Methylene Blue: A Revolutionary Anti-Aging Molecule? [Study 202]
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- เผยแพร่เมื่อ 8 ก.ค. 2024
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Reference:
[1] Xue H, Thaivalappil A, Cao K. The Potentials of Methylene Blue as an Anti-Aging Drug. Cells. 2021;10(12):3379. Published 2021 Dec 1. doi:10.3390/cells10123379
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#methyleneblue #antiaging #antiagingremedy
![METHYLENE BLUE: Impacts Longevity By Boosting Mitochondrial Efficiency [2024]](http://i.ytimg.com/vi/UV9qeSoUsy0/mqdefault.jpg)
![METHYLENE BLUE: Impacts Longevity By Boosting Mitochondrial Efficiency [2024]](/img/tr.png)
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Methylene Blue is exciting for the reasons mentioned, but the data is lacking. If you have had personal experiences using it, I'd like to hear your experience.
I have been drinking it for 6 months, I only drink water and add 30 or so drops to every gallon (gallon sized water bottle). I no longer get sore from the gym, my calorie burn jumped when taking it. I have not been sick since. The water bottle required cleaning once a week before and now I never need to clean it. It has helped my elbow nerve issues significantly. I always have energy and am turning 48 in November but physically feel like I am in my twenties.
Been drinking it once a day in the morning ( 1.5ml of a 1 percent solution which is equivalent to 15mg), have felt an extremely considerable difference in my general wellbeing, feeling overall more energetic, my memory is alot clearer and finding aerobic exercise far easier than I would usually, haven't noticed any negative side effects as of yet.
I appreciate your work so much one love from 🇯🇲🇯🇲🇯🇲🇯🇲🇯🇲🇯🇲🇯🇲🇯🇲
I take Blu Brain methyl blue for 3-4 days a week for 2-3 wks. It helps me a lot during the day, including when I used it to run 105 miles in an ultra race. 🧠💙
@@markuskempus78 great job maan
I've never been a fan of blue, so I just take the Meth part. Really boosts my energy
😂
😂
Change dealer. The best Meth is blue.
This dude I met named Eisenberg said blue meth is where it's at.
Still laughing.
I learned of MB through this video and went down the rabbit hole. I got really sick a few years ago and have dealt with symptoms (pain, brain fog, etc) since. I've tried many different supplememts to varrying effect but nothing ever took my symptoms away. I figured, what the hell do i got to lose and ordered some of this a few days ago.
Oh my god... I have never felt more profound relief in my life. Literally EVERYTHING went away within just a couple hours. This is just my anecdote, but wow has this been a god send. Thank you for putting me on to this stuff.
Where'd you get it? Dude do you have a link?
I've been using MB and it helped a ton for brain fog too.
Something I recently found that has cleared up nearly all of my remaining symptoms, including PEM, is Boron. I'm taking 12mg of a supplement containing Boron Citrate, Aspartate, and Glycinate
@@munen343I bought mine on Amazon. Make sure it's Pharmaceutical Grade
This sounds like a commercial
hi is it all of this stuff in one glass ?
Thx
In our neck of the woods, when I was a small child - 40 years ago, Eastern Europe - the doctors used it against throat infections.
and we still use it, just in pills. Crazy how the other parts of the world are just hearing about it now
Exciting. It's made from synthesized Smurfs blood incase you didn't watch the video
Way to just tell everyone... geez... 😛
@@Physionic 🤣
@@richardmalone3172
Wow, good for you. Meanwhile on pasta grannies videos with many healthy Italian women (few men) 90-103 Italian woman who still walks 2km a day, feeds her chickens and makes her own pasta. Obv wine and olive oil too.😉 Many others from diff areas of Eur and Greece plus local eccentric centenarians w/crazy diets (corn flakes w/apple juice vs milk etc) but sharp as a tack and still active. Incl a 98 yo who lives on her own, does steps mult times per day has her cocktail and 1-2 puffs of a cigar DAILY. No joke. Many of them are on little to no meds. Not sure but they and those like the late Dr Ellesworth Wareham are my dream. 😉😂 You’ll prob live to 99 yo too and better shape then me. ✌️
@@richardmalone3172 People like you are so inspiring. I want to be like you when I become 69 years young. 👍
@@BakamonNO it’s not hard. Just don’t stop.
In the 80's in Romania, when we were little and got sore throats mom painted us with MB in the throat on the mangles. The bottle of MB was bought at the pharmacy as medicine as the first step against sore throat in case of colds.
I thought mangles were a fixture in my great grandparents' laundry room.
@@tactileslut
Maybe I should have said throat glands.. I don't have any word for it. Sorry English is my third language.
@@user-zd6ow2gt7i It's my first and I'm still not good with it. Five decades and counting...
Third language? Bine făcut! Bravo! I think you (very obviously) referred to tonsils 😊
@@user-zd6ow2gt7i"mandle" yes. Slavic word. Tonsils or almond shaped things
Within three days of starting meth blue, I had significant improvement in my very, very long covid.
how is it taken? IV, oral
@@okie4400 I think there is more than one way available, but orally is most common. I was instructed to put five drops in a glass of water and sip on it slowly for about 40 minutes. It's very easy and inexpensive.
Please share where I can get it, Im also suffering from long covid. I cant find it anywhere here in Belgium
@@wzupppp Amazon
@@wzupppp Amazon $26 super cheap
I am takeing mb for two months now. My athletic performance has significantly improved. Much more than with creatine or any other supplement.
Can we know your age? thanks.
@andrewj4426 you thanked too soon.
When I was a kid I kept tropical fish as a hobby. Methylene Blue was ofren used as a sort of cure all for fish diseases. This was 50 years ago, so apparently at least some people knew about it before now.
Still widely available for fungus infections and wounds in fish tanks / aquaria.
And the fish is still alive today? Amazing.
Same here. Used it to cure fungus and bacterial diseases in my fish by adding one drop per gallon of water, if I remember correctly.
Sounds fishy to me
@@MrBlaxjax close your eyes and swallow. Picture your girlfriend
My father a physician would have us put a little methylene blue on mouth ulcers. They healed quickly.
Oh smart!
My experience was the first time I took it was before bed. 10 drops in 250ml of water. I slept well but when I woke up I felt very in control of getting up at any time I wished. I normally set my alarm on snooze but didnt feel like I needed to as I was tired but somehow alert. I noticed a couple other things. I dont normally think about it but I woke up with a sense of smell. I could smell and hear things I don't normally notice on my waking up and walk commute. Was very interesting.
Been using MB for a few months with my wife, it helps a lot in dealing with stress and ptsr. I'm using 10 drops per day deluted in water, with taurine. It starts working within 5-10 minutes. At some point I thought to substitute bulletproof coffee with MB, but ended up doing both =) Some people suggest doing MB interveinly, but I'm not apt for it yet. I've noticed that I can run like in my childhood, without any thought of getting tired at least for some time (I'm around 40yo). But you'd better be careful, sudden bursts in stamina could be tricky - I've hurt my legs, and it took me 2 weeks to recover.
Same here!
It's like being a cook and getting the sharpest knives ever. Caution is warranted.
I'm 60 and I started taking 2 drops in a glass of OJ in the morning a month ago and it felt like my brain fog was lifting, my memory recall for words definitely improved somewhat. I switched to taking it before I go to bed and my broken sleep has completely stopped. For the last week, I have slept right through until morning, something that hasn't happened in years. (I can usually get the odd night in without waking up once, but a whole week in a row was unheard of.) I ordered the MB skin products and have been using them for a week - yesterday I had 2 people comment on how good my skin is looking but that could be because I'm also getting proper sleep now. (I've read that when you mix it with OJ it stops staining your teeth blue. So far, so good. Note: I have been taking Vit C every day for the past 3 years, so it's not the Vit C in the OJ.)
Thank you for sharing.
Is the skin product topical? Does it stain blue?
What is OJ?
OJ is orange juice I guess
Sugar water! Eat the orange include the fiber! @@mathieuforpub2302
for one of the oldest compounds ever, dont you find it kind of curious that "we dont have enough research on it"? i bet if we dont have it at this point, then we never will, theres just no incentive to research a drug that is un-patentable, so it will be forever ignored by research from here on in favor of new patented drugs
Apart from all the research done by national health organisations around the world who would be absolutely interested in such a wonder drug if it helped people be healthier. The whole world is not just the USA and "big pharma".....
Good point…
@@MichaelGGarrySechenov institute used it to treat covid so... Some research is done here and there.
@MichaelGGarry it is though... the US is the largest demographic to the pharmaceutical industry. the US subsidizes medicine for the rest of the world. pharma is among the largest advertisers in the US and the largest lobbyists.
@@MichaelGGarry oh my naive friend. whoever it is that operates the U.S from the shadows surely has its slimey tentacles in whatever developed country you come from. believe it
At 71,definitely think it is worth taking...anything that improves redox in the electron transport chain gets my vote.I take 15 mg every other day (having experimented with several dosing strategies).Helps with sustainable energy all day long and a feeling of resilience (yes,resilience is such a nebulous term - but best fit).
How many drops are that (15 mg)? All at the same time or do you spread it over the day? I'm about your age, hence curious about your particulars.
@surajitgoswami1871 Do 30 drops
(15 mg) first thing in the morning every other day.I don't have any health issues but continue to experiment with dosing.
Current plan is to finish current bottle then stop for a bit to assess differences with out MB.
Very interesting Bob. May I ask where you get yours? What brand etc?
30 drops? I need 6 to feel like i am impervious to alcohol and weed, still go out for a run afterwards
From what I've heard from Dr. Gonzalez-Lima in a more recnt interview, the trick particularly for the senior citizen is to just see the pee till the hint of blue is gone (after starting with a very low dose, say 3 drops). For me it took two days (48 hours and the first few times after the first dose the pee was clear and the blueness appearred after half a day of the morning dose) and I shifted to just two drops with "wait till the pee clears approach". In my opinion, 30 drops could be even fatal - this is "poison at higher doses" you're dealing with.@@m4inline
I started taking MB in capsule form. I've noticed that it seems to give me sustained energy and motivation late in the day. I like coffee, but it gives me an afternoon crash. MB seems to come on slower, but helps me to be much more productive in the afternoon and evening. Sometimes it seems like too much energy, like I might be inclined to work late and not sleep as much.
I'm 63, and as kids, we played with methylene blue in our chemistry sets. It was also used as a dye for making cell walls to improve microscope 🔬 viewing.
Ahhhh...yeah i remember that! Onion cells!
I used them before in a bio lab and it turns out, yeasts and other microbes can use in lieu of oxygen! Seriously, the used form is colorless so you get a solution that is less blue by the hour
Same
😮Wow! @@hcn6708
I didn’t read every comment here but from here and others that talked about it. I don’t see one negative comment about MB.
If you take SSRI's you shouldn't take it I understand.
Thanks, i just started low dose MB.
It literally makes me happy 🌞
Low dose.?how many drops.?
Right???!!!
You said you’ll wait for the research to be done before deciding. Well, since most research is now funded by the pharmaceutical industry, and MB can’t be patented, I don’t think we’ll be seeing any research soon. I’m 67 and I don’t have time to wait. Im convinced enough and have been taking pharmaceutical grade MB 1% at 2 drops twice a day with red and near infrared light therapy.
I have been taking 10 drops in a glass of water, daily, for about 6 weeks. I find it to be fantastic. I have more focus and energy, yet no feeling of buzz or rush. I do believe that this works at the level of the MItochondria, and not by direct stimulation of hormonal pathways. Strong mitochondria are crucial. MB can play several different roles in the Electron Transport Chain.
It effects the neurotransmitters serotonin, norepinephrine, dopamine, acetylcholine, blocks nitric oxide which can cause hypertension. Be careful with dosing. Can cause serotonin syndrome which can be fatal
MB has also been used against brain fog due to neurological adverse effects of chemo.
Methylene Blue has had a relatively menial role in medicine up until this time. It has been used as a practical liquid dye to detect fluid movement in some situations (primarily to detect fistulae, etc.). It also is used to demonstrate communication between different anatomic spaces for surgical applications.
Methylene Blue is also used to treat clinically significant methemoglobinemia.
Prussian Blue is different, but comes to mind because at one time, I was the principal investigator for Prussian Blue (Radiogardase), an orphan drug, which is used for both Thallium and Radiocesium poisoning. It is a non-sequitur, but I reflexively think of Prussian Blue when I hear the term Methylene Blue.... :)
1-2 drops a day is all that I need to feel as good as I did at 25-30...@64
My cat is named Cheeseburger and when you said "Cheeseburgers!" she looked up from her paw grooming
❤❤❤😂
If it's good enough to bathe my goldfish in, then its good enough for me to drink a gallon
That settles it. Thank you, Zach.
😂😂
You’re supposed to take a bath and add 20 drops to simulate being in an aquarium. Bye bye fungal infections.
Please use Medical Grade
I may be jaded, but since MB is cheap to make and can't be patented at this point - i expect obsfucation from pharma
Nonsense, they would just combine it with another drug, make it controlled release, then patent it and make billions.
MB is being used by hospitals right now. This is not UGL and untested as the YTer says.
For anyone who wants to use it only use USP or Medical Grade one without Heavy Metals
i take MB with ascorbic acid since 2018 and still love it
MB saved my daughter’s life!
How? We need more
Info
I was given MB last year by a pharmacist while vacationing in South America. I had a UTI and it was a Sunday morning so I couldn’t find a doctor in the small town I was visiting before I had to catch a flight back next morning. It definitely resolved the symptoms - probably faster than some antibiotics. It didn’t clear the infection but it gave me a chance to make it back home comfortably and then arrange to see my doctor a few days later for antibiotics. That being said, I didn’t notice a remarkable improvement in energy but, between the uti and jet lag, I wasn’t feeling nearly as crappy as one would expect… 🧐
What was the dose?
a full pipette, so about 1ml of 1% solution is more than enough. Your pee will turn a greenish-blue colour for a day or 2 @@abominabelle
Where do live? Not North America, because no jet lag unless traveling East-West. Or maybe you just meant "travel fatigue"?
Methylene blue was used back in the day as a treatment for UTI but has fallen out of favor for newer antibiotics, you can still find it in some Rx formulations such as Urelle.
@@lookupEdwardBernays You can definitely find pharmaceutical grade methylene blue, it comes as an injection solution with the brand name ProvayBlue. It's also available from compounding pharmacies who use pharmaceutical grade powder to make capsules of varying strengths.
My mom was in the ICU, her organs were shutting down, they put her in a MB IV 1x per day, it was truly amazing how she responded to it, the physicians were very impressed. She was suffering from hypotension. MB does in fact have clinical uses despite what YTer says. DYOR but in certain doses and circumstances it can be life saving wonder drug
One of the main side effects of methylene blue is hypertension so this could have helped her. Glad to hear your mother was able to be recover.
@@mirzatajic89greatly
Treating it is really challenging when the patient is also experiencing pain because most pain killers lower BP too.
Been taking 5 drops twice a day. Not sure i would want to live without it. Cured my life long cronic fatigue
That sounds amazing
I just started taking it again, after being off for months, due to crazy fatigue.... which caused some depression. The MB fixed the depression almost immediately..... and is helping with the fatigue as well.
Ty bro for covering Aging and Longevity. Im glad youre getting views and recognition.
Important note: do not confuse ROS (reactive oxygen species) with ROUS (rodents of unusual size).
Methylene Blue only has protective effects against one of them.
Inconceivable!
Love the Princess Bride reference!
Please do not confuse ROUS with Capybaras, only the Capybaras are adorable, even though both are ROUS.
I was thinking the same thing when he started saying ROS
We used it in surgery to see if the kidneys would perfuse and locate ureters. Also, it was considered an irritant for nervous tissue and we wouldn’t use it as a marking agent during neurosurgery.
Thank you for this exciting new information. forward to learning more as more research is done.
nice topic. I experimented with it (USP grade) for a few years because of a history of chronic insomnia and a concussion. Didn't notice any surface-level benefits but it consistently brought my mildly elevated creatinine and BUN back into normal range. This was transient for a couple months maybe before they would go back up. Dose didn't seem to matter, either. I was testing 100 micrograms to 15-20mg.
Good report. thank you.
Been taking it since the beginning of Covid. Not sure if it was the reason I didn't catch Covid but but the rest of my family (4 others) all caught it. Other than that I noticed it gives me a slight energy kick. It also improved my long distance eye sight such that I don't need to wear glasses when driving. Hasn't done much for my close up vision but has helped with eye strain to some extent. It seems to have also helped my teeth as well. I don't seem to be getting plaque like I used to,
How many drop did you take a day ?
I use a spray bottle into my mouth. 5 sprays in the morning and 5 sprays at night MB is diluted to 1% @@erwinj7257
I think its unlikely to have helped as it damages your Nitric Oxide production, effectively causing premature signs of aging and weakened immune function. Taking it long term like that is potentially functionally aging parts of your system by decades, for a temporary boost to certain cognitive areas. You know, you do you, but I'd recommend careful research.
@@LordVictorHalgaardYou're saying MB is damaging? Can you tell me more as I am currently taking this
@@ARC_VR Like I said, it reduces nitric oxide, which can be quite bad in the long run. Low nitric oxide is part of why old people start struggling with immune health, high blood pressure, diabetes, muscle soreness, erectile dysfunction etc. Its used as a marker of age.
I'm taking a microbiology class right now, and we use Methylene Blue to stain bacteria. I saw the the title of this video, and was like "Why are you drinking bacterial dye"? Most of the dyes we use are labeled as poisons in our lab, so this was intriguing that people are using MB for anti-aging.
and as with all things, the dosage makes the poison @@ChessMasterNate
Yes, but do not mention that : it contains Arsenic, Lead, Mercury, Cadmium and other heavy metals.
It is also chloride.
And the most basic thing for me is that : it blocks the entire solar light spectrum that mitochondria need to produce water and energy through the natural electron chain.
If you block natural light, you create all these dysfunctions of diseases in our modern world.
I some areas it increases aging rather than reducing it.
Needs to be USP or Pharmaceutical grade to take internally.
Your approach is amazing. Like. My best loved old Professors, for some reason everything you say gets etched into my brain.
thank you.
I use it in combination with red light/ near infrared light therapy. Be prepared to get blue contaminations hared to remove. Like in the kitchen after spillen the water solution. Or in the toiliet, the blue haze. Cleaning can be started using ascorbid acid. That is the powder also sold as vitamin C. I have a bottle of that, and rubbing that on the blue surface typically removes the blue dye.
Please continue your work in understanding MB, it is the only molecule I have found that can free me from Adderall. with MB I can concentrate without the side effects of Adderall on my personality
what dose do you take?
25 mg of MB
@@micdargis thank you!
@@micdargis It's been 4 months, how is going? Are you still using MB?
@@somethingsburning774 Yes, but 15mg is enough now. Maybe it’s a cumulative effect, I don’t know
What scared the hell out of me was seeing a picture of a cross sectioned brain where apparently methylene blue had dyed the whole brain a blueish tint. If I hadn't seen that I was probably going to order some to try.
It will dye living tissues temporarily yes, but not permanent, only permanent on dead tissue etc.
well yes that is something it does but of course the person was taking way too much. Have you ever seen a brain of someone that drank too much water too fast? it will be twice the size of a normal brain and they will be dead. you only need to drink 4 gallons of water in 1 hour without sweating or peeing and this will happen. too much of a good thing is not good.
I've seen that too, but that was the result of a seriously large dose. Perhaps even in a hospital setting to reverse cyanide or CO poisoning. This dye will leave your organs if you stop taking it.
Using this daily now, it does feel like an anti depressend. Overall mood and memory is better and really cant say if my overal health improved. Probadly, but the main effect is my memory and focus.
Thanks for explaining this. I agree with you, its better to wait until this has more studies on it.
It has been used for over 100 years.....how much more waiting?
I've been taking MB for 6 years at the 1mg/kg level (5mg/kg is considered max safe). Wonderful stuff, I mainly started taking it for brain and eye health but it is beneficial for many other things.
Where can I purchase it, thank you!
Is there specific time you have to drink it? Before or after meals?
Interesting. Do you take it oraly or IV?
what (specific research/anecdote) made you take MB? what are the other benefits you mentioned? Any side effects (like turning into a smurf)?
Can you list the things that you find it beneficial for? I only take 0.5mg/kg. Would I be better off taking a higher dose?
Helps in stroke recovery as well.
In surgery MB would be used to mark cancer cells often in breast cancer surgery, lymph node tail marker as well in radical breast mastectomy
7th week,15ml every morning. thinking is clearer and endurence is up.
Long time viewer, first time commenting. Thanks for the great information and often humorous delivery.
I have taken MB very low dose orally off and on for 9 months. Generally only positive results besides the blue pee.
Given that its half life is reported to be a few hours, I have begun dosing at 2 drops (1 mg) twice a day, and I am experiencing similar positive results like better concentration, more energy, improved mood. (previously I dosed from 2 drops up to 16 drops ONCE a day)
I am however concerned about contaminants and I am taking the USP grade MB, but even at those amounts it could be cumulatively toxic.
So presently trying 1-3 drops twice a day, then taking a couple / few days off every week or two.
I am unsure of any cumulative dosage effect when taking MB X days in a row.
I am a 60 YRO male, and also use Red light therapy. (also trying to figure out the minimum effective dosage there)
So unsure about anti-aging effects, but each day is better.
What I have seen no one address is whether it affects the gut biome adversely. Isn't this kind of an obvious question ❓
Yes! Run advertisements and keep doing what you love. It’s not selling out, it is providing the means for growth. It would not sway my opinion about your work; your research is high quality. Just sell as much sponsorship as you can and survive. This is growing pains and it is good!
It is still used in Vietnam for urinary track infection. First time I heard of it when i was prescribed it. It was very common here 50 years ago
Thank you once again for a really comprehendible explanation for the person with one or two biology classes. I hope to thank you in person one day. I shall be the person with a bluish complexion.
😂😂😂❤
I have been doing MB for a month now and yes my urine is usually greenish, I also do other supplements so I can state that it alone is why I feel so much better.
what benefits are you feeling?
Which dose works the best in your opinion?
A video about Methylene Blue’s history as an Emergency Room treatment/remedy would be interesting. I’m very curious as to how people figured out they could drink it safely, and I’m not sure what the true ER history is, whether there is truly an old saying: “When you don’t know what else to do, Methylene Blue” but I’ve seen in several places that MB has been mainstay of U.S. ERs for more than 100 years, which if true is pretty interesting considering it’s medical properties haven’t been closely studied. Do a video on all of that!
your curiosity statement can stem to everything mankind have ingested since time itself! lol
hey Nicolas, first of all, I'm so happy to see your channel blow up! You definitely deserve it, great content.
Secondly, I have sort of a request. If you're planning to make more videos about methylene blue, could you please also explain how and why does it somehow interfere with SSRI's? I really wanted to try it out, however I'm on Escitalopram and taking MB could have fatal consequences, at least that's what I read. I'd be very interested in your explanation about how these two drugs interact in a deadly way. Thanks!
Dr. Been, has a video on MB. He says it is MAOI inhibitor, thus interacts with SSRI to raise the blood pressure and give hypertensive crisis.
Syrian Rue tincture is also an maoi and has a similar effect but is natural. If I was you I would ditch the SSRI and experiment.
Thank you. Will try it! Also switched to Statins from Niacin based on your reading of the research, particularly when it is not expensive and I have a good cardiologist.
Wowza, if this channel is promoting statins, known to cause a myriad of serious neurological problems, I'm out.
Try nattokinease instead of statins
Thanks for covering this - if you're looking for anecdotes, there are plenty of threads on longecity going back 15 years or more. Also, you might be interested on the effect on progeria cells (not in vivo).
"“We tried very hard to examine the effect of methylene blue on all known progeria symptoms within the cell. It seems that methylene blue rescues every affected structure within the cell. When we looked at the treated cells, it was hard to tell that they were progeria cells at all. It’s like magic.” ~ Dr Zheng-Mei Xiong
If you fancy a simple experiment - put some 1% on you skin for an hour (it will come off!) - it was for me remarkably hydrating.
Do you have the name of this study?
Would love to see a video on astaxanthin, specifically the brand Valasta and its unique delivery mechanism.
What about the nitric oxide inhibiting action!? Not a desirable side affect. 🤔
I really like this dude, I like he's channel.
"We don't have enough research on it." Maybe not in these niche tertiary-benefit uses.
Methylene Blue is actually very well studied though, with medical uses in critical care settings for refractory vasoplegia, scavenging free nitrous oxide and limiting its effects in the vasculature.
I love how the wellness community repurposes a known compound with previously unrealized benefits and acts like they just made fire the first time.
I'm on the kindergarten part of this. I like the way you explain this.
when I was a kid I often used methylene blue to treat a tank of tropical fish that had some fungus ick
Can you look into molecular hydrogen and the studies which talk about the health benefits, it apparently works at reducing ROS as well.
This stuff is used in fish aquariums to prevent diseases.
Fun fact: A "kicker," also called a side card, is a card in a poker hand that does not itself take part in determining the rank of the hand, but that may be used to break ties between hands of the same rank.
It's an old gambling term. Now you know.
It's an electron acceptor, so it will help balance NADh to NAD+ ratio, but there are better alternatives.
What are the better alternatives?
Worth mentioning that it dyes your brain and turns it blue.
Cool.
@@incognitotorpedo42I agree, I'm gonna surprise the medical examiner when they pop my noggin open 💙🩵💙🩵💙
I am sure it will come as no surprise to you Nick that the Stapler is a heavy meth user. Being a 1960's model stapler I have a lot of electron slippage I need to control. Seems to have subjectively helped with mental clarity to a degree. Blue is also used even today in hospital ER's to treat various forms of poisoning. My wife once had a bad reaction to an over the counter, rash and some difficulty breathing. A shot of meth and 30 seconds later she was fine and back to nagging me as usual. It also makes a phenomenal carpet, tongue and teeth stainer - The Stapler
I remember in the Reservetrol controversy hearing that some of the beneficial effects falsely attributed to Reservetrol were instead caused by the dye used in the experiments. out of curiosity, was the dye Methylene Blue?
I don't think so but I caught that fact too ! I love taking MB. It seems to really be a good anti-depressant and I do feel more energetic when taking it. Also take NAC. That seems to have similar benefits as MB
nope.
The dye used was a fluorescent, so it was not MB.
Just be aware that NAC thins out the blood there @@shelleybevacqua . If you start bruising or bleeding too easily, or developing weird blood vessel formations like spider-veins or cherry anginomas, consider switching to L-Cysteine. The Acetyl part in N-Acetyl-Cysteine is responsible for lowering blood platelet count, just like with Aspirin (aka. Acetyl-salicylic Acid)
methylene-blue IS fluorescent tho @@davidmannion5362 ...it's actually a property that changes with oxygen concentration, hence why it's so useful as a dye in microscopy.
Thanks, Nick! Isn't there some solid data on using MB for malaria and for cyanide poisoning? I hope you can expand on it.
I've been taking it orally for about 3 months. At 60 years old, it is giving me sustained energy. Also do red-light therapy and heard that's a good combo...
I only know it as a dye used in cancer detection, and it is used routinely for that. Esp oral cancer detection. Had no clue it was used for direct systemic effects by anyone.
Funny enough, we use MB before on our tropical fish when they were unwell. It never killed the fish, and sometimes it does help them survive.
Good.
My sister was taking this, not sure if she still is.
I was using a lot of other antioxidants but now Im thinking I might give this a shot.
A shot would be dangerous. Just use it orally
@@m4inline got it..take a shot, not a shot👍
I'll have to dig into it, but I remember MB being related to radiation, as in taking to help stop radiation poisoning
I like your way to explain
Thank you
I LOVE supplementing MB, feels amazing
I've only been using it for a short while, but the change is remarkable. I'm using a commerical medicinal dilution used to treat UTI's sold by Bjain pharmaceuticals in New Delhi. It does also increase my BP, which is the one bad side effect. It gives a tremendous boost in energy and cognitive ability from just a few drops in my morning coffee. Definitely the real deal.
Thank you for sharing, Jay.
@@Physionic No worries. Thought you might want to know about the BP thing. It's not an insignificant increase. My 32 year-old daughter tried it and also found it effective.
Where can I buy it?
@@opamp7292 E-Bay, as a homeopathic, shipped by international mail to US. Try 3 drops/day to start, go up/down from there. Keep close track of your blood pressure.
What is BP?
Why is everyone talking in acronyms? 😮
I try to stay away from dyes in gen based on studies to date but stay open minded. Interesting. Thx.
Yes we should not jump to conclusions. We already have other molecules that perform the same functions that we know are safe. We have a slew of antioxidants glutathione being only one of many. We have the salvage pathway to vastly increase the recovery and reuse of NAD+ efficiently generated from NMN. We have AKG possibly the most efficient fuel for ATP. We have molecules like spermadine to protect DNA. Cyanidin and fucouidan to activate SIRT 6. Quercetin which perfoms many functions. Fisetin which when used correctly is a powerful senolytic. Many more.
Please provide info on using fisetin
@googbert Rimon on Wellness Messiah recently reported on a flawed test showing it was ineffective. Fisetin is a class of molecules called polyphenol which is what gives color to fruits and vegetables. Among its uses is as a senolytic which means it programs old worn out cells that don't function, don't reproduce and can excrete toxins damaging other cells to die. I think it comes from strawberries. It is identical to the molecule quercetin except for one additional OH group. The flaw in the test was giving the mice small doses daily. Rimon says that the proper dose is 20 mg per kg of body weight once every one to three months you want it in your system in a high enough concentration and then out. So I weigh close to 240 pounds which is 110 kg so my dose would be 2200 milligrams or 2.2 grams. That's 11 20 mg pills taken at the same time. Rimon,if you're reading this tell me if I got anything wrong. I suggest you visit his site. He'll even tell you why he disagrees with some things David Sinclair does.
7:30 When ROS interacts with fatty deposits in your skin it rusts them. Same process as what happens to a banana when it turns brown. That’s what those brown aging spots are. You are rusting. And if the rust is showing up on the outside, wait until you see the inside !
Unlike some of the antioxidants you mentioned MB is a single electron donor/acceptor. It has relatively stable semiquinone radicals. Flavins also act similarly. Benefits of MB vs flavins would depend on their redox potential, which I cannot recall offhand
I learned recently that Methylene Blue can disrupt Nitric Oxide which is a very important molecule for heart health. Do you have any thoughts on that?
I want to know more about this
@@ARC_VR Ya me too. I'm bummed that beets are very helpful to get NOx but are very high in oxaIates which aren't good for anybody.
Me too.
If you do enough research you'll find that NO causes more harm than good by a large margin.
HEY NICK, THANKS FOR ANSWERING MY QUESTION. HA!HA!
IL-11 looks pretty interesting. Would like to hear your take on the research recently presented by Dr Cook.
It also may help with urinary tract infections.
Jesse Pinkman and Walter White invented Methylene Blue. From what I can tell the energy boost you get is like next level.
😂
Another medication that is more chemical in nature is Dimethyl sulfoxide (DMSO) DMSO. Have you ever done a video in that? I'd like to see it if you have.
We used methylene blue in radiological imaging as a substance that shows up under
infrared. Injecting it into a milk duct in the breast allows that duct to show up under IR in surgery and be removed. Is this the same methylene blue??
my wife used methylene blue to get off prozac and Adderall . quit cold turkey and started taking MB for 2 months and it worked for her
Hi. May I ask the dosage age uses? How many drops and is it every day?
@nadianiyazi7250 she was taking a 00 capsule and filling it up about 90 percent. I think about 20 drops . and swallowing it twice a day . I would always start with less and see how you feel and then go up.
"it feels like this topic came to me from the depths of the internet" ...what can I say except you're welcome.
But yea, the reason Methylene Blue acts like an antidepressant completely unlike other antioxidants which are for the most part sedative is because at initial high concentrations it's actually pro-oxidative. Quite powerfully so. It'll dry out the skin around your mouth after you apply a ml to the back of your throat (common sore throat treatment). So initially it prompts the body to produce more of its own antioxidants... then becomes a net antioxidant when it eventually dilutes. It's so powerful that it used to be used as a treatment for cyanide poisoning.
To keep from staining your teeth or mouth, I put 10 drops MB in less than 1/2 c water, stir in tsp. of calcium ascorbate powder(vitamin c), 1tsp lemon juice -real lemon is fine and stir and let it sit for 5 minutes. You actually see it go completely clear before you drink it. Not a bad taste either.
I used it in my fishtanks years ago.
@physionic I got pulled into using OneSkin the key ingredient being the OS-01 peptide. It was hawked by Dr. Sinclair on this podcast. Anyways, I was hoping to get your intuitive feeling on what would have better synergy. OS-01 with methylene blue, or 0S-01 with retinol A?