Methylene Blue is exciting for the reasons mentioned, but the data is lacking. If you have had personal experiences using it, I'd like to hear your experience.
I have been drinking it for 6 months, I only drink water and add 30 or so drops to every gallon (gallon sized water bottle). I no longer get sore from the gym, my calorie burn jumped when taking it. I have not been sick since. The water bottle required cleaning once a week before and now I never need to clean it. It has helped my elbow nerve issues significantly. I always have energy and am turning 48 in November but physically feel like I am in my twenties.
Been drinking it once a day in the morning ( 1.5ml of a 1 percent solution which is equivalent to 15mg), have felt an extremely considerable difference in my general wellbeing, feeling overall more energetic, my memory is alot clearer and finding aerobic exercise far easier than I would usually, haven't noticed any negative side effects as of yet.
I take Blu Brain methyl blue for 3-4 days a week for 2-3 wks. It helps me a lot during the day, including when I used it to run 105 miles in an ultra race. 🧠💙
I learned of MB through this video and went down the rabbit hole. I got really sick a few years ago and have dealt with symptoms (pain, brain fog, etc) since. I've tried many different supplememts to varrying effect but nothing ever took my symptoms away. I figured, what the hell do i got to lose and ordered some of this a few days ago. Oh my god... I have never felt more profound relief in my life. Literally EVERYTHING went away within just a couple hours. This is just my anecdote, but wow has this been a god send. Thank you for putting me on to this stuff.
I've been using MB and it helped a ton for brain fog too. Something I recently found that has cleared up nearly all of my remaining symptoms, including PEM, is Boron. I'm taking 12mg of a supplement containing Boron Citrate, Aspartate, and Glycinate
In the 80's in Romania, when we were little and got sore throats mom painted us with MB in the throat on the mangles. The bottle of MB was bought at the pharmacy as medicine as the first step against sore throat in case of colds.
@@jvlbme here is the US. They use it in nebulizers at hospitals for respiratory conditions and for carbon monoxide poisoning intravenously. Of course it works. It's been a standard of care for 150+ years. Accredited emergency departments *must* have a supply on hand at all times.
Increased energy, I don’t get gassed as fast when working out, cleared my brain fog, and somewhat cleared up my depression and made me less anxious. I’m sure it works differently for everyone but, I even noticed my hair feels healthier, and quit thinning. It’s definitely worth a shot if you’re curious I’d definitely say it’s benefitted me.
@@FormlessJKD17 I am doing 15 mg / day, methylene blue with Shoden ashwgandha, taking them together 4 days on, 3 days off. As with any compound that is non mineral, vitamin or amino acid-based, you have to cycle it, because of the tolerance build up.
@@richardmalone3172 Wow, good for you. Meanwhile on pasta grannies videos with many healthy Italian women (few men) 90-103 Italian woman who still walks 2km a day, feeds her chickens and makes her own pasta. Obv wine and olive oil too.😉 Many others from diff areas of Eur and Greece plus local eccentric centenarians w/crazy diets (corn flakes w/apple juice vs milk etc) but sharp as a tack and still active. Incl a 98 yo who lives on her own, does steps mult times per day has her cocktail and 1-2 puffs of a cigar DAILY. No joke. Many of them are on little to no meds. Not sure but they and those like the late Dr Ellesworth Wareham are my dream. 😉😂 You’ll prob live to 99 yo too and better shape then me. ✌️
My experience was the first time I took it was before bed. 10 drops in 250ml of water. I slept well but when I woke up I felt very in control of getting up at any time I wished. I normally set my alarm on snooze but didnt feel like I needed to as I was tired but somehow alert. I noticed a couple other things. I dont normally think about it but I woke up with a sense of smell. I could smell and hear things I don't normally notice on my waking up and walk commute. Was very interesting.
When I was a kid I kept tropical fish as a hobby. Methylene Blue was ofren used as a sort of cure all for fish diseases. This was 50 years ago, so apparently at least some people knew about it before now.
@@okie4400 I think there is more than one way available, but orally is most common. I was instructed to put five drops in a glass of water and sip on it slowly for about 40 minutes. It's very easy and inexpensive.
Been using MB for a few months with my wife, it helps a lot in dealing with stress and ptsr. I'm using 10 drops per day deluted in water, with taurine. It starts working within 5-10 minutes. At some point I thought to substitute bulletproof coffee with MB, but ended up doing both =) Some people suggest doing MB interveinly, but I'm not apt for it yet. I've noticed that I can run like in my childhood, without any thought of getting tired at least for some time (I'm around 40yo). But you'd better be careful, sudden bursts in stamina could be tricky - I've hurt my legs, and it took me 2 weeks to recover.
At 71,definitely think it is worth taking...anything that improves redox in the electron transport chain gets my vote.I take 15 mg every other day (having experimented with several dosing strategies).Helps with sustainable energy all day long and a feeling of resilience (yes,resilience is such a nebulous term - but best fit).
@surajitgoswami1871 Do 30 drops (15 mg) first thing in the morning every other day.I don't have any health issues but continue to experiment with dosing. Current plan is to finish current bottle then stop for a bit to assess differences with out MB.
From what I've heard from Dr. Gonzalez-Lima in a more recnt interview, the trick particularly for the senior citizen is to just see the pee till the hint of blue is gone (after starting with a very low dose, say 3 drops). For me it took two days (48 hours and the first few times after the first dose the pee was clear and the blueness appearred after half a day of the morning dose) and I shifted to just two drops with "wait till the pee clears approach". In my opinion, 30 drops could be even fatal - this is "poison at higher doses" you're dealing with.@@m4inline
I started taking MB in capsule form. I've noticed that it seems to give me sustained energy and motivation late in the day. I like coffee, but it gives me an afternoon crash. MB seems to come on slower, but helps me to be much more productive in the afternoon and evening. Sometimes it seems like too much energy, like I might be inclined to work late and not sleep as much.
I'm 60 and I started taking 2 drops in a glass of OJ in the morning a month ago and it felt like my brain fog was lifting, my memory recall for words definitely improved somewhat. I switched to taking it before I go to bed and my broken sleep has completely stopped. For the last week, I have slept right through until morning, something that hasn't happened in years. (I can usually get the odd night in without waking up once, but a whole week in a row was unheard of.) I ordered the MB skin products and have been using them for a week - yesterday I had 2 people comment on how good my skin is looking but that could be because I'm also getting proper sleep now. (I've read that when you mix it with OJ it stops staining your teeth blue. So far, so good. Note: I have been taking Vit C every day for the past 3 years, so it's not the Vit C in the OJ.)
I'm 63, and as kids, we played with methylene blue in our chemistry sets. It was also used as a dye for making cell walls to improve microscope 🔬 viewing.
I used them before in a bio lab and it turns out, yeasts and other microbes can use in lieu of oxygen! Seriously, the used form is colorless so you get a solution that is less blue by the hour
My mom was in the ICU, her organs were shutting down, they put her in a MB IV 1x per day, it was truly amazing how she responded to it, the physicians were very impressed. She was suffering from hypotension. MB does in fact have clinical uses despite what YTer says. DYOR but in certain doses and circumstances it can be life saving wonder drug
Anestesiologists disscus it on their subreddits. It last ditch effort to throw something in bleak dituation during intensive care, worst it can do is color patient blue.
I cant find any my country, just the regular type from a pharmacy, and it's very cheap like 2$ per 20 ml bottle. I am not sure if I should still take it...
I have been taking 10 drops in a glass of water, daily, for about 6 weeks. I find it to be fantastic. I have more focus and energy, yet no feeling of buzz or rush. I do believe that this works at the level of the MItochondria, and not by direct stimulation of hormonal pathways. Strong mitochondria are crucial. MB can play several different roles in the Electron Transport Chain.
It effects the neurotransmitters serotonin, norepinephrine, dopamine, acetylcholine, blocks nitric oxide which can cause hypertension. Be careful with dosing. Can cause serotonin syndrome which can be fatal
Been taking it since the beginning of Covid. Not sure if it was the reason I didn't catch Covid but but the rest of my family (4 others) all caught it. Other than that I noticed it gives me a slight energy kick. It also improved my long distance eye sight such that I don't need to wear glasses when driving. Hasn't done much for my close up vision but has helped with eye strain to some extent. It seems to have also helped my teeth as well. I don't seem to be getting plaque like I used to,
I think its unlikely to have helped as it damages your Nitric Oxide production, effectively causing premature signs of aging and weakened immune function. Taking it long term like that is potentially functionally aging parts of your system by decades, for a temporary boost to certain cognitive areas. You know, you do you, but I'd recommend careful research.
@@ARC_VR Like I said, it reduces nitric oxide, which can be quite bad in the long run. Low nitric oxide is part of why old people start struggling with immune health, high blood pressure, diabetes, muscle soreness, erectile dysfunction etc. Its used as a marker of age.
I use it in combination with red light/ near infrared light therapy. Be prepared to get blue contaminations hared to remove. Like in the kitchen after spillen the water solution. Or in the toiliet, the blue haze. Cleaning can be started using ascorbid acid. That is the powder also sold as vitamin C. I have a bottle of that, and rubbing that on the blue surface typically removes the blue dye.
You said you’ll wait for the research to be done before deciding. Well, since most research is now funded by the pharmaceutical industry, and MB can’t be patented, I don’t think we’ll be seeing any research soon. I’m 67 and I don’t have time to wait. Im convinced enough and have been taking pharmaceutical grade MB 1% at 2 drops twice a day with red and near infrared light therapy.
Methylene Blue has had a relatively menial role in medicine up until this time. It has been used as a practical liquid dye to detect fluid movement in some situations (primarily to detect fistulae, etc.). It also is used to demonstrate communication between different anatomic spaces for surgical applications. Methylene Blue is also used to treat clinically significant methemoglobinemia. Prussian Blue is different, but comes to mind because at one time, I was the principal investigator for Prussian Blue (Radiogardase), an orphan drug, which is used for both Thallium and Radiocesium poisoning. It is a non-sequitur, but I reflexively think of Prussian Blue when I hear the term Methylene Blue.... :)
Important note: do not confuse ROS (reactive oxygen species) with ROUS (rodents of unusual size). Methylene Blue only has protective effects against one of them.
We used it in surgery to see if the kidneys would perfuse and locate ureters. Also, it was considered an irritant for nervous tissue and we wouldn’t use it as a marking agent during neurosurgery.
nice topic. I experimented with it (USP grade) for a few years because of a history of chronic insomnia and a concussion. Didn't notice any surface-level benefits but it consistently brought my mildly elevated creatinine and BUN back into normal range. This was transient for a couple months maybe before they would go back up. Dose didn't seem to matter, either. I was testing 100 micrograms to 15-20mg.
Using this daily now, it does feel like an anti depressend. Overall mood and memory is better and really cant say if my overal health improved. Probadly, but the main effect is my memory and focus.
Long time viewer, first time commenting. Thanks for the great information and often humorous delivery. I have taken MB very low dose orally off and on for 9 months. Generally only positive results besides the blue pee. Given that its half life is reported to be a few hours, I have begun dosing at 2 drops (1 mg) twice a day, and I am experiencing similar positive results like better concentration, more energy, improved mood. (previously I dosed from 2 drops up to 16 drops ONCE a day) I am however concerned about contaminants and I am taking the USP grade MB, but even at those amounts it could be cumulatively toxic. So presently trying 1-3 drops twice a day, then taking a couple / few days off every week or two. I am unsure of any cumulative dosage effect when taking MB X days in a row. I am a 60 YRO male, and also use Red light therapy. (also trying to figure out the minimum effective dosage there) So unsure about anti-aging effects, but each day is better.
Please continue your work in understanding MB, it is the only molecule I have found that can free me from Adderall. with MB I can concentrate without the side effects of Adderall on my personality
I was given MB last year by a pharmacist while vacationing in South America. I had a UTI and it was a Sunday morning so I couldn’t find a doctor in the small town I was visiting before I had to catch a flight back next morning. It definitely resolved the symptoms - probably faster than some antibiotics. It didn’t clear the infection but it gave me a chance to make it back home comfortably and then arrange to see my doctor a few days later for antibiotics. That being said, I didn’t notice a remarkable improvement in energy but, between the uti and jet lag, I wasn’t feeling nearly as crappy as one would expect… 🧐
Methylene blue was used back in the day as a treatment for UTI but has fallen out of favor for newer antibiotics, you can still find it in some Rx formulations such as Urelle.
@@StrengthGuilds You can definitely find pharmaceutical grade methylene blue, it comes as an injection solution with the brand name ProvayBlue. It's also available from compounding pharmacies who use pharmaceutical grade powder to make capsules of varying strengths.
I remember in the Reservetrol controversy hearing that some of the beneficial effects falsely attributed to Reservetrol were instead caused by the dye used in the experiments. out of curiosity, was the dye Methylene Blue?
I don't think so but I caught that fact too ! I love taking MB. It seems to really be a good anti-depressant and I do feel more energetic when taking it. Also take NAC. That seems to have similar benefits as MB
Just be aware that NAC thins out the blood there @@shelleybevacqua . If you start bruising or bleeding too easily, or developing weird blood vessel formations like spider-veins or cherry anginomas, consider switching to L-Cysteine. The Acetyl part in N-Acetyl-Cysteine is responsible for lowering blood platelet count, just like with Aspirin (aka. Acetyl-salicylic Acid)
methylene-blue IS fluorescent tho @@davidmannion5362 ...it's actually a property that changes with oxygen concentration, hence why it's so useful as a dye in microscopy.
It's really expensive and I think I developed a permanent tolerance to it after a month. The first month I took it, I was full of energy all day. That effect faded over the second month. I tried taking it again after not taking it for 6 months and couldn't feel anything from it.
for one of the oldest compounds ever, dont you find it kind of curious that "we dont have enough research on it"? i bet if we dont have it at this point, then we never will, theres just no incentive to research a drug that is un-patentable, so it will be forever ignored by research from here on in favor of new patented drugs
Apart from all the research done by national health organisations around the world who would be absolutely interested in such a wonder drug if it helped people be healthier. The whole world is not just the USA and "big pharma".....
@MichaelGGarry it is though... the US is the largest demographic to the pharmaceutical industry. the US subsidizes medicine for the rest of the world. pharma is among the largest advertisers in the US and the largest lobbyists.
@@MichaelGGarry oh my naive friend. whoever it is that operates the U.S from the shadows surely has its slimey tentacles in whatever developed country you come from. believe it
I have been doing MB for a month now and yes my urine is usually greenish, I also do other supplements so I can state that it alone is why I feel so much better.
Thanks for covering this - if you're looking for anecdotes, there are plenty of threads on longecity going back 15 years or more. Also, you might be interested on the effect on progeria cells (not in vivo). "“We tried very hard to examine the effect of methylene blue on all known progeria symptoms within the cell. It seems that methylene blue rescues every affected structure within the cell. When we looked at the treated cells, it was hard to tell that they were progeria cells at all. It’s like magic.” ~ Dr Zheng-Mei Xiong If you fancy a simple experiment - put some 1% on you skin for an hour (it will come off!) - it was for me remarkably hydrating.
I'm taking a microbiology class right now, and we use Methylene Blue to stain bacteria. I saw the the title of this video, and was like "Why are you drinking bacterial dye"? Most of the dyes we use are labeled as poisons in our lab, so this was intriguing that people are using MB for anti-aging.
Yes, but do not mention that : it contains Arsenic, Lead, Mercury, Cadmium and other heavy metals. It is also chloride. And the most basic thing for me is that : it blocks the entire solar light spectrum that mitochondria need to produce water and energy through the natural electron chain. If you block natural light, you create all these dysfunctions of diseases in our modern world.
A video about Methylene Blue’s history as an Emergency Room treatment/remedy would be interesting. I’m very curious as to how people figured out they could drink it safely, and I’m not sure what the true ER history is, whether there is truly an old saying: “When you don’t know what else to do, Methylene Blue” but I’ve seen in several places that MB has been mainstay of U.S. ERs for more than 100 years, which if true is pretty interesting considering it’s medical properties haven’t been closely studied. Do a video on all of that!
Thanks, Nick! Isn't there some solid data on using MB for malaria and for cyanide poisoning? I hope you can expand on it. I've been taking it orally for about 3 months. At 60 years old, it is giving me sustained energy. Also do red-light therapy and heard that's a good combo...
I've only been using it for a short while, but the change is remarkable. I'm using a commerical medicinal dilution used to treat UTI's sold by Bjain pharmaceuticals in New Delhi. It does also increase my BP, which is the one bad side effect. It gives a tremendous boost in energy and cognitive ability from just a few drops in my morning coffee. Definitely the real deal.
@@Physionic No worries. Thought you might want to know about the BP thing. It's not an insignificant increase. My 32 year-old daughter tried it and also found it effective.
@@opamp7292 E-Bay, as a homeopathic, shipped by international mail to US. Try 3 drops/day to start, go up/down from there. Keep close track of your blood pressure.
@@deborahbattleson2226 someone above said " We already have other molecules that perform the same functions that we know are safe. We have a slew of antioxidants glutathione being only one of many. We have the salvage pathway to vastly increase the recovery and reuse of NAD+ efficiently generated from NMN. We have AKG possibly the most efficient fuel for ATP. We have molecules like spermadine to protect DNA. Cyanidin and fucouidan to activate SIRT 6. Quercetin which perfoms many functions. Fisetin which when used correctly is a powerful senolytic. Many more."
hey Nicolas, first of all, I'm so happy to see your channel blow up! You definitely deserve it, great content. Secondly, I have sort of a request. If you're planning to make more videos about methylene blue, could you please also explain how and why does it somehow interfere with SSRI's? I really wanted to try it out, however I'm on Escitalopram and taking MB could have fatal consequences, at least that's what I read. I'd be very interested in your explanation about how these two drugs interact in a deadly way. Thanks!
@nadianiyazi7250 she was taking a 00 capsule and filling it up about 90 percent. I think about 20 drops . and swallowing it twice a day . I would always start with less and see how you feel and then go up.
Used MB twice hoping it would help me. I went through massive stressors some years back (I was 51) which almost killed me really. It has taken me years to regain some health and brain function. As I age it has gotten harder to mitigate the detrimental effects of stress. So I've looked for things over the years that might help that process, MB is one of the things I tried. The first time I took it it didn't seem to do anything for me. I am very cautious about the things I take (especially experimental things) because I've learned over the years that they can crash me. So I took MB for a short period of time according to most directions on the net. It really didn't seem to do anything for me so I stopped taking it. I tried it again some time later and it had a very detrimental effect on my brain. My brain function was already bad enough but MB made it many times worse. I could not think at all, made my brain hurt and it felt like something had taken over my brain. It took a little over a week for the symptoms to subside. It wasn't a pleasant experience. Won't do it again.
I got shocking headaches but I believe it was detoxing chemicals out . I took a break now back having low doses 5 drops 💦 in water Also depends on quality and where u bought from it could have heavy metals in it . Hope your doing ok . Try a parasite cleanse
Yes we should not jump to conclusions. We already have other molecules that perform the same functions that we know are safe. We have a slew of antioxidants glutathione being only one of many. We have the salvage pathway to vastly increase the recovery and reuse of NAD+ efficiently generated from NMN. We have AKG possibly the most efficient fuel for ATP. We have molecules like spermadine to protect DNA. Cyanidin and fucouidan to activate SIRT 6. Quercetin which perfoms many functions. Fisetin which when used correctly is a powerful senolytic. Many more.
@googbert Rimon on Wellness Messiah recently reported on a flawed test showing it was ineffective. Fisetin is a class of molecules called polyphenol which is what gives color to fruits and vegetables. Among its uses is as a senolytic which means it programs old worn out cells that don't function, don't reproduce and can excrete toxins damaging other cells to die. I think it comes from strawberries. It is identical to the molecule quercetin except for one additional OH group. The flaw in the test was giving the mice small doses daily. Rimon says that the proper dose is 20 mg per kg of body weight once every one to three months you want it in your system in a high enough concentration and then out. So I weigh close to 240 pounds which is 110 kg so my dose would be 2200 milligrams or 2.2 grams. That's 11 20 mg pills taken at the same time. Rimon,if you're reading this tell me if I got anything wrong. I suggest you visit his site. He'll even tell you why he disagrees with some things David Sinclair does.
Thank you once again for a really comprehendible explanation for the person with one or two biology classes. I hope to thank you in person one day. I shall be the person with a bluish complexion.
more research : it contains Arsenic, Lead, Mercury, Cadmium and other heavy metals. It is also chloride. And the most basic thing for me is that : it blocks the entire solar light spectrum that mitochondria need to produce water and energy through the natural electron chain. If you block natural light, you create all these dysfunctions of diseases in our modern world.
Just found out methylene blue inhibits nitric oxide synthesis… how can you take the MB for mitichondrial and immune support, while keeping healthy nitric oxide levels for cardiovascular/ immune support.
What scared the hell out of me was seeing a picture of a cross sectioned brain where apparently methylene blue had dyed the whole brain a blueish tint. If I hadn't seen that I was probably going to order some to try.
well yes that is something it does but of course the person was taking way too much. Have you ever seen a brain of someone that drank too much water too fast? it will be twice the size of a normal brain and they will be dead. you only need to drink 4 gallons of water in 1 hour without sweating or peeing and this will happen. too much of a good thing is not good.
I've seen that too, but that was the result of a seriously large dose. Perhaps even in a hospital setting to reverse cyanide or CO poisoning. This dye will leave your organs if you stop taking it.
We used methylene blue in radiological imaging as a substance that shows up under infrared. Injecting it into a milk duct in the breast allows that duct to show up under IR in surgery and be removed. Is this the same methylene blue??
I've been playing around with this applying it to the skin, super diluted so it's a very pale blue water. The first two days I had too much energy and couldn't sleep so I backed off. Also it made my kidneys cranky. Today I started again and splashed it just on my face. A couple of effects: it instantly clears the sinuses and gives mental clarity.
I have been trying to take this since I struggle with low energy. Even just one drop in the water sometimes irritate my stomach. I want to be able to get used to taking it so that I can increase it to about 5 -10 drops..... >_
I've been taking MB for 6 years at the 1mg/kg level (5mg/kg is considered max safe). Wonderful stuff, I mainly started taking it for brain and eye health but it is beneficial for many other things.
Yes! Run advertisements and keep doing what you love. It’s not selling out, it is providing the means for growth. It would not sway my opinion about your work; your research is high quality. Just sell as much sponsorship as you can and survive. This is growing pains and it is good!
I am sure it will come as no surprise to you Nick that the Stapler is a heavy meth user. Being a 1960's model stapler I have a lot of electron slippage I need to control. Seems to have subjectively helped with mental clarity to a degree. Blue is also used even today in hospital ER's to treat various forms of poisoning. My wife once had a bad reaction to an over the counter, rash and some difficulty breathing. A shot of meth and 30 seconds later she was fine and back to nagging me as usual. It also makes a phenomenal carpet, tongue and teeth stainer - The Stapler
I took it for a couple of months because it's supposed to have neurological benefits. I'm in my 60s and I'm having a really difficult time with my short-term memory which is an unnerving experience. I think it was starting to help but I don't think I took it long enough. I also think I might have been taking too much and that is why I was having stomach pain. There is supposed to be a point where taking more rather than less is counterproductive. When I did stop, I was surprised that it took me 3 or 4 days to stop streaming green urine.
If your pee is green/blue you are taking too much and are literally peeing $$$$ down the drain. Spread the dose out over the day and/or lower it. over-saturation is bad and MB at that point will cause more problems that it fixes like high blood pressure.
@@Dodgerzden WAY TOO MUCH yikes even worse if you took that much just once a day and not spread out with 1 dropper full 3 times a day. Most only need about 10 drops of 1% 3 times day. A little goes a long way. Now if you have a UTI then doing what you did is the way to do it until the UTI is gone.
Another medication that is more chemical in nature is Dimethyl sulfoxide (DMSO) DMSO. Have you ever done a video in that? I'd like to see it if you have.
Thank you. Will try it! Also switched to Statins from Niacin based on your reading of the research, particularly when it is not expensive and I have a good cardiologist.
There isn't much data on it as an anti-aging drug, true, but there is tons of data on it. It isn't really a strange compound, but its interactions with human biochemistry is absolutely unexpected (I mean once we understood it's properties its interactions make perfect sense, but it is pretty weird that blue jean dye just happens to have those properties)
Fun fact: A "kicker," also called a side card, is a card in a poker hand that does not itself take part in determining the rank of the hand, but that may be used to break ties between hands of the same rank. It's an old gambling term. Now you know.
I just started taking it again, after being off for months, due to crazy fatigue.... which caused some depression. The MB fixed the depression almost immediately..... and is helping with the fatigue as well.
I have a question...Curcumin inhibits ATP-synthase to reduce the number of ATP molecules, and that is supposed to be good. Doesn't Methylene Blue do the exact opposite by supporting ATP-synthase? Why are they both good?
@physionic I got pulled into using OneSkin the key ingredient being the OS-01 peptide. It was hawked by Dr. Sinclair on this podcast. Anyways, I was hoping to get your intuitive feeling on what would have better synergy. OS-01 with methylene blue, or 0S-01 with retinol A?
I only learned of the existence of Methylene Blue a couple of weeks ago, through some channel called Nootropics or something like that. Anyway, in the comment section, the guy who posted the video answered someone's question...the person had asked if there are any other supplements that should not be taken whilst taking meth blue...he said CoQ10 should be avoided (and another couple, which I do not remember). Do you know why this may be?
I'd guess he thinks it's be pointless considering electrons are being delivered directly to complex 4, but if that's his thought process (no idea if it is), then he's forgetting that Complex 2 also delivers electrons. Either way, he may still be right, but I don't know for certain.
apparently SSRI's may risk seratonin syndrome with MB (also since MB is an MAOI inhibitor watch for aged cheeses, fermented foods and the like) ...so i've heard
@@redberries8039 True. Sounds like the problem has only been observed with IV dosing in the 1 to 8 mg/kg range. I've combined low dose oral MB with an SSRI without any problems.
I tried the earth harmony brand and very slowly worked my way up to 15 drops a day but started getting light headaches and other symptoms of seratonin syndrome. So I stopped for a few days and tried again. Now I have those same symptoms even at 3 drops a day. I’m not taking any contraindicatiors. The earth harmony brand is pharmaceutical grade but has something called liquid gold which the BpH brand doesn’t. Do you think I should switch to BpH ?
![These Molecules Reversed Aging by... YEARS! [TRIIM Study Explained - Study 216]](http://i.ytimg.com/vi/rVoxfABoHh4/mqdefault.jpg)
Methylene Blue is exciting for the reasons mentioned, but the data is lacking. If you have had personal experiences using it, I'd like to hear your experience.
I have been drinking it for 6 months, I only drink water and add 30 or so drops to every gallon (gallon sized water bottle). I no longer get sore from the gym, my calorie burn jumped when taking it. I have not been sick since. The water bottle required cleaning once a week before and now I never need to clean it. It has helped my elbow nerve issues significantly. I always have energy and am turning 48 in November but physically feel like I am in my twenties.
Been drinking it once a day in the morning ( 1.5ml of a 1 percent solution which is equivalent to 15mg), have felt an extremely considerable difference in my general wellbeing, feeling overall more energetic, my memory is alot clearer and finding aerobic exercise far easier than I would usually, haven't noticed any negative side effects as of yet.
I appreciate your work so much one love from 🇯🇲🇯🇲🇯🇲🇯🇲🇯🇲🇯🇲🇯🇲🇯🇲
I take Blu Brain methyl blue for 3-4 days a week for 2-3 wks. It helps me a lot during the day, including when I used it to run 105 miles in an ultra race. 🧠💙
@@markuskempus788 great job maan
I learned of MB through this video and went down the rabbit hole. I got really sick a few years ago and have dealt with symptoms (pain, brain fog, etc) since. I've tried many different supplememts to varrying effect but nothing ever took my symptoms away. I figured, what the hell do i got to lose and ordered some of this a few days ago.
Oh my god... I have never felt more profound relief in my life. Literally EVERYTHING went away within just a couple hours. This is just my anecdote, but wow has this been a god send. Thank you for putting me on to this stuff.
Where'd you get it? Dude do you have a link?
I've been using MB and it helped a ton for brain fog too.
Something I recently found that has cleared up nearly all of my remaining symptoms, including PEM, is Boron. I'm taking 12mg of a supplement containing Boron Citrate, Aspartate, and Glycinate
@@MeepzilluhI bought mine on Amazon. Make sure it's Pharmaceutical Grade
This sounds like a commercial
hi is it all of this stuff in one glass ?
Thx
In the 80's in Romania, when we were little and got sore throats mom painted us with MB in the throat on the mangles. The bottle of MB was bought at the pharmacy as medicine as the first step against sore throat in case of colds.
I thought mangles were a fixture in my great grandparents' laundry room.
@@tactileslut
Maybe I should have said throat glands.. I don't have any word for it. Sorry English is my third language.
@@CameliaLagerström It's my first and I'm still not good with it. Five decades and counting...
Third language? Bine făcut! Bravo! I think you (very obviously) referred to tonsils 😊
@@CameliaLagerström"mandle" yes. Slavic word. Tonsils or almond shaped things
In our neck of the woods, when I was a small child - 40 years ago, Eastern Europe - the doctors used it against throat infections.
and we still use it, just in pills. Crazy how the other parts of the world are just hearing about it now
They do here, and they still use it for various respiratory conditions via aerosol application.
@@homomorphic Where is "here", and you mean they use it in nasal sprays? Or inhalers? Or in the air?
And does it work?
@@jvlbme here is the US. They use it in nebulizers at hospitals for respiratory conditions and for carbon monoxide poisoning intravenously.
Of course it works. It's been a standard of care for 150+ years. Accredited emergency departments *must* have a supply on hand at all times.
Increased energy, I don’t get gassed as fast when working out, cleared my brain fog, and somewhat cleared up my depression and made me less anxious. I’m sure it works differently for everyone but, I even noticed my hair feels healthier, and quit thinning. It’s definitely worth a shot if you’re curious I’d definitely say it’s benefitted me.
Got rid of the runny nose I'd had for two years and I no longer have to take allergy pills for hay fever.
That's great! Can i ask what brand, and where you purchased it from? TIA
What was your starting dose? And how many times do you take it in a week? What's your age?
@@FormlessJKD17 I am doing 15 mg / day, methylene blue with Shoden ashwgandha, taking them together 4 days on, 3 days off. As with any compound that is non mineral, vitamin or amino acid-based, you have to cycle it, because of the tolerance build up.
I am takeing mb for two months now. My athletic performance has significantly improved. Much more than with creatine or any other supplement.
Can we know your age? thanks.
@andrewj4426 you thanked too soon.
It is still used in Vietnam for urinary track infection. First time I heard of it when i was prescribed it. It was very common here 50 years ago
I've never been a fan of blue, so I just take the Meth part. Really boosts my energy
😂
😂
Change dealer. The best Meth is blue.
This dude I met named Eisenberg said blue meth is where it's at.
Still laughing.
Exciting. It's made from synthesized Smurfs blood incase you didn't watch the video
Way to just tell everyone... geez... 😛
@@Physionic 🤣
@@richardmalone3172
Wow, good for you. Meanwhile on pasta grannies videos with many healthy Italian women (few men) 90-103 Italian woman who still walks 2km a day, feeds her chickens and makes her own pasta. Obv wine and olive oil too.😉 Many others from diff areas of Eur and Greece plus local eccentric centenarians w/crazy diets (corn flakes w/apple juice vs milk etc) but sharp as a tack and still active. Incl a 98 yo who lives on her own, does steps mult times per day has her cocktail and 1-2 puffs of a cigar DAILY. No joke. Many of them are on little to no meds. Not sure but they and those like the late Dr Ellesworth Wareham are my dream. 😉😂 You’ll prob live to 99 yo too and better shape then me. ✌️
@@richardmalone3172 People like you are so inspiring. I want to be like you when I become 69 years young. 👍
@@Web3Dre it’s not hard. Just don’t stop.
My experience was the first time I took it was before bed. 10 drops in 250ml of water. I slept well but when I woke up I felt very in control of getting up at any time I wished. I normally set my alarm on snooze but didnt feel like I needed to as I was tired but somehow alert. I noticed a couple other things. I dont normally think about it but I woke up with a sense of smell. I could smell and hear things I don't normally notice on my waking up and walk commute. Was very interesting.
Do you still take it? Which brand?
My father a physician would have us put a little methylene blue on mouth ulcers. They healed quickly.
Oh smart!
When I was a kid I kept tropical fish as a hobby. Methylene Blue was ofren used as a sort of cure all for fish diseases. This was 50 years ago, so apparently at least some people knew about it before now.
Still widely available for fungus infections and wounds in fish tanks / aquaria.
And the fish is still alive today? Amazing.
Same here. Used it to cure fungus and bacterial diseases in my fish by adding one drop per gallon of water, if I remember correctly.
Sounds fishy to me
@@MrBlaxjax close your eyes and swallow. Picture your girlfriend
Within three days of starting meth blue, I had significant improvement in my very, very long covid.
how is it taken? IV, oral
@@okie4400 I think there is more than one way available, but orally is most common. I was instructed to put five drops in a glass of water and sip on it slowly for about 40 minutes. It's very easy and inexpensive.
Please share where I can get it, Im also suffering from long covid. I cant find it anywhere here in Belgium
@@wzupppp Amazon
@@wzupppp Amazon $26 super cheap
Been using MB for a few months with my wife, it helps a lot in dealing with stress and ptsr. I'm using 10 drops per day deluted in water, with taurine. It starts working within 5-10 minutes. At some point I thought to substitute bulletproof coffee with MB, but ended up doing both =) Some people suggest doing MB interveinly, but I'm not apt for it yet. I've noticed that I can run like in my childhood, without any thought of getting tired at least for some time (I'm around 40yo). But you'd better be careful, sudden bursts in stamina could be tricky - I've hurt my legs, and it took me 2 weeks to recover.
Same here!
It's like being a cook and getting the sharpest knives ever. Caution is warranted.
😂
At 71,definitely think it is worth taking...anything that improves redox in the electron transport chain gets my vote.I take 15 mg every other day (having experimented with several dosing strategies).Helps with sustainable energy all day long and a feeling of resilience (yes,resilience is such a nebulous term - but best fit).
How many drops are that (15 mg)? All at the same time or do you spread it over the day? I'm about your age, hence curious about your particulars.
@surajitgoswami1871 Do 30 drops
(15 mg) first thing in the morning every other day.I don't have any health issues but continue to experiment with dosing.
Current plan is to finish current bottle then stop for a bit to assess differences with out MB.
Very interesting Bob. May I ask where you get yours? What brand etc?
30 drops? I need 6 to feel like i am impervious to alcohol and weed, still go out for a run afterwards
From what I've heard from Dr. Gonzalez-Lima in a more recnt interview, the trick particularly for the senior citizen is to just see the pee till the hint of blue is gone (after starting with a very low dose, say 3 drops). For me it took two days (48 hours and the first few times after the first dose the pee was clear and the blueness appearred after half a day of the morning dose) and I shifted to just two drops with "wait till the pee clears approach". In my opinion, 30 drops could be even fatal - this is "poison at higher doses" you're dealing with.@@m4inline
I started taking MB in capsule form. I've noticed that it seems to give me sustained energy and motivation late in the day. I like coffee, but it gives me an afternoon crash. MB seems to come on slower, but helps me to be much more productive in the afternoon and evening. Sometimes it seems like too much energy, like I might be inclined to work late and not sleep as much.
I'm 60 and I started taking 2 drops in a glass of OJ in the morning a month ago and it felt like my brain fog was lifting, my memory recall for words definitely improved somewhat. I switched to taking it before I go to bed and my broken sleep has completely stopped. For the last week, I have slept right through until morning, something that hasn't happened in years. (I can usually get the odd night in without waking up once, but a whole week in a row was unheard of.) I ordered the MB skin products and have been using them for a week - yesterday I had 2 people comment on how good my skin is looking but that could be because I'm also getting proper sleep now. (I've read that when you mix it with OJ it stops staining your teeth blue. So far, so good. Note: I have been taking Vit C every day for the past 3 years, so it's not the Vit C in the OJ.)
Thank you for sharing.
Is the skin product topical? Does it stain blue?
What is OJ?
OJ is orange juice I guess
Sugar water! Eat the orange include the fiber! @@mathieuforpub2302
I'm 63, and as kids, we played with methylene blue in our chemistry sets. It was also used as a dye for making cell walls to improve microscope 🔬 viewing.
Ahhhh...yeah i remember that! Onion cells!
I used them before in a bio lab and it turns out, yeasts and other microbes can use in lieu of oxygen! Seriously, the used form is colorless so you get a solution that is less blue by the hour
Same
😮Wow! @@hcn6708
MB saved my daughter’s life!
you probably wont read this...yt arent notifying comments on topic such as this@@contagiousintelligence5007
What was the condition for which it gave a solution?
My cat is named Cheeseburger and when you said "Cheeseburgers!" she looked up from her paw grooming
❤❤❤😂
My mom was in the ICU, her organs were shutting down, they put her in a MB IV 1x per day, it was truly amazing how she responded to it, the physicians were very impressed. She was suffering from hypotension. MB does in fact have clinical uses despite what YTer says. DYOR but in certain doses and circumstances it can be life saving wonder drug
One of the main side effects of methylene blue is hypertension so this could have helped her. Glad to hear your mother was able to be recover.
@@mirzatajic89greatly
Treating it is really challenging when the patient is also experiencing pain because most pain killers lower BP too.
Anestesiologists disscus it on their subreddits. It last ditch effort to throw something in bleak dituation during intensive care, worst it can do is color patient blue.
Thanks, i just started low dose MB.
It literally makes me happy 🌞
Low dose.?how many drops.?
Right???!!!
Which brand do you use please?
For anyone who wants to use it only use USP or Medical Grade one without Heavy Metals
I cant find any my country, just the regular type from a pharmacy, and it's very cheap like 2$ per 20 ml bottle. I am not sure if I should still take it...
I have been taking 10 drops in a glass of water, daily, for about 6 weeks. I find it to be fantastic. I have more focus and energy, yet no feeling of buzz or rush. I do believe that this works at the level of the MItochondria, and not by direct stimulation of hormonal pathways. Strong mitochondria are crucial. MB can play several different roles in the Electron Transport Chain.
It effects the neurotransmitters serotonin, norepinephrine, dopamine, acetylcholine, blocks nitric oxide which can cause hypertension. Be careful with dosing. Can cause serotonin syndrome which can be fatal
Which brand do you use please?
Been taking it since the beginning of Covid. Not sure if it was the reason I didn't catch Covid but but the rest of my family (4 others) all caught it. Other than that I noticed it gives me a slight energy kick. It also improved my long distance eye sight such that I don't need to wear glasses when driving. Hasn't done much for my close up vision but has helped with eye strain to some extent. It seems to have also helped my teeth as well. I don't seem to be getting plaque like I used to,
How many drop did you take a day ?
I use a spray bottle into my mouth. 5 sprays in the morning and 5 sprays at night MB is diluted to 1% @@erwinj7257
I think its unlikely to have helped as it damages your Nitric Oxide production, effectively causing premature signs of aging and weakened immune function. Taking it long term like that is potentially functionally aging parts of your system by decades, for a temporary boost to certain cognitive areas. You know, you do you, but I'd recommend careful research.
@@LordVictorHalgaardYou're saying MB is damaging? Can you tell me more as I am currently taking this
@@ARC_VR Like I said, it reduces nitric oxide, which can be quite bad in the long run. Low nitric oxide is part of why old people start struggling with immune health, high blood pressure, diabetes, muscle soreness, erectile dysfunction etc. Its used as a marker of age.
I use it in combination with red light/ near infrared light therapy. Be prepared to get blue contaminations hared to remove. Like in the kitchen after spillen the water solution. Or in the toiliet, the blue haze. Cleaning can be started using ascorbid acid. That is the powder also sold as vitamin C. I have a bottle of that, and rubbing that on the blue surface typically removes the blue dye.
You said you’ll wait for the research to be done before deciding. Well, since most research is now funded by the pharmaceutical industry, and MB can’t be patented, I don’t think we’ll be seeing any research soon. I’m 67 and I don’t have time to wait. Im convinced enough and have been taking pharmaceutical grade MB 1% at 2 drops twice a day with red and near infrared light therapy.
i take MB with ascorbic acid since 2018 and still love it
I may be jaded, but since MB is cheap to make and can't be patented at this point - i expect obfuscation from pharma
Nonsense, they would just combine it with another drug, make it controlled release, then patent it and make billions.
MB is being used by hospitals right now. This is not UGL and untested as the YTer says.
*Obfuscation
@@goodbonezz1289 ty - corrected
It was shown effective for covid 19 and nobody talked about it so yes they do exactly that.
MB has also been used against brain fog due to neurological adverse effects of chemo.
Methylene Blue has had a relatively menial role in medicine up until this time. It has been used as a practical liquid dye to detect fluid movement in some situations (primarily to detect fistulae, etc.). It also is used to demonstrate communication between different anatomic spaces for surgical applications.
Methylene Blue is also used to treat clinically significant methemoglobinemia.
Prussian Blue is different, but comes to mind because at one time, I was the principal investigator for Prussian Blue (Radiogardase), an orphan drug, which is used for both Thallium and Radiocesium poisoning. It is a non-sequitur, but I reflexively think of Prussian Blue when I hear the term Methylene Blue.... :)
Tons of research on this. I started taking it for my lyme disease treatment.
Important note: do not confuse ROS (reactive oxygen species) with ROUS (rodents of unusual size).
Methylene Blue only has protective effects against one of them.
Inconceivable!
Love the Princess Bride reference!
Please do not confuse ROUS with Capybaras, only the Capybaras are adorable, even though both are ROUS.
I was thinking the same thing when he started saying ROS
If it's good enough to bathe my goldfish in, then its good enough for me to drink a gallon
That settles it. Thank you, Zach.
You’re supposed to take a bath and add 20 drops to simulate being in an aquarium. Bye bye fungal infections.
Please use Medical Grade
What about the nitric oxide inhibiting action!? Not a desirable side affect. 🤔
We used it in surgery to see if the kidneys would perfuse and locate ureters. Also, it was considered an irritant for nervous tissue and we wouldn’t use it as a marking agent during neurosurgery.
nice topic. I experimented with it (USP grade) for a few years because of a history of chronic insomnia and a concussion. Didn't notice any surface-level benefits but it consistently brought my mildly elevated creatinine and BUN back into normal range. This was transient for a couple months maybe before they would go back up. Dose didn't seem to matter, either. I was testing 100 micrograms to 15-20mg.
Using this daily now, it does feel like an anti depressend. Overall mood and memory is better and really cant say if my overal health improved. Probadly, but the main effect is my memory and focus.
Long time viewer, first time commenting. Thanks for the great information and often humorous delivery.
I have taken MB very low dose orally off and on for 9 months. Generally only positive results besides the blue pee.
Given that its half life is reported to be a few hours, I have begun dosing at 2 drops (1 mg) twice a day, and I am experiencing similar positive results like better concentration, more energy, improved mood. (previously I dosed from 2 drops up to 16 drops ONCE a day)
I am however concerned about contaminants and I am taking the USP grade MB, but even at those amounts it could be cumulatively toxic.
So presently trying 1-3 drops twice a day, then taking a couple / few days off every week or two.
I am unsure of any cumulative dosage effect when taking MB X days in a row.
I am a 60 YRO male, and also use Red light therapy. (also trying to figure out the minimum effective dosage there)
So unsure about anti-aging effects, but each day is better.
Please continue your work in understanding MB, it is the only molecule I have found that can free me from Adderall. with MB I can concentrate without the side effects of Adderall on my personality
what dose do you take?
25 mg of MB
@@micdargis thank you!
@@micdargis It's been 4 months, how is going? Are you still using MB?
@@somethingsburning774 Yes, but 15mg is enough now. Maybe it’s a cumulative effect, I don’t know
I was given MB last year by a pharmacist while vacationing in South America. I had a UTI and it was a Sunday morning so I couldn’t find a doctor in the small town I was visiting before I had to catch a flight back next morning. It definitely resolved the symptoms - probably faster than some antibiotics. It didn’t clear the infection but it gave me a chance to make it back home comfortably and then arrange to see my doctor a few days later for antibiotics. That being said, I didn’t notice a remarkable improvement in energy but, between the uti and jet lag, I wasn’t feeling nearly as crappy as one would expect… 🧐
What was the dose?
a full pipette, so about 1ml of 1% solution is more than enough. Your pee will turn a greenish-blue colour for a day or 2 @@abominabelle
Where do live? Not North America, because no jet lag unless traveling East-West. Or maybe you just meant "travel fatigue"?
Methylene blue was used back in the day as a treatment for UTI but has fallen out of favor for newer antibiotics, you can still find it in some Rx formulations such as Urelle.
@@StrengthGuilds You can definitely find pharmaceutical grade methylene blue, it comes as an injection solution with the brand name ProvayBlue. It's also available from compounding pharmacies who use pharmaceutical grade powder to make capsules of varying strengths.
I remember in the Reservetrol controversy hearing that some of the beneficial effects falsely attributed to Reservetrol were instead caused by the dye used in the experiments. out of curiosity, was the dye Methylene Blue?
I don't think so but I caught that fact too ! I love taking MB. It seems to really be a good anti-depressant and I do feel more energetic when taking it. Also take NAC. That seems to have similar benefits as MB
nope.
The dye used was a fluorescent, so it was not MB.
Just be aware that NAC thins out the blood there @@shelleybevacqua . If you start bruising or bleeding too easily, or developing weird blood vessel formations like spider-veins or cherry anginomas, consider switching to L-Cysteine. The Acetyl part in N-Acetyl-Cysteine is responsible for lowering blood platelet count, just like with Aspirin (aka. Acetyl-salicylic Acid)
methylene-blue IS fluorescent tho @@davidmannion5362 ...it's actually a property that changes with oxygen concentration, hence why it's so useful as a dye in microscopy.
I didn’t read every comment here but from here and others that talked about it. I don’t see one negative comment about MB.
If you take SSRI's you shouldn't take it I understand.
It's really expensive and I think I developed a permanent tolerance to it after a month. The first month I took it, I was full of energy all day. That effect faded over the second month. I tried taking it again after not taking it for 6 months and couldn't feel anything from it.
Helps in stroke recovery as well.
1-2 drops a day is all that I need to feel as good as I did at 25-30...@64
Ty bro for covering Aging and Longevity. Im glad youre getting views and recognition.
for one of the oldest compounds ever, dont you find it kind of curious that "we dont have enough research on it"? i bet if we dont have it at this point, then we never will, theres just no incentive to research a drug that is un-patentable, so it will be forever ignored by research from here on in favor of new patented drugs
Apart from all the research done by national health organisations around the world who would be absolutely interested in such a wonder drug if it helped people be healthier. The whole world is not just the USA and "big pharma".....
Good point…
@@MichaelGGarrySechenov institute used it to treat covid so... Some research is done here and there.
@MichaelGGarry it is though... the US is the largest demographic to the pharmaceutical industry. the US subsidizes medicine for the rest of the world. pharma is among the largest advertisers in the US and the largest lobbyists.
@@MichaelGGarry oh my naive friend. whoever it is that operates the U.S from the shadows surely has its slimey tentacles in whatever developed country you come from. believe it
I have been doing MB for a month now and yes my urine is usually greenish, I also do other supplements so I can state that it alone is why I feel so much better.
what benefits are you feeling?
Which dose works the best in your opinion?
Thanks for covering this - if you're looking for anecdotes, there are plenty of threads on longecity going back 15 years or more. Also, you might be interested on the effect on progeria cells (not in vivo).
"“We tried very hard to examine the effect of methylene blue on all known progeria symptoms within the cell. It seems that methylene blue rescues every affected structure within the cell. When we looked at the treated cells, it was hard to tell that they were progeria cells at all. It’s like magic.” ~ Dr Zheng-Mei Xiong
If you fancy a simple experiment - put some 1% on you skin for an hour (it will come off!) - it was for me remarkably hydrating.
Do you have the name of this study?
I'm taking a microbiology class right now, and we use Methylene Blue to stain bacteria. I saw the the title of this video, and was like "Why are you drinking bacterial dye"? Most of the dyes we use are labeled as poisons in our lab, so this was intriguing that people are using MB for anti-aging.
and as with all things, the dosage makes the poison @@ChessMasterNate
Yes, but do not mention that : it contains Arsenic, Lead, Mercury, Cadmium and other heavy metals.
It is also chloride.
And the most basic thing for me is that : it blocks the entire solar light spectrum that mitochondria need to produce water and energy through the natural electron chain.
If you block natural light, you create all these dysfunctions of diseases in our modern world.
I some areas it increases aging rather than reducing it.
Needs to be USP or Pharmaceutical grade to take internally.
Well I have been drinking it before bed for 2 weeks and my brain fog and my skin have improved like night and day.
A video about Methylene Blue’s history as an Emergency Room treatment/remedy would be interesting. I’m very curious as to how people figured out they could drink it safely, and I’m not sure what the true ER history is, whether there is truly an old saying: “When you don’t know what else to do, Methylene Blue” but I’ve seen in several places that MB has been mainstay of U.S. ERs for more than 100 years, which if true is pretty interesting considering it’s medical properties haven’t been closely studied. Do a video on all of that!
your curiosity statement can stem to everything mankind have ingested since time itself! lol
Would love to see a video on astaxanthin, specifically the brand Valasta and its unique delivery mechanism.
Thanks, Nick! Isn't there some solid data on using MB for malaria and for cyanide poisoning? I hope you can expand on it.
I've been taking it orally for about 3 months. At 60 years old, it is giving me sustained energy. Also do red-light therapy and heard that's a good combo...
I learned recently that Methylene Blue can disrupt Nitric Oxide which is a very important molecule for heart health. Do you have any thoughts on that?
I want to know more about this
@@ARC_VR Ya me too. I'm bummed that beets are very helpful to get NOx but are very high in oxaIates which aren't good for anybody.
Me too.
If you do enough research you'll find that NO causes more harm than good by a large margin.
My sister was taking this, not sure if she still is.
I was using a lot of other antioxidants but now Im thinking I might give this a shot.
A shot would be dangerous. Just use it orally
@@m4inline got it..take a shot, not a shot👍
I've only been using it for a short while, but the change is remarkable. I'm using a commerical medicinal dilution used to treat UTI's sold by Bjain pharmaceuticals in New Delhi. It does also increase my BP, which is the one bad side effect. It gives a tremendous boost in energy and cognitive ability from just a few drops in my morning coffee. Definitely the real deal.
Thank you for sharing, Jay.
@@Physionic No worries. Thought you might want to know about the BP thing. It's not an insignificant increase. My 32 year-old daughter tried it and also found it effective.
Where can I buy it?
@@opamp7292 E-Bay, as a homeopathic, shipped by international mail to US. Try 3 drops/day to start, go up/down from there. Keep close track of your blood pressure.
What is BP?
Why is everyone talking in acronyms? 😮
It's an electron acceptor, so it will help balance NADh to NAD+ ratio, but there are better alternatives.
What are the better alternatives?
@@deborahbattleson2226crickets
@@deborahbattleson2226 someone above said " We already have other molecules that perform the same functions that we know are safe. We have a slew of antioxidants glutathione being only one of many. We have the salvage pathway to vastly increase the recovery and reuse of NAD+ efficiently generated from NMN. We have AKG possibly the most efficient fuel for ATP. We have molecules like spermadine to protect DNA. Cyanidin and fucouidan to activate SIRT 6. Quercetin which perfoms many functions. Fisetin which when used correctly is a powerful senolytic. Many more."
hey Nicolas, first of all, I'm so happy to see your channel blow up! You definitely deserve it, great content.
Secondly, I have sort of a request. If you're planning to make more videos about methylene blue, could you please also explain how and why does it somehow interfere with SSRI's? I really wanted to try it out, however I'm on Escitalopram and taking MB could have fatal consequences, at least that's what I read. I'd be very interested in your explanation about how these two drugs interact in a deadly way. Thanks!
Dr. Been, has a video on MB. He says it is MAOI inhibitor, thus interacts with SSRI to raise the blood pressure and give hypertensive crisis.
Syrian Rue tincture is also an maoi and has a similar effect but is natural. If I was you I would ditch the SSRI and experiment.
my wife used methylene blue to get off prozac and Adderall . quit cold turkey and started taking MB for 2 months and it worked for her
Hi. May I ask the dosage age uses? How many drops and is it every day?
@nadianiyazi7250 she was taking a 00 capsule and filling it up about 90 percent. I think about 20 drops . and swallowing it twice a day . I would always start with less and see how you feel and then go up.
Your approach is amazing. Like. My best loved old Professors, for some reason everything you say gets etched into my brain.
Used MB twice hoping it would help me. I went through massive stressors some years back (I was 51) which almost killed me really. It has taken me years to regain some health and brain function. As I age it has gotten harder to mitigate the detrimental effects of stress. So I've looked for things over the years that might help that process, MB is one of the things I tried. The first time I took it it didn't seem to do anything for me. I am very cautious about the things I take (especially experimental things) because I've learned over the years that they can crash me. So I took MB for a short period of time according to most directions on the net. It really didn't seem to do anything for me so I stopped taking it. I tried it again some time later and it had a very detrimental effect on my brain. My brain function was already bad enough but MB made it many times worse. I could not think at all, made my brain hurt and it felt like something had taken over my brain. It took a little over a week for the symptoms to subside. It wasn't a pleasant experience. Won't do it again.
I got shocking headaches but I believe it was detoxing chemicals out .
I took a break now back having low doses
5 drops 💦 in water
Also depends on quality and where u bought from it could have heavy metals in it .
Hope your doing ok .
Try a parasite cleanse
Yes we should not jump to conclusions. We already have other molecules that perform the same functions that we know are safe. We have a slew of antioxidants glutathione being only one of many. We have the salvage pathway to vastly increase the recovery and reuse of NAD+ efficiently generated from NMN. We have AKG possibly the most efficient fuel for ATP. We have molecules like spermadine to protect DNA. Cyanidin and fucouidan to activate SIRT 6. Quercetin which perfoms many functions. Fisetin which when used correctly is a powerful senolytic. Many more.
Please provide info on using fisetin
@googbert Rimon on Wellness Messiah recently reported on a flawed test showing it was ineffective. Fisetin is a class of molecules called polyphenol which is what gives color to fruits and vegetables. Among its uses is as a senolytic which means it programs old worn out cells that don't function, don't reproduce and can excrete toxins damaging other cells to die. I think it comes from strawberries. It is identical to the molecule quercetin except for one additional OH group. The flaw in the test was giving the mice small doses daily. Rimon says that the proper dose is 20 mg per kg of body weight once every one to three months you want it in your system in a high enough concentration and then out. So I weigh close to 240 pounds which is 110 kg so my dose would be 2200 milligrams or 2.2 grams. That's 11 20 mg pills taken at the same time. Rimon,if you're reading this tell me if I got anything wrong. I suggest you visit his site. He'll even tell you why he disagrees with some things David Sinclair does.
Thank you once again for a really comprehendible explanation for the person with one or two biology classes. I hope to thank you in person one day. I shall be the person with a bluish complexion.
😂😂😂❤
If it is so good at blocking UV does it impede vitamin D production?
I would guess yes.
@@Physionic you guess wrong
more research : it contains Arsenic, Lead, Mercury, Cadmium and other heavy metals.
It is also chloride.
And the most basic thing for me is that : it blocks the entire solar light spectrum that mitochondria need to produce water and energy through the natural electron chain.
If you block natural light, you create all these dysfunctions of diseases in our modern world.
Just found out methylene blue inhibits nitric oxide synthesis… how can you take the MB for mitichondrial and immune support, while keeping healthy nitric oxide levels for cardiovascular/ immune support.
In surgery MB would be used to mark cancer cells often in breast cancer surgery, lymph node tail marker as well in radical breast mastectomy
7th week,15ml every morning. thinking is clearer and endurence is up.
Can you look into molecular hydrogen and the studies which talk about the health benefits, it apparently works at reducing ROS as well.
Thanks for explaining this. I agree with you, its better to wait until this has more studies on it.
It has been used for over 100 years.....how much more waiting?
What scared the hell out of me was seeing a picture of a cross sectioned brain where apparently methylene blue had dyed the whole brain a blueish tint. If I hadn't seen that I was probably going to order some to try.
It will dye living tissues temporarily yes, but not permanent, only permanent on dead tissue etc.
well yes that is something it does but of course the person was taking way too much. Have you ever seen a brain of someone that drank too much water too fast? it will be twice the size of a normal brain and they will be dead. you only need to drink 4 gallons of water in 1 hour without sweating or peeing and this will happen. too much of a good thing is not good.
I've seen that too, but that was the result of a seriously large dose. Perhaps even in a hospital setting to reverse cyanide or CO poisoning. This dye will leave your organs if you stop taking it.
We used methylene blue in radiological imaging as a substance that shows up under
infrared. Injecting it into a milk duct in the breast allows that duct to show up under IR in surgery and be removed. Is this the same methylene blue??
thank you.
Loving you getting your geek on ❤! Thx for the methylene blue info !
I've been playing around with this applying it to the skin, super diluted so it's a very pale blue water. The first two days I had too much energy and couldn't sleep so I backed off. Also it made my kidneys cranky. Today I started again and splashed it just on my face. A couple of effects: it instantly clears the sinuses and gives mental clarity.
What I have seen no one address is whether it affects the gut biome adversely. Isn't this kind of an obvious question ❓
What do you think about Brian Johnson's ideas and protocol?
I have been trying to take this since I struggle with low energy. Even just one drop in the water sometimes irritate my stomach. I want to be able to get used to taking it so that I can increase it to about 5 -10 drops..... >_
I've been taking MB for 6 years at the 1mg/kg level (5mg/kg is considered max safe). Wonderful stuff, I mainly started taking it for brain and eye health but it is beneficial for many other things.
Where can I purchase it, thank you!
Is there specific time you have to drink it? Before or after meals?
Interesting. Do you take it oraly or IV?
what (specific research/anecdote) made you take MB? what are the other benefits you mentioned? Any side effects (like turning into a smurf)?
Can you list the things that you find it beneficial for? I only take 0.5mg/kg. Would I be better off taking a higher dose?
Yes! Run advertisements and keep doing what you love. It’s not selling out, it is providing the means for growth. It would not sway my opinion about your work; your research is high quality. Just sell as much sponsorship as you can and survive. This is growing pains and it is good!
I am sure it will come as no surprise to you Nick that the Stapler is a heavy meth user. Being a 1960's model stapler I have a lot of electron slippage I need to control. Seems to have subjectively helped with mental clarity to a degree. Blue is also used even today in hospital ER's to treat various forms of poisoning. My wife once had a bad reaction to an over the counter, rash and some difficulty breathing. A shot of meth and 30 seconds later she was fine and back to nagging me as usual. It also makes a phenomenal carpet, tongue and teeth stainer - The Stapler
I took it for a couple of months because it's supposed to have neurological benefits. I'm in my 60s and I'm having a really difficult time with my short-term memory which is an unnerving experience. I think it was starting to help but I don't think I took it long enough. I also think I might have been taking too much and that is why I was having stomach pain. There is supposed to be a point where taking more rather than less is counterproductive. When I did stop, I was surprised that it took me 3 or 4 days to stop streaming green urine.
1-3 drops a day works wonders....
@@masterspin7796 I was doing 1-3 droppers full.
If your pee is green/blue you are taking too much and are literally peeing $$$$ down the drain. Spread the dose out over the day and/or lower it. over-saturation is bad and MB at that point will cause more problems that it fixes like high blood pressure.
@@Dodgerzden WAY TOO MUCH yikes even worse if you took that much just once a day and not spread out with 1 dropper full 3 times a day. Most only need about 10 drops of 1% 3 times day. A little goes a long way. Now if you have a UTI then doing what you did is the way to do it until the UTI is gone.
@@macheadg5er I think at the end I was putting it in my coffee and slowly siping on the coffee because I didn't taste by doing it that way.
I LOVE supplementing MB, feels amazing
Another medication that is more chemical in nature is Dimethyl sulfoxide (DMSO) DMSO. Have you ever done a video in that? I'd like to see it if you have.
when I was a kid I often used methylene blue to treat a tank of tropical fish that had some fungus ick
Chris Masterjohn PhD has the most in depth analysis of MB that I have seen.
Thank you for this exciting new information. forward to learning more as more research is done.
Thank you. Will try it! Also switched to Statins from Niacin based on your reading of the research, particularly when it is not expensive and I have a good cardiologist.
Wowza, if this channel is promoting statins, known to cause a myriad of serious neurological problems, I'm out.
Try nattokinease instead of statins
There isn't much data on it as an anti-aging drug, true, but there is tons of data on it. It isn't really a strange compound, but its interactions with human biochemistry is absolutely unexpected (I mean once we understood it's properties its interactions make perfect sense, but it is pretty weird that blue jean dye just happens to have those properties)
Decreases connectivity in visual motor loop, and can cause hypertension.
Fun fact: A "kicker," also called a side card, is a card in a poker hand that does not itself take part in determining the rank of the hand, but that may be used to break ties between hands of the same rank.
It's an old gambling term. Now you know.
Been taking 5 drops twice a day. Not sure i would want to live without it. Cured my life long cronic fatigue
That sounds amazing
I just started taking it again, after being off for months, due to crazy fatigue.... which caused some depression. The MB fixed the depression almost immediately..... and is helping with the fatigue as well.
I have a question...Curcumin inhibits ATP-synthase to reduce the number of ATP molecules, and that is supposed to be good. Doesn't Methylene Blue do the exact opposite by supporting ATP-synthase? Why are they both good?
Sounds like a good question
Thank you for this video. I just have vitalia pharma solution use extern 1% liquid can i use this for my health??
@physionic I got pulled into using OneSkin the key ingredient being the OS-01 peptide. It was hawked by Dr. Sinclair on this podcast. Anyways, I was hoping to get your intuitive feeling on what would have better synergy. OS-01 with methylene blue, or 0S-01 with retinol A?
I only learned of the existence of Methylene Blue a couple of weeks ago, through some channel called Nootropics or something like that. Anyway, in the comment section, the guy who posted the video answered someone's question...the person had asked if there are any other supplements that should not be taken whilst taking meth blue...he said CoQ10 should be avoided (and another couple, which I do not remember). Do you know why this may be?
I'd guess he thinks it's be pointless considering electrons are being delivered directly to complex 4, but if that's his thought process (no idea if it is), then he's forgetting that Complex 2 also delivers electrons. Either way, he may still be right, but I don't know for certain.
@@Physionic Thank you. I take CoQ10 so was curious. I think I shall wait until I learn more about meth blue before considering it
apparently SSRI's may risk seratonin syndrome with MB (also since MB is an MAOI inhibitor watch for aged cheeses, fermented foods and the like) ...so i've heard
@@redberries8039very interesting! can you expand on this? I have a very high fermented food diet due to intestinal issues.
@@redberries8039 True. Sounds like the problem has only been observed with IV dosing in the 1 to 8 mg/kg range. I've combined low dose oral MB with an SSRI without any problems.
I'll have to dig into it, but I remember MB being related to radiation, as in taking to help stop radiation poisoning
Good report. thank you.
Fun video! Thank you. 🙏☺️
I tried the earth harmony brand and very slowly worked my way up to 15 drops a day but started getting light headaches and other symptoms of seratonin syndrome. So I stopped for a few days and tried again. Now I have those same symptoms even at 3 drops a day. I’m not taking any contraindicatiors. The earth harmony brand is pharmaceutical grade but has something called liquid gold which the BpH brand doesn’t. Do you think I should switch to BpH ?
i think that one is concentrated. too much of anything is bad