vulnerable areas like watershed zones, exacerbating neuronal damage and cognitive decline. This may also impair the clearance of amyloid-beta proteins, contributing to Alzheimer’s pathology, or trigger inflammatory responses that promote neurodegeneration. The combination of vascular damage, reduced perfusion, and possible neurodegenerative processes creates a high risk for vascular dementia, especially when compounded by cardiac dysfunction or overly aggressive blood pressure treatment in older individuals.
I am not married, I am not lonely, I've been married twice, I guess if I want to go insane I'll get married if I want to stay sane I'll stay the way I am. LOL I live alone I don't want no one in my space.😂 I've got plenty to do, I'm not doing all that stuff. 😂. I'm very happy and I'd like to keep it that way. I am 60+ yrs Healthy 😊. And I'm normal weight, no fat just muscle 💪. I wish someone would give me some weight 🤣. All that food I eat isn't giving any, keeps flowing out the other end. 😮. My weight does fluctuate sometimes I wear a size one sometimes I wear a size 3 sometimes I wear size 5 LOL My entire life. Must just be normal for me 😂 I do have a trampoline. Love it and my vision is perfect. Thanks
Thank you so much for this amazing video! I need some advice: I have a SafePal wallet with USDT, and I have the seed phrase. (alarm fetch churn bridge exercise tape speak race clerk couch crater letter). How should I go about transferring them to Binance?
Thanks for this! I've started looking into the blood pressure risk, thanks to your previous mention, and found that orthostatic hypotension (a drop in blood pressure upon standing) is also a risk factor. I have both. 🤦♀️ I might mitigate OH because I use my calf muscles when I stand (by squatting). Those muscles are responsible for pushing the blood back up the body. There's research being done on this. Doesn't help that I've had a desk job for years. Sigh.
Do you think the metabolic syndrom, should actually include brain and lung in the overall alghoritm? I do see in many things you mention, you could always end up on the overall alignement of metabolic syndrome parameters...
Regarding the obesity factor... You mentioned that losing a percentage of your body weight would provide some protection against dementia... Which is interesting...I would think that your weight would have to become "normal" to provide a benefit... For example, if it's based on percentage then you could weigh 300 lbs, lose 5% and weigh 285 lbs and get the benefit. Can you explain?
I understand that people not watching your whole video is an issue for you, but it would be very useful for everyone with a recap. The lack of them often makes me find other sources of information despite my preference for your teaching. I like your going in depth, but makes retention more difficult, especially when you don't summarize. It's common for TH-camrs to do that now; most creators even introduce chapters, which also allows for repetition. Perhaps I've simply got worse memory than most of your potential audience, or maybe I'm more interested in details. anyway... There you have my verbose five cents.
The mRNA vaccine group exhibited a significantly higher incidence of AD (Odds Ratio [OR]: 1.225; 95% Confidence Interval [CI]: 1.025-1.464; p = 0.026) and MCI (OR: 2.377; CI: 1.845-3.064; p < 0.001) compared to the unvaccinated group.
Unknown. I'd consider that the lowest time period for risk, but there's definitely need for further investigation to tease out those details - it's something I expect to do.
What about the familial mutation in the JR2R3 area of a TAU protein whereas the proline is changed to leucine, thus potentially causing manufacture of amyloid fibrils? As described here th-cam.com/video/ahDSjRLb2Hk/w-d-xo.htmlsi=RsmtnhHMaOBrnIhc
I wonder if those parameters will change with the next generation. The generation that these data are based on were not users of technology, and their definition of success would include being married. So, less interaction with social media and internet content, and lower self image. I am 69, and have a low amount of in person social interactions, but I am more aware of scientific developments, politics, literature, etc than most others my age. I dont think dementia is a risk for me, at least not in regard to social interaction.
I am convinced that we’re looking at dementia wrongly like it’s a category. I am convinced many people could live with dementia and have happy lies and I think there are many different kinds and some of its vascular and it’s just a diminishing and when someone suffering from it, we should all rally around them And try to cheer them up and see what we can do instead where secluding people likw we are doing. Something about it seems like a function of the market to me and could be corrected. I almost can’t type this because I’m the one that made the most mistakes and I see the import of it now and it’s too late.
It sounds too simple to be real, but its starting seem a lot like not being with it makes you permanently out of it. Like, if you put someone in solitary confinement for years, they would come out with dementia.
Risk factors shouldn't be seen as '100% causative', but as contributors that could lead to an outcome. A person could reduce risk in 4/6 areas and still never develop dementia.
If you say yes..its' meant to be an introvert or even an super introvert... Haaa and nope.. I' m best served in living in the wood- champs .. etc I just crave the calm...😊..even doable 10 kms far from Zürich..😂🎉❤
Put time stamps and allow commenters to summarise videos. TH-cam algorithm will help you if you do that. Opposite of what you think of it, which is that you think the youtube algorithm demotes it. This is frustrating to watch your videos
I have the data from hundreds of my videos that disagrees with your perspective on timestamps - you’ll notice most others don’t put timestamps for 15 minute videos either, there’s good reason for that. If my videos are frustrating to you, you’re free to not watch them - I respect your choice.
@@Physionic I cant not watch them. That is why I have put this above comment in. If not summarise, some text list or something which all youtubers give in the video, just one slide that is, within 3 minutes of video. Or at least dont delete comments nor ban such users who summarise or list out. If the list is interesting then people will watch the video full anyway. You have mistaken youtube algorithm, or your sample size on this is too small.
I usually offer a short take-away/conclusion at the end, just skip to the end of my videos, then. I don’t need more data on timestamps - it’s 100% of videos, all the time, do worse with timestamps. I don’t need to screw myself more just to get to the same conclusion, haha. I’m also trying to attract people who want to learn which means they invest the 10-15 minutes so they learn the context of the work instead of this tiktok style, contextless BS I see all too common on social media. If 15 minutes of time is too much time to learn weeks worth of work, then I genuinely don’t want that person watching - they aren’t my intended audience. Learning takes work and it takes patience, assuming you want a *good* education, and if a 15 minute video is the barrier between a fleshed out, explained solution pulling together many studies that take weeks to analyze and put together, then I actively don’t want to attract those people.
@@Physionic Thanks for the reply. It is not that i watch all your videos in short form. The videos of topics which interest me i do watch your full video. But I dont want to spend full time on some videos on topics which I am not that interested. I will skip towards the end as you suggested for such videos in future. Just not deleting user comments nor banning users who summarise would be sufficient. Or one slide of the list would be good too, which can be put just after 1 minute which is the auto play length on TV.
I'll see what I can do about timestamps - it might be possible to find a middle ground. I still can't have people posting summaries and lists of all the work - those are killer to the video performance, and when I spend 3-500$ making the video (not including my time), it hurts my ability to continue this work, so that's a no-go.
Hey Physionic, I realized your videos are a lot softer than other videos on the TH-cam platform. If you could increase the volume of your videos, that would be greatly appreciated. Thanks!
Hypothesis: Alzheimer’s Disease as a Cardiovascular Condition Driven by Heart Contractility and System Coherence Alzheimer’s disease (AD) is typically regarded as a neurodegenerative condition characterised by the accumulation of tau proteins and amyloid-beta plaques in the brain. However, I propose that Alzheimer’s may also be understood as a cardiovascular condition, fundamentally driven by heart contractility and the body’s overall system coherence. This hypothesis is based on the role that the heart plays in generating sufficient arterial pressure to push cerebrospinal fluid (CSF) through the brain’s perivascular space (PVS), thereby clearing neurotoxic waste products. The studies attached to this hypothesis-the BALTAZAR study, which explores the effects of caffeine on CSF biomarkers in Alzheimer’s, and the PVS research on CSF flow-are foundational to this argument. Key Mechanisms 1. Heart Contractility and Arterial Pulsations: The heart’s contractility is a key driver of arterial pulsatility, which is critical for generating the necessary pressure to push CSF through the glymphatic system in the brain. The PVS study demonstrates that arterial pressure drives CSF flow, which is essential for clearing metabolic waste, including tau and amyloid-beta proteins. Therefore, when heart contractility is weakened, CSF flow diminishes, resulting in the accumulation of waste products that contribute to Alzheimer’s pathology. 2. Caffeine’s Role in Enhancing Contractility: The BALTAZAR study provides evidence that caffeine consumption is associated with improved CSF biomarker profiles in individuals with mild cognitive impairment. Caffeine increases heart contractility and arterial pressure, which, according to the PVS study, would enhance the flow of CSF through the brain. This suggests that caffeine’s protective effects against Alzheimer’s could stem from its ability to maintain or increase heart contractility, facilitating better clearance of neurotoxic proteins from the brain. 3. System Coherence: Heart contractility is not purely a mechanical phenomenon; it is also influenced by the coherence of the mind-body system. In this context, coherence refers to the harmonious functioning of consciousness, the mind, and the body. Consciousness, though separate from the mind and body, can influence their collaboration. When individuals are mentally engaged and consciously aware, heart rate variability (HRV) tends to be high, indicating a coherent system. This coherence can directly enhance heart contractility, thus maintaining effective arterial pressure and CSF flow. Conversely, when coherence is low (due to mental disengagement or stress), heart contractility weakens, exacerbating the risk of neurodegenerative conditions like Alzheimer’s. Electromagnetic Considerations The heart’s contractility and the body’s overall coherence can be further understood through the lens of electromagnetism. The heart generates a strong electromagnetic field that interacts with the body’s systems, including the brain. In this model: - Electricity represents the physical matter of the body. - Magnetism represents the energy or mental processes. - Electromagnetism represents the conscious coherence that binds the system together. Strong heart contractions generate a more coherent and synchronised electromagnetic field, which helps align both mental coherence and physical coherence. If heart contractility is compromised, the body’s electromagnetic field weakens, reducing overall system coherence and potentially accelerating neurodegenerative processes. Hypothesis Implications for Alzheimer’s Treatment If Alzheimer’s is indeed linked to heart contractility and systemic coherence, future treatments should focus not only on neurological factors but also on improving heart function and enhancing coherence. Such treatments could include: 1. Pharmacological interventions that improve heart contractility, such as rapamycin (please see attached study) or other cardiovascular agents. 2. Lifestyle interventions that enhance mental and physical coherence, including meditation, exercise, and heart-rate variability training. 3. Comprehensive cardiovascular monitoring in Alzheimer’s patients, focusing on contractility and arterial pulsations as key indicators of brain waste clearance efficiency. Conclusion Alzheimer’s disease should be considered, at least in part, a cardiovascular condition where the failure of heart contractility and system coherence leads to the accumulation of waste products in the brain. By addressing heart health and promoting systemic coherence, we may be able to prevent or slow the progression of Alzheimer’s. The attached research on the PVS system and the effects of caffeine on Alzheimer’s biomarkers provides empirical support for this hypothesis, offering a new lens through which to explore both the causes and treatments of neurodegenerative diseases. PVS Research doi.org/10.1073/pnas.2407246121 BALTAZAR cohort study doi.org/10.1002/alz.14169 Rapamycin Study doi.org/10.1111/acel.13086
There is a theory that the amyloid plaques are a symptom, not a cause; that they are the brain immune system's attempt to contain an infection or other negative influence.
@@Weberkooks Bro what are you smoking of course he didnt have Dementia. From what ive read he was living with his grand parents coz his parents or one of them had a mental issue, now some say his at some point one of his grand parents developed it or his father actually developed it. but in any case there a lot common theme both in a Dementia patient and usually the main protagonist of the his works. the alienation, the inevitability of Cuthulhu and the main protagonist death.... .
Social isolation: here is another perspective on that and it really is in your attitude: Learn to love solitude To love to be with only yourself more often. A person has to learn this from childhood to be able to be alone. That's not to say "to be lonely". It means to be able to not be bored/lonely by oneself. That doesn’t mean you should be lonely, but that you shouldn’t grow bored with yourself because people who grow bored in their own company seem to me in danger, from a self-esteem point of view."
Not sure about drop in bloood pressure before dementia diagnosis. I can think only about case where drop is not a preaccessor to dementia. Drop in blood pressure while being with atherosclerosis - brain have less blood and dementia from here. But I can't think about other way around - where BP drop is caused from the same pathological process as dementia.
Obesity is a key for long happy life. You are getting dopamine eating whatever you want in any amounts. And also you are getting sympathy from other people for your illness.
Great addition to the previous video on dementia. One thing I think a lot of medical professionals and health influencers alike are overlooking is the effect of poor oral health on cognitive decline and dementia risk. The mouth is the gateway to the rest of the body, and pathogenic bacteria that cause chronic inflammation in the gums and jawbones, particularly due to periodontal disease (which is disturbingly common), can spread to other parts of the body, including the brain, and cause chronic inflammation there as well, increasing the risk of neurodegenerative diseases like dementia. It seems to be more than just correlation (people with dementia struggling to keep up with oral health), as periodontal disease often predates the development of dementia, and some of the pathogenic bacteria heavily implicated in periodontal disease, like Porphyromonas Gingivalis, increase the risk of beta-amyloid plaques in the brain, which is heavily implicated in the development of neurodegenerative diseases. Poor oral health seems to have causative relation with a very large number of other common diseases as well. I'd say, good oral health is one of the often overlooked pillars of overall health and longevity. Oh, and pets help with fighting feelings of social isolation and loneliness. Dogs, for example, are no replacement for human contact, but I honestly never feel lonely with my trusty little pupper by my side, and there's research backing this up as well...
That's actually discussed in the extended version. It wasn't added to the 'probable' risk factors, because while it is on the radar, it doesn't have quite the level of evidence needed to graduate to that point yet - we'll see in the future... Good point!
@Physionic thanks for the response! If I had the disposable income I'd definitely subscribe to the physionic insiders...
Brillante ❤ your totally right 😊
Please never lose how informative you are as your channel grows!
The channel won’t grow if I lose that :)
I don’t want dementia chiefly because I don’t want to forget to watch this channel. Love this channel and Nic. ❤
Thanks :)
3:30 Whew, im technically not socially isolated! Yay! I'll never give up living alone either way, it's just too good.
🙋♀️😂
I'm socially isolated on purpose. Family stresses me out and the stress will probably contribute to my possible eventual dementia. I do meet with my bff every other week. That's plenty enough for me.
@@nunyabeezwacks1408 Same, I do enjoy social interactions when its certain people at certain times, but there is a level of peace and happiness that can only be achieved when I am alone. I also never feel lonely. I think I am just built differently. I also wonder if the longevity studies on the benefits for married people differ between men and women. Love the username by the way!
Let’s hear it for the technical social butterflies!
@@TheCookiecupcakes There are some effects that are more pronounced in men, mainly the ones relating to health (the current theory is that married men visit the doctor more often due to pressure from their wives), but as far as I'm aware all the positive impacts observed are valid both for men and women, HOWEVER, as I mentioned in another comment, most of those studies compare "currently married people" vs "currently unmarried people", with the later including divorced and widowed people, but when you instead compare "currently married people" vs "people who NEVER married", then most of the differences are gone, so it seems that the negative outcomes in "currently unmarried people" are mostly driven by the negative emotional impacts of getting a divorce or your partner dying.
On the air pollution subject:
A stupidly effective air cleaner can be built for about $50-100 using a box fan and taping one merv 13 or higher to the intake side or building a sort of cube out of four filters and the box fan with the fan facing upward. Using a device like that can decrease the pollutant concentration in your bedroom , for example, and therefore reduce your overall exposure to air pollution. You can also purchase hepa air cleaners that are more elegant but cost more.
Regarding marriage, the VA also found an association between marriage and life expectancy. Vets that are married live longer
Very interesting - thanks for sharing!
It just seems that way... someone had to say it 🙂
That's because they have their wives to make them go to the doctor when needed.
Marriage: because veterans always need an impossible mission! 😂😂😂😂
"Being married" is too simplistic. The question should be: "Is the relationship with your spouse a relatively pleasant and fulfilling one? Or are you generally miserable around them, but lack the motivation, energy and discipline to change the situation for the better? If its the latter, I believe your dementia risk is not being mitigated by being married.
As an A1 64yr. male; my isolation is more about me being an introvert; not; that I can't be chatty small talk but it is my autism.
I wonder if isolation for somebody with autism might improve their longevity. That being with people wears them down.
@Kermit_T_Frog It is the stress of people that is avoided; not want of isolation. I'm very productive with my projects.
My two daughters have autism. When I was young about 4 years old I would stutter. I knew what I wanted to say but the words never entered my brain. The doctor told my mother to just let me speak slowly until I got out what I wanted to say. Then after growing up I never talked a lot while the other kids were talking a lot more. My dad said I was an introvert. I didn't know what to talk about and so I only really had one friend who was like me. I am still like that I can't remember the word I want until an hour later when it pops into my head. Far to late for a fluent conversation. But I know when I get short sleep for a few days in a row, maybe 5 hours for 4 or 5 days , my ability to speak gets a lot better and I sound like an orator. I have no idea why it happens. My older daughter is 4 and she is learning a lot of words now but only for the last 6 months and single words mostly. She seems to be getting better just the last few weeks. My second daughter just turned 3 and only says two words maybe. She is autistic also but not diagnosed yet, waiting for the appointment for the specialist which takes over a year. I am 68 now and have 4 daughter. 2 older daughters in their 20's. I think the autism is due to epigenetic changes in DNA and it could be a very natural response to some environmental factor. After all many autistic people can concentrate on one topic and this is how new inventions pop up.
I used to pound on the piano as a kid and other kids did the same , playing random notes but my daughter turns on the piano and plays the notes one at a time up and down the piano and then different instruments and will play one note for about 5 minutes until it drives you crazy. I don't know if she is memorizing the sound of a single note? I just let her play all she can because she seems to like it. I try to teach her some basic songs and will see what happens.
@jeffguarino2097 I hope all goes well for you and your children.
Exercise reduces the risk of cataract's and macular degeneration.
Thanks!
Wow Marc - really generous of you. I almost wish you had joined the Insiders so I can offer more benefit to you, but I appreciate this nonetheless. Thank you.
Regarding marital status, there is also the fact that "unmarried people" cohorts usually include divorced and widowed people, and many of the associations between "unmarried status" and things like depression and lower life satisfaction go away when you compare "married vs never married" rather than "married vs currently unmarried".
EDIT: I know Nick was joking, but that idea of "getting desperate and rushing to find someone to marry due to being scared by the statistics on the negative outcomes for unmarried people" could actually increase your chances of having said negative outcomes, given that doing so may end up leading you to get into a bad marriage and then divorce, which seems to be the group that is really driving the negative effects seen in unmarried cohorts.
3:06 bro(er- I mean, Doctor), this is one of the things that makes you so unique as an expert health advocate. You have a great sense of humor without escaping out of making legitimate analytical claims.
Thanks :)
I know this guy and he had a mother that died with dementia, an older sister that died with dementia, and he did basically nothing about it and now he has dementia. And here's the thing, he is strongly social. Always around his friends though it was probably a group of 10 or so. He is a talker, but seldom learned new skills really beyond doing some house cleaning. He probably borders on obese and eats what he feels like eating. He hates vegetables. Everyone gets more isolated as they get older. I think it can be mentally stimulating if you are introduced to new ideas, but I have my doubts about people sitting together on a couch watching television. I can't believe that would stop anything. I would rather be out hiking, studying anything, learning an instrument, programming, and fixing things around the house, not just keeping it clean. I think it's mainly atrophy.
I think just going on TH-cam and bouncing your ideas off other people and arguing is helpful. I also just read that people who like to complain seem to live longer. Maybe it is because they don't take any shit and don't stew in their emotions and just let it all out.
If you have vision problems you can’t read. Reading is stimulating so that tallies. My mother in law has macular degeneration. She used to read a lot but that is now too difficult. She just got diagnosed with vascular dementia, which I guess has the same causes, so two factors together.
Vision loss also makes you less confident to walk, let alone run or cycle.
This video gave me deep belly laughs, thank you kind sir. After dealing with Dementia on a nationwide scale the past four years, it made me realize that the brain is the most interesting thing in the world to me. We know less about brains, than we do about space, or the depths of the ocean.
You brought up air pollutants. There is another that most people aren't aware of which comes off of tires, asphalt and brakes. It's a very very fine black powder or soot that shows when it accumulates. Since I live in an urban environment with high traffic, I've witnessed it over time. It is so fine it doesn't come out of carpet with vacuuming; it must me cleaned out professionally.
Check out frying food, it spits up all kinds of tiny oil particles and other burnt stuff and you breath this in and it can go to your brain. So maybe it is better to eat out or not fry food at home, or get an extra heavy duty hood for your oven to blow this stuff outside.
I also read that most of the fine plastic in the air, that is world wide now, does not come from your home plastic that you recycle but it comes from cars and roads, tires wearing down. This all goes into the air and spreads worldwide .
Exposure to nanoparticles during cooking causes changes to brain activity similar to that observed in early-stage Alzheimer’s disease, finds new research from Nazarbayev University School of Engineering and Digital Sciences (NU SEDS).x
People with high BP are told to decrease salt intake. Should they also restrict sugar? Fructose converts to uric acid, which decreases nitric oxide. Increased insulin retains salt. Both increase BP.
Superb as always from Nicolas Verhoeven. I suspect you've already thought of this Nic but wanted to leave it open to the audience, but I think the high blood pressure through a large chunk of life followed by a sudden phase of low blood pressure prior to dementia is indeed probably not causative in itself regarding dementia - but rather a predictable pattern. It may reflect the bulk of one's adult life working (and/or the bulk of one's adult life in a phase of work where one has a lot of agency or is doing very stimulating work), followed by retirement or moving to a final phase of less agency/being simply less stimulated. I don't have the stats, but there's considerable research showing an overall decline in health for retired people and there's a lot of advice on having a plan to have stimulating hobbies etc when that time comes. If one connects it to the research that you have excellent summarised in these 2 related videos, then this would correlate nicely with retirement/demotion/boredom in the tail end of on'e career with less stimulation of the your mind depending on one's job, less social interaction, less movement leading to lower cardiovascular health, less likely to bother get hearing aids (less frequent need for it with increased isolation), more likely to be depressed as you no longer have a job that may have defined who one is to a potentially unhealthy degree etc. Obviously I'm basing this on logic and probability built on the data you have analysed here and on other research showing patterns post-retirement, so I'm not sure it is correct of course. However, usually 'counter-intuitive' and dramatic physiological changes like this are not causative, but rather correlative. I'm a software guy, but I used to be a molecular biologist and initially worked in medical research and then biotech - once a scientist, always one I guess. Not that all scientists understand logic, or even how to be a good scientist for that matter. I'd like to commend you on being one of the very few communicators in this space that consistently delivers value. In fact I can't think of anyone I'd rank higher in the pursuit of your 2 stated goals of making medical research understandable, and empowerment of non science 'trained' individuals in who to deconstruct medical research (and by extension a lot of scientific research). I wish you continued success and thank you for the tremendous value you create and share.
That's an interesting hypothesis. It's true that retirement can hit some people extremely hard, which could play a major factor. I think there's a lot there that still needs to be figured out. I appreciate you speculating on the topic - makes for interesting reading!
@@Physionic Yes of course - far too many moving parts to figure out in a single long term study, but fun to speculate on. Ultimately it's probably wise to make decisions /plans based on a combination of data, logic, and probability. Sometimes awaiting the burden of ultimate proof is indeed a burden. The key is not go beyond that by communicating something probable (or seemingly probable based on X,Y, and Z) as if it were written in the stars and/or proven - which is what the majority of youtube bro-culture (you know, the ones that think data is made of cherries) indulges in (at least in my perhaps not modest enough opinion)
That’s hard to read without paragraphs.
Similarly to vision loss, hearing loss is also a risk factor for cognitive impairment and dementia. I suppose isolation is, once again, the key - loss of senses isolates one from the world and from other people.
Watching your videos is a delight: they are both informative and hilarious. 😅Going to join the Insider's soon.
About the correlation between social isolation and dementia... maybe the arrow of causation is from the latter to the former. How could that be elucidated?
Thanks for your help. Very great, thanks for caring.
When The ratio of LDL to HDL is high (more LDL than HDL particles) in the blood there is a disruption of the performance of cardiovascular wall repair. A dietary intake high in fried food using seed oil has a high LDL dietary intake is very common in the American diet. A dietary intake high in Omega 3 will increase the level of HDL and improves the performance of cardiovascular inner wall repair.
As pointed out in the video, there have been studies showing an association between brain health and exercise. However, considering that cardiovascular health is also linked to brain health, this link could be explaining the mechanism behind the improved brain health from exercise. Exercise improves cardiovascular health which leads to improved brain health.
Here's an idea about the blood pressure drop prior to dementia onset - maybe it's related to a decline in sympathetic activity that precedes dementia?
Not all hypertension is caused by obesity or salt intake, some people just have overactive sympathetic nervous systems. Maybe whatever causes dementia just causes less sympathetic activity in general (which would lower BP). Like maybe the proteins that cause dementia also inhibit response to things like adrenaline.
Too true. I like the idea. Thanks for sharing.
Seems like a worthwhile hypothesis, if you believe as I do that the body is supremely intelligent.
High BP is in many cases an adaptive response to obstruction(s). Perhaps at some point the body realizes the futility/danger of prolonged increases of BP and finally gives up on brain health and seeks to lower BP to reduce damage beginning to occur from hbp elsewhere in the body.
Thank you so much for all your efforts in sharing such valuable information! I would love to hear your opinion on recent studies showing a link between anti depressant usage and dementia. 😊
Were there drugs used to reduce the blood pressure like beta blockers? If reduced blood pressure also means reduced blood circulation volume , i imagine reduced performance of kidney and liver function, leaving more toxins in circulation.
Good thinking - the analysis didn't get into those details, but I like your thinking here.
statins also may cause dementia
MCT oil is the best supplement for this!
In regard to the higher LDL it maybe useful to to breakdown the percentage difference between healthy LDL to oxidized LDL as it pertains to the connection to Dementia
dementia bad imo
I think we can agree there... maybe...
I wonder to what extent social isolation rather than being a risk factor for dementia is instead a leading indicator of undiagnosed dementia, i.e. if behavioural changes brought about by the early stages of dementia are leading to social isolation?
7:51 I have a hypothesis: the first few years when hypertension starts, endothelial damage in the arteries supplying the brain accrues leading to repair with cholesterol and other clotting molecules creating scar tissue, plaque, and calcifications which narrow the arteries leading to ischemia in the brain which starts the brain tissue degradation process that leads to dementia. At the early stages of dementia, before behavioral symptoms manifest but blood pressure had already been observed to be high, the subject in question is put on blood pressure lowering medication and is also encouraged to change their diet and other lifestyle aspects but the combo frequently over-corrects blood pressure making it even harder for blood and oxygen to be pumped through the already ischemic arteries in the neck and head. This combo of initial damage from the start of the hypertension topped off with the over-corrected blood pressure a few years later leads to a double whammy of blood and oxygen deprivation to brain tissue, accelerating the manifestation of dementia symptoms.
Creative and cool mechanism. I like it.
What about sugar and high carbs that convert to glucose in nanoseconds? Some medical people are calling dementia type 3 diabetes.
That seems to be missing a ton of context. Carbs are glucose, so I’m not sure what’s meant by “converted to glucose in nanoseconds”?
@@Physionic once things like bread and pasta (carbs) go into the mouth and mixes with saliva it turns into glucose in nanoseconds.
Diabetes isn't caused by carbs. People who have diabetes handle glucose badly. Prevent diabetes, by eating healthy (which includes healthy carbs like beans and whole grains), and you can handle carbs from fruit fine.
@@Physionicdo you think you could get through to people about something like carb quality? The difference between added sugar and beans or fruit, for instance.
They cause diabetes in lab rats by overfeeding them fat. It's not about the carbs, it's about overeating.
Dementia got me married.
There are probably easier ways, like going on a date to start...
😂
@@Physionic
That's amateur talk.
Oh dear.
😂😅
Hello from Poland where rural areas have more air pollution than cities 👌
How does that happen?
Fascinating - why is that?
@@Physionic Poland is still using coal for a lot of heating. There's a lot of infrastructure deficits and a lot of houses still use individual coal furnaces for getting their heat in the winter and hot water throughout the year. Whereas cities have central heating/thermal plants and gas for the most part.
Heat pumps are getting more popular but coal is being phased out very slowly and we seem to love it for some reason.
The key is WHERE. Some rural areas use low quality coal as fuel sometimes moist woods or even waste like plastics with old fashion cold burning.
That's very problematic especially in winters. Air pollution is mostly quantify as PM2.5 or PM10 particles in ppm units. Most cities limited their car traffic to prefer more eco form of public transporting.
But I bet wooden smoke is less harmful than oil or diesel fumes with heavy metals residues or coal/plastic smoke.
I think it would’ve been more clarifying to separate the different forms of dementia. For example, the typical cardiovascular risk factors are hardly surprising as risk factors for vascular dementia
Grandkids help. I'm involving a 15 yr old grandson in some of my projects.
Regarding low blood pressure and less flow thru brain. I think that's a big factor in brain health. I am hardcore on inversion and hang upside down for 15 minutes per day. It's well know to improve mood and help with anxiety and depression. IMO I think it's a preventive maintenance thing you can do for the brain. Of course all the other factors like diet, exercise and social interactions need to be done too.
How about the number of times you've had covid? Or if you have long Covid? Or having an autoimmune disease (which increases inflammation levels)? These are pretty widespread, and should have some effect on dementia too.
To the question about why blood pressure suddenly goes down before a dementia diagnosis, I think I might have a hypothesis. Perhaps a person who did not take care of their health for most of their life is now experiencing health issues stemming from their bad lifestyle so they see a doctor. The doctor makes them get all kinds of checks done and sees that that person has all kinds of issues and one of them is high blood pressure so they give them blood pressure meds. Now that person is regularly getting check ups done because they have to and one of the things that get found later on is dementia. Blood pressure is not causative in this case but it is correlated.
Basically what I'm saying is a lifestyle that causes high blood pressure might also cause elevated dementia risk and when one health issue gets discovered the others are soon to follow.
Trifecta! Intelligent, handsome and a metal head.
Do having dogs count as being social?
That's a great question! My gut instinct is that it does, especially if you talk to them like they're people, as many do.
I could also see the answer being no, because maybe the preventative factor is that you need back and forth communication, specifically interpreting the language of another human and responding to it appropriately.
Maybe the truth is in the middle, dogs mitigate the risk but not as much as humans 🤷🏽
About the blood pressure-dementia phenomenon, here's my guess:
Chronic hypertension damages small blood vessels in the brain, leading to structural changes, impaired cerebral autoregulation, and reduced resilience to changes in blood pressure. A sudden drop in blood pressure after years of hypertension can cause cerebral hypoperfusion, particularly in vulnerable areas like watershed zones, exacerbating neuronal damage and cognitive decline. This may also impair the clearance of amyloid-beta proteins, contributing to Alzheimer’s pathology, or trigger inflammatory responses that promote neurodegeneration. The combination of vascular damage, reduced perfusion, and possible neurodegenerative processes creates a high risk for vascular dementia, especially when compounded by cardiac dysfunction or overly aggressive blood pressure treatment in older individuals.
I appreciate your sense of humour 😆 You make science fun 😊
Thanks Connie!
Loss of hearing too!
Audio is a very complex stimulus.
I am not married, I am not lonely, I've been married twice, I guess if I want to go insane I'll get married if I want to stay sane I'll stay the way I am. LOL I live alone I don't want no one in my space.😂 I've got plenty to do, I'm not doing all that stuff. 😂. I'm very happy and I'd like to keep it that way. I am 60+ yrs Healthy 😊. And I'm normal weight, no fat just muscle 💪. I wish someone would give me some weight 🤣. All that food I eat isn't giving any, keeps flowing out the other end. 😮. My weight does fluctuate sometimes I wear a size one sometimes I wear a size 3 sometimes I wear size 5 LOL My entire life. Must just be normal for me 😂 I do have a trampoline. Love it and my vision is perfect. Thanks
What about poor sleep quality ?
A Dr I watch says there is a correlation with mold toxicity and dementia/Alzheimers.
I think the stress of group activities once a week would kill me long before dementia sets in. Once a year is enough for me.
Thank you so much for this amazing video! I need some advice: I have a SafePal wallet with USDT, and I have the seed phrase. (alarm fetch churn bridge exercise tape speak race clerk couch crater letter). How should I go about transferring them to Binance?
1. ~ 12.
...
13. Poison in the food. (including pesticides, sugar and carbs)
14. Poison in the water.
15. Poison in the air.
It's criminal.
15. Poison
Thanks for this! I've started looking into the blood pressure risk, thanks to your previous mention, and found that orthostatic hypotension (a drop in blood pressure upon standing) is also a risk factor. I have both. 🤦♀️ I might mitigate OH because I use my calf muscles when I stand (by squatting). Those muscles are responsible for pushing the blood back up the body. There's research being done on this. Doesn't help that I've had a desk job for years. Sigh.
I love smart people😊
Do you think the metabolic syndrom, should actually include brain and lung in the overall alghoritm? I do see in many things you mention, you could always end up on the overall alignement of metabolic syndrome parameters...
I always see better after ur videos
I wonder if cataracts are a risk factor for dementia or if they have a common risk factor that expresses it;s self as cataracts and dementia.
Regarding the obesity factor... You mentioned that losing a percentage of your body weight would provide some protection against dementia... Which is interesting...I would think that your weight would have to become "normal" to provide a benefit... For example, if it's based on percentage then you could weigh 300 lbs, lose 5% and weigh 285 lbs and get the benefit. Can you explain?
All types of LDL a risk factor or only the plaque-building type?
Aren't we past believing there is only one LDL and it is bad?
Anything on hearing loss?
How does all of this compare to the risk of hereditary dementia?
Nic is pat of my social network.
What a coincidence, I'm safe from dementia now was in my wedding vows.
I understand that people not watching your whole video is an issue for you, but it would be very useful for everyone with a recap. The lack of them often makes me find other sources of information despite my preference for your teaching. I like your going in depth, but makes retention more difficult, especially when you don't summarize. It's common for TH-camrs to do that now; most creators even introduce chapters, which also allows for repetition.
Perhaps I've simply got worse memory than most of your potential audience, or maybe I'm more interested in details.
anyway... There you have my verbose five cents.
I’ll work on recaps at the end. That’s something I can do. Probably can’t do chapters though.
@@PhysionicThat's great, thank you.
I thought I saw somewhere that methylene blue eye drops can reverse cataracts.
Would be more curious to see the effects of economic inequality on all aspects of our health.
Maybe not so much economic inequality but too many people spending their money on junk/processed foods.
Socially isolated aren't senile, just out of practice
The mRNA vaccine group exhibited a significantly higher incidence of AD (Odds Ratio [OR]: 1.225; 95% Confidence Interval [CI]: 1.025-1.464; p = 0.026) and MCI (OR: 2.377; CI: 1.845-3.064; p < 0.001) compared to the unvaccinated group.
Fixing the air quality in your residence is low-hanging fruit.
do you still get dementia if you're socially isolated but in your 30s?
Good question.
Unknown. I'd consider that the lowest time period for risk, but there's definitely need for further investigation to tease out those details - it's something I expect to do.
Dementia is thekey for a healthy Parent-Childern relationships.
What about the familial mutation in the JR2R3 area of a TAU protein whereas the proline is changed to leucine, thus potentially causing manufacture of amyloid fibrils? As described here
th-cam.com/video/ahDSjRLb2Hk/w-d-xo.htmlsi=RsmtnhHMaOBrnIhc
I wonder if those parameters will change with the next generation. The generation that these data are based on were not users of technology, and their definition of success would include being married. So, less interaction with social media and internet content, and lower self image. I am 69, and have a low amount of in person social interactions, but I am more aware of scientific developments, politics, literature, etc than most others my age. I dont think dementia is a risk for me, at least not in regard to social interaction.
I am convinced that we’re looking at dementia wrongly like it’s a category. I am convinced many people could live with dementia and have happy lies and I think there are many different kinds and some of its vascular and it’s just a diminishing and when someone suffering from it, we should all rally around them And try to cheer them up and see what we can do instead where secluding people likw we are doing. Something about it seems like a function of the market to me and could be corrected. I almost can’t type this because I’m the one that made the most mistakes and I see the import of it now and it’s too late.
Do you think animal companions count as friends?😅
Another one: loss of hearing.
It sounds too simple to be real, but its starting seem a lot like not being with it makes you permanently out of it. Like, if you put someone in solitary confinement for years, they would come out with dementia.
Risk factors shouldn't be seen as '100% causative', but as contributors that could lead to an outcome. A person could reduce risk in 4/6 areas and still never develop dementia.
@Physionic jeez man... youre so pro solitary confinement it makes me sick.
Definitely what I said :)
@@Physionic 😁
Low blood pressure would cause lower oxygenation to the brain causing altered mental status.
That’s a cool idea!
Hhahaha....colesterol !, of course...man...Poderoso caballero es Don dinero !!!
If you say yes..its' meant to be an introvert or even an super introvert... Haaa and nope.. I' m best served in living in the wood- champs .. etc I just crave the calm...😊..even doable 10 kms far from Zürich..😂🎉❤
Dementia already has a grip on you. Been writing long?
@@dcjohnson2208 MEAN SPIRITED!
@dcjohnson2208 somebody taught us: don't make assumptions...a certain Mr Ruiz..or so...😆
Where it might decreased dementia risk, it might increase depression risk. (It’s a joke don’t ban me.)😂
😂
Wow I'm so early
Put time stamps and allow commenters to summarise videos. TH-cam algorithm will help you if you do that. Opposite of what you think of it, which is that you think the youtube algorithm demotes it. This is frustrating to watch your videos
I have the data from hundreds of my videos that disagrees with your perspective on timestamps - you’ll notice most others don’t put timestamps for 15 minute videos either, there’s good reason for that. If my videos are frustrating to you, you’re free to not watch them - I respect your choice.
@@Physionic I cant not watch them. That is why I have put this above comment in. If not summarise, some text list or something which all youtubers give in the video, just one slide that is, within 3 minutes of video.
Or at least dont delete comments nor ban such users who summarise or list out. If the list is interesting then people will watch the video full anyway. You have mistaken youtube algorithm, or your sample size on this is too small.
I usually offer a short take-away/conclusion at the end, just skip to the end of my videos, then.
I don’t need more data on timestamps - it’s 100% of videos, all the time, do worse with timestamps. I don’t need to screw myself more just to get to the same conclusion, haha. I’m also trying to attract people who want to learn which means they invest the 10-15 minutes so they learn the context of the work instead of this tiktok style, contextless BS I see all too common on social media. If 15 minutes of time is too much time to learn weeks worth of work, then I genuinely don’t want that person watching - they aren’t my intended audience. Learning takes work and it takes patience, assuming you want a *good* education, and if a 15 minute video is the barrier between a fleshed out, explained solution pulling together many studies that take weeks to analyze and put together, then I actively don’t want to attract those people.
@@Physionic Thanks for the reply. It is not that i watch all your videos in short form. The videos of topics which interest me i do watch your full video. But I dont want to spend full time on some videos on topics which I am not that interested. I will skip towards the end as you suggested for such videos in future.
Just not deleting user comments nor banning users who summarise would be sufficient. Or one slide of the list would be good too, which can be put just after 1 minute which is the auto play length on TV.
I'll see what I can do about timestamps - it might be possible to find a middle ground. I still can't have people posting summaries and lists of all the work - those are killer to the video performance, and when I spend 3-500$ making the video (not including my time), it hurts my ability to continue this work, so that's a no-go.
Hey Physionic, I realized your videos are a lot softer than other videos on the TH-cam platform. If you could increase the volume of your videos, that would be greatly appreciated. Thanks!
Hypothesis: Alzheimer’s Disease as a Cardiovascular Condition Driven by Heart Contractility and System Coherence
Alzheimer’s disease (AD) is typically regarded as a neurodegenerative condition characterised by the accumulation of tau proteins and amyloid-beta plaques in the brain. However, I propose that Alzheimer’s may also be understood as a cardiovascular condition, fundamentally driven by heart contractility and the body’s overall system coherence. This hypothesis is based on the role that the heart plays in generating sufficient arterial pressure to push cerebrospinal fluid (CSF) through the brain’s perivascular space (PVS), thereby clearing neurotoxic waste products. The studies attached to this hypothesis-the BALTAZAR study, which explores the effects of caffeine on CSF biomarkers in Alzheimer’s, and the PVS research on CSF flow-are foundational to this argument.
Key Mechanisms
1. Heart Contractility and Arterial Pulsations:
The heart’s contractility is a key driver of arterial pulsatility, which is critical for generating the necessary pressure to push CSF through the glymphatic system in the brain. The PVS study demonstrates that arterial pressure drives CSF flow, which is essential for clearing metabolic waste, including tau and amyloid-beta proteins. Therefore, when heart contractility is weakened, CSF flow diminishes, resulting in the accumulation of waste products that contribute to Alzheimer’s pathology.
2. Caffeine’s Role in Enhancing Contractility:
The BALTAZAR study provides evidence that caffeine consumption is associated with improved CSF biomarker profiles in individuals with mild cognitive impairment. Caffeine increases heart contractility and arterial pressure, which, according to the PVS study, would enhance the flow of CSF through the brain. This suggests that caffeine’s protective effects against Alzheimer’s could stem from its ability to maintain or increase heart contractility, facilitating better clearance of neurotoxic proteins from the brain.
3. System Coherence:
Heart contractility is not purely a mechanical phenomenon; it is also influenced by the coherence of the mind-body system. In this context, coherence refers to the harmonious functioning of consciousness, the mind, and the body. Consciousness, though separate from the mind and body, can influence their collaboration. When individuals are mentally engaged and consciously aware, heart rate variability (HRV) tends to be high, indicating a coherent system. This coherence can directly enhance heart contractility, thus maintaining effective arterial pressure and CSF flow. Conversely, when coherence is low (due to mental disengagement or stress), heart contractility weakens, exacerbating the risk of neurodegenerative conditions like Alzheimer’s.
Electromagnetic Considerations
The heart’s contractility and the body’s overall coherence can be further understood through the lens of electromagnetism. The heart generates a strong electromagnetic field that interacts with the body’s systems, including the brain. In this model:
- Electricity represents the physical matter of the body.
- Magnetism represents the energy or mental processes.
- Electromagnetism represents the conscious coherence that binds the system together.
Strong heart contractions generate a more coherent and synchronised electromagnetic field, which helps align both mental coherence and physical coherence. If heart contractility is compromised, the body’s electromagnetic field weakens, reducing overall system coherence and potentially accelerating neurodegenerative processes.
Hypothesis Implications for Alzheimer’s Treatment
If Alzheimer’s is indeed linked to heart contractility and systemic coherence, future treatments should focus not only on neurological factors but also on improving heart function and enhancing coherence. Such treatments could include:
1. Pharmacological interventions that improve heart contractility, such as rapamycin (please see attached study) or other cardiovascular agents.
2. Lifestyle interventions that enhance mental and physical coherence, including meditation, exercise, and heart-rate variability training.
3. Comprehensive cardiovascular monitoring in Alzheimer’s patients, focusing on contractility and arterial pulsations as key indicators of brain waste clearance efficiency.
Conclusion
Alzheimer’s disease should be considered, at least in part, a cardiovascular condition where the failure of heart contractility and system coherence leads to the accumulation of waste products in the brain. By addressing heart health and promoting systemic coherence, we may be able to prevent or slow the progression of Alzheimer’s. The attached research on the PVS system and the effects of caffeine on Alzheimer’s biomarkers provides empirical support for this hypothesis, offering a new lens through which to explore both the causes and treatments of neurodegenerative diseases.
PVS Research doi.org/10.1073/pnas.2407246121
BALTAZAR cohort study
doi.org/10.1002/alz.14169
Rapamycin Study
doi.org/10.1111/acel.13086
There is a theory that the amyloid plaques are a symptom, not a cause; that they are the brain immune system's attempt to contain an infection or other negative influence.
Just being alive these days is a risk factor for dementia.
That's literally true - aging is a factor, but it's currently non-modifiable (as defined)
so not really liking people isn't really 'social isolation', right? As a bonus, I still have my last marriage certificate....
👍
I get no girls, I'll get dementia
Which games do you play with your buddies Nick? :)
🥰
Dementia is literally the inspiration for love-craftian horror.
No it isn't? HP lovecraft didn't have dementia when he was writing his work and he is the inspiration for the genre. Made up.
@@Weberkooks Pretty sure he meant this tongue in cheek.
@@Weberkooks Bro what are you smoking of course he didnt have Dementia. From what ive read he was living with his grand parents coz his parents or one of them had a mental issue, now some say his at some point one of his grand parents developed it or his father actually developed it. but in any case there a lot common theme both in a Dementia patient and usually the main protagonist of the his works. the alienation, the inevitability of Cuthulhu and the main protagonist death.... .
Marriage helps but not a monogamy one! One women drives you crazy! :)))))))
Marriage definitely shortens a man's life.
Social isolation: here is another perspective on that and it really is in your attitude:
Learn to love solitude
To love to be with only yourself more often.
A person has to learn this from childhood to be able to be alone.
That's not to say "to be lonely".
It means to be able to not be bored/lonely by oneself.
That doesn’t mean you should be lonely, but that you shouldn’t grow bored with yourself because people who grow bored in their own company seem to me in danger, from a self-esteem point of view."
Not sure about drop in bloood pressure before dementia diagnosis. I can think only about case where drop is not a preaccessor to dementia. Drop in blood pressure while being with atherosclerosis - brain have less blood and dementia from here. But I can't think about other way around - where BP drop is caused from the same pathological process as dementia.
Obesity is a key for long happy life. You are getting dopamine eating whatever you want in any amounts. And also you are getting sympathy from other people for your illness.