I believe this is the mechanism used in prokaryotes not eukaryotes. Eukaryotic cells are theorised to use nicks made in the newly synthesised strands for this recognition to occur
Hello you are doing a great job, your videos are so helpful, however, I think polymerase III will be recruited, not polymerase I at 14.50 in the repair process. Kindly clarify
all ur videos are soooo helpfull ... i lov listening to ur teaching.... u really nw how to teach... and in nucleotide excision repair u havent mentioned about uvr A forming complex with uvr B .... other than that evrthngs just too gud... thankyou !!
Thank you so much sir for the explanation!! But, the part where you say helicase or UvrD cleaves the DNA is bit wrong I think. Helicase is required to open the 2 stands of DNA and it is accompanied by exonuclease 1 to cleave the oligonucleotide.
This video is amazing but I I have a question. For the step that the segment that contains the mismatch is cleaved out, is the UvrD helicase doing the job, or is there another exonuclease presented in the process? Thank you!
Yes, uvrD removes the incised region of DNA containing the lesion by breaking hydrogen bonds between the parent and daughter strands, so an exonuclease is not required. (Although the excised DNA may later be degraded by a ubiquitous exonuclease that is not specific to the mismatch repair pathway)
thank u very much for ur lecture... bt plz explain about the basic difference between methyl mismstch repair and base exision repair.... only mutS mutL and mutH r participating in methyl mismatch repair unlike in base exision repair... dats it??? plz explain....
lol... wtf... this is like a convoluted mix of MDMR, BER and NER.... Deamination is mostly repaired by BER, MDMR does use the MUT complex, but UvrD (Uvr helicase) is from NER... used in excising something like a thymine dimer, UV damage... hence the "UVR" UV repair in the name, this mostly (as I'm sure there are exceptions) does not happen right after DNA replication, MDMR is to fix replication errors, hence why there is no methylation on the strands... Please, if you are watching this video, these are 3 different processes, this vid is very very mixed up.
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9years after, still very relevant. Thanks for saving us during examinations 😅 and explaining so simply ❤
All the best for future
Bruhh I’ll cry…so grateful to Almighty that I flounder your channel😭❤️
All the best
you are a gift to future doctors of this world thanks for making us better
Sir iam from kerala.. Ur lectures are superb.... Explanation is..perfect
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Yo malayali
you are a great teacher, you make every purpose for every process so clear and comprehensive. Make more videos like these, its great help.
you are an angel in our bad time :) thank you!
Great thanks Sir.... I watches only u r videos..... Bcaz it is too simple and in detailed..... Thnx a lot
.no lectures as like u
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You are doing a great work sir...Lots of respect and gratitude for you 💓
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I Love the way you explain everything! Thank you for your help
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As it is your video is outstanding. This video is uploaded very early but still it's working is fresh and Waooooo👨🏫👌👍
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I hv exam period.. ur videos r helping me lot.. . 😍
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Excellent,I also watched the base mismatch repair and nucleotide excision repair videos ,,, great illustrations...
You are saviour, appreciate your hardwork. Your lectures are really helpful. Thanks alot dude
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I lost my notes on this topic.. thank you soooo much for the work you do!!!
Sir you are doing a grt job keep it up its very helpful
I love your video man .. keep sharing your knowledge please .. many thanks and love from Bristol-UK, Abdul
I believe this is the mechanism used in prokaryotes not eukaryotes. Eukaryotic cells are theorised to use nicks made in the newly synthesised strands for this recognition to occur
If it wasn't for you I'd be in a very bad situation. Thanks a lot I wish you all the best.
Sir , I am very happy by getting your videos. U are just amazing..my concepts are clear after listening your videos.thank you very much sir.🙏🙏🙏🙏🙏
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thanks somu bro.. it's easy and helpful...
u are intelligent
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@@shomusbiologyofficial.. ☺☺ keep sharing knowledge... god bless u bro☺
Splendid brother💙💙
Thank you
Just love your explanation and after watch ur lecture it is easy to understand thank you
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It’s DNA polymerase III that fills the gap(acc. to Watson). Other than that your video is a life saver 😁😁
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Hello you are doing a great job, your videos are so helpful, however, I think polymerase III will be recruited, not polymerase I at 14.50 in the repair process. Kindly clarify
You are just superb.. No words
Thank you
thank you so much ! Gracias !! your video helped me a lot ! thank you all the way from mexico !!
+Grethel Meza thank you. Glad you liked my lectures and
all ur videos are soooo helpfull ... i lov listening to ur teaching.... u really nw how to teach... and in nucleotide excision repair u havent mentioned about uvr A forming complex with uvr B .... other than that evrthngs just too gud... thankyou !!
+suraksha jkumar thank you. Glad you liked my lectures
Thanks a lot from Norway! This is so helpful.
Thank you. Glad you liked my lectures
Thank you so much for making mutation easy❤️
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Thank you so much sir for the explanation!! But, the part where you say helicase or UvrD cleaves the DNA is bit wrong I think. Helicase is required to open the 2 stands of DNA and it is accompanied by exonuclease 1 to cleave the oligonucleotide.
This video is amazing but I I have a question. For the step that the segment that contains the mismatch is cleaved out, is the UvrD helicase doing the job, or is there another exonuclease presented in the process? Thank you!
Yes, uvrD removes the incised region of DNA containing the lesion by breaking hydrogen bonds between the parent and daughter strands, so an exonuclease is not required. (Although the excised DNA may later be degraded by a ubiquitous exonuclease that is not specific to the mismatch repair pathway)
Thanks so much. Your explanations are so clear! :D
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Thank you sir.your vedios helps up in our bed time
i don't why every word you say make sense to all the words in my chapter that i was trying ages ago to understand 😀
+Undeadkitty c'v thank you for watching
Thanks a lot ....bro!! your so helpful and even your making biology more favorite
Outstanding daada ❤️❤️
Thank you
Very helpful, but I have found that MutH binds at hemimethylated sites along the daughter DNA and that at the end works Pol III not Pol I
Thank you for your videos...they are very helpful
Excellent explanation sir.
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Crystal clear understanding .
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Appreciate your work and efforts tx man
Excellent explanation ❤
Thank you
thank u very much for ur lecture... bt plz explain about the basic difference between methyl mismstch repair and base exision repair.... only mutS mutL and mutH r participating in methyl mismatch repair unlike in base exision repair... dats it??? plz explain....
Sir... U have explained very nicely...but i have one doubt.which dna pol will come....dna pol I or dna pol III?
Thanks, you really really helped me a lot!
Man that was reeeally awesome ❤ it helped me a lot, thank you very much
thank u sooo much for giving us this knowledge.....it will definitely help me in my upcoming exams....:-)
Very nice explanation thank you
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Very good lecture sir..thank you..
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I think DNA polymerase III in prokaryotes and DNA€ in eukaryotes will work.
this is a very helpful video. Thank you !
Iam owe to sir a lot..🙏🙏literally appritiable..
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Sir,,why not DNA pol.lll is used here ,, instead of DNA pol l
Video is superb but more time is utilised for explanation
can you please make a full video on axis formation in Drosophila it will be very helpful :)
This is so helpful. Thank you so much :)
+akansha narayan you're welcome
Thank you Sir ....Thank you.. 👌👌💞👍🤗🙂
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Helpful sir thank you.
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Sir can I get the materials
Best video!!! But why every time and always having having having and having???🙄🙄🙄
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Can this method repair dystrophin gene which causes DMD or BMD?
DNApolymerase I or III in 2nd last step ?
This is awesome 🥰🥰🥰
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Thank u so much sir
U are great
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Mut L attach non methylated strand or methylated strand??
very much useful easily understandable thank you
Thanks a lot for your vedio it will help me a lots
Thankyou so much sir 😊🙏
You're welcome
Can cell uses all the repair mechanism to repair the damage
Yes
what is the importance of dna replicatio.? pls tell me
Life saviour ❤️
Thank you
U teach very well thank u:))
Is this about E.Coli ?
hi sir can you please make a video on lac operon and trp operon translation if you can than it will be helpful to me
+Manas Roy it's already made. Please check.
Tqsm sir❤
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this is for prkaryotes any thing for eukaryotes
Cheers man, very helpful
Am here after 9 yrs.
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Me too 😁
Really helpful
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Pol I or III??? will fill
Make a video about epigenetic....
You helped me alot freind
Thank u so much sir
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Thanq ..u r a saviour
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But role of mutL is unknown written in pathfinder book
Very clear
You're welcome
lol... wtf... this is like a convoluted mix of MDMR, BER and NER.... Deamination is mostly repaired by BER, MDMR does use the MUT complex, but UvrD (Uvr helicase) is from NER... used in excising something like a thymine dimer, UV damage... hence the "UVR" UV repair in the name, this mostly (as I'm sure there are exceptions) does not happen right after DNA replication, MDMR is to fix replication errors, hence why there is no methylation on the strands...
Please, if you are watching this video, these are 3 different processes, this vid is very very mixed up.
Ty😊
Amazing amazing amazing
Thank you
Excellent !
No, it was horrible... I'm not kidding, complete nonsense video.
thank you sir
Must h distinguish between new and old strand not mut L
Life saviour 😍
+Ashna Mohanpersad thank you. Glad it helped
@@shomusbiologyofficial sir please upload the materials particularly this topic MMR
well explained
So nice
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Worldwide liked vedieos
Thank you
nice job