As someone who suffered from severe anxiety and depression, I did one really big dose twice in my life... Once a 5gram dose of mushrooms while laying in the dark listening to a peaceful meditation playlist and it cured my depression condition. Once 3 hits of LSD while listening to Alan Watts recordings and lectures and it cured my anxiety condition and gave me a whole new perspective on life. I still get sad but it's nothing like the debilitating depression I would get for seemingly no reason. The sadness always has a good logical deep rooted cause and I can literally pull myself out of it when I remember my trip... And anxiety has turned into excitement. Soo many years taking mood stabilizers and anti anxiety meds with 0 results... Psychedelics saved my life. And I've never felt the need to do them again.
Why so few views and likes? It's so well researched and presented, and it's exactly what people who suffer from depression not well managed by conventional medications need to hear.
Thank you for being so grounded in your videos, Manish! I refer many people to your channel. Appreciate very much that you say that psychedelics don't do the work; that they just amplify realizations and what you do with them is up to you.
That's the thing that bugs me most about standard anti-depressants - no highs, no lows - is that really living life to the fullest? Fixing symptoms is not fixing the problem. Psychedelics, especially Psilocybin have great potential to "reboot" mental perspective in just a few (or even one) experience, but definitely not a "one size fits all" solution to the complexity of mental issues, especially depression.
Sadly,for many of us, SSRIs don't even fix the symptoms of depression. After taking them for a few years, I sensed that they weren't doing anything positive for me anymore: stopping verified that suspicion. I've never tried psilocybin, but I found that a single dose of DMT left me feeling better than I had felt for years. Sadly, the antidepressant effect of the DMT only lasted a couple weeks. DMT had another positive effect that has lasted much longer, though: after that single dose, I lost my desire to smoke tobacco, and I haven't used any for more than two months, with no cravings. Uncanny. Oddly, the DMT doesn't seem to create any addictive feelings: as pleasant as the experience was, I'm not craving more. (Which is good, because I have no source for it.)
True. I quit antidepressants 2 months ago and feel better. They basically boost your mood t zero and up, at the same by clipping strong positive and negative emotions. Shrooms feels better for sure
Looking at that comparison, paper from the best I can tell it was purely examining the pharmacological outcomes. I wasn't aware many folks were advocating psilocybin as a medicine without accompanying psychotherapy. A cool study would be Psilocybin + Specific Therapy vs. Escitalopram + Same Therapy
I've been on SSRI's and or SNRI's for about 25 years. I took 1.5 grams of psilocybin mushrooms and felt zero effect. I have taken them before and know what to expect, so I was disappointed. I waited two weeks, and tried 3.5 grams in one sitting. Still, No Bueno. Zip, zero, nada. I'm afraid to go much higher. I currently take Cymbalta and Pristiq (an ER version of Effexor). I believe both are SNRI's. Is it even possible for me to try psilocybin therapy without discontinuing my antidepressants first?
I find those studies interesting, because I've always been told that psychedelics and ssris have some sort of cross tolerance. If that isn't the case then thats really cool
SSRI's reduce the effect of LSD I can personally attest to this. I double my dose for the same effect on citilopram 20mg, took me several trips over a year to reach that dose and I'm now tapering off and looking forward to just using 167ug again.
Can you please site the studies you reference? Otherwise people could think you are making all of this up. Also it would be nice to cross reference the studies with this video.
How do you not end up getting serotonin syndrome with the SSRIs + Psycadelics? I get that you clearly don't, does it require a norepinephrine too? ...while typing this you talk about a future video on serotonin syndrome, so it serves me right for starting to type my comment early! I'm fairly sure I had a couple of mild occurrences of SS when I was on an SNRI. Then I finally got to the end of the waiting list for ADHD treatment and, what do you know, the ADHD meds work great, the SNRI never did. We really skew the data by holding back treatment like ADHD treatment. It means everyone goes through anti-depressants first and I suspect that makes them seem particularly useless because half the time they're not the relevant treatment in any way.
I love the obnoxious and unscientific backbone of this video implying that antidepressants and bad for us and psychedelics are good. Good thing medicine neuroscience arent places for nuance and individualized care discussion!
![[안방1열 풀캠4K] 베이비몬스터 'DRIP' (BABYMONSTER FullCam)│@SBS Inkigayo 241110](http://i.ytimg.com/vi/AQ4RIghEvUs/mqdefault.jpg)
As someone who suffered from severe anxiety and depression, I did one really big dose twice in my life...
Once a 5gram dose of mushrooms while laying in the dark listening to a peaceful meditation playlist and it cured my depression condition.
Once 3 hits of LSD while listening to Alan Watts recordings and lectures and it cured my anxiety condition and gave me a whole new perspective on life.
I still get sad but it's nothing like the debilitating depression I would get for seemingly no reason. The sadness always has a good logical deep rooted cause and I can literally pull myself out of it when I remember my trip...
And anxiety has turned into excitement.
Soo many years taking mood stabilizers and anti anxiety meds with 0 results... Psychedelics saved my life.
And I've never felt the need to do them again.
Why so few views and likes? It's so well researched and presented, and it's exactly what people who suffer from depression not well managed by conventional medications need to hear.
Thank you for being so grounded in your videos, Manish! I refer many people to your channel. Appreciate very much that you say that psychedelics don't do the work; that they just amplify realizations and what you do with them is up to you.
Psychedelics are just an amazing discovery.
Is it just me or the editing has also improved along with the thumbnail 🔥🔥
That's the thing that bugs me most about standard anti-depressants - no highs, no lows - is that really living life to the fullest? Fixing symptoms is not fixing the problem. Psychedelics, especially Psilocybin have great potential to "reboot" mental perspective in just a few (or even one) experience, but definitely not a "one size fits all" solution to the complexity of mental issues, especially depression.
Sadly,for many of us, SSRIs don't even fix the symptoms of depression. After taking them for a few years, I sensed that they weren't doing anything positive for me anymore: stopping verified that suspicion. I've never tried psilocybin, but I found that a single dose of DMT left me feeling better than I had felt for years. Sadly, the antidepressant effect of the DMT only lasted a couple weeks. DMT had another positive effect that has lasted much longer, though: after that single dose, I lost my desire to smoke tobacco, and I haven't used any for more than two months, with no cravings. Uncanny. Oddly, the DMT doesn't seem to create any addictive feelings: as pleasant as the experience was, I'm not craving more. (Which is good, because I have no source for it.)
True. I quit antidepressants 2 months ago and feel better. They basically boost your mood t zero and up, at the same by clipping strong positive and negative emotions. Shrooms feels better for sure
Looking at that comparison, paper from the best I can tell it was purely examining the pharmacological outcomes. I wasn't aware many folks were advocating psilocybin as a medicine without accompanying psychotherapy.
A cool study would be Psilocybin + Specific Therapy vs. Escitalopram + Same Therapy
I've been on SSRI's and or SNRI's for about 25 years. I took 1.5 grams of psilocybin mushrooms and felt zero effect. I have taken them before and know what to expect, so I was disappointed.
I waited two weeks, and tried 3.5 grams in one sitting. Still, No Bueno. Zip, zero, nada. I'm afraid to go much higher.
I currently take Cymbalta and Pristiq (an ER version of Effexor). I believe both are SNRI's.
Is it even possible for me to try psilocybin therapy without discontinuing my antidepressants first?
Great to see you back to making content?
Top notch thumbnail on this one.
Great content and very informational 👏🏼
Buen trabajo amigo!!! gracias
Every effect mentioned is precisely what I experience. Psilocybin seems to be a hidden gift from God.
I'm curious how escitalopram influences MDMA. High risk for serotonin syndrome I guess?
Great video, thank you :)
I find those studies interesting, because I've always been told that psychedelics and ssris have some sort of cross tolerance. If that isn't the case then thats really cool
SSRI's reduce the effect of LSD I can personally attest to this. I double my dose for the same effect on citilopram 20mg, took me several trips over a year to reach that dose and I'm now tapering off and looking forward to just using 167ug again.
Does DMT have MAOI too?
How about Celexa
Can you please site the studies you reference? Otherwise people could think you are making all of this up. Also it would be nice to cross reference the studies with this video.
How do you not end up getting serotonin syndrome with the SSRIs + Psycadelics? I get that you clearly don't, does it require a norepinephrine too? ...while typing this you talk about a future video on serotonin syndrome, so it serves me right for starting to type my comment early! I'm fairly sure I had a couple of mild occurrences of SS when I was on an SNRI. Then I finally got to the end of the waiting list for ADHD treatment and, what do you know, the ADHD meds work great, the SNRI never did. We really skew the data by holding back treatment like ADHD treatment. It means everyone goes through anti-depressants first and I suspect that makes them seem particularly useless because half the time they're not the relevant treatment in any way.
Google LASD GANGS
'promo sm' 😳
I love the obnoxious and unscientific backbone of this video implying that antidepressants and bad for us and psychedelics are good. Good thing medicine neuroscience arent places for nuance and individualized care discussion!