How Does Keto Affect A Bipolar Brain? A New $6M Randomized Controlled Trial
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- เผยแพร่เมื่อ 4 มิ.ย. 2024
- Baszucki Group awarded $6 million to a research team led by University of Pittsburgh Psychiatry professor and researcher, Dr. Mary Phillips that will explore mechanisms of ketogenic therapy for bipolar disorder. This is the second grant in Baszucki Group’s newly-announced research program: ReThink Bipolar: Researching Therapeutic Integration of Nutritional Ketosis in Bipolar Disorder.
The grant will fund an ambitious, multidisciplinary study at the University of Pittsburgh unites neuroscience, mitochondrial biology, and cellular models to explore the underlying mechanisms of the therapeutic effect of the keto diet for bipolar disorder. The study will investigate the relationship between gene expression, mitochondrial function, and brain markers associated with a ketogenic diet’s impact on symptoms of mania and hypomania
This complex study has a clinical intervention and will examine biomarkers, looking at neuroimaging and analyzing mitochondrial function in stem cells, as well as having a murine trial component. Dr. Bret Scher interviews three key players in the study:
Mary Phillips, MD, Distinguished Professor of Psychiatry, Clinical and Translational Science, and Bioengineering, and Pittsburgh Foundation-Emmerling Endowed Chair in Psychotic Disorders in the Department of Psychiatry at the University of Pittsburgh
www.psychiatry.pitt.edu/about...
X: @MaryPhillips23
Colleen McClung, PhD, Professor of Psychiatry and Clinical and Translational Science at the University of Pittsburgh
www.psychiatry.pitt.edu/about...
X: @McClungColleen
Ana Andreazza, PhD, Professor of Pharmacology & Toxicology and Psychiatry at the University of Toronto.
psychiatry.utoronto.ca/facult...
X: @anacandreazza
The research team also includes:
Zachary Freyberg, MD, PhD, Associate Professor of Psychiatry and Cell Biology, University of Pittsburgh
psychiatry.pitt.edu/about-us/...
X: @zfreyberg
Link to the press release: prn.to/3PwSufs
Learn more about Baszucki Group research funding in the field of metabolic psychiatry: baszuckigroup.com/our-work/me...
Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at metabolicmind.org/
About us:
Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
Timestamps:
0:00 Introduction
1:43 An overview of the Pittsburgh keto for bipolar study
5:28 What happens to the body when there is too much dopamine?
8:39 The study's hypothesis
10:15 The study's protocol
13:32 Is the study in-person only?
15:07 GABA and dopamine in a bipolar brain
16:41 The balance between research and clinical practice
19:24 The mouse component of the study - Dr. Colleen McClung
25:16 The mitochondria component of the study
#MetabolicMind
#KetoForMentalHealth
#MetabolicPsychiatry
#MetabolicNeuroscience
#KetogenicMetabolicTherapy
#NutritionalKetosis
#MentalIllness
#MedicalKeto
#KetogenicTherapy
#Mitochondria
#CellularHealth
#Dopamine
#GABA
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I've been doing keto for 10 months now for weight loss and have coincidentally managed to reduce my bipolar meds to a quarter of my initial dose over this period of time (very slowly).
How? You have a doctor who willing to work with you? I can not find one so far.
@nitpm8088 no, my doctor won't help, I've been doing it on my own and very slowly.
Hello… Thank God for your research… as a 60 year old woman with bipolar…. waited my entire life for some kind of research to go in a different direction besides prescription medication’s …. ♥️♥️♥️♥️
Science FTW! Thanks for everyone's continued efforts and advocacy.
So excited about this groundbreaking study!
Dr. Phillips is amazing - thank you Dr. Scher & Metabolic Mind for doing this interview.
Dyane Harwood, co-host of the new "Our Healing Journey with Metabolic Psychiatry"
Podcast with Michael Belanger
I can't wait to hear about the results of all those wonderfully interesting studies!
Metabolism and Mitochondrial Function in my considered judgment are the major factors that are involved in all or almost all chronic diseases including most so-called "mental disorders"! I am a retired physician and have experienced a 50-pound weight loss with a ketogenic diet. I am off diabetes medicine, off amlodipine for hypertension, of a statin for hyperlipidemia. My seasonal affective disorder is improved by 75% and my psychomotor energy is improved. I have ADHD but have been off Adderall for 5 years because of I have paroxysmal atrial fibrillation. I have some problems with attention and focus, but I would estimate that a ketogenic diet has allowed me to get along reasonably well without the Adderall. I hope my own experience encourages others. I do recommend books by Georgia Ede, MD; and Chris Palmer MD. I would be remiss were I not to mention that walking 3 to 5 miles a day has been helpful. The question remains whether I would have had the psychomotor energy and concentration to pursue and stick to my walking had I not adopted a ketogenic diet??
Are they looking for more participants for this study? I would love to be in some sort of study! I am on bipolar/adgd spectrum currently on ketogenic diet under guideence of Nicole Laurant. I would be willing to travel, I have relatives in Pittsburg area.
Yes, the study is currently enrolling! You learn more about the RCT and reach out to the coordinators here: bit.ly/3veLZqU
That's a pity.. participants need to be between the age of 18 and 30, I'm 50 next year. Nevermind. Wishing it all the best,so interesting.
It is interesting. It does give me hope. I started doing Keto now carnivore for almost four years. It would be interesting to see how a carnivore would do in a study like this. Many carnivores are saying that fruits and vegetables are causing inflammation. The study in mice vs humans I’m not placing any comfort in that. We react totally differently and our way of eating is so different. Maybe a study using dogs. Would be more useful. After all you would feed dogs meat only. As in no kibble so no dry food which has a lot of processed food in it. Feeding dogs meat and fresh raw meat would be healthy for them. But would anyone do a study like this? The dog food industry would loose money. Even with this study I worry that whatever discovery happens that it would be silenced. As in if being on a ketogenic diet or carnivore diet you no longer need medication. This also would not be great for big pharma. Where is the money in it? I have not been on any antidepressants or even any anti inflammatory medication for four years. I save a lot of money I’m not having to pay for medication. I still go see my doctor and seek out therapy when needed. Life goes on and there are stressors but I can handle them better because I have cognitive function and clarity. Versus before I could not process my feelings and my behaviour was volatile.
Sounds brilliant except it is puzzling how mice can be an appropriate focus group in such a complex research area?
Thanks for sharing! It's hard to be patient for the results of studies related to keto. I'm real curious about what they can find to predict who keto will work for. I hope for more studies like this for other mental health issues (schizophrenia, anxiety, depression, ocd, etc). I'm amused that mice can have a keto diet.
Thank you, so exciting!
Great news!
I wonder if this would be relevant to those with a COMT enzyme gene mutation. Under 20 grams of carbs daily for therapeutic ketosis?
I have a hypothesis. We're overthinking this, if keto helps for a lot of wildly different symptoms then it can't be just affecting some neurotransmitter or another, it must be more basic than that.
I think we have a long evolutionary history of living on fat and a short history of living on carbs. Different parts of brain have adjusted to recent evolutionary pressures at different rates. When anything goes wrong with glucose metabolism the activity in some parts of brain doesn't match the others and disturbs the normal balance of activation-inhibition that produces the mind.
Keto helps because it takes us back to old and trusted metabolic pathways and levels the activities. You can't really have genetic problems with fat and ketone metabolism because those would simply be fatal in early development.
Maybe some parts of brain need more energy, they are the first to suffer but their complimentary systems in other parts of brain are still working fine at normal levels of activity.
I think she's oversimplified it for the purpose of easier communication, I would assume she's say the GABA balancing is a downstream rather than direct effect.
Maybe.
Another idea is that keto as such doesn't stabilize anything in particular but only provides a stable energetic environment that the brain can use to stabilize itself over time. Glucose levels vary a lot on high carb diet and that never allows the brain to create a long-term stable configuration of metabolic rates between different parts.
Imagine a complex machinery with lots of parts working through material inputs at different rates. It takes time to adjust the flow rates on each of them to balance the load. But if your input electric power is unstable then balancing everything becomes impossible, because the varied input affects each part differently and imbalance everything shortly after you've matched it.
Dude, that’s fucking brilliant. PLEASE write a research paper. That makes total sense bc all the most brilliant people seem to have mental disorders.
WHat about the role of reduced inflammation when one is in dietary meetabolic Ketosis?
I always see tons of videos about depression and bipolar on keto/carnivore but never on panic attacks. Does it have the opposite effect on panic attacks?
Some people report beneficial results for anxiety. This is an area we hope more researchers will explore.
Hello, i have one Question. How long will it take to get the results of the studies?
Unfortunately, these studies take time. Recruiting tends to be the slowest part. But we can hope that, with the growing enthusiasm for dietary therapies, they will recruit quickly. The results may take a year or so.
Thanks for your answer! I‘m from Austria and would like to be part of this campaign. I suffer also from schizophrenia/bipolar for about 6 years now. I tried keto last year for about 6 month. unfortunately i broke up and ended up in the Hospital, but now i would give it another shot😅
If GABA is the key, then how can we introduce GABA into our bodies, would GABA supplements work ?? I heard that it doesn't cross the blood brain barrier, hence why it won't work.
What supplements can we take to increase GABA or glutamine, or glutathione.
A general rule of thumb is that it's best to do it endogenously and let the body make it than to try to take supplements!
For GABA it's weird. Some people can indeed absorb it and it can have a brain effect. Some don't. However it's hard to say that GABA will reach the desired places in the brain. So endogenous is best.
Things like meditation. Slow controlled breathing sessions. Cutting out excess dopaminergic / stimulating activity. Can increase GABA.
Magnesium, pre-/pro-biotics, L-theanine, B6 (and possibly potassium) are GABA Cofactors. Also read GABA supplements cannot pass the BBB and high doses can result in a negative feedback loop.
My understanding is that Gaba supplements can get you into trouble because they downregulate endogenous production.
@@jan_ellison_baszucki Yes, if the body is reaching an artificial GABA effect that the body does not want to reach, it will downregulate and further cause trouble if you stop taking it.
but this happens if you have sharp increases in GABA that goes beyond a certain measure, or chronic intake of it.
I believe elevated Uric Acid levels (long-term) is one possible Mind & Body inflammatory biomarker for Bipolar Disorder.
Fructose is the only carbohydrate to produce Uric acid. Uric acid in the brain blocks mitochondrial ATP and can trigger low energy levels in the brain. Elevated Uric acid is linked with dementia. So this makes sense as to why keto can benefit mental health.
Any suggestions about when ketogenic diet leads to insomnia?
Good question. One tip we often hear is eating the majority of the day's carbs later in the day. But here is a written guide that may have some suggestions. We hope that helps! perfectketo.com/keto-insomnia/
We have a video addressing hypomania that addresses this question.
@@jan_ellison_baszucki Thank you; I'll check it out. Appreciate any help. Sleep doctor was not familiar with addressing keto-caused insomnia.
@@jan_ellison_baszuckithanks for everything you do!
Ridiculous amount of money.
"The Bipolar Brain"? How in this reductionist world would one Operationally Define such an entity. LOL Psychiatry!! Trauma in it's myriad manifestations. C'mon with the downstream "guesses."
Can’t wait for you to have them back on the show! A very interesting study!