Cannabinoid Hyperemesis Syndrome (CHS): Unraveling the Gordian Knot - Ethan Russo, MD
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- เผยแพร่เมื่อ 25 ต.ค. 2024
- Tags: CBG, Cannabinoid Hyperemesis Syndrome, CHS, High Dose THC, CNR1, Chronic Use, Science, Cyclical Vomiting Syndrome
Ethan Russo, MD, presents "Cannabinoid Hyperemesis Syndrome (CHS): Unraveling the Gordian Knot" at CannMed 24.
Cannabinoid hyperemesis syndrome (CHS) is an enigmatic constellation of symptoms and signs first reported in 2004 in Australia, consisting of intractable vomiting, abdominal pain and hot water bathing behavior that represents one of the few true contraindications to cannabis usage. CHS solely occurs in the context of heavy chronic use of cannabis or products containing high amounts of tetrahydrocannabinol (THC) or other CB1 receptor agonists.
The syndrome is increasingly identified, particularly in the USA, where estimates of its prevalence range from 350K to 2.5M affected patients. It is associated with frequent emergency visits for treatment and diagnosis, with high diagnostic expense ($30-90K) and general resistance to treatment with anti-emetics and analgesics. Considerable morbidity and even some fatalities related to hyponatremia-associated vomiting have been reported.
The definitive treatment is abstention from cannabis usage, but cutaneous application of capsaicin ointment (TRPV1 agonist/desensitizer) can provide symptomatic relief. Prior studies hypothesized that the pathophysiology/biochemical basis of CHS might relate to biphasic dose responses to THC, a paradoxical shift of THC from partial agonist to antagonist of CB1, or to changes in the TRPV1 receptor. In 2021, the authors were part of a team with EndocannaDNA that investigated a possible genetic basis for CHS that could explain its pathophysiology (Russo et al, 2021).
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The worst part is the cycle you get into when you use pot for the acute symptoms without knowing you’re turning it into a chronic problem
CHS was by far the worst pain Ive ever felt in my life. I remember sitting on the edge of my bed for 20 hours straight bawling, begging for it to stop. I thought I was dying. Id never heard of CHS. Then came the justifying, then came the testing different strains, methods, potencies.... Finally I realized I would never be the same and accepted defeat. Yesterday was 1 year off and Im a normal person again. Is it benign for most, sure. But more and more people are coming to me with the symptoms. The biggest I see are the anxiety, the stabbing stomach pains, the loss of appetite and the morning sickness. Thanks for what you do
It's not all that painful. Sounds like you have another problem besides CHS.
It is that painful for some
@@sheilamoon1752 bull. I know I've had it three times
I have been dealing with this since I started smoking in high school and didn't know what it was. Last year, I found out what CHS was. My symptoms have never been as severe as I have heard from others' testimonials. Over the past year, I have had it come back twice, but I am now much more aware of the symptoms and have learned to take breaks and to slow down my use when I'm not having symptoms. Abstinence is not the only answer.
Thanks for all the info today ✌️💀👍
Mold toxicity from improperly drying cannabis.
in my hypothesis this only happens when people use products that have a million pesticides, microbial toxins etc. speaker sounds slightly biased in delivery. funny how you disregard this instantly.
have you asked patients what their products limits for testing are? are the compounds available to be tested for? no, bc there was over 150+ pesticides in cali packs.
ignorant research imo.
You couldn't be more wrong lol
I agree! Based on personal experience and massive amounts of research about this, i have come to this conclusion as well.
@@amberfarley2605 I've read reports from people that grow their own organically that still got CHS so you're dead wrong
In my experience, your hypothesis is wrong! I live in a state that has some of the most strict laws against pesticides and other chemicals when it comes to cultivating cannabis. I only get my stuff from legal medical dispensaries, and I have been diagnosed with this syndrome. So, it has nothing to do with pesticides.
@@kevinmeyer8233 i help create the test. i know the results.
@growermindset CHS also seen in patients who source cannabis from licensed sources where plants are grown organically, without pesticides. Common denominator is high frequency of smoking/vaping high levels of THC.