244 ‒ The history of the cell, cell therapy, gene therapy, and more | Siddhartha Mukherjee

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  • เผยแพร่เมื่อ 9 มิ.ย. 2024
  • Watch the full episode and view show notes here: bit.ly/3krhSr0
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    We discuss:
    0:00:00 - Intro
    0:00:08 - How the cell brings the genome to life, and how Sid’s recent book fits into his prior work to tell a story
    0:09:13 - How the germ theory of disease and an understanding of the cell fueled a big leap in medicine
    0:18:46 - What is the evolutionary drive for multicellular life?
    0:29:21 - Four types of cell therapies and the challenges of gene therapy
    0:42:09 - CAR T-cell therapy: promising gene therapy for cancer
    0:48:25 - The possibility of using gene therapy to treat germline mutations like sickle cell disease
    0:52:54 - The incredible revolution of gene editing with CRISPR
    1:02:13 - Ethical questions around human gene editing
    1:14:24 - The complex role of genetics in mental illness
    1:20:33 - Two types of problems in science: the “eye in the sandstorm” problem and the “sand in the eye” problem
    1:23:38 - Understanding neural networks: an example of the “sand in the eye” problem being solved
    1:33:16 - Importance of learning by doing: comparing the learning styles of a doctoral student to a medical student
    1:38:45 - Sid’s unique and brilliant style of writing
    1:44:34 - Falling as the leading cause of accidental death: a liability of multicellular existence
    1:49:05 - Sid’s struggle with depression and his desire to change the stigma around mental illness
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