Mechanisms of Spasticity and Baclofen [Biochemical & Macroscopic]

In this video, we explore the mechanisms of spasticity and baclofen, the major drug used in the treatment of spasticity. Also be sure to check out my video on the Modified Ashworth Scale!
Modified Ashworth Scale | • Modified Ashworth Scal...
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[@balanchaevtukuncho3660]

Very informative, please keep on doing these amazing videos

[@estherbanda-rb3iq]

This video is very nice,l have learnt about spacisity

[@denisebanto3185]

Thank you!

[@nickminazhetdinov8410]

¡Hola! I have a question, but it's not really related to the video. I read ''The science and practice of strength training by Vladimir Zatsiorsky, William J Kraemer, Andrew C. Fry.
In the book, the Golgi tendon organ and muscle spindles are introduced from practical standpoind. I've watched your videos and other people's videos, so I have an understanding of the myotatic reflex and the GTO reflex
''Golgi tendon organs are arranged in series with
the muscle fibers. These receptors are sensitive to FORCES developed in the muscle rather than to lengthchanges as is the case with muscle spindles. If muscletension increases SHARPLY, the Golgi tendon reflex evokes the inhibition of muscle action.''
''If athletes, even
strong ones, are not accustomed to such exercises, the activity of the extensor muscles during takeoff is
inhibited by the Golgi tendon reflex. Because of this,
even world-class weightlifters cannot compete with triple jumpers in drop jumping''
Well
1) There is a tendency in which, the faster an action is, the less tension is produced. Jumpers have about 0.11-0.13 seconds on the ground, which is too little to reach complete (fused) tetanus. So it brings me to suspect that ordinary triple jumpers produce less tension than world-class weightlifters when they train, lifters have enough time in the weight room
2) If the GTOs are only sensitive to forces developed (and this is introduced everywhere), then heavy lifting should be a great way to get the GTOs adapted, so that they can tolerate higher tension without shuting muscles down. But in a research back in 1985, a bunch of scientists (P.V. Komi, K. Hákkinen) divided experienced athletes into two groups - one would do heavy lifting (70%-100% from 1 rep max) for the next 24 weeks, the other would do explosive jump training for the next 24 weeks (that's what is incorrectly called plyometric training nowadays). They told athletes to drop down from 20cm-40cm-60cm-80cm-100cm and measured how high they could bounce up from those heights. What they found is that, heavy lifting and gains in strength produced very little gains in 20cm-40cm (17% increase in pefrormance in jumping from 20cm and 6% increase in performance from 40cm) drop jumps and no gains in 60cm-80cm-100cm drop jumps. Whereas the jumping group improved their performance by 30%-40% in every jump. The explanation for such results is that the strength that lifters gained can't be realized in drop jumps because the GTOs weren't used to sharp spikes of tension and they would shut everything down
I don't think jumping from 60cm has bigger force requirements than heavy lifting, but already there, at that point, when the downward phase on the ground gets so fast and muscles lengthen so fast, muscle spindels get an insane stimulus for contraction and the contraction happens so fast, GTOs don't seem to tolerate that rate of tension development. What do you think about? This little detail may not show up in videos and articles because in videos and articles, mostly basic concepts are introduced. But I've been looking for an aswer for a week, so could you tell me if Zatsiorsky and his comrades are right? It seems to be pretty logical that GTOs react not only to total tension but they can also shut everything down if tension increases rapidly, even if the total tension is not that big

[@sterlingray3982]

Cannabis is more effective at treating muscle spasticity.

[@CatalystUniversity]

I've never read anything on it specifically, but I would not be surprised.

[@sterlingray3982]

@@CatalystUniversity Big Pharma would rather we poison ourselves with their snake oil. The gloves are off.

[@sterlingray3982]

@Harry Prentice And watching us die. My former doctor recommended that I take celebrex for my arthritis. Wasn't that drug pulled off the market 15 yrs ago for causing heart complications?

[@sterlingray3982]

@Harry Prentice Great way to make us into cardiac patients. I was also suppose to have spinal surgery because myofacial pain syndrome is caused by the bones and not the muscles. At what point do people realize how ludicrous the medical system is?

[@sterlingray3982]

@Harry Prentice I've reduced a substantial amount of stress by detaching from this matrix. Peace be with you.