I am 213 years old and I credit intermittent fasting consisting of sometimes as much as 2 days between blood meals as well as staying out of direct sunlight.
It's amazing to me how upset some people get when you say IF isn't BETTER but just as good as other forms of calorie restriction. It means there's plenty of options and you can choose the diet you like the best. The "diet superiority complex" is a bizarre one. If you like IF great, it's just not magic.
Big fan of Carbon Diet Coach. Been using it since early this year after being stuck in a weight loss plateau. It helped get things kick started and back to losing weight. Has been very helpful
Hi Dr. Norton, Thanks for these insights. I am a biochemist and never worked with animal models (more cell culture) and I did not know how animal studies are conducted in the nutrional science space. Really interesting to me. Thanks for explaining it. Looking forward to hearing more great content! Love your breakdowns of these studies!
I think the other thing to note about intermittent fasting is that for someone is obese it may not be an easy task when they start out learning to listen to their body. It can feel like starvation, what works for some doesn't work for all. I like that you left it open ended to each person's preferences.
@QuentinStyger may I ask, why are you comfortable using the term 'fatty'? It's not a problem I have, if I don't work out, I literally don't need to eat. Maybe try meditating? Might cure the need to call people 'fatties' too.
Much easier to fast for 24-48 hours once a week than to feel deprived of food and thinking about food every day. Plus it teaches you about satiety and that we don’t have to be eating all the time
Scoping review meaning: analyzing a wide range of research and non-research material to: Map key concepts Identify types of evidence Find gaps in research Provide direction for future research Inform practice, programs, and policy
An important question that seems to be missing from many studies on intermittent fasting is what is the effect of exercise and intermittent fasting vs. no exercise and intermittent fasting?
What are you trying to figure out? Exercise is basically exercise. The only real difference is during what window are you exercising, as in, are you doing it while you are fasted opposed to after feeding, during feeding window, etc. Also you have to factor in are you on low carb, an average diet, carnivore, etc. For the most part, the only real change would be on energy levels and fuel source. Unless you are eating 100% fat, you should have glycogen stores that you can pull from, and for most resistance training, it is more than enough energy to get you through your workout, unless you are just sitting in the gym for 2 hours doing crazy volume. This matters far less on a normal diet, especially when training after a feeding. If you're on carnivore it can be a bit different, but once you are fat adapted (burning fat as your main source of energy) then it doesn't matter a crazy amount, but at the end of the day, carbs are your body's preferred fuel source. Hopefully this helps.
N of 1 here but I used IF to reduce body weight without exercising and lost a lot of muscle mass. Never been fat, just over "recommended" weight but went from that to extra skinny. Now I exercise regularly (mostly resistance) and eat moderately and regained a lot of weight but body fat is still low.
@@mestrinimaster3602 Losing muscle mass during weight loss is common, especially when you do not resistance train and you are in way too deep of a caloric deficit. I did something similar and ended up losing a little over 100lbs in a year, but I lost a lot of muscle as well. That's the reason people on things like ozempic lose a lot of muscle, and why most doctors recommend that patients resistance train while on it.
They always compare IF to CR. Why don't they compare groups eating "maintenance" level amount of calories, either using IF or just eating normally throughout the day? As in, eat enough not to lose weight. That way, the effect of the fasting component could be evaluated, right?
A workout analogy...you could workout 2/3 times a week, or 15mins a day, but everyday. Many prefer the former, same with eating. You could watch, measure you diet every meal, intermittent fast, say, weekly or a multi-day extended fast 3 or 4 times a year...your personal choice. Many prefer working out 2-3x weekly/ extended fast 3-4x yearly
It’s important to understand the practical reality of these tools. Things like intermittent fasting, ADF, Low carb/Keto are TOOLS that more easily enable caloric restriction, to get better results. Of course they have a few benefits independent from CR but they are powerful METHODS to more easily reduce caloric intake without counting or using a calculator.
"If you're already at a healthy body weight, there's probably no benefit to calorie restriction" Fascinating point I'm in a different place. Great muscle mass, thanks partly to you and other similar TH-camrs. Great cardio fitness - same thanks generally. 28% body fat. I try to eat healthy and reduce calories, but whether it's snacks or thanksgiving dinner or ice cream, it ain't working. I could skip lunch as a form of IF or calorie restriction. But I'm concerned this would reduce muscle mass because my regular meals are high protein. Thoughts?
And thankyou so much for saying type 2 diabetes. So may people group type one and 2 together. When as you know type one is autoimmune. Nothing to do with weight and lifestyle ♥️
I haven't even started the video and I can tell hes going to say people who are in a calorie deficit in general will have the same effect. It has nothing to do with the time windows.
So obese animals live longer than lean ones. Like the lean wild animals live half as long as their domestic counterparts. 90% of people that do calorie restriction end up as fat or fatter than where they started, probably 99% if you exclude bodybuilders. Surely the blood markers are way worse when they get back to the starting point again. Don't know if there are any studies on this, but yiu would think testing should only be done after like 6 months of maintenance. Bloodwork of a person after dropping 10kg compared to after gaining 10kg in my case was extremely different, even though I was eating exactly the same, just less exercise and cooler months
Autophagy is a constant process in the body, regardless of what fasting advocates might suggest. It is enhanced by calorie restriction, which explains why autophagy spikes during fasting. However, this increase is not exclusive to fasting - any form of calorie restriction will trigger a similar response. When calorie restriction balances out over the course of the day, it results in the same amount of autophagy. Moreover, autophagy is not always beneficial. In some cases, it can actually support the growth of certain cancers. Tumor cells, for example, can take advantage of autophagy to survive and thrive, even in nutrient deprived environments. So, while autophagy is essential for cellular maintenance, it is not ALWAYS a positive process in the body.
So muslims do IF as a mater of course for among other things Ramadan, for 29/30 days. They are a rarely overweight people. Does that population live significantly longer than other populations? Do middle eastern people who practice the Islamic faith live longer than middle easterners that do not? Should be a pretty easy study to do.
Hi Layne, I have asked this before. Can you address the work of Dr. Longo. He is promoting prolonged fasting, well actually these days fasting mimicking diet only. Dr Longo claims the magical beneifits of fasting dont really start before day two or three
Bravo again! I wonder when people will stop associating all health benefits to diet. Diet is just the fueling parts of a healthy exercise program (cardio and weight lifting). Is it because consisent exercise is not easy ?
Not forgetting the psychological effect. Worrying and stressing about every minute detail of your diet probably undos most of the benefits of a "perfect diet"
There are various mechanism that calorie restriction do not have that its showing in the literature, for example recovering of the mucin layer after damage from meal consumption. wich a long fasting seems to provide the most relief to recover this layer that it is altered on large meals. on aged people this layer seems to be very affected and lets things like digestive enzimes go though the body lymphs and blood, generating damage in the organs. autodigestion from damaged mucin that is recovered with a good fasting. this is one example of an unique mechanism outside of calories.
Calories don't matter or they matter....different foods cause different results outside calories calculation. I can eat at least 500cal more of meat compared to bread for example and not gain a single pound. Have done that experiment many times...
It's because meat contains protein, and your body has to work harder to digest protein than it does carbs and fat. Therefore, your net calories from 500 calories of meat are actually considerably lower than from 500 calories of bread.
@@StraightEdgeJunkie Also meat contains fat witch changes the hormonal response dramatically. Its way way more complicated than calories in/calories out. Who counts NET calories of those who preach the in/out principle?
Everyone who knows what they're talking about knows that net calories are accounted for in calories in, calories out. That's in fact what it means. Of course, it's impossible to accurately measure net calories, but it's not relevant since you can get close enough with trial and error. Calories in, calories out just is what it is - counting calories is a human tool that attempts to measure calories in, calories out. These are two separate things. Counting calories is not perfect, but it's good enough when you know what you're doing. We all know food labels aren't precisely accurate, but the actual number doesn't matter if you find the calorie amount for you that leads to fat loss. Let's say I'm eating 1,900 calories as per a calorie tracking app. And I lose fat. Is it actually 1,900 calories? Most likely not; I would say with 100% certainty it's not. But it doesn't matter because whatever the calorie amount is, it leads to fat loss. And that's the data I need. Also, any kind of a different hormonal response from fat vs. any other macro doesn't matter. We have loads of trials comparing low fat vs. high fat diets, and as long as calories and protein are equated, they all lead to the same fat loss. It's actually been shown that low fat diets lead to ever so slightly more fat loss, but it's not clinically significant and likely just down to it taking a bit more energy to digest carbs than it does fat.
@@StraightEdgeJunkie I count and measure for more than 5 years now. I'm pro at that you can easily say. And despite that I'm doing it I know this is not the way. Let me give another example - at different stages I was consuming around 1500-1800cal not being able to lose a single point. After refeeding I was losing weight easily at 2300-2400cal. What does that say about calories in/out theory? Same amount of protein, same weight, same work every single day and yet that happens. That is hormones for you...the body is extremely smart and on top of that could change the bmr accourding to your input and hormone state. Same calories, same macros, insulin, testosterone and cortisol matter a LOT. The body is not a food burning furnace (witch is how the calories are counted btw).
@@user-ij8no5zw6u- That's actually rather simple, and lots of people experience that. I've had similar experiences. When you consume fewer calories for an extended period of time, your calories OUT goes down. This is a survival mechanism we have to keep us from starving. Then you reintroduce calories into your diet, and it's possible that as your calories OUT increase, it actually leads to a deficit for a period of time. It's actually fairly common and not strange at all. It's debated how strong of an effect this is, etc., and whether or not refeeding is an effective tool to use in fat loss, but it's definitely a thing. It's all accounted for in calories in, calories out. What hormones are you referring to, exactly?
Layne is way to biased to look at this topic. Layne omits the multi day fast studies. He even admitted there was a study showing extra fat loss in a 36 hour fast even though weekly calories were equated and then he conveniently leaves that out from then on as it doesn’t fit his narrative Intermittent fasting doesn’t seem to increase longetivity I think from the research unless the eating window is over 12 hours long.
Just a stupid though I had, is extra fat the problem or the fact that people with extra fat eat too much, increasing sugar, cholesterol, etc in the blood. If you had a metaphorical person to whom you inject subcutaneous fat making them obese, but they eat normally, how would that person's health be like? Not a real world scenario, though, so just a dumb thought.
Obesity tend to increase things like inflammation and insulin resistance. Cholesterol is more about diet (too much saturated fat, perhaps too little fibers). Blood sugar is usually not a problem on its own.
Aight... If I'm critical, which u are all the time sir, which we all LOVE btw PLZ don't stop 😆 lol. This calorie restriction in primates bit is kinda flimsy (animal studies, not human), saying "a bunch of other metabolic markers are gonna be out of whack" isn't exactly super scientific and kindaaa sounds like something some of these charlatan "dieticians" say if I'm being honest 😳😬 and how many studies in women with PCOS are we talking here? Genuinely asking cuz I haven't done the research lol, but it sounded like just one study to me based on the way u talked about it. Cuz if we are just talking one study, that better be one DAMN good study 😂 lol. I'd love to hear your retorts, and I mean this in the most positive, constructive and friendly way possible. Love ur shite mate 😎🤘
I love your balanced, nuanced analyses. Btw "Amount of food" is correct. "Amount of calories" is incorrect. "Number of calories" is correct. Please. 😉🖖🏻
A lot of longevity experts look at anthropological data to determine this. IE, lots of places people were starved for whatever reason, they tended to live longer than someone well fed in another place. This sort of glosses over the fact, that they prolly just were less likely to be pillaged, so lived longer just cause they weren't getting raided for their food since they didn't have any.
Same story all the time. IF = calorie control. It is time to drop that fad and move on to looking what real fasting does vs calorie control. Fasting for a human is several days without calories not some hours. There is some promises there based on animal models, but data on human would set the record straight.
There does not seem to be anything special about blue zones (we now know that the idea of blue zones comes down to bad data), but copying healthy people seems to be a good idea.
Still no evidence about how long you need to fast to induce autophagy in humans. Exercise also increases autophagy. How are you measuring mitochondrial function?
Intermittent fasting is just the "new convert effect" When you first do it it works great and then after awhile it becomes "the new normal" and you realize why play this silly game when to stop and start eating?
Nice summary. Other than the cringy "human control studies" you managed to control the yelling enough I was able to watch the whole presentation. Thinking about subscribing.
I'm 172 years old and I credit intermittent fasting.
💪😆
Hi Bryan
Member Civil War, it was good intermittent fasting when contractors steal shipment of hardtack?
I am 213 years old and I credit intermittent fasting consisting of sometimes as much as 2 days between blood meals as well as staying out of direct sunlight.
Congrats 🎉🎉🎉
Layne is gift to those that listen
It's amazing to me how upset some people get when you say IF isn't BETTER but just as good as other forms of calorie restriction. It means there's plenty of options and you can choose the diet you like the best. The "diet superiority complex" is a bizarre one. If you like IF great, it's just not magic.
Big fan of Carbon Diet Coach. Been using it since early this year after being stuck in a weight loss plateau. It helped get things kick started and back to losing weight. Has been very helpful
You don’t have to count calories once you at a healthy weight but you do have to pay attention.
And exercise, or just don't be sedentary
Hi Dr. Norton, Thanks for these insights. I am a biochemist and never worked with animal models (more cell culture) and I did not know how animal studies are conducted in the nutrional science space. Really interesting to me. Thanks for explaining it. Looking forward to hearing more great content! Love your breakdowns of these studies!
I think the other thing to note about intermittent fasting is that for someone is obese it may not be an easy task when they start out learning to listen to their body. It can feel like starvation, what works for some doesn't work for all. I like that you left it open ended to each person's preferences.
@QuentinStyger may I ask, why are you comfortable using the term 'fatty'? It's not a problem I have, if I don't work out, I literally don't need to eat. Maybe try meditating? Might cure the need to call people 'fatties' too.
@@leialuminous looking at his profile pic, he needs to be able to feel superior about something
Much easier to fast for 24-48 hours once a week than to feel deprived of food and thinking about food every day.
Plus it teaches you about satiety and that we don’t have to be eating all the time
Scoping review meaning:
analyzing a wide range of research and non-research material to:
Map key concepts
Identify types of evidence
Find gaps in research
Provide direction for future research
Inform practice, programs, and policy
I was blind but then i started intermitting fasting. Now i work as a air traffic control.
Choose your restriction or choose your medicines!
An important question that seems to be missing from many studies on intermittent fasting is what is the effect of exercise and intermittent fasting vs. no exercise and intermittent fasting?
What are you trying to figure out? Exercise is basically exercise. The only real difference is during what window are you exercising, as in, are you doing it while you are fasted opposed to after feeding, during feeding window, etc. Also you have to factor in are you on low carb, an average diet, carnivore, etc. For the most part, the only real change would be on energy levels and fuel source. Unless you are eating 100% fat, you should have glycogen stores that you can pull from, and for most resistance training, it is more than enough energy to get you through your workout, unless you are just sitting in the gym for 2 hours doing crazy volume. This matters far less on a normal diet, especially when training after a feeding. If you're on carnivore it can be a bit different, but once you are fat adapted (burning fat as your main source of energy) then it doesn't matter a crazy amount, but at the end of the day, carbs are your body's preferred fuel source. Hopefully this helps.
N of 1 here but I used IF to reduce body weight without exercising and lost a lot of muscle mass. Never been fat, just over "recommended" weight but went from that to extra skinny.
Now I exercise regularly (mostly resistance) and eat moderately and regained a lot of weight but body fat is still low.
@@mestrinimaster3602 Losing muscle mass during weight loss is common, especially when you do not resistance train and you are in way too deep of a caloric deficit. I did something similar and ended up losing a little over 100lbs in a year, but I lost a lot of muscle as well. That's the reason people on things like ozempic lose a lot of muscle, and why most doctors recommend that patients resistance train while on it.
Well done!
They always compare IF to CR. Why don't they compare groups eating "maintenance" level amount of calories, either using IF or just eating normally throughout the day? As in, eat enough not to lose weight. That way, the effect of the fasting component could be evaluated, right?
Good point
@@geraldfriend256 Agreed
Faircpoint 👍
Really appreciate your breakdowns of this stuff. FTA
Thanks
A workout analogy...you could workout 2/3 times a week, or 15mins a day, but everyday. Many prefer the former, same with eating. You could watch, measure you diet every meal, intermittent fast, say, weekly or a multi-day extended fast 3 or 4 times a year...your personal choice. Many prefer working out 2-3x weekly/ extended fast 3-4x yearly
It’s important to understand the practical reality of these tools. Things like intermittent fasting, ADF, Low carb/Keto are TOOLS that more easily enable caloric restriction, to get better results. Of course they have a few benefits independent from CR but they are powerful METHODS to more easily reduce caloric intake without counting or using a calculator.
"If you're already at a healthy body weight, there's probably no benefit to calorie restriction"
Fascinating point
I'm in a different place. Great muscle mass, thanks partly to you and other similar TH-camrs. Great cardio fitness - same thanks generally. 28% body fat.
I try to eat healthy and reduce calories, but whether it's snacks or thanksgiving dinner or ice cream, it ain't working.
I could skip lunch as a form of IF or calorie restriction. But I'm concerned this would reduce muscle mass because my regular meals are high protein. Thoughts?
Occasional fasting, probably once a week or fortnight might help.
How bout both Layne?
I was born before the big bang when was such a hard time to find food so I was forced to do If, never knew that was the key to my longevity.
🙏
And thankyou so much for saying type 2 diabetes. So may people group type one and 2 together. When as you know type one is autoimmune. Nothing to do with weight and lifestyle ♥️
Why would anyone still publish in an MDPI journal? Most of their journals are considered predatory.
I haven't even started the video and I can tell hes going to say people who are in a calorie deficit in general will have the same effect. It has nothing to do with the time windows.
What about blood lipids etc
So obese animals live longer than lean ones. Like the lean wild animals live half as long as their domestic counterparts.
90% of people that do calorie restriction end up as fat or fatter than where they started, probably 99% if you exclude bodybuilders. Surely the blood markers are way worse when they get back to the starting point again. Don't know if there are any studies on this, but yiu would think testing should only be done after like 6 months of maintenance. Bloodwork of a person after dropping 10kg compared to after gaining 10kg in my case was extremely different, even though I was eating exactly the same, just less exercise and cooler months
What about for mental clarity, brain fog?
Personally, I use cardio and weight lifting for a total of about 10hrs/week to prevent brain fog and increase mental clarity, not diet.
How are those measured and are there studies that shows that IF helps?
@@Greg_Chocki.f. undoubtedly helps with brain fog and mental clarity,try it give it time and see.dont need studies
Don't stop doing the H.R.C.T. ...EVER!!!!!
Didn't it become popular because of the word/process: Autophagy?
Autophagy is a constant process in the body, regardless of what fasting advocates might suggest. It is enhanced by calorie restriction, which explains why autophagy spikes during fasting. However, this increase is not exclusive to fasting - any form of calorie restriction will trigger a similar response. When calorie restriction balances out over the course of the day, it results in the same amount of autophagy.
Moreover, autophagy is not always beneficial. In some cases, it can actually support the growth of certain cancers. Tumor cells, for example, can take advantage of autophagy to survive and thrive, even in nutrient deprived environments. So, while autophagy is essential for cellular maintenance, it is not ALWAYS a positive process in the body.
@@StraightEdgeJunkie Excellent explanation. - Kris
Bump 💪🏼
So muslims do IF as a mater of course for among other things Ramadan, for 29/30 days. They are a rarely overweight people.
Does that population live significantly longer than other populations?
Do middle eastern people who practice the Islamic faith live longer than middle easterners that do not?
Should be a pretty easy study to do.
I won the Al Gore Rhythm Ugly Sweater Contest because of intermittent fasting.
Healthy heart for longevity!
HIIT most important, then resistance training.
For Algore-rythm
👍👍👍
Hi Layne,
I have asked this before. Can you address the work of Dr. Longo. He is promoting prolonged fasting, well actually these days fasting mimicking diet only.
Dr Longo claims the magical beneifits of fasting dont really start before day two or three
Bravo again! I wonder when people will stop associating all health benefits to diet. Diet is just the fueling parts of a healthy exercise program (cardio and weight lifting). Is it because consisent exercise is not easy ?
Not forgetting the psychological effect. Worrying and stressing about every minute detail of your diet probably undos most of the benefits of a "perfect diet"
There are various mechanism that calorie restriction do not have that its showing in the literature, for example recovering of the mucin layer after damage from meal consumption. wich a long fasting seems to provide the most relief to recover this layer that it is altered on large meals. on aged people this layer seems to be very affected and lets things like digestive enzimes go though the body lymphs and blood, generating damage in the organs. autodigestion from damaged mucin that is recovered with a good fasting. this is one example of an unique mechanism outside of calories.
💪🏿Let’s go!💪🏿
I haven’t done IF in a few years. It hasn’t fit with my current goals.
Longevity organ vs. mortality organ, I like that
Calories don't matter or they matter....different foods cause different results outside calories calculation. I can eat at least 500cal more of meat compared to bread for example and not gain a single pound. Have done that experiment many times...
It's because meat contains protein, and your body has to work harder to digest protein than it does carbs and fat. Therefore, your net calories from 500 calories of meat are actually considerably lower than from 500 calories of bread.
@@StraightEdgeJunkie Also meat contains fat witch changes the hormonal response dramatically. Its way way more complicated than calories in/calories out. Who counts NET calories of those who preach the in/out principle?
Everyone who knows what they're talking about knows that net calories are accounted for in calories in, calories out. That's in fact what it means. Of course, it's impossible to accurately measure net calories, but it's not relevant since you can get close enough with trial and error. Calories in, calories out just is what it is - counting calories is a human tool that attempts to measure calories in, calories out. These are two separate things. Counting calories is not perfect, but it's good enough when you know what you're doing. We all know food labels aren't precisely accurate, but the actual number doesn't matter if you find the calorie amount for you that leads to fat loss. Let's say I'm eating 1,900 calories as per a calorie tracking app. And I lose fat. Is it actually 1,900 calories? Most likely not; I would say with 100% certainty it's not. But it doesn't matter because whatever the calorie amount is, it leads to fat loss. And that's the data I need.
Also, any kind of a different hormonal response from fat vs. any other macro doesn't matter. We have loads of trials comparing low fat vs. high fat diets, and as long as calories and protein are equated, they all lead to the same fat loss. It's actually been shown that low fat diets lead to ever so slightly more fat loss, but it's not clinically significant and likely just down to it taking a bit more energy to digest carbs than it does fat.
@@StraightEdgeJunkie I count and measure for more than 5 years now. I'm pro at that you can easily say. And despite that I'm doing it I know this is not the way. Let me give another example - at different stages I was consuming around 1500-1800cal not being able to lose a single point. After refeeding I was losing weight easily at 2300-2400cal. What does that say about calories in/out theory? Same amount of protein, same weight, same work every single day and yet that happens. That is hormones for you...the body is extremely smart and on top of that could change the bmr accourding to your input and hormone state. Same calories, same macros, insulin, testosterone and cortisol matter a LOT. The body is not a food burning furnace (witch is how the calories are counted btw).
@@user-ij8no5zw6u- That's actually rather simple, and lots of people experience that. I've had similar experiences. When you consume fewer calories for an extended period of time, your calories OUT goes down. This is a survival mechanism we have to keep us from starving. Then you reintroduce calories into your diet, and it's possible that as your calories OUT increase, it actually leads to a deficit for a period of time. It's actually fairly common and not strange at all. It's debated how strong of an effect this is, etc., and whether or not refeeding is an effective tool to use in fat loss, but it's definitely a thing. It's all accounted for in calories in, calories out.
What hormones are you referring to, exactly?
FTA!!!
If u do any amount of not snacking all damn day youll likely be less obese and thus healthier
Less vs Fewer bro
👍💪
Layne is way to biased to look at this topic. Layne omits the multi day fast studies. He even admitted there was a study showing extra fat loss in a 36 hour fast even though weekly calories were equated and then he conveniently leaves that out from then on as it doesn’t fit his narrative
Intermittent fasting doesn’t seem to increase longetivity I think from the research unless the eating window is over 12 hours long.
Mine Workers don t do fasting,and are not in overweight or Obese
5/2 fasting (36 hr. fasts) is the bomb! Combined with zone 2 cardio it's even better.
Water fasting over 24 hours seriously degrades both my Z2 and my resistance training workouts.
FTA
Who wants to live forever anyway? 😂
youl never see a obese person live to 80+
@logananthony-vc6rj JFC chill tf out man
Exactly, here for a big time not a long time!
Yaman 😎
Layne's content 10/10
Layne's Carbon App 4/10
Why 4/10? I've been looking at it for a while and it seems to be decent. What are your thoughts? - Kris
fta
Just a stupid though I had, is extra fat the problem or the fact that people with extra fat eat too much, increasing sugar, cholesterol, etc in the blood.
If you had a metaphorical person to whom you inject subcutaneous fat making them obese, but they eat normally, how would that person's health be like?
Not a real world scenario, though, so just a dumb thought.
Obesity tend to increase things like inflammation and insulin resistance. Cholesterol is more about diet (too much saturated fat, perhaps too little fibers). Blood sugar is usually not a problem on its own.
Aight... If I'm critical, which u are all the time sir, which we all LOVE btw PLZ don't stop 😆 lol. This calorie restriction in primates bit is kinda flimsy (animal studies, not human), saying "a bunch of other metabolic markers are gonna be out of whack" isn't exactly super scientific and kindaaa sounds like something some of these charlatan "dieticians" say if I'm being honest 😳😬 and how many studies in women with PCOS are we talking here? Genuinely asking cuz I haven't done the research lol, but it sounded like just one study to me based on the way u talked about it. Cuz if we are just talking one study, that better be one DAMN good study 😂 lol. I'd love to hear your retorts, and I mean this in the most positive, constructive and friendly way possible. Love ur shite mate 😎🤘
I love your balanced, nuanced analyses.
Btw
"Amount of food" is correct.
"Amount of calories" is incorrect.
"Number of calories" is correct.
Please. 😉🖖🏻
A lot of longevity experts look at anthropological data to determine this. IE, lots of places people were starved for whatever reason, they tended to live longer than someone well fed in another place. This sort of glosses over the fact, that they prolly just were less likely to be pillaged, so lived longer just cause they weren't getting raided for their food since they didn't have any.
Thanks for that useless piece of information and not commenting on anything said in the video
Same story all the time. IF = calorie control.
It is time to drop that fad and move on to looking what real fasting does vs calorie control.
Fasting for a human is several days without calories not some hours.
There is some promises there based on animal models, but data on human would set the record straight.
0:12 I don't know why he keeps doing the "H... R... C... T..." thing when he sounds like he's cringing at himself as he does it. Please just stahp.
You must be new
I intermittent fasting when i sleep. I wake up at 4.15 every day, at 4.35 am already after shower, eating my first breakfast:)
For the algorithm
Layne is being exposed and I'm here for it.
You know what does improve longevity? Eating and copying lifestyle traits of people living in blue zones. Eat healthy, be active, live long.
There does not seem to be anything special about blue zones (we now know that the idea of blue zones comes down to bad data), but copying healthy people seems to be a good idea.
Lots of scepticism now that blue zones are even a thing.
I'm healthy and I choose IF over low calories because of autophagy, mitochondria function, slow aging and better skin.
You get the same benefits, as per Dr Layne's videos regarding IF.
Still no evidence about how long you need to fast to induce autophagy in humans. Exercise also increases autophagy. How are you measuring mitochondrial function?
Intermittent fasting is just the "new convert effect"
When you first do it it works great and then after awhile it becomes "the new normal" and you realize why play this silly game when to stop and start eating?
Nice summary. Other than the cringy "human control studies" you managed to control the yelling enough I was able to watch the whole presentation. Thinking about subscribing.
U new here? He does that every time lol. It's kind of a bit at this point 😊
He has issues!
how come nobody talks about IF can increase the risk of kidney stone and gallstones??!!
Im guessing your not an i.f. fan?
For the algorithm
FTA!!!!
For the algorithm
For the algorithm