A/Prof. Ken Sikaris - 'Fatty Liver & Chemical Pathology'
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- เผยแพร่เมื่อ 30 ก.ย. 2024
- A graduate of the University of Melbourne, Dr Sikaris trained at the Royal Melbourne, Queen Victoria, and Prince Henry's Heidelberg Repatriation Hospitals. He obtained fellowships from the Royal College of Pathologists of Australasia and the Australasian Association of Clinical Biochemists in 1992 and 1997 respectively.
Dr Sikaris was Director of Chemical Pathology at St Vincent's Hospital in Melbourne between 1993 and 1996. A NATA-accredited laboratory assessor, Dr Sikaris specialises in Prostate Specific Antigen, cholesterol and quality assurance and is currently chair of the International Federation of Clinical Chemistry Committee on Analytical Quality. His expertise is highly sought and he has presented extensively at national and international symposiums.
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Brilliant! It was my fawtty liver during my heavy drinking and SAD eating days that got me off the booze and eating better. 17 years dry and 35lbs down.
From my own experience, it is 100% true that (1) a 10%-15% weight loss reverses fatty liver to normal (2) a very low carb / no added sugar diet is very effective .... works in ~ 1.5 months for my case (3) liver function markers like ALT GGT, high blood pressure, triglyceride also normalised with reversal.
For those suffering from fatty liver disease, listen to the good professor’s advice and regain your health.
Thanks a lot 😇🙏🥰
Frankly I gave up on Drs knowledge. And it saved my life. I went out after my Dr totally ignored me, discovered a thing called M2PK (pyruvate kinase), not part of Australian diagnostic criteria, got tested (only one Lab in Australia tests for it, if you request), it came back High, indicating a possible tumor. Got a SECOND colonoscopy 5 months after the first by a GI specialist.......and Bingo! there it was, in the right colon, 1cm of the type that rapidly go aggressive. I was supposed to wait 5 years. lol So now I have obtained from Schebo biotec Germany, the in-house M2PK test kit. So I can test myself every year.
Which company does the test?
I'm glad you mentioned that the LCHF diet is a particularly good way to treat fatty liver disease.
Sure, since LCHF means little to no dietary sugar. No dietary sucrose plus intermittent fasting is what I prefer to do.
A Keto/carnivore diet has steadily improved my liver panel to normal and beyond, even with cirrhosis. You definitely want you liver function to be as good as possible.
This should be required viewing for every GP, nurse, specialist and patient, man, woman and child! Does that cover everyone?
A failsafe wording against any unintended omission might have completed the sentence as follows. "This should be required viewing for every GP, nurse, specialist and patient, man, woman, child and variations thereupon." On a point of grammatical pedantry, the exclamation mark is unecessary and even inappropriate, as your sentence is neither conveying surprise nor stating anything astonishing, even if what it is stating is novel and highly poignant :-))
No, my ex is a cyclops.
Fire your doctor. Eat meat. Thrive.
Great presentation, thank you. 3 years ago my BMI was 32 and I had NAFLD. We changed our family diet 2 years ago, I lost about 30kg and my BMI is 24. ALT and AST are less than 15, TGI is less than 1.0, no fatty liver more.
After being diagnosed with liver inflammation and offered no solution by my Dr, I researched diet and went keto carnivore and cut down drinking and reduced my ALT level from 510 ( around 15 times normal range ) to 60 in a couple of months. My Dr was so surprised he printed off a graph showing the drastic drop in numbers.
Low Carb Down Under utterly rocks my world. Very intelligent and credentialed speakers. Thanks so much.
Great information- Im one of the TOFI - fit and excercised/ didnt have soft drinks nor sweets yet had "fat infiltration" in the liver!!! Currently doing low carb and yet to return to be tested.
Hi Ken, so sorry about your accident. That must have been an awful time. Glad you are back again giving your talks. Thankyou for recovering!!!
Thanks Jenny. The months it took to recover are trivial compared to what could have happened. Good health requires some effort, but it is our greatest blessing.
ALT and AST also go up for as long as 12 days following intense exercise, because they are released by damaged muscle cells. Study published a few years ago, available online.
What a great lecture! Although not mentioned I am sure fasting also reverses fatty liver.
Highly informative and understandable.
I asked my GP what I should do about my high trigs. His reply “they go up and down anyway”. Medical schools do not give sufficient emphasis on the basic science as a source of advice about health and wellbeing. Unlike drug companies that invest in a sales team to pedal nasty stuff like statins.
Society needs to here more clear and thoughtful presentations as this.
Carbs drive the triglycerides up, way up and what is the job of the triglycerides????..triglycerides are a type of fat (lipid) found in your blood. When you eat, your body converts any calories it doesn't need to use right away into triglycerides ( what your body doesn't use it stores)....Intermittent fasting helps, along with a low carb diet....When the doctor gets you to do a blood test and tells you to fast between 9 to 12 hour what happens??? So if you go 12 hours or over that time the LDL will be sky high why? This is what usually happens when you do Intermittent fasting, the LDL always shows up so high....so they tell you you have a big cholesterol problem....lol Now take these pills that will now destroy your heart along with some other vital organs. Thank you doctor....what was that oath you took to do no harm? They tell you you are fat or obese, morbidly obese but they don't tell you that if you lose even 5% or 10% of your body weight that the fatty liver will go away. Instead of saying you need to lose all that weight why don't they tell you the percentage needed in body loss to help you. No they would rather you get stuck on statins for the rest of your life which will destroy you etc....This man actually tells you right at the end of the video....the truth that your doctor is not going to tell you...I had fatty liver, I lost 10 kilos and next blood test it was gone.
Brilliant post.... 👍
In 2014, when I turned 40, my ALT was 28, in 2018 it went to 43 and an MRI showed moderate fatty liver. Doctor never thought to mention anything with the spike in ALT. I immediately cut fructose/sucrose but still had simple starches. I supplemented with L-Carnitine to shuttle fat to cells and took enzymes to support my liver in the breakdown of fats and proteins with Amylase, Protease 3.0, 4.5, 6.0 and Bromelain. 2019, at 45 years old, ALT was down to 23, even with a body weight of 242 pounds (i do exercise).
15:46 "Most of our transplants will be for metabolic-syndrome-related fatty liver disease."
thank you for uploading this gem.
loved this lecture. great delivery and great info. keep up the wonderful work, sir.
The best voice on blood lipids... unfortunately one that seldom speaks.
I recently had a blood test and Glucose Tolerance Test (2 months postpartum after having had gestational diabetes and a c-section - I'm 44). I'd been eating low carb and was (still am) breastfeeding my then 2 month old baby. I lost the 10 kg I had put on during pregnancy by about 10 weeks postpartum eating low carb / keto (and didn't personally have any trouble producing enough breastmilk although I didn't the first two times on a regular (less healthy) diet either.
When I tried to reintroduce a few carbs just to see what would happen (and also because I'd been having increased heart palpitations and wanted to see if it could be to do with low carb / keto), about 3 kg came back in the first week and I now sit at that weight, which makes me a bit overweight.
My ALT was 23 and my AST was 20. My GTT results and insulin test, which I had to beg my doctor for, were: GTT Fasting 4.4 mmol / 1h: 12.1 mmol / 2h: 6.5 mmol. I thought I might be diagnosed with diabetes with that 1h result being over 11 mmol but all that was written on the lab report was that I may be glucose intolerant and that I should retest in a year's time. My fasting insulin was 6.3 mU/L. (Apparently normal in Australia but when I asked someone on the diabetes forum in the UK, over there I may have been told that my insulin level was slightly elevated. My insulin/glucose HOMA was 1.2. (under 2 is okay).
My young doctor was more interested in my cholesterol results however, even though I have since read that cholesterol is still normally elevated while breastfeeding and for at least 3 months after surgery (this was 2 months post c-section for me). I'm not sure how elevated is okay though but here were my results:
TC 8.7 mmol / Trigs 0.7 / HDL 2.89 mmol. I think my ratio is okay despite the total being on the higher side... My doctor thought I should quit the keto diet (and eat Mediterranean instead) and quit breastfeeding so I could start a statin... I haven't touched a statin yet.
My question is, with my lipids being like that; my ALT being 23; and my 1h of the GTT being 12.1 mmol, I obviously have some metabolic derangement here, don't I? I mean I had gestational diabetes this time so that's a fairly obvious indication too. But if I am breastfeeding still, how much does that affect results of cholesterol and blood glucose levels? I think breastfeeding it helps bring down blood glucose and I was actually breastfeeding during the GTT but I hadn't had 150g of carbs for the 3 days prior - probably 75g for the 2 days prior only, so maybe that gave me extra intolerance? Although one of the true T2 diabetics on that UK forum I mentioned, who has reversed his diabetes with low carb/ keto, said his GTT was not even quite as high as mine at the 1h and 2h... and this man had T2 and had truly been on a keto diet with almost no carbs right before his GTT test...
Anyway, I am thankful there are people like you informing us of these things so when our doctors don't notice the results being slightly elevated, we can see it for ourselves and endeavour to do something about it rather than waiting till it becomes a worse diagnosis.
Thank you for sharing the very interesting situation of breastfeeding and blood test results. I believe good breast milk has high cholesterol and growing baby brain needs lots of cholesterol. Just that alone makes it strange to me that anyone would want to lower cholesterol in breastfeeding mother. I have heard that traditionally African mothers would introduce low carb to babies as they developed. .? Hope you and your family are healthy and happy. Thanks for sharing.
Thank you Ken, Thank you low carb down under.
Real great information. 👍
I wonder how many fatty livers are transplanted.
Thank you the free education
This was very informative for a layman like myself👍
Thanks Ken. Sorry to hear about your accident and it's great to see you back.
well, weight loss is not the same like body fat loss. weight loss in general is not the perfect guideline here. if you cut off a leg then you lost weight, but that doesn't change anything regarding the liver.
body fat loss through diet is the right key word here. and that is different from "weight loss" because you do not want to lose muscle (or legs).
and the highest rate of body fat loss compared to other weight is achieved with - drumroll - of course - KETO! why? because it switches to fat burning mode away from carb/protein burning.
and of course low carb is not keto.
Thanks for pointing out that we can't just cut off an arm or leg to get healthier.
Keto is too generic: also margarine is keto, but its shit.
I know skinny people who ate a ton of sugar. What about them? If obesity is a marker minus the drinking what does that say about the skinny person who eats a term of sugar
Scary for me, with fatty liver. A good wakeup call. Thank you!
My ast went from 33 to 31 and my alt from 35 to 24. I thought both were within the normal range but the ratios are completely different. Can someone interpret this for me. Are my results better or worse?
Amazing, Thank you professor!
Dr Ken SIkARIS, you talks are always the best explained !!!
So body surfing is bad for your liver. I get it.
Hi Dr.Ken Sikaris. Thanks very much for this great lecture however I am puzzled as to how purely losing weight irrespective of whether that's low carb high fat or or low-fat high carb makes no difference. Surely if you're still adding fuel to the fire ie sugars and fructose this must affect the reversal of NAFLD?
While there is a clear advantage of low carb (sugar) in both preventing further fat accumulation as well as fat adaption (ie increase the preferential use of fat as fuel), you can also switch to fat burning by ‘starving’ or having any diet which is simply low in calories.
SIBO also causes a fatty liver. Are the consequences the same? I’m doubtful
I imagine a fatty liver could also contribute to SIBO if the fatty liver inhibits adequate bile production, as bile helps to wash out potential bacterial overgrowth in the small intestine.
Do you know the mechanism by which SIBO causes fatty liver?
The blocked/malfunctioning bile/ducts seems a reasonable hypothesis. But do you your reason? Might it be an inflammatory response to sibo?
Can liver scarring be reversed if the source of scarring is removed?
The liver is the ONLY organ to regenerate itself. I would think because of that capability, I don't see why not.🤔🤔🤔
@@gtm5650 I think you're right in saying that the liver can regenerate itself however I believe if there is scarring this cannot be be regenerated. uihc.org/health-topics/liver-disease-frequently-asked-questions
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This is a serious concern. I wonder how we can educate people of this condition that think eating fructose is ok. I will share this.
(Flippancy alert). Does it also give you fatty balls? Because such a health warning would sure motivate the male half of humanity to go LCHF. On the subject on fatty liver and LCHF, I had fatty liver last week, but within less than a minute of my ketogenic lunch it was gone. My fatty liver? A tin of finest Fois Gras. Gobbled down in thirty seconds flat = ...gone!
so no fruits anymore because of no fructose??
No. Just no sucrose. So,, no cakes, pies, soft drinks, etc. Even processed foods are suspect, as so many have added sugar (sucrose). Reading labels reveals that. Whole foods seems the way to go.
As for fruits, there is a positive association between fruit and health.
In his talk, he mentioned that fructose is metabolized unless glucose was also present, and it is present in sucrose, in which case the fructose is converted into fat.
Eating an apple a day is not going to kill you unless you're washing it down with a can of coke.
@Hans If you've watched his videos, you would know by now that Fructose cannot be used directly by the body's cells. Instead the Liver must convert it first. If blood sugar levels are low, then it gets converted to Glucose and Glycogen. Unfortunately, for most folks, when they eat fruit and fruit juice, their blood sugar levels are already high, so the liver converts it to triglyceride (fat) and ships it out or store it in the liver (thus fatty liver). Therefore, it's a good idea to minimize your fruit intake and definitely no fruit juice. If you want more anti-oxidants in your diet, you can get more anti-oxidants from a cup of coffee than you can from any fruit.
It depends on your personal situation and your goal.
Less fruits, yes. But particular no fruit juices, where 1 glass contains the sugar and the fructose of 4-6 whole oranges or apples, and no so called „soft“ drinks which are full of sugar and high fructose con syrup. These „soft“ drinks kills your liver.
so, now what?? where are the suggestions to get rid of the FL, "just" loosing weight?? which diet? certainly not Keto??
Hans Markowski - Hi Hans! Though it seems counterintuitive, the High Fat, Moderate Protein, LOW Carbohydrate Diet WITH Intermittent Fasting is the way to go. Low Carb prevents Spiking Insulin, which leads to Fat Storage in the Body. The Ketogenic Diet Foods are also Low Inflammatory and also allow the Body to burn off its Fat Store for Energy.
Intermittent Fasting helps to quickly get Blood insulin back to Normal Levels and keep it there most of the Day. Autophagy, the Body’s Recycling Process, can begin once Fasting has proceeded for about 16 hours or more. Prolonged Multi-Day Fasting is even more effective. Fasting takes the energy needed for metabolizing Food, and allows it to be utilized for regenerating the damaged Liver.
So NO mixing glucose (sugary foods) with fructose since it leads to conversion of fructose into fat. And keto is the best since it's low carb high fat diet and you're not suppose to consume neither glucose nor fructose.
Hans Markowski
Losing weight or restricting carbs will get rid of fatty liver. Keto diet restricts carbs, so it will be effective in reversing fatty liver, along with fasting.
Umm, yes, keto. Hence the channel you are watching, low carb....
He didn't mention intermittent or extended fasting, maybe because of where he was speaking. Check out videos by Dr Jason Fung.