Can we stop MS and ALS? | Michael C. Levin | TEDxUniversityofSaskatchewan
ฝัง
- เผยแพร่เมื่อ 4 มี.ค. 2024
- Most persons living with multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) continue to get worse. Researchers and healthcare providers don’t know why, or how to stop it. Although the two diseases are different, they share the common feature of nerve cell death in the brain and spinal cord. Our research team has discovered how nerve cells like these die, and designed new drugs to both stop cell death and encourage regeneration! By stopping nerve cell death and promoting their recovery, we believe we can stop MS and ALS in their tracks, improving the lives of persons living with these devastating diseases. Dr. Michael C. Levin (MD) is the Saskatchewan Multiple Sclerosis (MS) Clinical Research Chair and Professor of Neurology at the University of Saskatchewan (USask) College of Medicine. An MS specialist and neuroscientist, Levin has been caring for persons living with MS and conducting research into the cause and treatments for MS for most of his career.
At the University of Tennessee Health Science Center, he was professor, Chief of the Neurology Service at the Memphis Veterans Affairs Medical Center, leading the MS clinic and performed research on RNA binding proteins in MS. His work has been published in top journals including The New England Journal of Medicine, Nature Medicine, Annals of Neurology, Glia, and Journal of Neuroscience Research. Dr. Levin and his team have received more than 100 awards for academic excellence. He is editor of the Neurology Section of the Merck Manual, on the Medical Advisory Committee of MS Canada and honored as one of the ‘Best Doctors in America’. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at www.ted.com/tedx
Why not just give the miracle drug right now to sufferers with such advanced cases of ALS that they literally have nothing to lose ? The problem with all those TED Innovations is that they take so long to come to fruition that it may not be in our lifetime .
just like hair growth lol, we've heard that a solution was very close for the past 30 years... they can't even grow one hair back. i understand it's not life threatening - hair lost - but it's very annoying. Good luck.
I agree. I find the scientific process ridiculous at times. Taking 5 years for trials and then another 5 years before production is WAY too long. People are suffering NOW. I am sure there are thousands who would be willing to try out the medication, I would for one.
Soo long 😭 why when we can pop up a Covid vaccine in next to no time. We don't care being guinea pigs we just want a life
Depends often on how it is given...tablet, infusion, lumbar puncture etc. Can the patient swallow? Van the tablet be crushed? What is the effect on the liver? These tests have to take safety of meds into account.
@@user-ts1hw3er8zcovid vax had 15 years of work on it and ppl still think it caused issues.
As a person with MS for 14 years, I clicked immediately!!
I immediately sent this to my brother whose wife has MS. I hope it's useful info. I am just now watching it!!
Really hope science finds a way to relief for you. Nothing but love to you
Watch „The living proof“, it’s a documentary.
Fifteen years for me. This is exciting!
I have als. I'm praying for a miracle
Diagnosed in September 2021 at 22 years old. You’re not alone!!
Thank you Dr for everything you do. I have been diagnosed with MS since 2 years. My first relapse has left me permanently blind in my left eye, i am still in my 20s. This is such a scary disease that leaves me fearing another attack every day. I hope your trials are successful and that you can speed through them as quickly as (scientifically) possible. This would be a game changer for tens of millions of people. Thank you and I hope to be taking the medication soon :)
What drug do you take? Kesimpta-Ocrevus?
@@martinschultz2631 currently on tecfidera - in the netherlands they still escalate and don't let you have the best medicine first for some reason. When I asked by neuro for ocrevus he proceeded to describe how someone died of it. and refused saying he would have to discuss internally with neurologists because it was a "strange request".. zero bedside manners. In my mind it isn't strange at all to want the best working medicine to prevent permanent damage and literal holes in my head.
Try fasting and the carnivore diet, help your body heal itself. Look up Dr Ken Berry or Dr Anthony Chaffee on TH-cam and just read the comments from people with MS they've helped. Drugs will never be the answer, the organisations that make them do not want you better, they want a lifelong customer.
This could be a huge breakthrough! Hope that the studies get the funding and prioritization they need.
As a person recently diagnosed with ALS I am intrigued.
Big thanks for this Doctor. People like you are our hope!
This is incredible! I can’t wait for it to help my MS and everyone with MS! Thank you for your research and your efforts!!
Wow! To see these images and to hear Dr. Levin's evidence, it is truly amazing. Huge tks to him and his colleagues. Now what will happen with this critical research?❤
Absolutely incredible... could this be the ending of the immense suffering?
I have a niece diagnosed with ALS in october 2023, given 6 months, shes dying slowly 💔 how would she get on the trials
I cannot thank you enough for this work. Please bring this to market as soon as you can. A lot of people could use this treatment.
In future, this measures will disseminated expand. Coming soon I think it will useful for people rally need it.
Amazing! Your work is so rewarding! 👏🏻
I congratulate Dr. Levin and his team. I hope he can continue to make progress. I have PPMS and really have just accepted it now. I do what I can, have not "given up", but I am a realist...
I have PPMS and its deteriorating daily. So when saw this videos my eyes open widely. Thanks dr we have hopes only because of ppl like you. Please share anything that comes up.
Thank God and God bless your endeavours, Dr.
No "god" was involved, all of them are imaginary.
What I do is Listen to Music to get Relaxed Deeply. Works for me.
yeah but what is the drug that you invented would be nice to hear
Diagnosed January of 2016. I would gladly join the clinical trials. Each year I lose a part of me. Not long now before I am wheelchair bound. If there is a 50/50 hope to gain 50% normality, I will gladly take it.
Whilst this is an encouraging video as to the excellent work done by Dr Levin and his team, it is also a bit disingenuous. It’s not possible to be fully confident of the treatment being effective for everyone with MS or ALS until the trials have been done. The trials can take many years, some can take 15 years or even more. Also medications have to be approved and this can also take time. As someone with MS I sincerely hope Dr Levin has hit on the cause of MS and ALS and the way to prevent disease progression, but it might be along time before we can all be confident of this and see any treatment become widely available. I think perhaps not in time for me and others - being as how I’m sixty, but I’ll keep my fingers crossed for the future and for those children and young adults currently having to live with these awful diseases.
Dr. Levin I was dx in 1989 at Elmhurst Hosp Queens. I am ppms 77f.
Nice to meet you and good luck with your work.
Best.
How is your walking, are to still able to walk?
@@Lordsofchaospodcast hi I kind of force myself. Pretend someone holding gun to your head. I have mobil scooter gogo had big fight with managed medicare to pay. I finally won case. Guess what never used once. I also have 3 wheel rollator. Very inconvenient storage bag design. Also no seat. Used 1-2 times. So how do I walk you ask?
Small shopping cart. Left hand. Right hand cane. A neuro once told me he had a ms pt exact same choice of cart, cane. I said, How long did she last? No answer, just smiled.
first here. I hope you get what you want in life
I lost my mother to ALS back in 1993. For years, I was afraid it is hereditary. Sometimes I am still afraid, as I am approaching the age when she fell sick. Every piece of new information is precious to me. Thank you very much.
I feel your pain! My mum died of it last year and my uncle when I was a teenager. I fear the same and no DR, I've asked appears to be able to confirm if I will also contract it too. It's a horrible disease. Thanks for sharing x
You should do a gen test, for piece of mind.
Had MS Dx in May 2011. It’s all good. What’s happening is happening , no reason to have self pity or resentment or depression. Acceptance is the answer to all problems.
Teach me how! My husband got diagnosed with ALS 3 months ago and I am simply devastated. We have kids. He makes the money. Our whole life has been turned upside down.
My sister dx’d about a year ago, from an active woman to not moving a finger, feeding tube, niv
So overwhelming
@@Libbertyone that is terrible. How old was she when she got diagnosed?
@@Lordsofchaospodcast 72
@@Libbertyone yes that makes sense why the decline was so fast. Getting diagnosed later in life usually results in a rapid progression of the disease. Im sorry you’ve all suffered. Have a good night.
was diagnosed with ms in october 2023 and just turned 22 the same day i was diagnosed.
Ive had it for over 15 years. I am grateful I am sill alive.
ALS? Or MS?
You have ALS or MS
My son is 33 and has Progressive MS. 5 years ago he lost his vision in one eye. He's a good person who has so many medical problems now. I stay up many nights worrying about him. I hope there's a cure. He doesn't want to have infusions with those dangerous medications. Thank you for trying to find cure.
Tysabri (an infusion) has been a game changer for me. !!
Richard
This offers hope for those struggling from MS😊
I have ms 20 yrs now. Dear Dr Levin, thank you! Will your very thorough "Aha moment" A1 protein breakthru get a most worthy research grant? Or will we hear the usual soundbite, "its years away still from testing, trials, approvals". Many a mice have benefited from yr A1 tests. When is it for us? 🤔🐦🙏😘🇨🇦
An awesome guy living off grid on an island for the past 8 years is slowly dying of Parkinson's. He has a channel of short videos on TH-cam and is very sick now. Hopefully somebody would reach out to him and help him. His name is Mark Hogben. 🧡🧡🧡🧡
What is the name of the drug and does Washington University in St.Louis participate in the clinical trail for this drug ?
What is the name of the drug?
So, is there a name for this new medication ???
Hi! Dr Levin needs a generous research grant to get his theory tested, then trial stages begin. If its showing good results, then it goes to next stages, expanding the # of ppl to join the research study medication, then hopefully, approvals. This is the Canadian protocol for any research projects. 😊
What’s the pathway of these “medications” - particularly with respect to the neurogenesis? This talk told me nothing. What were the results in the mice? Really annoying.
Strikes me as too confident. Not a good sign.
Spoiler alert. No. Diagnosed 5/2022 (ALS)
Please sir help me my name is MOSAROF I'm from Bangladesh I'm 35 year old I'm suffering MND ALS disses one year please can you help me sir please
AP ko kia Alamat symptoms Hain.
My mother is suffering from this disease 💔
were u from bro
These drug inovations are well and good, but people who are suffering now have to wait 10 to 15 years to get them. Patients now will not befefit from these drugs if you have especially ALS. There got to be away to get these drugs to petients quikly to save lives.
Sucks this entire video is being heard through my left ear
I think there is a company in Australia progressing to 2/3 that has a drug that induces autophagy of mislocated protein from the nucleus. Phase 1 trial showed a potential slowing of ALS by 58% based on ALSFRS score
Do you recall the company?. Thanks
@@jackyeferreira5039 Hi there, I believe the company is called Pharmaust and the drug is Monepantel. All the best
L,
@JasonBeckerOfficial This is phenomenal.