Cognitive decline is one of the most insidious diseases. Any serious research into slowing or preventing it is important, and I appreciate you covering it.
This kind of niche content is why I subscribed. Your views might tank for this specific video for now but you’re the one producing this kind of content. I love that you’re staying true to what you want to create instead of catering to the mainstream algorithm. Thank you for what you do
What if not knowing what Klotho was was WHY we clicked on the video so that we could find out? Physionic doing a video on Klotho seems like a perfect opportunity to learn what it is and why Klotho matters.
Kommentar für den Algorhithmus. Ich sehe mir deine freien Videos sehr gerne an. Sie sind informativ und Du steckst eine Menge Energie in die Recherche. Danke dafür.
I appreciate your humor in both the measure of its subtlety and the, at times, unpredictability of its arrival. Regarding your video(s): I'm not here for the overwhelming, clickbait, highly contrasted thumbnail magnets that are almost everywhere on the 'tube. ||| I'm here for your content, your delivery and the detailed information I glean from it all. Please continue your exquisite work I intend to join Physionic Insiders at some point nearing the future.
I'm 71. Have been following all the longevity channels for more than five years and trying as many of the supplements as possible. It does seem resistance training has helped the most.
I find resistance work absolutely great and along with watching what I eat and when I eat (and resistance to cravings which are different to hunger) and minimising dis-stress / maintaining a pma I find them most influential in maximising my metabolic health and mental performance. You have given no details as to what and how much you train so I will just generalise - focus on resistance work for larger muscle groups especially lower body, take you sets and reps to close to the most you can manage before you cant do any more, making sure you maintain good form and core switched on. Expect to feel tired after this. Here is the possibly critical thing I would suggest for you - take as many days as you need to recover some energy then do it again. Could be anywhere from a 2 day break to a week. Physionic has a couple of great videos also. If you find you are tired all the time then that is indicative of a more insidious health problem and you need to investigate that with whoever you trust. Otherwise just leave as long as you break as you need to let your body adapt, regain some energy and go again. My experience is that persistence over the long term is much more effective than trying to train more frequently and get quick response
@@belfedhaltayeb8958 I take a bunch of supplements, but a short list for you might be CoQ10, vitamin .D3. I take the Life Extension 2 a Day multi vitamin and their B complex.Niacin might help. But you have to try them out one by one, it is crap shoot. The CoQ10 did help my thinking.
Thanks Physionic. I've been attempting to treat my mothers dementia for the last 6 years. This sort of content really helps open up new potential avenues of research and treatment that I can go down. It's very much appreciated.
Have you checked out the Bright Focus Foundation? They keep up with & fund research. They also include an easy way to find clinical studies to participate in if that interests you. Also, Cognitive Vitality has pulled together research & rated interventions including drugs, supplements, etc. for their effects on Alzheimer's & dementia. This was developed by the Alzheimer's Drug Discovery Foundation. Good luck!
@@richards6269 have you tried some supplements? Astaxanthin showed benefits in terms of amyloid aggregates, and also egcg has benefits in tdp 43 protein, make sure you have high dose, egcg has to be taken fasted and astaxanthin after a fatty meal, astaxanthin at least 10-12 mg, i use 24 mg, egcg 300 mg at least, on pubmed you find everything
Exercise, exercise, exercise. That seems to be the answer for so many things. I only wish that produced the rare essence of motivation. Well, maybe I'll make a New Year's resolution this year.
That's the shame, as people don't have to be gym junkies to get a lot of the benefits , just doing some squats every day while waiting for jug to boil , waving some 5KG dumbbells around while watching some TV , a few calf raises in the checkout line, using the stairs etc. If people just modify their diets by 20% , did 3 hours of exercise a week, they would get easily 50% of benefits or us more determine folks . Just staying active, walking briskly , gardening , dancing , no high sugar products , more fiber and a few more veggies will again get you big benefits and just make your life happier . People are weird
It’s actually kinda fun when you use gadgets to track your stats and ‘level up’ them like in a video game. Also I reward myself with new workout/running shoes :)
I use a hypnosis cd, there's one for motivation to exercise. I find it really works. I usually listen while having an afternoon lie down on the days I visit the gym. I'm 75 female on a low carb diet.
Klotho along with Foxo were discovered fairly recently by a French lab from Lakesis, amd oil derived from the resin of the ancient mastic trees on the Greek island of Chios. Lakesis, when used topically, has anti-aging characteristics for the skin. With daily use, in 28 days the fibroblasts of a 57 year old returned to the same condition as a 34 year old. There is just one skincare product in North america I know of using this ( Mastic by VivaLaCara) . Very interesting to find it's other properties.
I keep preaching and preaching and preaching about exercise (especially resistance, but also a mix of resistance and cardio), clean eating, and good sleep/stress management. I sometimes feel like I am an outcast because people just don't want to listen. It is so frustrating! Thanks for a video that adds more good information for this constant battle.
You know that Nick is totally on fire when he makes a totally whack joke ...and he doesn't even slow himself down to say "that was a totally whack joke" keep on rocking Doc Nick
Clotho or Klotho, is a mythological figure. She is the youngest goddess of the Three Fates or Moirai. In ancient Greek mythology, she spins the thread of human life, her sisters draw out and cut the thread. Her Roman equivalent is Nona.
That was fun, do it again! :). If I'm not mistaken, there are studies (I don't know how good those studies are) that also show calorie restriction paired with high protein diets can increase klotho as well.
One of the best "cognitive preserved" seniors I know is a lifelong power lifter - Jan Luka. He is 75 yo now, still lifts and coaches people and talking to him is as good as it was 20 years ago - it was when I first met him and started training with him.
Stuff you'll never get from your doctor! Until it's too late. Nice work. Tell the people who don't want to think while watching to pay attention. There is likely some beneficial effect.
Exercise strikes again! Thanks. BTW An Interment Fasting Klotho study was done in lab of Sandrine Thuret and published in 2021 in Molecular Psychiatry "Intermittent fasting enhances long-term memory consolidation adult hippocampal neurogenesis, and expression of longevity gene Klotho" Open access.
I think an important point that’s missing from the video is how does platelet activation by Klotho improve cognitive ability? Like what’s THAT mechanism? Is it actually an effect of platelet factor 4 and signaling that comes downstream of Klotho? Would increasing platelet factor 4 in the brain independently of Klotho have the same effect?
Excellent work!! The best short presentation on klotho I've come across. Thorough and with enough detail to satisfy the layperson and the biochemist. As always, humour and humility are the hallmarks.
I know someone who is 4/4 and doesn’t have the helpful kllotho gene mutation. Sending this video so he does more resistance training. Great and helpful video!
I only have an MBA and didn't have any issues understanding it. Probably due to the lovely and snarky comments/asides. Even if you were painfully difficult to listen to, I'd soldier through it since I have a strong family history of dementia. Funny how exercise seems to always have a beneficial effect.
Man this was very interesting and Not as difficult to follow compared with Other Uploads you did . Luckyly we are Not at one of These " Guru Channels" where we seek sensations and "Groundbreaking" Data all the time. You explain the Data and i try to follow.. Greetings Tobias
Excellent work! You crammed a lot in, I got the main points and was interested in the charts, You made me laugh and you gave me another reason to get back to the weight room. A number one IMO.
some sort of intervention is available now. I have been taking klotho for 3 years. There is a fb group and there are people who have been taking it for 5 years.
@ I don‘t have facebook unfortunatly, where do you get klotho from? LEXEO is also testing gene therapy for E4/E4 AD patients, seems to reduce Tau in them. Im also in contact with duke university. They use epigenome-editing approach to reduce the gene expression. Unfortunatly everything in medicine moves very slowly. Im 37 years old so I still have some hope
VO2Max is a marker of good cardiovascular health. It doesn't mean you have to do specific exercises to raise your VO2Max, but when it's low, then you'll get to a point where you can't be self sufficient (think going out to buy groceries, climb some flights of stairs without gasping for air, etc). Considering the expected decline with age, if you don't have a very good VO2Max right now, then after some decades you'll be barely able to get out of a chair.
There actually is a youtube influencer who injected herself with klotho. I don't remember how it worked but I think it was like Moderna's RNA vaccine. She has a company that helps her clients go to Mexico to get this treatment that's not legal in the US. One thing I like about your channel is that you aren't trying to sell people unproven medical treatments.
Thanks for the great video! Would really like to see you go over the numerous studies on AHCC (Active Hexose Correlated Compound) and tell us what the verdict is on that supplement. Wondering if you've ever heard of it? Check it out. 🙂
Thank you 😊 I was thinking about turmeric. Its bioavalability is very low. Maybe its main action is in the gut by interfering with phosphates absorption and consequently improving kidney function, kidney is the main culprit in Klotho gen regulation after all. Interesting to know your thoughts about this subject. In India people consume a lot of turmeric, but also milk products. Apart of strong antibacterial action preventing diarrhea, it might has a other 'topical', in the gut, effect.
Sounds promising, though for now, seems we only have access to a “maybe-boost” from behavioral effects. I’ve known for a dozen+ years I have one marker for the big A and watched my mom die twice with it. Bits of hope: always been an avid learner and have been doing resistance training (lifting) since I was 16. I’m nearly 58 now and no lie, still look as buff as you, Phys and have even retained my glutes. 😊 All natty. But, the big unknown always lingers. It sucks.
![Taurine: Aging Backwards? [Study 193 Analysis]](http://i.ytimg.com/vi/PNJpM0ac0GU/mqdefault.jpg)
I don't care if this doesn't have mainstream appeal, this is why I subscribe, deep diving into some novel biochemical substances. Colour me intrigued.
Same.. 💞
@nickgrossman2385 yep. I love this❤
yes it actually makes it better.
I'm right there with'ya.
Cognitive decline is one of the most insidious diseases. Any serious research into slowing or preventing it is important, and I appreciate you covering it.
So many variables in ppls lives /genes that could have affect. The brain is the final frontier IMO.
@@gdiup9241
🎉 a few years ago, someone doing gut life told me the gut was the “final frontier”! Guess we’ve still got a lot to learn.
This kind of niche content is why I subscribed. Your views might tank for this specific video for now but you’re the one producing this kind of content. I love that you’re staying true to what you want to create instead of catering to the mainstream algorithm. Thank you for what you do
Thank you ☺️
What if not knowing what Klotho was was WHY we clicked on the video so that we could find out? Physionic doing a video on Klotho seems like a perfect opportunity to learn what it is and why Klotho matters.
Kommentar für den Algorhithmus. Ich sehe mir deine freien Videos sehr gerne an. Sie sind informativ und Du steckst eine Menge Energie in die Recherche. Danke dafür.
Danke Popel, das macht mich froh!
I just want to note: this hasn’t been up 6hours and it already has 6K likes! Not to mention the # of views & comments!
🎉You rock🎉
Edit; views have increased from 6K + to 7K+ in 20 minutes!
I appreciate your humor in both the measure of its subtlety and the, at times, unpredictability of its arrival.
Regarding your video(s):
I'm not here for the overwhelming, clickbait, highly contrasted thumbnail magnets that are almost everywhere on the 'tube. ||| I'm here for your content, your delivery and the detailed information I glean from it all.
Please continue your exquisite work I intend to join Physionic Insiders at some point nearing the future.
You sound like you wear a top hat and a monocle haha
When I hear Klotho, I think of an alien from a distant planet.
That’s Klaatu.
Marvel villain.
Me too!
When I read Matsubara, I think about...
Klotho Barada Nicto
I'm 71. Have been following all the longevity channels for more than five years and trying as many of the supplements as possible. It does seem resistance training has helped the most.
Im 69 and,and having some signs of memory loss,i tried training, but experience a lot tiredness...any suggestions please ... thanks
I find resistance work absolutely great and along with watching what I eat and when I eat (and resistance to cravings which are different to hunger) and minimising dis-stress / maintaining a pma I find them most influential in maximising my metabolic health and mental performance. You have given no details as to what and how much you train so I will just generalise - focus on resistance work for larger muscle groups especially lower body, take you sets and reps to close to the most you can manage before you cant do any more, making sure you maintain good form and core switched on. Expect to feel tired after this.
Here is the possibly critical thing I would suggest for you - take as many days as you need to recover some energy then do it again. Could be anywhere from a 2 day break to a week. Physionic has a couple of great videos also.
If you find you are tired all the time then that is indicative of a more insidious health problem and you need to investigate that with whoever you trust. Otherwise just leave as long as you break as you need to let your body adapt, regain some energy and go again. My experience is that persistence over the long term is much more effective than trying to train more frequently and get quick response
@@belfedhaltayeb8958 I take a bunch of supplements, but a short list for you might be CoQ10, vitamin .D3. I take the Life Extension 2 a Day multi vitamin and their B complex.Niacin might help. But you have to try them out one by one, it is crap shoot. The CoQ10 did help my thinking.
Resistance training helps avoid my ongoing Sarcopenia. Thanks Melville Jayathissa, aged 77, from sunny Malaysia
Here for the information - keep cranking it out!
Strange how it comes down to exercise 90% of the time 💪🏽
Thanks Physionic. I've been attempting to treat my mothers dementia for the last 6 years. This sort of content really helps open up new potential avenues of research and treatment that I can go down. It's very much appreciated.
Have you checked out the Bright Focus Foundation? They keep up with & fund research. They also include an easy way to find clinical studies to participate in if that interests you.
Also, Cognitive Vitality has pulled together research & rated interventions including drugs, supplements, etc. for their effects on Alzheimer's & dementia. This was developed by the Alzheimer's Drug Discovery Foundation. Good luck!
Carnivore diet, sunlight in bare eyes and on as much skin as possible❤❤
@@aprilgarnett55 Funny you should say carnivore. The current experiment we're doing has a similar effect to carnivore. Thanks for your comment.
@@richards6269 have you tried some supplements? Astaxanthin showed benefits in terms of amyloid aggregates, and also egcg has benefits in tdp 43 protein, make sure you have high dose, egcg has to be taken fasted and astaxanthin after a fatty meal, astaxanthin at least 10-12 mg, i use 24 mg, egcg 300 mg at least, on pubmed you find everything
@@aprilgarnett55holy shit, you are out of your depth. Don’t go promoting random crap for serious problems. You are not qualified.
Exercise, exercise, exercise. That seems to be the answer for so many things. I only wish that produced the rare essence of motivation. Well, maybe I'll make a New Year's resolution this year.
That's the shame, as people don't have to be gym junkies to get a lot of the benefits , just doing some squats every day while waiting for jug to boil , waving some 5KG dumbbells around while watching some TV , a few calf raises in the checkout line, using the stairs etc. If people just modify their diets by 20% , did 3 hours of exercise a week, they would get easily 50% of benefits or us more determine folks . Just staying active, walking briskly , gardening , dancing , no high sugar products , more fiber and a few more veggies will again get you big benefits and just make your life happier . People are weird
It’s actually kinda fun when you use gadgets to track your stats and ‘level up’ them like in a video game. Also I reward myself with new workout/running shoes :)
You cannot out exercise a bad diet. I think Jim Fixx proved that years ago.
I use a hypnosis cd, there's one for motivation to exercise. I find it really works. I usually listen while having an afternoon lie down on the days I visit the gym. I'm 75 female on a low carb diet.
Kloto is gold!! On a serious note, your releases are consistently good 👍👍👍 and no it was not too complex for me, and i do appreciate the rigor 😊😊😊
Thanks, good to know!
@@Physionic Just chiming in to also say I appreciate the rigor.
When it's a video about Klotho from you, I want to listen and learn ❤️ loved it!
Thank you :)
This level of analysis and instruction is why I’m here! Thank you!!
Klotho along with Foxo were discovered fairly recently by a French lab from Lakesis, amd oil derived from the resin of the ancient mastic trees on the Greek island of Chios. Lakesis, when used topically, has anti-aging characteristics for the skin. With daily use, in 28 days the fibroblasts of a 57 year old returned to the same condition as a 34 year old. There is just one skincare product in North america I know of using this ( Mastic by VivaLaCara) . Very interesting to find it's other properties.
Someone on internet board I used to frequent found a lab to manufacture foxo and perhaps klotho and they had a group buy for foxo and perhaps klotho.
Thanks doc
My dad and Gmother has Alzheimers.
I'm definitely happy you covered this!
I keep preaching and preaching and preaching about exercise (especially resistance, but also a mix of resistance and cardio), clean eating, and good sleep/stress management. I sometimes feel like I am an outcast because people just don't want to listen. It is so frustrating! Thanks for a video that adds more good information for this constant battle.
Low / no (cardio)
Mitochondria grows best with explosive movement. Not sustained monotony.
Commenting and sharing and liking just for your algorithm
I appreciate you
Thanks James :)
@ you’ll be on Joe Rogan in no time!
You know that Nick is totally on fire when he makes a totally whack joke ...and he doesn't even slow himself down to say "that was a totally whack joke"
keep on rocking Doc Nick
We’re here for complicated. Always go for it!
Klotho, coming to a theater near you
Klotho vs Mothra
This is an important topic, especially for those with the APOE 3/4 or 4/4
Clotho or Klotho, is a mythological figure. She is the youngest goddess of the Three Fates or Moirai. In ancient Greek mythology, she spins the thread of human life, her sisters draw out and cut the thread. Her Roman equivalent is Nona.
That was fun, do it again! :). If I'm not mistaken, there are studies (I don't know how good those studies are) that also show calorie restriction paired with high protein diets can increase klotho as well.
Wow, this is a homerun! If people do not watch this, they may already have been impacted!
So you did a 12 min video to tell me to exercise ?
Thank you :)
Please, do one on basal ganglia calcifications 🙏
Thanks to Nick for introducing this topic
One of the best "cognitive preserved" seniors I know is a lifelong power lifter - Jan Luka. He is 75 yo now, still lifts and coaches people and talking to him is as good as it was 20 years ago - it was when I first met him and started training with him.
Stuff you'll never get from your doctor! Until it's too late. Nice work. Tell the people who don't want to think while watching to pay attention. There is likely some beneficial effect.
I don't want to think but I habitually think and it's hard to stop.
I tell myself to put it down and back away.
This is interesting. When will the English version become available?
Bwah!
😄
Thanks for another great video :) One more reason to keep my exercise going on and not breaking the cycle :)
I love intellectual videos like this. Teach me more random science. I don't need random humor or bad jokes. I'm hear for the cutting edge science.
Exercise strikes again! Thanks. BTW An Interment Fasting Klotho study was done in lab of Sandrine Thuret and published in 2021 in Molecular Psychiatry "Intermittent fasting enhances long-term memory consolidation adult hippocampal neurogenesis, and expression of longevity gene Klotho" Open access.
Oooou, I will read this, thank you :)
Thank you! I was wondering if a fasting and exercise protocol might enhance these...
Exercise fixes everything!!!!
Just keep lifting heavy things. AKA stressing the body.
Thank you, access to information like this is important for me and my family.
I love brain health videos ❤. Also this was def not too complicated at all. All the best science channels are heavily complex though and I love it.
Wow. It’s like outer space this stuff. We’ve just discovered the planet Klotho and there’s life there!
Thanks!
Thank you :)
I think an important point that’s missing from the video is how does platelet activation by Klotho improve cognitive ability? Like what’s THAT mechanism? Is it actually an effect of platelet factor 4 and signaling that comes downstream of Klotho? Would increasing platelet factor 4 in the brain independently of Klotho have the same effect?
Commenting just to help out with engagement. Hello folks, what a great video.
Great Information , Thank you !! Doc... Can you do a video on prostate💊
I think this is an awesome video, not to deep. Thank you very much and have a Merry Christmas!
Excellent work!! The best short presentation on klotho I've come across. Thorough and with enough detail to satisfy the layperson and the biochemist. As always, humour and humility are the hallmarks.
What was the point? What did he want to use as a treatment?
Thank you for sharing this information Physionic. Excellent video 👍💪
Glad it was helpful!
Love you brother! Soooo funny! 😂
Great vid, commenting for the algorithm!
Thanks for that!
Commenting to support the complexity!
Thanks!
It would be pretty iconic if this video outperforms others 🎉❤
Great video. Thanks Physionic!!
Really appreciate the work you put into these videos, Nic. You’re also an excellent educator❤️
Thanks Cheryl!
Fascinating. Thanks for making complex research accessible. Now I am going to go and try and make me some Klotho.
You do that :)
Thank you! Always fascinating with a sprinkle of humor. Love your videos.
I know someone who is 4/4 and doesn’t have the helpful kllotho gene mutation. Sending this video so he does more resistance training. Great and helpful video!
I only have an MBA and didn't have any issues understanding it. Probably due to the lovely and snarky comments/asides. Even if you were painfully difficult to listen to, I'd soldier through it since I have a strong family history of dementia.
Funny how exercise seems to always have a beneficial effect.
Man this was very interesting and Not as difficult to follow compared with Other Uploads you did . Luckyly we are Not at one of These " Guru Channels" where we seek sensations and "Groundbreaking" Data all the time. You explain the Data and i try to follow..
Greetings
Tobias
Excellent work! You crammed a lot in, I got the main points and was interested in the charts, You made me laugh and you gave me another reason to get back to the weight room. A number one IMO.
Hot damn. Got a degree in biology and this is the first time hearing about klotho
You can’t know everything . I have degree in biology, in pharmacy , ms in clinical nutrition and ms in clinical pharmacy. Still here… learning
Great Work, 😊
Really interesting, thank you
EGCG, Gotu Kola + Korean Red Ginseng, Vit C, Vit E, GABA, NAC, Vit B12 all increase Klotho levels.
So great to learn more about Klotho!
This is actually very informative. Happy to have watched til the end.
Great stuff!
Here's a comment to help with the algorithms. Love your work, Nic.
Thanks for that!
At 10:00 is some really good info
I want all videos presented like this
Fantastic! Now I am fully armed for 'Cocktail Party Conversation' where I can sound like I know sh&t!
😂
Well alrighty!!! Good video!!! Excellent takeaway!!!
Glad you liked it!
As always thanks for breaking things down into a digestable segment. Love your work! Now, i want to see the mice beating the researchers at Chess😂
Anyone who claims this video is too complex could possibly benefit from klotho injections.
Nice rabbithole, merry christmas!
This ist fantastic content! Thank you!
Thank you for this!
As Always. Great work Nic!
Thank you Nick, you're gold❤
Great info! Thanks for the detailed explanation 🙏🏼
I am Apoe4 +
Hoping for some sort of intervention in the next years. Klotho sounds promising, thanks for this info!
some sort of intervention is available now. I have been taking klotho for 3 years. There is a fb group and there are people who have been taking it for 5 years.
@ I don‘t have facebook unfortunatly, where do you get klotho from? LEXEO is also testing gene therapy for E4/E4 AD patients, seems to reduce Tau in them. Im also in contact with duke university. They use epigenome-editing approach to reduce the gene expression. Unfortunatly everything in medicine moves very slowly. Im 37 years old so I still have some hope
Great video, as always! What are you thoughts on phosphatidylserine. Would you consider doing a video on it?
great vid ! keep 'em coming !
Offtopic: Is V02 max that important for lifespan? I see it mainly mentioned by Peter Attia?
VO2Max is a marker of good cardiovascular health. It doesn't mean you have to do specific exercises to raise your VO2Max, but when it's low, then you'll get to a point where you can't be self sufficient (think going out to buy groceries, climb some flights of stairs without gasping for air, etc). Considering the expected decline with age, if you don't have a very good VO2Max right now, then after some decades you'll be barely able to get out of a chair.
@@pedro.almeida Very well put. Plus. I guess. exercise can also prevent some types of cardiovascular disease.
I clicked just to see what Klotho is. Thanks for the info!
Take that deep dive, go for it!
I might not care about klotho but I care about dementia. My mom died from it when she wasn't even 70.
Is dementia the same as Alzheimer's? My father had dementia, it's a dreadful condition for all involved.
I come for the nerd humor but stay for the snark. Klotho is a bonus.
😂
Of course it will have huge appeal. People like their brains 🧠
There actually is a youtube influencer who injected herself with klotho. I don't remember how it worked but I think it was like Moderna's RNA vaccine. She has a company that helps her clients go to Mexico to get this treatment that's not legal in the US. One thing I like about your channel is that you aren't trying to sell people unproven medical treatments.
I bet if we renamed it "Brain Enhancement Factor Alpha" it would get more interest. Wasn't Klotho an abstract expressionist painter?
If only :-P
Rothko.
@gracecarter7575 It was joke.
@ and a good one!
😊Not hard to understand at all. Klotho good, Exercise good. Exercise more get more Klotho.
PhD please.😄
is there another way to enhance it for individuals who cannot do resistance training?
EGCG, Gotu Kola + Korean Red Ginseng, Vit C, Vit E, GABA, NAC, Vit B12 all increase Klotho levels
Good sleep, intermittent fasting and aerobic activity.
Thanks for the great video! Would really like to see you go over the numerous studies on AHCC (Active Hexose Correlated Compound) and tell us what the verdict is on that supplement. Wondering if you've ever heard of it? Check it out. 🙂
Thanks again for the excellent content! This is why I watch your channel, versus the algorithm chasing clickbait crowd.
Thank you 😊
I was thinking about turmeric. Its bioavalability is very low. Maybe its main action is in the gut by interfering with phosphates absorption and consequently improving kidney function, kidney is the main culprit in Klotho gen regulation after all.
Interesting to know your thoughts about this subject.
In India people consume a lot of turmeric, but also milk products. Apart of strong antibacterial action preventing diarrhea, it might has a other 'topical', in the gut, effect.
Does a relationship exist between creatine supplementation and klotho?
No science on that as far as I'm aware
Information gives power
Sounds promising, though for now, seems we only have access to a “maybe-boost” from behavioral effects. I’ve known for a dozen+ years I have one marker for the big A and watched my mom die twice with it. Bits of hope: always been an avid learner and have been doing resistance training (lifting) since I was 16. I’m nearly 58 now and no lie, still look as buff as you, Phys and have even retained my glutes. 😊 All natty. But, the big unknown always lingers. It sucks.
So are there any precursors to klotho that maybe we can supplement? Also, does it improve or reverse the effects of dementia or just prevents it?
EGCG, Gotu Kola + Korean Red Ginseng, Vit C, Vit E, GABA, NAC, Vit B12 all increase Klotho levels
Maybe totally unrelated, but does this imply any cognitive effects of anti platelet medication?
I view all Physio-Nics.