Rybelsus: Oral Ozempic? | Dr. Dan Obesity Expert
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- เผยแพร่เมื่อ 25 ส.ค. 2024
- Have you heard of Oral Ozempic? It’s all over the news headlines as of late. Have you heard of Rybelsus? Same same, but different?
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A little while ago (okay, more like a year or two), I made a video comparing Ozempic to Rybelsus and talking about how it's kind of the inferior form of Ozempic. Is this still true?
Let’s get into it.
References:
▪️ Knop FK, Aroda VR, do Vale RD, Holst-Hansen T, Laursen PN, Rosenstock J, Rubino DM, Garvey WT; OASIS 1 Investigators. Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2023 Jun 23:S0140-6736(23)01185-6. doi: 10.1016/S0140-6736(23)01185-6. Epub ahead of print. PMID: 37385278.
▪️ Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021 Mar 18;384(11):989-1002. doi: 10.1056/NEJMoa2032183. Epub 2021 Feb 10. PMID: 33567185.
▪️ Rodbard HW, Dougherty T, Taddei-Allen P. Efficacy of oral semaglutide: overview of the PIONEER clinical trial program and implications for managed care. Am J Manag Care. 2020 Dec;26(16 Suppl):S335-S343. doi: 10.37765/ajmc.2020.88554. PMID: 33439582.
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Related weight loss medication videos:
▪️ Rybelsus: Ozempic’s Least Favourite Sibling: • Rybelsus. Ozempic’s le...
▪️ Ozempic: The Game Changer: • Ozempic: The Game Changer
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Video Topics: medication for weight loss injection, benefits of prescription weight loss, medication management, medical weight loss, weight management, weight loss medications, weight loss injections, obesity treatment, medically supervised weight loss, rybelsus, ozempic, oral ozempic, semaglutide
#rybelsus #ozempicweightloss #obesitymedicine
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My dad takes it for type 2 diabetes. Just walks 20mons a day. Disnt change diet drastically and went from 100kg to a steady 76kg in 3 mths. Amazing medicine.
What daily dosage goes he take ?
I've been on Rybelsus for 3 months, from the 3mg for a month, then the 7mg for another month, and finally 7mg. I lost just over half a stone. In that time, I felt weaker, tired, and became exhausted very quickly, feeling unable to do anything. I lost my appetite. I went back to the doctor who checked my pulse and decided to give me an ECG and discovered i had an irregular heartbeat. The doctor put me on blood thinners because I was at risk of developing a blood clot, which could lead to a stroke. I asked if this could be anything to do with the rybelsus medication and was told there were no reports of any side effects to an irregular heartbeat. However, I decided to look at the manufacturers website and found that an irregular heartbeat was a listed side effect. I decided to stop taking the rybelsus medication and return to my original diabetic medication. Thankfully, with in 36 hours, my heart rhythm returned to normal. I did not feel tired, exhausted, and felt like a new man. My doctor is trying to persuade me to go back on the rybelsus medication.
Taking Ryebelsus daily is a daily reminder that you are investing in your health. Maybe healthy habits will follow.
Yup!
I have access to both but I prefer Rybelsus!
Remember to have a good protein diet and exercise coz you will loose muscle.
Vielen, vielen Dank für diesen Beitrag!!
My pleasure!
During the initial 60 days, I shed 30 pounds by using Rybelsus at doses of 3mg and 7mg. Yet, in the subsequent 60 days, I've observed no further weight loss while consuming Rybelsus 14mg, and my hunger levels remain unchanged. Is this lack of progress typical, and would it be wise to persist with Rybelsus 14mg?
It makes me hungrier it’s so weird 😢
I think perhaps your body got used to the medication, not sure tho.
Excellent video, you covered all basis and I thank you.
On the Rybelsus right now just 3mg because at the dokter we cant get Ozempic anymore, im a diabetes 2 patiënt and for me this stuff works wonders finally got my diabetes under control….slowly stopping my Gliclazide medication ( the not good medication with loads off side effects ). The only side effect i have is Some wierd nausia and sometimes dizzy. Atleast i got Some stuff that helps me.
I have been put on "Trulicity " whats the diffrence with that and ozempic.
I wonder if the oral version will be any cheaper, considering there is no pen involved, which is expensive to manufacture.
At present Rybelsus 14mg daily $260/month; Ozempic 1mg once weekly $250/month. So likely not. The technology and need for a daily pill is what will drive up cost.
Where are you finding ozempic for that price? It’s $1k a month.
@@MsBianca78 In Canada. Dr. Dan is based in Canada. It’s sad that they are charging so much in other countries.
@@MsBianca78it is 170USD roughly a month in japan, even cheaper
@@Reshika_2310It’s $156 in Brazil, and no prescription needed for the name brand Ozempic
I'm on Rybelsus, in Europe. My daily dose is 14mg.
Given the dosage in the trial was 50mg,should I expect my results to be significantly less good than using Ozempic?
I started on Ozempic but moved to Rybelsus because Ozempic became almost unobtainable. Since then, my weight loss has flatlined.
By the way, I also dislike the daily tablet. I have found it hard to consistently use it. My day starts with a glass of OJ or a mug of tea and habit means I often sleepwalk through making tea or opening the juice, so a day wasted!
It looks like the 50mg tab and wegovy at 2.4mg once weekly have comparable results over 68 weeks. So you will probably be splitting hairs as to which is more benefit. It would more be what works best for you.
Wow hard to believe you are over weight If find taking a tablet once a day to much hassle 😐
@@MearnieToon I am overweight. I was discussing a relative difference and one that in practice has an effect on the effectiveness of the drug.
As you probably know, many people stop using many types of medication that have a beneficial effect because of the manner in which they are administered.
I fully intend to continue with Rybelsus, but I can understand that some people might not.
Having been in the position of being able to use both forms, it seems reasonable to have a preference based upon the usage of the drug.
@@theofficialdrdan sadly, as noted above, I am on the standard dosage, not 50mg.
How does the absorption process work when administered orally? As I understand these peptides are considered too big to enter the blood through the intestine or stomach and that is why it needs to be injected? Is this the reason for the high dose of "oral ozempic"?
Yes
Im obesity person want to lose weight my dr given me this medicine know im on 7mg my question is do i really really lose weight its unbelievable i have hypothyroidism do i need to go to the gym while taking this medication please help
I am diabetes type II. Do I have to take these pills for a long time? or this can be stopped after my weight is controlled?
99.9% of people are unable to control their weight long term and as such need to keep taking them..
I have a question 😢 my appetite INCREASED rather than decreased whilst on Ozempic/ Rybelsus. I have tried both. At 14mg Rybelsus/ 1mg Ozempic. Any understanding as to why? It’s not super drastic but noticeable .
I toyed with combining it with SGLT2 for a while. And I am not even diabetic. Maybe I lowered my blood sugar too low? I measure it and it isn’t and I don’t have symptoms of low blood sugar though
Likely not eating enough. Diet was low I'm nutrients prior to drug. Add drug nutrient level went even lower and biology said not happening and is ramping appetite up to over power drug. Need to focus on nutrition first consistently.
@@theofficialdrdan makes sense thank you ☺️
Can this be taken with Jardiance 10mg daily ?
Can I take two 14g of rybelsus? I used to take 1mg of ozempic years ago.
Great video! One of the downsides to the injection is the long lasting nature after taking it. It is a long time to wait for side effects to resolve when starting or ramping up the medication. The doctor should be able to take much quicker action on the medication dose (including discontinuing) for a daily pill. Or maybe that is a downside due to the ease of quitting the medication. Did this study show a higher "quit" rate due to side effects than Ozempic/Wagovy?
Semaglutide is the molecule in both as such the kinetics is the same. Whether you take the molecule oral or via injection that dose will last in the system for ~4-5 weeks. The quit rates in the Wegovy vs. Rybelsus studies are about the same.
how do I get the top off
My doctor gave me a sample and said to use it for weight loss and I'm supposed to start it tomorrow
How did it go?? Mind giving me a update 😅
@jenay561 um to be honest, I never took it. He said it was just to not make me hungry but im not hungry on my own so I just never took it.
My Dr is about to start me on 14mg Rybelsus and I am scared. Is this drug safe long term for real?
Did you start? How’s it going?
@@amylee9 I did! lost a chunk of weight so far and my type 2 diabetes is more controlled than it's ever been. I had some side effects for the first 13 days then they all settled down.
@@Nyansalot awesome. Thank you
How did you take it? First thing when you wake up? With a meal? Without a meal?
Many GLP-1 medication patients complain that hunger suppression only lasts for a few days after taking their once-a-week injection. I have to wonder if a once-a-day pill would help with this.
Depends. What is often occurring here is not the drug wearing off its people not eating enough to lose weight quickly. Therefore, their hunger is way up and when the drug decreases in serum concentration slightly they note an increase in appetite. Oral formulation likely won't affect much if the individual is not eating enough.
They can’t keep eating poorly.
@DrDan That’s a great explanation, and one that I didn’t consider… previously thought it was all about the drug half-lifeing out of your system. 🤔
Btw, did talk to Dave over at Man on the Mounjaro… he’s totally down to have you guest, and likely has contacted you by now. Hopefully you two can make it work schedules-wise. 👍
Having used both oral and injected versions, my experience is that both have been effective in terms of appetite suppression. However, I have not been trying to control my calorie intake. I was advised to listen to my body and early in the process I made a conscious effort to eat regularly even if I did not feel at all hungry. Later the degree of appetite suppression reduced and at that point I ate when I felt hungry and continued to lose weight. Since starting, at no point did I count calories.
@Aki-wq6xh
Don't you have your own physician?
I have absorption problems .Should I ask for Ozempic?
You should discuss with your doctor (Never change and/or discontinue treatment without consulting your doctor). If you are just taking the pill because you are scared of the injection, I have to say the reality of the injection with Ozempic was not as scary as the imagined horror for me.
All depends. You would have to review with your doctor and pharmacist as to what might be the best option for you.
Why ozempic is 1mg and the oral one is at 50mg?
Is like having 50 ozempics per weak ?
Very big difference when injecting something directly into the subcutaneous tissue vs. taking a pill and asking it to go through the GI tract etc.
Im confused what is the difference between ozempic and Wegovy?
Ozempic is indicated for diabetes. Wegovy is indicated for obesity. Both contain Semaglutide!
Does anybody know if Wegovy is available in Canada yet? If so, what’s the monthly cost? I’m on Ozempic 1mg/week and it costs $250 per month. I’m worried that if my doctor bumps me up to 2mg/week my costs will double.
@Papini All the Ozempic doses cost the same, last I checked (at least it’s that way here in the US).
I switched from saxenda to what I thought was mounjaro, and not paying attention now realize I have ozempic. I now know mounjaro isn't available in Canada until 2024. I'm disappointed in the change. But maybe will see better results?
@lady From the clinical trials they’ve run, Ozempic does seem to be a more potent med than Saxenda (assuming equivalent doses).
So yeah, all else being equal (diet, exercise) you should probably see better results on Ozempic.
I'm wonder would 50 mgs be too much for someone with diabetes, like it may bring it down too low.
Mechanism shuts off when blood sugars are in the normal range.
@@theofficialdrdan*NO IT DOES NOT*
I am on 14mg Oral Semaglutide as part of a clinical study in the UK.
I started with 3mg for 28days
Then 7mg for 56 days
Started on 14mg 3days ago.
My blood sugar this afternoon 2 hrs after a meal of steak, half a cup of Broccoli with butter was 3.5mmol/L or (63mgdl/L).
I feel the low blood sugar its so uncomfortable.
I will see about riding it out for a week or 2 or drop out.
My doctor prescribed me this medicine and didn’t take any whatsoever.. diet and exercise and now my latest A1C test 2 days ago was at 5.5 … no kidding ask me how and gladly will reply 😁
Congrats! Keep it up!
Do share what you did!
If I’m non diabetic patient, can I take apple cider vinegar when I’m on rybelsus ?
Does apple cider vinegar decrease efficacy of oral semaglutide?
Why would you want to take something that tastes bad and only has evidence for wearing down enamel?
So to get that 50ml dose i would have to take 3.5 pills at once per day
Unfortunately you can't take multiple pills as the drug doesn't absorbed properly. Due to the mechanism of absorption. So you'd be wasting 3.5 pills
@@theofficialdrdanso how can we achieve the 50mg mark ??
@bhumikaarora889 when a new pill with the 50mg in it comes out.
@@theofficialdrdan they need to hurry up and get it on the market because right now the 7mg i am on isn't doing jack for my A1c that the shot did. Unfortunately since the FDA released it for weight loss my prescription was always on backorder for over a month or more and so all the progress made to lower my A1c, glucose levels, blood pressure and yes some weight (not the huge amount everyone taking it for weight loss has gotten).
Right now Rybelsus is the only one not being placed on backorder which is insane that medication for diabetics is tossed around as the magic cure for obesity when studies show that exercise and a whole food/raw vegan diet nearly or completely reverses diabetes.
Unfortunately for me i don't live in a household that is economically affordable for me alone to go full raw vegan. I can't afford to purchase the food my family eats along side everything i would need.
So for now i limit the processed foods as well as any meat and dairy i eat.
With Ozempic i was able to bring down all my numbers without going full vegan (i do plan on going that route in the future)
@@bhumikaarora889 while you wait for that to happen look into fully raw vegan diet. There are a bunch of videos and studies showing it actually works to reduce the effects of diabetes. If you can't go full vegan you can always split your week to half vegan or 5 days go vegan and 2 days say Sat and Sun as your "cheat" or "meat and carb" days.
Give it a try and say in 2wks or 30 days let us all know the results.