For dosing, application, and other details - I cover those topics in the full version of this video, found in my Insiders Site: bit.ly/PhysionicInsiders *My recommendation for a NAC supplement* *: amzn.to/3YIfScO *My recommendation for Glycine supplement* *: amzn.to/3S7Upr6 Both links are affiliate links - however, I have no relationship to either brand. * = Verified via independent laboratory.
I made it to the DNA repair section - and I’ve been taking 12 grams of both NAC & Glycine for the past 2 years (ever since the first study) - I’m 52, and I am at my healthiest and physical best in performance in my life.
@@osbornecyber - recommended 6 - 10 grams of each split for twice a day dose on an empty stomach. You can go higher if tolerated. I started at 6 grams and I'm now at 8 grams...about a week trial for each increase. Also check for need of folate and B vitamins to go with. I'm researching now.
I am a physician and watched your clip a few times- May God bless you for the depth and breadth that you put into the preparation of this clip- Best info I have seen on TH-cam yet!- Thank you and please keep them coming
@@andrewj4426Drs really know nothing about supplements! I hate when someone says speak with your Dr before taking something n see what they think. What a joke. The only thing they know about are big pharma drugs. My Dr didn't even know what kettlebell training was when she asked me what type of exercise I do😂
I m here…at the DNA repair proteins…and this is not only fascinating, but you explain it so well that even I can understand it! Thank you! My husband was diagnosed with stage 4 cancer 2 months ago. I discovered your podcast about studies combining fasting (causing autophage) with chemo. We do intermittent fasting, 20 hours a day. He was considered terminal, and two months later his blood levels of alpha fetylprotein show barely any cancer left! A short way to go, but the doctors are amazed. (We also cut out sugar, carbs, starches and most sugar substitutes, which ‘feed” cancer according to some other studies I found.) These studies need to make it out to the general population, and you are helping make that happen!
I had to chuckle when you mentioned that 80% of your viewers skip to the conclusions in your videos, but I am not one of them. I do not have the background to process most of the research studies you cite, but am deeply interested in gaining some insight into their outcomes. You are my Rosetta Stone that bridges my world to this knowledge. You have the ability to consume this research and pigeonhole all of the useful nuggets and, in turn, allow me to attempt to gorge on those morsels. Not only do I consume your videos in their entirety, but I frequently find myself rewinding and re-reviewing items that I didn’t understand the first (or second or third) time. You are a marvelous resource and I very much appreciate your exhaustive efforts. It opens up a view not typically available to a layman which allows me the equivalent of speed reading with my eyes closed. 😊😊😊
I watched this video all the way to 57.43. Mesmerized!! I’m an 83-year-old female who has been playing “supplement roulette” for years in an effort to avoid all contact with allopathic physicians. Your information and the way you present it have cleared the air for me. As soon as I make a few financial adjustments, I will join your Insiders Club. Thank you for being who you are.
Interesting. I'm curious how you decided on what amounts of glycine and NAC to take. It would be amazing if it really is having an effect, but if you feel good, that in itself is a good thing.
I'm a physician/nerd and made it to the DNA repair section. Your videos are fantastic and I often send some of my more inquisitive patients to some of your content for further explanation. I'd comment more, but this video is 4 months old and I'm not sure you'd even see this comment at this point! Keep up the great work.
72 yr old welder with a 6th grade education commenting on you teaching @ minute 33:20, dude I am learning to learn. The problem if their is one, your making sense. I am able to communicate with you thru grace of God and spell check. I can not afford to be an insider, of which you deserve just compensation. I admire your father as I see him in you, I liked your video with him and his coffee shop/mugs. In 1957 @ 6 yrs of age I wanted to build a DNA module out of styrofoam. Thank you for your time, I am living my dreams. mike&gina in Tennessee, in Love, in Christ
this is science not god. according to science there is no evidence that he exists. So why are you using god and christ in litterly every second sentence of your comment which is commenting science?
I'm 47 and started taking GlyNAC a couple of weeks ago, and the changes are mind-boggling. Better mood, more energy, no pain anywhere, tinnitus gone, WAY better attention/focus, no brain fog ever, no sugar cravings, more motivation. What the hell?! I'm shocked out of my mind. I thought I'd maybe feel a little more energy--this was not expected. Why are we not hearing more about this?! Edit 4 months later: I still take it every day with breaks now and then because I do that with most of my supplements. I still feel much better when I take it, but it doesn't effect me as strongly as when I first started. I DO still feel better mood, less brain fog, easier sleep, and simply better in general when I take it vs not. Just like with any supplement, it will effect different people differently. Clearly, there's something in GlyNAC that my body really wants/needs. Perhaps it's something I don't naturally make well or don't absorb well via food. If it does nothing for YOU, then maybe you just don't need it and should look elsewhere for something that clears up your issues. Also, I don't know what about my post triggered demanding people, but people who comment on youtube aren't here to be your answer bot. Do your own research. I did mine, and don't know why people can't do a "what's the dosage for GlyNAC" google or AI search... or just look on the friggin bottle when you buy it.
I started taking 600 mg NAC and 1000 mg glycine per day about 2 wks ago, and think I am feeling more energetic. Just curious as to what dose you are taking of each--
As you requested, I'm writing to let you know that I made it through the part where you described the DNA Repair Protein's activity in the repair of DNA damage as it winds around the histone proteins. I have to say, you're the first researcher that I've heard, mention the process of Ubiquination. I am incredibly fascinated by the topic of epigenetics! I got my introduction to the topic by reading Nessa Carey's book "The Epigenetic Revolution", where I learned of methyl- and acetyl- epigenetic tagging, to increase or dampen the transcription of the tagged portions of the DNA molecule. I was in intellectual heaven! I hungered for more so I bought a textbook on the subject and quickly realized that I didn't have sufficient brain power to assimilate and utilize all of the data that was quickly being yielded by the nascent field. Thank God for scientists/researchers like you! I appreciate your breaking down the research and science for mere mortals like me!
Made it as well, this was well presented and the slides are awesome. Fascinating how brainless proteins can repair tagged, ie phosphorolated sections of DNA. Another topic, but amazing.
Listened all the way through. Your detailed explanations are immensely valuable & greatly appreciated. I’m a 32 yr old Truck driver & your videos are helping me fix & repair health issues I’m experiencing so I’m very grateful for every detail. Thanks
This 69-year-old woman, in the middle of a 4-day fast, deep into ketosis, and très nerdy (took a bunch of calculus, chemistry and physics courses a few years ago - new stuff for an art history major) decided to watch this video that TH-cam kindly stuck into my feed, and it was ABSOLUTELY FASCINATING!!! Hell yes I made it to the DNA repair proteins and continued right on to the end. I'd like to watch the Insiders' material, but the paywall is too steep for me (I'm a woman who majored in art history, for god's sake; my Social Security income is a pittance!). But I'll find out what the recommended dose is, never fear, then mosey on over to Amazon and get me some of this stuff. Thanks a lot, kid. I've liked, subscribed, and signed up for all notifications. I look forward to watching all your previous and future videos. *I just noticed your pinned post, where you give recommendations for dosages and brands. Thanks!
I started taking both glyNAC and liposomal Glutathione two months ago, after seeing this and looking at a few peer-reviewed studies. I was only taking it for broad generic reasons - but after about a week I suddenly noticed that my ['incurable'] post-chemotherapy neuropathy was noticeably better. After a certain point (around one, one-and a half years), supposedly the pain and pins-and-needles of neuropathy after chemo don't improve. And there is no treatment - pain killers don't work - although for a very few anti-depressants help slightly, but I don't want to mess with my healthy brain and would rather just cope with the pain. But so long as I take it daily, each day it is slightly better, continuously; and now two months on my neuropathy is nearly gone. It is rarely 'painful', mostly just tingling. So is my 'burning mouth syndrome', also something for which there is supposedly no treatment. I'm stunned and delighted. Thank you for putting me onto it - even if you didn't recommend it for peripheral neuropathy! I hope this comment might help someone else.
Taking GlyNAC is great but be aware cells requires different amount of glutathione and you risk to deregulate (having to much) if taking liposomal glutathione, there is a phenomenon known as “reductive stress” when ROS is decreased too much, it can result in cellular damage
Great news. I have a friend with diabetes who said he appears to have neuropathy. It seems that his arms or wrists and hands have a lot of pain. I am thinking this might help.
@@glenntimberlake2413something you may want to mention to your friend is to look at Vit B6 toxicity. When I started taking a B complex, even multivitamin with higher B6, my neuropathy flares up. Super weird but now that I’ve figured it out I like to make sure others dealing with neuropathy know as well.
Be careful with liposomal glutathione. There are concerns that liposomal glutathione supplementation could be dangerous, because of too much glutathione too fast.
Thank you both. Much appreciated. I have mostly been taking GlyNAC only occasionally the liposomal glutathione. A year on the neuropathy is almost entirely gone and I'm thinking of discontinuing or at least taking breaks. I haven't experienced any I'll effects but if course there might be some I don't perceive.
I have never subscribed to any TH-cam channel. Ever. But scanning this video while working late changed everything. Definitely one of the fastest, most informative one-hour lectures I've ever attended. And for someone with inattentive ADHD, that's saying something. As much as I enjoy learning, especially from scientific and medical lectures, I'm never able to watch more than a few minutes at a time and stay engaged, no matter how interested I am in the subject. After about five to seven minutes, I'm a "skipper". But you called us "skippers" out from the beginning. I felt guilty when you explained how it impacted your analytics (I'm also autistic, so anything about data catches my attention). I figured I'd keep the video playing in the background while working in order to help your algorithm. That lasted maybe three minutes. Then I couldn't do anything BUT watch the video. And yes, to the end. That thee minutes was so impressive, I left the work computer, jumped on the home laptop and created a TH-cam account specifically to subscribe so I don't miss any more videos from you. I can hardly wait to wrap up work and get lost in this channel's video library! Thank you, thank you, thank you, thank you, thank you.
I followed I’m at DNA repair I so happy I can follow you. I’m agramma and have the time Abdul have become totally engulfed in mitochondria and atophagy sp? Because since Covid all hells turned my life upside down. So I’m down for alll the info you want to give!
Made it. I am 55 in the worst shape of my life, but I have steady with the help of people like you have been bouncing back. Fingers crossed. I could walk away health till week 0
I'm at the DNA repair section, great info, I'm a 72 year old retired Bio Medical Engineer who dabbles in Sports Physiology and Molecular Science to support my training as a Cyclist and ex Triathlete.. Loving your subjects....well done
Made it to the DNA repair protein section and it’s me who should be thanking you, I have searched a LOT of TH-cam channels and I have never see anything like you presented. Amazing job!!!
Yes, I’m 67 yrs young & have been taking NAC for only 2 months & recently added Glycine & have been feeling even better. I’ve been taking multiple vitamins since I was 10 yrs old, thanks to my mom and I appreciate the deep dive into GlyNac so thank you… I subscribed 😎
I'm 64 and had a triple bypass on June 26. I appreciate you making this easy to understand. I was never interested in biology until I started watching you, now I'm fascinated by it! I got to the DNA study and will stay 'till the end. Thanks!
77 yo and just added to my stack and started taking NAC + L glycine. I'll continue taking for the years I have left. I've never had a health issue except for HBP. Thanks for all the information you provide us. You do a brilliant job. New subscriber.
Thank you a thousand times for this - for an unexpected reason. I began taking GlyNAC after watching this as well as Liposomal Glutathione, since at least one non-rodent study I found said that did escape the rigours of our digestion. A week later out of the blue I suddenly noticed the constant burning pain in my feet from post-chemotherapy neuropathy was reduced. I cast my mind back to what that might have been due to - since I'm well past the point where the oncologists told me it would no longer improve, and the levels I had I was stuck with for life. I could only think of one change to my diet and it was the GlyNAC/Glutathione. Of course there is always the placebo effect - even if I didn't take it for neuropathy and had no expectation it would help. However, that was four months ago. Every day that I took two doses, it was a tiny bit better. Ever time noticed it wasn't better, I realised I'd forgotten one or both doses. Four months on, it is about 75% better, and I'd describe it as 'tingling pins and needles' rather than 'burning pain'; even if I've walked 15 kilometres that day. This is really life-changing for me. I hope it might someone else with supposedly untreatable 'neuropathy'. Thank you for this video!!
do you take the supplement called “GlynacET” on Amazon or do you take the powders that the speaker recommends? My husband has cancer and has the neuropathy from chemo. Thank you
@@Lulu-kt6gr Hi Lulu, so sorry to hear about your husband. I hope this might help but of course it's only one person's experience and might be meaningless. I hope you find something that works for him. I've done two things - and I can't tell any difference between them when I swap back and forth. (1) Liposomal Glutathione (2) 'Glynac' - I bought Glycine and N-Ac separately as capsules on ebay (I'm in Britain, so finding this might be different for you.) So it's a few months off a year from doing this, about 10 months I guess. The neuropathy hasn't gone completely, but some days I don't feel it at all and other days there's a slight buzz or burn but nothing like it was. I think I might need to take a higher dose - routinely I've been taking around 1000 mg of each once a day, but you can certainly take more. One unexpected discovery is if you buy powdered Glycine, it looks and tastes EXACTLY like sugar - amazing, a natural sweetener with no aftertaste that is actually good for you! So I've started adding it to things as a healthy sweetener. Only downside is it's not cheap, so it would be expensive if you made it a total sugar replacement for cooking and baking. But if you can afford it, worth experimenting with! Good luck and I hope it helps.
@@Lulu-kt6gr I have taken them separately (not that brand; I'm in the UK) and as liposomal glutathione. They seem to be equally effective. After a year, it's pretty much gone now.
Don’t worry there are those of us who watch your whole thing and understand what you’re talking about. This is very impressive to me. I have health issues. I’m trying to fix the doctors have it wrong so far I watch all of your stuff and I take because of yourpodcast that’s when I started following you. What an amazing amazing supplement.
Thank you very much for the well-considered content! Watched the whole thing 😄 There’s no need for you to thank people though, it’s the other way round! Keep up the great work 😄
I made it to the DNA portion and find this overall topic fascinating. I have a degree in biology (from about 45 years ago) but only skipped through this aspect of cellular functionality and longevity factors. This in-depth discussion is really valuable, and I appreciate you taking the time to present this in such rich detail.
Just a layman here, a lifetime student of learning, board certified nerd and kudos for your podcasts, I am liking how you break it down into bugs bunny language I can absorb. Now have enough info to begin a dosing protocol for GlyNac. Good work, Doctor Physonic
Of course I am listening to the whole thing. I find it easier to put it on 1.5 times speed but find your presentations. Brilliant! I wish just one of my college professors was as good as you at presenting information. Thanks.🙏🏼
Fantastic presentation! I have learnt so much. In 2008 I was diagnosed with ms; my relapses are more often and my recovery it’s harder and harder. I have never been a fan on DMT’s but after my last relapse from August last year, I have done some intense research on some vitamins and amino acids, and peptides. Wish I had all day to go through this but it’s impossible. Now, I am getting stronger and stronger by the day only because of supplements like glutathione, NAC, NMN, silicium, lions mane, Vit A, D + K2, and some others. If my health condition is being kept under control is not because of the DMT’s, it’s because of the extra supplements I have been taking. But this is what I do for me; please do your research and read about all side effects and what might interact with what ever other meds. I’m not on any atm; just vitamins, good food, god’s blessings and being mindful of triggers around me. And my both arms swing back and forward during walking just as a it should. I’m so grateful for such videos; I am healthier because of such videos. Thank you so so much.
Pay attention to directly supplementing with Glutathione as some studies show it can reduce the bodies ability to produce it. NAC and Glycine seem to be much better as they are percursor of Glutathione and the body will be producing it on it's own with this raw material...!!!
I’m 70 and have been taking glynac for a month,the change is amazing!Anyone who’s older needs to give this a try,it’s unbelievable the energy and the way I feel since taking this is just fantastic 😊
As a fellow engineer I love this type of nerdy videos. When it comes to the human research I would love to see more details on lifestyle for compared groups. For sure the 24 years old are mostly healthy, but 74 years old would have loads of health issues, and would take number of meds. Their diet would probably also look different. I would personally rather see hbA1C in the insulin resistance stats then HOMA - IR. By all means I loved that video and it flew like 5 minutes to me. Please keep them coming 😉
I would love to see that, too, N. Thanks for the support - you're not the only engineer I've heard from, but I love you guys (the way you think). Thanks!
yes, hba1c is for sure one of the most important markers. and because blood tests are usually done in a fasted state, a PYY, GLP-1, CCK measurement would be very interesting too and a correlation with HOMA-IR and hba1c
@@ERICROJO156 nothing wrong nerdy. It's just the interest in a single subject or type of information above and beyond any casual interest. I personally nerd out daily on various subjects. It's how I de-stress and engage my little kid wonder at the marvels of the world.
Well I must live on a different planet because most of the @70 year-old persons I know do not take a "number of meds". They have some health issues I'd say but don't run to the gp for help easily. They take suitable supplements, love nature, eat well and are not indisposed. What might be particular about them is their curiosity about learning and life. Life-long learners who continually adapt. In these cases, the old model idea of what age sort of looks like, is not followed. One of my relatives said 80 is the new 50. She bikes daily and wins in her handicap at golf continually. She is just one of the coterie I mentioned.
Made it from beginning to end. Loved the in-depth of each study. My husband and I are both type 1 diabetic (we met at diabetes camp back in the early nineties 🥴). So we have spent our lives doing what we can to maintain our health and prove those predictors outcomes for us circa 1980s medicine as wrong. Five kids and a life full of mountain biking, road cycling and backpacking later we are still looking to do better. This is super promising as something to try. Thanks!
Try the Coimbra Protocol with lots of vitamin D but only under a physician's care. It helped a friend of mine regenerate his pancreas through stopping all the autoinflammation in it.
I'm a nerdifiable 63yrs old and I've made it to the DNA repair section. This is absolutely fascinating and I will definitely share. I'm now going to start taking GlyNAC. Thank you!
I watched the entire video and subscribed. I would like to thank you for such a detailed explanation. I started taking NAC and Glycine months ago after I briefly heard of the benefits but I was too lazy to review the studies. Personally, I think you did an excellent job reviewing the studies.
Hi from the 🇬🇧 I watched the whole video start to finish. Thank you for explaining everything so well. I am 67 and I have started a lifestyle change to improve my health and fitness. I am researching the science to help me understand the things I could be doing to improve the odds of a long, healthy life.
Hello, I am a business nerd at heart but I find the human body a fascinating machine.I am searching for a healthier longer life like most people watching this channel. After watching just one of your videos I got hooked. I subscribed and been watching it for weeks now. My wife tells me to change the channel and stop geeking out. I told her your content is not only well thought out but extremely fascinating. Great job and keep up the amazing work. Roger
As I understand it, one can take glycine and NAC together as seperate supplements; they don't have to come combined in one supplement. May be a lot less expensive to get each of those separately.
I was riveted through the entire presentation !!! Nerd alert!!!! I am female, 65 and have been taking GlyNac for about 8 months. The DONOTAGE product is what I started with but I feel it’s insufficient so I take it in powder form also 3 to 1 glycine to NAC. I’m 5’6” 135 lbs, I do yoga 3 days a week and various workouts the 4 other days. I have been intermittent fasting since 2019. Focus is build muscle, retain flexibility and have fun !!
I teach AP biology so I love this material! Part of my job is trying to get kids to read primary research. Watching your material is helpful for students to think like a scientist.
Im not a nerd. Im older and I do watch your entire presentations and empliment them. Im a female, in her 70s going on 50ish 🤷♀️. I do appreciate all the work you put into these presentations. Thank you for all you do.
I got to the DNA repair section. This is at least my 3rd time. I was listening during my massage this morning and my massage therapist asked me to forward this to her and later same day was listening to the rest when a nursing friend got in my car and she asked me to forward to her as well. Many health minded people are interested and enjoying your material, myself included!👍
I made it to the DNA repair section. I'm in my 30's and got type 2 diabetes 4 years ago. I'm not what you would consider overweight (not ever in my life) and the information doctors were giving me on diabetes was the total opposite of what I'm seeing with your videos. I'm still fighting to reverse my diabetes and your videos are a great help in understanding what this battle is all about. Thank you.
You might consider supplementing with a whole food source of Glucose Tolerance Factor (GTF) chromium. Back in 1959 an NIH study found that a deficiency causes diabetes. Gluco-Sugar Balance by Food Research has been recommended.
@@chidude I've never heard of GTF Chromium. If you have the chance send me a link to that NIH study you're talking about. I found one but I don't think it's the one you're talking about.
I am 73 and started taking a glutathione supplement orally that reduced the components of glutathione to nano sized particles for instant absorption via sublingual. I was recovering from covid19 and found within 2 weeks my ability to workout was greatly enhanced. After 4 weeks it was greatly enhanced, and I no longer had to use my knee braces to support my impaired miniscus on my left knee and a patella on my right knee that had been fractured 2 years earlier and had not healed properly. That was last September. I know can play pickleball several times a week here in Florida 2-3 hours at a time, without using knee braces, and I outlast most seniors my age here in The Villages. I just ordered NAC and Glycine to be part of my daily vitamin supplementation, but I get instant recovery using my hyrostat glutathione in between matches anytime I start feeling tired. I do maintain my electrolytes during play, especially with summer tempartures now in the 80's and 90's.
Not only did I get to the DNA repair part, but as a first time on your channel, I enjoy your educational style and cadence, and have learned some things I didn't know. And, yes, I am a nerd, lol.
As per instructed, I am at the half way point, DNA repair. I am 74 retired IT/Cyber DIY guy who 5 years old went back for a Masters in TESOL and a move back to Japan for better lifestyle and food so I could lose weight and gain back some health. The Masters research taught me about research which I am thriving on as it relates to aging. In my IT prior life I spent 5 years at NIH/NIA as an Info Sec guy in an environment that greatly concerns me as I get older. Why is it we wait till it is almost too late to do anything about it? I did my thesis on Teaching English to elderly Japanese (average age 83) that have a great concern about preventing dementia. I learned from my students. I want to do anything and everything to live a full energetic life as long as possible. So Now I march down the supplement trail based on the evidence and research in the literature so easily available at ones finger tips. Please continue your current format, nerds need details, details, down the rabbit hole we go, and yet if strapped for time, jump ahead to the conclusion. Great channel, now I need to get my OLDER Brother a retired Medical Dr. to see this video and channel. From the Outskirts of Tokyo at University while I teach IT in a science dept with Micro Algae experiments.
I love videos that give insight to the science and biology behind nutrition and supplementation. I’m not in the health field in any way. Yet, it’s my greatest area of interest out side of my profession. Your break down of the studies was very helpful. Usually I read the stories on my own, annotate it, and then share the info. Thanks for the short cut. Videos like this are are better than binging a Netflix series. Thanks for sharing this info with ALL the details! 👍
Yes, I'm following all the way to the end. You've taught me a lot about the microbiology of the cell. I'm 72. Also, I started glynac supplements because of your explanations.
I really love and appreciate your complete review. Perfect. I am a naturopathic doctor AND science geek who is profoundly aware how little people understand the research, and by people I include doctors. So THANK YOU.
I also made it through the dna section. I find it not only useful, but really fascinating. You explain how it works in an easy to understand manner. Thanks for making it enjoyable.
As a fit 64 year old I found this study very interesting and I did watch till the DNA repair protein and will watch to the end, so far this looks very promising fingers crossed no cancer risk 🤞
Yes, I`m at the DNA repair. I`ve watched this more than once while learning more about it all. NAC has helped me a lot and because of you I`ve added Glycine to the mix along with Taurine and others.
Tremendous explanation. I learned about this combo, read the original papers and have been using it for ~ 2 years. My health has never been better. I dance in and out ketosis effortlessly, like a young child. So, I eat carbs, and I still generate ketones. Meaning, to me, I get access to all 3 major fuel sources all the time. One interesting thing I have noticed is that my caffeine sensitivity seems to remain/reset at the caffeine naive user level.
Me too!!! I’be been taking 12 grams of each a day split into a morning and evening dose for the past 2 years…. I weigh 190 pounds with approx 10% body fat and I am 52 years old - What dosage are you taking
@@lynnwilliams5432 The science seems to show that for longevity it pays to eat protein on one exercise day per week, or even every two weeks which is how long it takes to lose the benefits of a day of exercise. But then go low protein the rest of the week and fast for at least 36 hours once a week. Also, HIIT is good for autophagy, not sustained exercise. Not advice, just what I'm learning.
I'm a nutrition and body hacking nerd. Thank you for taking the time to analyze all this data. You earned a new subscriber 😎. I've been using NAC since early covid.
This stuff is so interesting. Im just a regular person but ive been researching how to get healthier after having my gall bladder removed 3 yrs ago. Its caused so many issues. These detailed videos going over studies and results really help lay people like myself make informed choices on what to take. I started NAC, Glycine, Taurine and 3 other supplements and Im finally feeling better. Thank you for doing these deep dive videos.
I got to the "nerd out" point. I appreciate the in-depth explanation. At 49 and in excellent health, but starting to learn all I can on increasing longevity and reversing age. I can tell you as an avid surfer for the past 15 years, I contribute this to looking much younger than my age. Trying to live stress free, giving up alcohol 12 years ago and trying to eat as healthy as possible have also been contributing factors. Trying to do everything to avoid Alzheimer's Disease that my dad has and his mom had. Thank you for this video.
The orthosilicic acid form of silica found in Fiji water is known to help detox aluminum from the brain; aluminum toxicity leads to Alzheimer's. To save money you can make the equivalent of Fiji water via Dr. Dennis Crousse's "silicade" recipe.
Made it to DNA repair and have been taking NAC/Glycine for a few months plus DMG. I intermittent fast daily, am physically active, and have never been in better health on all levels. Im a 25yr cert. Nutritionist, been studying health and nutrition mainly as a passion and personal health, but give suggestions to others almost daily. I really enjoy the breaking down of the processes because it helps me articulate my knowledge to ppl. For example, yesterday in the grocery store, trying to educate someone on nutrient inhibitors in certain vegetables; even though I understand, its good to have proper understanding on all levels before introducing to others.
@M.C. Who should not eat oxalates? For most people, oxalate is completely harmless, and they simply pee it out in their urine. But for people who have a tendency to form certain types of kidney stones, eating a diet high in oxalate can increase the risk of another kidney stone.May 4, 2022
@ladydrgnfly921 Dimethyglycine: A naturally occurring derivative of the amino acid glycine which supports the bodies metabolic processes and promotes neurological and brain function.
Dear professor, your words are a gift and your desire to educate people that wish to help themselves is beyond generous. I am a high school dropout and I can understand you 😉. I have been taking many supplements and generally I have a very healthy unprocessed veg diet. After 2 weeks of supplementing with NAC at 600mg 1st week to 1200 mg 2nd week I have felt physically better, at 48 years old I have noticed my energy is improving, less tiredness and greater muscle energy and less stiffness. 💪 To note I have noticed less bloating from food at the 1200mg per day, I am losing weight, fat, not muscle, it appears.
Hi, so i also made it to the DNA repair section. And actually i am a big fan of the detailed explanations, of understanding the mechanism in general. There are to many of those, who tell us the conclusions alone, and to few of those, who, like you, take us through the entire journey of „how“. Great job, thanks!
Thank you for your analysis of these foods. I usually combine Glycine, NAC and Glutamic Acid every night before bed. I knew that combination was a great way to clean the cells. You gave me a lot more information about the underlying mechanisms. I appreciate your time. By the way, I don't think it's a good idea to eat NAC without also eating B-Complex. Otherwise you increase the risk of increasing Homocysteine in the blood vessels. I think homocysteine is one of the leading causes of diminished metabolic capacity as we age.
"Hey! I got to the DNA repair proteins!" :) As a 69.9-year-old UK man, I've experienced firsthand the transformative power of changing my diet. This led me to explore biochemistry. After struggling with numerous health issues for over 25 years, adopting a keto/carnivore diet has freed me from conditions like nodular scerising Hodgkin's lymphoma, type 2 diabetes, and more. This led me to explore biochemistry. As a former electronics/computer engineer, I find your videos fascinating and appreciate how they allow me to "nerd out" while expanding my biochemistry knowledge. Although I may not grasp everything, I can follow your explanations, and I'm grateful for your efforts. Thank you for sharing your knowledge and helping me broaden my understanding!
I found this very interesting. Thank you for the in depth information. It would be interesting if a similar study was done with varying dosages of GlyNAC to determine if there is a dose dependent benefit of this supplement.
Hey, I got to the DNA repair protein section! Although I have to confess that a lot of it is over my head, but that's why I like it when individuals like yourself break information down for the rest of us.
Thank you for this presentation. Have been listening to podcasts about mitochondria/ oxidative stress/ autophagy/ Glutathione/ NAC/ glycine etc, for years. Cannot say, that I fully understand it however am familiar with all the jargon. I feel you have explained this study sooo well. Will pass this video to friends as it gives a very clear explanation of the possible benefits from supplementation and it's connection to oxidative stress. I do sometimes wonder whether it might not be necessary to supplement daily but rather a couple of times per week, to get the same effect but studies don't seem to attempt this. Need more "groups" in these studies.
Made it to the DNA analytics. Tried it myself: Sinuses opened, lungs opened, and energy increased significantly over time. 3.5 weeks in now. I've had no headaches in 3.5 weeks.
I made it to the halfway point. My reason for watching this is because I have been supplementing with glycine and NAC every day(since 3 months ago). It's not an easy routine to upkeep unless I have a strong conviction for doing it. I put my body through a lot of stress(exercise, 22% incline, tredmill HIIT's, 1min sprints/30-60min), and I experience a lot of inflammation. I love the workout, but my heart hurts after a good one. I do everything I can to downplay the inflammation and take glycine, and NAC is one of my ways. I appreciate finding out why glycine and NAC supplementation works backed by real evidence. I don't really have time to properly research the subject or have the necessary background to understand this kind of material. I gotta say that I couldn't have understood this without physionic's thorough explanation. Thanks, brother.
I watch the whole thing and enjoy it very much. I am 78 years old former scientist trying to figure out if my quality of life can be improved. You really left me in suspense regarding study 119 which I will read for myself.
Just discovered your channel. Am older white male; 6ft 3in, 205lbs. Recently learned abt autophagy via cardiologist in FL. Was eating in time restricted window already. Changed to 6 hr window a few months ago. Have been taking NAC, Quercetin, Vit C, Vit D, and others thru-out the pandemic. Vit D blood level is at 70 ng/ml. Watched all of video. Found it very interesting. May look into Glycine. Have been a distance swimmer for decades. With time limited eating & much less sugar, think autophagy is wrkng. My blood pressure is at normal levels. Sleeping pulse rate was in low 50s. Recently is consistently going down to 48 to 44, on most nights. Very well done video. Many thanks. 🤔🤔😁
I’m 73. Healthy and thin. Very active. Watched the entire video. Very fascinating. I’m definitely not a nerd! But great job explaining this to a non nerd. Began supplementing recently.
Hi Nicolas, I saw the whole video, it's not new to me as I already saw much other vids before here on TH-cam. That said, I found your presentation relaxed and easy to understand 👍 I'm personally taking those supplements since arround one year, NAC = 1800mg and Glycine = +/- 5gr every day and don't feel any side effects. But, I've to confess that I'm taking also a big numbers of supplements like fisetin, AAKG, CoQ10, glucosamine + MSM + chrondroitine, lithium orotate 10mg, spermidine, citicoline, piracetam, sulforaphane, lutein, zeoxanthin, tumeric, quercetin, NMN, resveratrol, creatine, magnesium, zinc, b-complex, vitamin C slow release, etc... and doing some power lifting and love to walk. I'm 61 and freshly retired, so the stress factor is also down. I'm taking glucosamine since my 38y because of a knee pain and never stopped taking that, the pain only came back if I stopped for 3 weeks or so... I think this supplement do make me look much younger than my age, people are always surprised when I say my real age. My 3 sisters are just a bit older (1-2y), no one took that supplement and they all look their age (we have the same parents)... Hope this can help other people looking for healthspan/lifespan.
I literally just took a screen shot of your comment to order some products for my mum. Taken together you must experience a great synergy of effect with a supplement regimen as comprehensive as that. It must be v.expensive on a monthly basis though, do you recommend anywhere in particular I imagine you source them from multiple places but I’d love to hear if you’ve found a way to cut costs? Thank you in advance 😃
@@AS-gz8oe Hi, I'm from Belgium, yes indeed this is at all not cheap, you've to look for the best price you can get into your country ! 12y ago I was a smoker and when I decided to stop with that costly addiction, I tought it was better to invest the same amount in "healthier plants" ! So I became interessed in all that "longevity" stuff. I'm not as smart as Mister Physionic but there is much information on the Internet, you've to read much about it and view much video content on YT. Then, you've to make your own opinion, choices and trials, all in function of your (or your mum) health condition and also your budget. If I had to limit the numbers I would stick with Glucosamine (Kirkland with MSM is excellent and cheap), GlyNac, Taurine 3-6gr, Creatine, Magnésium Taurate, Vit C slow release, Vit B complex, Melatonin < 3mg and Lithium Orotate. For mental aid: Piracetam and Citicoline.
I will watch the full video, because this subject is very interesting. I'm currently supplementing with a low dose of NAC and Glycine. (2 times a day of 500 mg NAC and 1000 mg of Glycine). What I remember from the research, is that they utilized much more! I speculate that keeping up the Glutathion level high will also help NAD+. Because that would reduce some NAD+ consumers. So I don't do anything extreme for that, just enough of B3, in the form of Nicotinamide. There are many who talk about precursors of NAD. But I think that we should focus more on reducing its consumers. I would also suggest that Taurin would keep the mitocondria from producing excessive ROS. So, some synergy there?
Thank you for the explanation. I never take the “conclusion “ as an information before listening to the explanation. And I apply that logic to everything in my life. Thank you again!
Watched entire video. Really interesting results in the human studies. A little saddened that the health benefits begin quickly reversing shortly after supplementation ceases but it’s good to know. GlyNac is a lifelong supplement
Got to the DNA repair proteins, I have no science background but as a previous cancer survivor ( bladder) and a heart attack survivor (2 of), I've been attempting to assist my body in its repair, never to late hopefully. Thank you for your efforts to explain in basic terms.
@@tendr247 A Pharmacist advised me to take CoQ10 ( CoEnzyme Q10) to assist in muscle recovery after my heart attack when I was left with 20% damage, as it took Paramedics an hour to reach me, then an hour to hospital. After 10 years on the CoQ10 there is no sign of damage reported at my regular checkups. The Pharmacist/Researcher was convinced that the heart can recover from damage but very slowly ( 2% per year), it seems he was correct.
I got to the DNA repair section. Fascinating and very informative. I became interested in GlyNAC not because of anti-ageing, initially but because of the restorative benefits of NAC for so many other issues. I am amazed, seriously. I initially took it *with* glutathione and at high dose when I didn’t know any better a few years ago. I stopped. Now there are so many videos since the FDA issues, I am now amazed by the information available and the possibilities. Thanks again, and you have a new subscriber🚀
I reached the DNA repair section, and looking forward to the remainder of the breakdown on GlyNAC. Thanks, my dude! I have learned a lot from your channel.
Hey! I got there to the DNA analysis too! It's heavy going for me as someone considered an arts person but I'm enjoying it and totally appreciate your detailed presentation. Ty!
I watched two of your videos from start to finish. I enjoyed watching you explain the meaning of the studies and comments. I did not skip any of your lecture.
I’ve been taking GlyNAC for 6 months and I’ve definitely noticed anecdotal improvements in my exercise performance, my skin, and overall well being. What is your opinion on the daily intake? I’m 50 years old and I’ve read that as you age, the more GlyNAC you should take. I’m currently taking 3 grams of each. Anyway, appreciate this!
Does NAC cause break down of the mucus lining ?I ask because I was prescribed Acetyl Cysteine for breaking up phlegm during a month long respiratory illness. But I also read it breaks down the mucus lining in the digestive track as well.
Being Nerd #4, enjoy your presentation and explanation. What makes your discussion is you lay it out, not only for the medical community but explain such that the general population can comprehend your findings., implications. Thank you spending the time to make this public.
Wow. I'm blown away by the content depth, illustrative graphics, pacing, and clear explanations of this video. Thoroughly enjoyed the entire video. How has GlyNAC been off my radar till now? Will research further. Thanks Nic. Can you do a video on mitichondrial uncoupling - mechanisms and agents?
Thank you, Luc. I deeply appreciate the kind words. I'd love to do that for you - I have a few videos that have discussed mitochondrial uncoupling, but not in any great detail. Unfortunately, I have a huge backlog of requests and videos already releasing, so it'll be many weeks. One day, when Physionic grows larger and I can have a team helping me, I hope to get content out faster - right now its just me!
Yep, I do watch your videos start to end, sometimes a month after you post them 😅 Damn, the results for gait speed and grip strength are incredible, literally, it seems to good to be true. Let's hope it is true this cheap supplement has much greater effects than the much more expensive NMN, NR, stem cell therapy, hormone replacement, etc.
Thanks, Mario! I was especially blown away by that, as well. It does seem too good to be true, but at least its been replicated once. I'm curious what other research groups will find.
I got to the DNA repair part. Having said that, I do listen at 1.75x so that helps. Also, I'm taking glyNAC (plus a bunch of other stuff) so its not just an academic discussion for me. I'd like to get sense of ideal dosage per kg. I'm leaning toward the 50-100mg/kg range but that is still rather large. Any info on this would be helpful.
Yes, I made it through to the DNA Repair Protein repair graphs, but only with 6 bites at your podcast. I am 72 and not a nerd, but I had bought Glycine, and then NAC, and then started taking both together after doing some research, a few weeks before seeing this amazingly detailed podcast.
Excellent explanation, Nicholas! I'm a medical doctor, but as you probably know, even MDs often jump to conclusions or just read the abstract. Instead, I wouldn't be able to really get the topic if I hadn't watched the entire video. Thank you for this insightful review. Congratulations! Claudio, UCSC University of Rome, IT
Fascinating! I wonder what the influence on telomere lengths is and, could you also research carnosine, taken pure or as precursor beta-alanine, related to this same subject? It's very much affecting the glycation process in the mitochondria. In this same league, it's also very interesting to research Melatonin production in the mitochondria as function of optical stimulation by infrared light and other wavelengths as well.
I definitely got to the DNA repair. I’m very interested in this for my 69 year old father who suffers from chronic pain, arthritis, and suffered a heart murmur after the Moderna vaccine. If GlyNAC can help him, I want him to get on it ASAP.
Glycine with nothing added is calming. Add NAC and magnesium taurate all at bedtime. Start low...I only take 600 mg of NAC and 2,000 of glycine. Probably will up Nac. Also with a meal I take methylated b- complex. Selenium. D3 , K in mornings.
🇬🇧57 yr old, 2 month long carnivore. Better collectively on overall health already! I've just ordered a supply of NAC. I was on the fence, but your fascinating info made me take the leap. 👍
![Anti-Aging through the ‘Power of Three’. [3 Studies]](http://i.ytimg.com/vi/FexQYKZP3ZQ/mqdefault.jpg)
![Anti-Aging through the ‘Power of Three’. [3 Studies]](/img/tr.png)
![Taurine: Aging Backwards? [Study 193 Analysis]](http://i.ytimg.com/vi/PNJpM0ac0GU/mqdefault.jpg)
![[Live] : ONE 169 วันนี้!! "อนาโตลี vs อูมาร์"](http://i.ytimg.com/vi/IK3YZVWuFJg/mqdefault.jpg)
For dosing, application, and other details - I cover those topics in the full version of this video, found in my Insiders Site: bit.ly/PhysionicInsiders
*My recommendation for a NAC supplement* *: amzn.to/3YIfScO
*My recommendation for Glycine supplement* *: amzn.to/3S7Upr6
Both links are affiliate links - however, I have no relationship to either brand.
* = Verified via independent laboratory.
Got to the DNA repair proteins....
How much should be taken per day of each?
I agree with StuartRossCraig
@@jeffreeOH Discussed in the full version.
@@Physionic hi there, i got to the dna repair protein :)
I made it to the DNA repair section - and I’ve been taking 12 grams of both NAC & Glycine for the past 2 years (ever since the first study) - I’m 52, and I am at my healthiest and physical best in performance in my life.
Please share how and when you take the supplements (capsules, powder, smoothies, etc.) and whether you experienced any side effects. Thank you.
@@osbornecyber - recommended 6 - 10 grams of each split for twice a day dose on an empty stomach. You can go higher if tolerated. I started at 6 grams and I'm now at 8 grams...about a week trial for each increase. Also check for need of folate and B vitamins to go with. I'm researching now.
STARTED TAKING ABOUT 7 WEEKS AGO. YOU CAN SEE THE RESULTS QUICKLY. AMAZING.
👍
Is this 12gr each person day ? Do you take it in one serving ?
I’m at the DNA repair slide. I am 87 years old and among the 12% metabolically healthy American cohort (BP=110/70 |A1c
Your brain is also in great shape still.
Gonna live to be pretty old if you keep this up, I betcha❤!
Wishing you all of the best wishes in the world
87!!!! And to another 87 good sir🎉
@MasterTBeast I was congratulating him being 87 😭, I’m only 26!! But good on you sir! To another 89 🎉🎉🎉
I am a physician and watched your clip a few times- May God bless you for the depth and breadth that you put into the preparation of this clip- Best info I have seen on TH-cam yet!- Thank you and please keep them coming
Glad it was helpful!
Congrats! My physician thinks when I say k2 that it's a mountain in Asia.
@@andrewj4426Drs really know nothing about supplements! I hate when someone says speak with your Dr before taking something n see what they think. What a joke. The only thing they know about are big pharma drugs. My Dr didn't even know what kettlebell training was when she asked me what type of exercise I do😂
@@andrewj4426
OMG sad but true.You're on your own to find answers. Ty Pysionic@@andrewj4426
I m here…at the DNA repair proteins…and this is not only fascinating, but you explain it so well that even I can understand it! Thank you!
My husband was diagnosed with stage 4 cancer 2 months ago. I discovered your podcast about studies combining fasting (causing autophage) with chemo. We do intermittent fasting, 20 hours a day.
He was considered terminal, and two months later his blood levels of alpha fetylprotein show barely any cancer left! A short way to go, but the doctors are amazed. (We also cut out sugar, carbs, starches and most sugar substitutes, which ‘feed” cancer according to some other studies I found.)
These studies need to make it out to the general population, and you are helping make that happen!
I’m really happy for you and your husband, Judith. Thank you for sharing. All the best to him.
Well done, removing sugar and carbs mean you're starving the cancer cells.
I had to chuckle when you mentioned that 80% of your viewers skip to the conclusions in your videos, but I am not one of them. I do not have the background to process most of the research studies you cite, but am deeply interested in gaining some insight into their outcomes. You are my Rosetta Stone that bridges my world to this knowledge. You have the ability to consume this research and pigeonhole all of the useful nuggets and, in turn, allow me to attempt to gorge on those morsels. Not only do I consume your videos in their entirety, but I frequently find myself rewinding and re-reviewing items that I didn’t understand the first (or second or third) time. You are a marvelous resource and I very much appreciate your exhaustive efforts. It opens up a view not typically available to a layman which allows me the equivalent of speed reading with my eyes closed. 😊😊😊
Got to the DNA
Me too! I come back often when I want to know something.
@@retiredbitjuggler3471 I couldn’t agree more!!!
I watched this video all the way to 57.43. Mesmerized!! I’m an 83-year-old female who has been playing “supplement roulette” for years in an effort to avoid all contact with allopathic physicians. Your information and the way you present it have cleared the air for me. As soon as I make a few financial adjustments, I will join your Insiders Club. Thank you for being who you are.
Thank you!!
I’m 61, lift heavy weights & take both glycine & NAC . I feel fantastic!! Thank you for this information 💯👍
Wonderful, Kim! Keep it up!
Interesting. I'm curious how you decided on what amounts of glycine and NAC to take. It would be amazing if it really is having an effect, but if you feel good, that in itself is a good thing.
How did you find your dose?
I just started to take it.
Why glycine instead of collagen? Wouldn't collagen be 33% glycine plus more good stuff?
I'm a physician/nerd and made it to the DNA repair section. Your videos are fantastic and I often send some of my more inquisitive patients to some of your content for further explanation. I'd comment more, but this video is 4 months old and I'm not sure you'd even see this comment at this point! Keep up the great work.
I saw it. Thank you so much, Dr. Smith!
72 yr old welder with a 6th grade education commenting on you teaching @ minute 33:20, dude I am learning to learn. The problem if their is one, your making sense. I am able to communicate with you thru grace of God and spell check. I can not afford to be an insider, of which you deserve just compensation. I admire your father as I see him in you, I liked your video with him and his coffee shop/mugs. In 1957 @ 6 yrs of age I wanted to build a DNA module out of styrofoam. Thank you for your time, I am living my dreams. mike&gina in Tennessee, in Love, in Christ
Yikes 😳
this is science not god. according to science there is no evidence that he exists. So why are you using god and christ in litterly every second sentence of your comment which is commenting science?
@@siclucealuckseasy
Trigger 😮
I'm 47 and started taking GlyNAC a couple of weeks ago, and the changes are mind-boggling. Better mood, more energy, no pain anywhere, tinnitus gone, WAY better attention/focus, no brain fog ever, no sugar cravings, more motivation. What the hell?! I'm shocked out of my mind. I thought I'd maybe feel a little more energy--this was not expected. Why are we not hearing more about this?!
Edit 4 months later: I still take it every day with breaks now and then because I do that with most of my supplements. I still feel much better when I take it, but it doesn't effect me as strongly as when I first started. I DO still feel better mood, less brain fog, easier sleep, and simply better in general when I take it vs not. Just like with any supplement, it will effect different people differently. Clearly, there's something in GlyNAC that my body really wants/needs. Perhaps it's something I don't naturally make well or don't absorb well via food. If it does nothing for YOU, then maybe you just don't need it and should look elsewhere for something that clears up your issues.
Also, I don't know what about my post triggered demanding people, but people who comment on youtube aren't here to be your answer bot. Do your own research. I did mine, and don't know why people can't do a "what's the dosage for GlyNAC" google or AI search... or just look on the friggin bottle when you buy it.
I glad to hear of all the positive benefits you have experienced, I am am 46 and only heard of glynac 1 hour ago, now I can't get some soon enough!
What dosages?
I started taking 600 mg NAC and 1000 mg glycine per day about 2 wks ago, and think I am feeling more energetic. Just curious as to what dose you are taking of each--
Hi,
Why don't you answer to the dosage question? YT censorship?
What dose?
As you requested, I'm writing to let you know that I made it through the part where you described the DNA Repair Protein's activity in the repair of DNA damage as it winds around the histone proteins. I have to say, you're the first researcher that I've heard, mention the process of Ubiquination. I am incredibly fascinated by the topic of epigenetics! I got my introduction to the topic by reading Nessa Carey's book "The Epigenetic Revolution", where I learned of methyl- and acetyl- epigenetic tagging, to increase or dampen the transcription of the tagged portions of the DNA molecule. I was in intellectual heaven! I hungered for more so I bought a textbook on the subject and quickly realized that I didn't have sufficient brain power to assimilate and utilize all of the data that was quickly being yielded by the nascent field. Thank God for scientists/researchers like you! I appreciate your breaking down the research and science for mere mortals like me!
Little bit of a ego you think
Made it as well, this was well presented and the slides are awesome.
Fascinating how brainless proteins can repair tagged, ie phosphorolated sections of DNA. Another topic, but amazing.
Listened all the way through. Your detailed explanations are immensely valuable & greatly appreciated.
I’m a 32 yr old Truck driver & your videos are helping me fix & repair health issues I’m experiencing so I’m very grateful for every detail. Thanks
Thank you! Safe travels!
At 73 (and I can attest to how quickly time flies) this is wonderful information! Thank you!
Great! Thank you!
This 69-year-old woman, in the middle of a 4-day fast, deep into ketosis, and très nerdy (took a bunch of calculus, chemistry and physics courses a few years ago - new stuff for an art history major) decided to watch this video that TH-cam kindly stuck into my feed, and it was ABSOLUTELY FASCINATING!!! Hell yes I made it to the DNA repair proteins and continued right on to the end. I'd like to watch the Insiders' material, but the paywall is too steep for me (I'm a woman who majored in art history, for god's sake; my Social Security income is a pittance!). But I'll find out what the recommended dose is, never fear, then mosey on over to Amazon and get me some of this stuff.
Thanks a lot, kid. I've liked, subscribed, and signed up for all notifications. I look forward to watching all your previous and future videos.
*I just noticed your pinned post, where you give recommendations for dosages and brands. Thanks!
I started taking both glyNAC and liposomal Glutathione two months ago, after seeing this and looking at a few peer-reviewed studies. I was only taking it for broad generic reasons - but after about a week I suddenly noticed that my ['incurable'] post-chemotherapy neuropathy was noticeably better.
After a certain point (around one, one-and a half years), supposedly the pain and pins-and-needles of neuropathy after chemo don't improve. And there is no treatment - pain killers don't work - although for a very few anti-depressants help slightly, but I don't want to mess with my healthy brain and would rather just cope with the pain.
But so long as I take it daily, each day it is slightly better, continuously; and now two months on my neuropathy is nearly gone. It is rarely 'painful', mostly just tingling. So is my 'burning mouth syndrome', also something for which there is supposedly no treatment.
I'm stunned and delighted. Thank you for putting me onto it - even if you didn't recommend it for peripheral neuropathy!
I hope this comment might help someone else.
Taking GlyNAC is great but be aware cells requires different amount of glutathione and you risk to deregulate (having to much) if taking liposomal glutathione, there is a phenomenon known as “reductive stress” when ROS is decreased too much, it can result in cellular damage
Great news.
I have a friend with diabetes who said he appears to have neuropathy. It seems that his arms or wrists and hands have a lot of pain. I am thinking this might help.
@@glenntimberlake2413something you may want to mention to your friend is to look at Vit B6 toxicity. When I started taking a B complex, even multivitamin with higher B6, my neuropathy flares up. Super weird but now that I’ve figured it out I like to make sure others dealing with neuropathy know as well.
Be careful with liposomal glutathione. There are concerns that liposomal glutathione supplementation could be dangerous, because of too much glutathione too fast.
Thank you both. Much appreciated. I have mostly been taking GlyNAC only occasionally the liposomal glutathione. A year on the neuropathy is almost entirely gone and I'm thinking of discontinuing or at least taking breaks. I haven't experienced any I'll effects but if course there might be some I don't perceive.
I have never subscribed to any TH-cam channel. Ever. But scanning this video while working late changed everything.
Definitely one of the fastest, most informative one-hour lectures I've ever attended. And for someone with inattentive ADHD, that's saying something. As much as I enjoy learning, especially from scientific and medical lectures, I'm never able to watch more than a few minutes at a time and stay engaged, no matter how interested I am in the subject. After about five to seven minutes, I'm a "skipper".
But you called us "skippers" out from the beginning. I felt guilty when you explained how it impacted your analytics (I'm also autistic, so anything about data catches my attention). I figured I'd keep the video playing in the background while working in order to help your algorithm. That lasted maybe three minutes. Then I couldn't do anything BUT watch the video. And yes, to the end.
That thee minutes was so impressive, I left the work computer, jumped on the home laptop and created a TH-cam account specifically to subscribe so I don't miss any more videos from you.
I can hardly wait to wrap up work and get lost in this channel's video library!
Thank you, thank you, thank you, thank you, thank you.
This really made me extremely happy, JM. Wow. Thank you for your kindness.
I followed I’m at DNA repair I so happy I can follow you. I’m agramma and have the time Abdul have become totally engulfed in mitochondria and atophagy sp? Because since Covid all hells turned my life upside down. So I’m down for alll the info you want to give!
I am an aging researcher myself so I watched the whole video. You always do a great job of going through papers.
Hey - thanks!
Made it. I am 55 in the worst shape of my life, but I have steady with the help of people like you have been bouncing back. Fingers crossed. I could walk away health till week 0
Not only did I make it to the DNA repair section. I listened to your video twice and I’m recommending it to my friends and family. Thank you!
Thank you so much!
Made it to the DNA repair section. As a molecular biologist it’s music to my ears!!!
Wonderful to have you, David - thanks!
Me too
Good to know 😀 We just got our NAC and Glycine.
Same here
Me too.😂
I'm at the DNA repair section, great info, I'm a 72 year old retired Bio Medical Engineer who dabbles in Sports Physiology and Molecular Science to support my training as a Cyclist and ex Triathlete.. Loving your subjects....well done
Made it to the DNA repair protein section and it’s me who should be thanking you, I have searched a LOT of TH-cam channels and I have never see anything like you presented. Amazing job!!!
Yes, I’m 67 yrs young & have been taking NAC for only 2 months & recently added Glycine & have been feeling
even better. I’ve been taking
multiple vitamins since I was
10 yrs old, thanks to my mom
and I appreciate the deep dive
into GlyNac so thank you… I
subscribed 😎
I'm 64 and had a triple bypass on June 26. I appreciate you making this easy to understand. I was never interested in biology until I started watching you, now I'm fascinated by it! I got to the DNA study and will stay 'till the end. Thanks!
77 yo and just added to my stack and started taking NAC + L glycine. I'll continue taking for the years I have left. I've never had a health issue except for HBP. Thanks for all the information you provide us. You do a brilliant job. New subscriber.
Thank you a thousand times for this - for an unexpected reason. I began taking GlyNAC after watching this as well as Liposomal Glutathione, since at least one non-rodent study I found said that did escape the rigours of our digestion.
A week later out of the blue I suddenly noticed the constant burning pain in my feet from post-chemotherapy neuropathy was reduced. I cast my mind back to what that might have been due to - since I'm well past the point where the oncologists told me it would no longer improve, and the levels I had I was stuck with for life. I could only think of one change to my diet and it was the GlyNAC/Glutathione.
Of course there is always the placebo effect - even if I didn't take it for neuropathy and had no expectation it would help.
However, that was four months ago. Every day that I took two doses, it was a tiny bit better. Ever time noticed it wasn't better, I realised I'd forgotten one or both doses.
Four months on, it is about 75% better, and I'd describe it as 'tingling pins and needles' rather than 'burning pain'; even if I've walked 15 kilometres that day.
This is really life-changing for me. I hope it might someone else with supposedly untreatable 'neuropathy'.
Thank you for this video!!
ditto, 78 male found refief.
do you take the supplement called “GlynacET” on Amazon or do you take the powders that the speaker recommends? My husband has cancer and has the neuropathy from chemo. Thank you
@@Lulu-kt6gr Hi Lulu, so sorry to hear about your husband. I hope this might help but of course it's only one person's experience and might be meaningless. I hope you find something that works for him.
I've done two things - and I can't tell any difference between them when I swap back and forth.
(1) Liposomal Glutathione
(2) 'Glynac' - I bought Glycine and N-Ac separately as capsules on ebay (I'm in Britain, so finding this might be different for you.)
So it's a few months off a year from doing this, about 10 months I guess. The neuropathy hasn't gone completely, but some days I don't feel it at all and other days there's a slight buzz or burn but nothing like it was.
I think I might need to take a higher dose - routinely I've been taking around 1000 mg of each once a day, but you can certainly take more.
One unexpected discovery is if you buy powdered Glycine, it looks and tastes EXACTLY like sugar - amazing, a natural sweetener with no aftertaste that is actually good for you! So I've started adding it to things as a healthy sweetener. Only downside is it's not cheap, so it would be expensive if you made it a total sugar replacement for cooking and baking. But if you can afford it, worth experimenting with!
Good luck and I hope it helps.
Thanks for sharing your experience. This really helps.
@@Lulu-kt6gr I have taken them separately (not that brand; I'm in the UK) and as liposomal glutathione. They seem to be equally effective. After a year, it's pretty much gone now.
Don’t worry there are those of us who watch your whole thing and understand what you’re talking about. This is very impressive to me. I have health issues. I’m trying to fix the doctors have it wrong so far I watch all of your stuff and I take because of yourpodcast that’s when I started following you. What an amazing amazing supplement.
Thank you very much for the well-considered content! Watched the whole thing 😄 There’s no need for you to thank people though, it’s the other way round! Keep up the great work 😄
Haha, well, still, I like to show my appreciation from time to time. Thanks, Stuart!
@@Physionic yes thank you. I went through it whole.
Very informative
I made it to the DNA portion and find this overall topic fascinating. I have a degree in biology (from about 45 years ago) but only skipped through this aspect of cellular functionality and longevity factors. This in-depth discussion is really valuable, and I appreciate you taking the time to present this in such rich detail.
Just a layman here, a lifetime student of learning, board certified nerd and kudos for your podcasts, I am liking how you break it down into bugs bunny language I can absorb. Now have enough info to begin a dosing protocol for GlyNac. Good work, Doctor Physonic
Thank you! Not a doctor yet (1 year!)
Of course I am listening to the whole thing. I find it easier to put it on 1.5 times speed but find your presentations. Brilliant! I wish just one of my college professors was as good as you at presenting information. Thanks.🙏🏼
Fantastic presentation! I have learnt so much. In 2008 I was diagnosed with ms; my relapses are more often and my recovery it’s harder and harder. I have never been a fan on DMT’s but after my last relapse from August last year, I have done some intense research on some vitamins and amino acids, and peptides. Wish I had all day to go through this but it’s impossible. Now, I am getting stronger and stronger by the day only because of supplements like glutathione, NAC, NMN, silicium, lions mane, Vit A, D + K2, and some others. If my health condition is being kept under control is not because of the DMT’s, it’s because of the extra supplements I have been taking. But this is what I do for me; please do your research and read about all side effects and what might interact with what ever other meds. I’m not on any atm; just vitamins, good food, god’s blessings and being mindful of triggers around me. And my both arms swing back and forward during walking just as a it should. I’m so grateful for such videos; I am healthier because of such videos. Thank you so so much.
Pay attention to directly supplementing with Glutathione as some studies show it can reduce the bodies ability to produce it.
NAC and Glycine seem to be much better as they are percursor of Glutathione and the body will be producing it on it's own with this
raw material...!!!
I’m 70 and have been taking glynac for a month,the change is amazing!Anyone who’s older needs to give this a try,it’s unbelievable the energy and the way I feel since taking this is just fantastic 😊
As a fellow engineer I love this type of nerdy videos.
When it comes to the human research I would love to see more details on lifestyle for compared groups.
For sure the 24 years old are mostly healthy, but 74 years old would have loads of health issues, and would take number of meds.
Their diet would probably also look different.
I would personally rather see hbA1C in the insulin resistance stats then HOMA - IR.
By all means I loved that video and it flew like 5 minutes to me.
Please keep them coming 😉
I would love to see that, too, N. Thanks for the support - you're not the only engineer I've heard from, but I love you guys (the way you think). Thanks!
yes, hba1c is for sure one of the most important markers. and because blood tests are usually done in a fasted state, a PYY, GLP-1, CCK measurement would be very interesting too and a correlation with HOMA-IR and hba1c
what's so nerdy about it? nothing nerdy about knowledge
@@ERICROJO156 nothing wrong nerdy. It's just the interest in a single subject or type of information above and beyond any casual interest. I personally nerd out daily on various subjects. It's how I de-stress and engage my little kid wonder at the marvels of the world.
Well I must live on a different planet because most of the @70 year-old persons I know do not take a "number of meds". They have some health issues I'd say but don't run to the gp for help easily. They take suitable supplements, love nature, eat well and are not indisposed. What might be particular about them is their curiosity about learning and life. Life-long learners who continually adapt. In these cases, the old model idea of what age sort of looks like, is not followed. One of my relatives said 80 is the new 50. She bikes daily and wins in her handicap at golf continually. She is just one of the coterie I mentioned.
Made it from beginning to end. Loved the in-depth of each study. My husband and I are both type 1 diabetic (we met at diabetes camp back in the early nineties 🥴). So we have spent our lives doing what we can to maintain our health and prove those predictors outcomes for us circa 1980s medicine as wrong. Five kids and a life full of mountain biking, road cycling and backpacking later we are still looking to do better. This is super promising as something to try. Thanks!
Thank you so much for sharing. You and your husband have really done wonderfully - I hope for continued success to both of you! My pleasure!
Check out berbarine and banaba leaf
Carnivorous diet is very helpful.
Try the Coimbra Protocol with lots of vitamin D but only under a physician's care. It helped a friend of mine regenerate his pancreas through stopping all the autoinflammation in it.
I'm a nerdifiable 63yrs old and I've made it to the DNA repair section. This is absolutely fascinating and I will definitely share. I'm now going to start taking GlyNAC. Thank you!
I watched the entire video and subscribed. I would like to thank you for such a detailed explanation. I started taking NAC and Glycine months ago after I briefly heard of the benefits but I was too lazy to review the studies. Personally, I think you did an excellent job reviewing the studies.
Hi from the 🇬🇧 I watched the whole video start to finish. Thank you for explaining everything so well. I am 67 and I have started a lifestyle change to improve my health and fitness. I am researching the science to help me understand the things I could be doing to improve the odds of a long, healthy life.
Thanks, Peter! Good to have you aboard!
Hello, I am a business nerd at heart but I find the human body a fascinating machine.I am searching for a healthier longer life like most people watching this channel. After watching just one of your videos I got hooked. I subscribed and been watching it for weeks now. My wife tells me to change the channel and stop geeking out. I told her your content is not only well thought out but extremely fascinating. Great job and keep up the amazing work.
Roger
As I understand it, one can take glycine and NAC together as seperate supplements; they don't have to come combined in one supplement. May be a lot less expensive to get each of those separately.
That's how I'm doing it because I already had the NAC.
Correct. This is how I do it.
Glycine Max is the Latin name for soybean , however most prefer glycine in processed form made in China, quite expensive and may cause nausea
@@BabyTreasureswhich brand of nac and glycine do you use thanks
@@drali19741 I have NAC from Swanson and Glycine from BulkSupplements.
Made it through the whole video. Your excitement was contagious. Can’t wait to see the follow up study. I hope the study doesn’t disappoint.
Thank you, Santa!
I was riveted through the entire presentation !!! Nerd alert!!!! I am female, 65 and have been taking GlyNac for about 8 months. The DONOTAGE product is what I started with but I feel it’s insufficient so I take it in powder form also 3 to 1 glycine to NAC. I’m 5’6” 135 lbs, I do yoga 3 days a week and various workouts the 4 other days. I have been intermittent fasting since 2019. Focus is build muscle, retain flexibility and have fun !!
I teach AP biology so I love this material! Part of my job is trying to get kids to read primary research. Watching your material is helpful for students to think like a scientist.
We need more people like you, Chad - reading primary literature is the way forward in my opinion.
Im not a nerd. Im older and I do watch your entire presentations and empliment them. Im a female, in her 70s going on 50ish 🤷♀️. I do appreciate all the work you put into these presentations. Thank you for all you do.
Thank you, Linda!
@@Physionic You're welcome Darlin
I got to the DNA repair section. This is at least my 3rd time.
I was listening during my massage this morning and my massage therapist asked me to forward this to her and later same day was listening to the rest when a nursing friend got in my car and she asked me to forward to her as well. Many health minded people are interested and enjoying your material, myself included!👍
Amazing, and thank you :)
I made it to the DNA repair section. I'm in my 30's and got type 2 diabetes 4 years ago. I'm not what you would consider overweight (not ever in my life) and the information doctors were giving me on diabetes was the total opposite of what I'm seeing with your videos. I'm still fighting to reverse my diabetes and your videos are a great help in understanding what this battle is all about. Thank you.
You might consider supplementing with a whole food source of Glucose Tolerance Factor (GTF) chromium. Back in 1959 an NIH study found that a deficiency causes diabetes. Gluco-Sugar Balance by Food Research has been recommended.
Maybe try Lo carb?
Keto
@@chidude I've never heard of GTF Chromium. If you have the chance send me a link to that NIH study you're talking about. I found one but I don't think it's the one you're talking about.
@@raymondspagnuolo8222 I'm already on a low carb diet and it's actually getting me very positive results.
I am 73 and started taking a glutathione supplement orally that reduced the components of glutathione to nano sized particles for instant absorption via sublingual. I was recovering from covid19 and found within 2 weeks my ability to workout was greatly enhanced. After 4 weeks it was greatly enhanced, and I no longer had to use my knee braces to support my impaired miniscus on my left knee and a patella on my right knee that had been fractured 2 years earlier and had not healed properly. That was last September. I know can play pickleball several times a week here in Florida 2-3 hours at a time, without using knee braces, and I outlast most seniors my age here in The Villages. I just ordered NAC and Glycine to be part of my daily vitamin supplementation, but I get instant recovery using my hyrostat glutathione in between matches anytime I start feeling tired. I do maintain my electrolytes during play, especially with summer tempartures now in the 80's and 90's.
I also made it to the DNA repair....I sometimes stop and later come back to watch your videos with my wife...Your channel is one of my favorites...
Not only did I get to the DNA repair part, but as a first time on your channel, I enjoy your educational style and cadence, and have learned some things I didn't know. And, yes, I am a nerd, lol.
Wonderful, birage. Thank you.
My first time watching your channel and I did watch the entire video and I have to say I was impressed. Thanks for all the work you put into it.
Kind of you, Jeffrey. Thank you.
As per instructed, I am at the half way point, DNA repair. I am 74 retired IT/Cyber DIY guy who 5 years old went back for a Masters in TESOL and a move back to Japan for better lifestyle and food so I could lose weight and gain back some health. The Masters research taught me about research which I am thriving on as it relates to aging. In my IT prior life I spent 5 years at NIH/NIA as an Info Sec guy in an environment that greatly concerns me as I get older. Why is it we wait till it is almost too late to do anything about it? I did my thesis on Teaching English to elderly Japanese (average age 83) that have a great concern about preventing dementia. I learned from my students. I want to do anything and everything to live a full energetic life as long as possible. So Now I march down the supplement trail based on the evidence and research in the literature so easily available at ones finger tips. Please continue your current format, nerds need details, details, down the rabbit hole we go, and yet if strapped for time, jump ahead to the conclusion. Great channel, now I need to get my OLDER Brother a retired Medical Dr. to see this video and channel. From the Outskirts of Tokyo at University while I teach IT in a science dept with Micro Algae experiments.
Thank you!
I love videos that give insight to the science and biology behind nutrition and supplementation. I’m not in the health field in any way. Yet, it’s my greatest area of interest out side of my profession. Your break down of the studies was very helpful. Usually I read the stories on my own, annotate it, and then share the info. Thanks for the short cut. Videos like this are are better than binging a Netflix series. Thanks for sharing this info with ALL the details! 👍
Thank you, Vivian.
Yes, I'm following all the way to the end. You've taught me a lot about the microbiology of the cell. I'm 72. Also, I started glynac supplements because of your explanations.
I really love and appreciate your complete review. Perfect. I am a naturopathic doctor AND science geek who is profoundly aware how little people understand the research, and by people I include doctors. So THANK YOU.
I also made it through the dna section. I find it not only useful, but really fascinating. You explain how it works in an easy to understand manner. Thanks for making it enjoyable.
As a fit 64 year old I found this study very interesting and I did watch till the DNA repair protein and will watch to the end, so far this looks very promising fingers crossed no cancer risk 🤞
Yes, I`m at the DNA repair. I`ve watched this more than once while learning more about it all. NAC has helped me a lot and because of you I`ve added Glycine to the mix along with Taurine and others.
Thank you
Tremendous explanation. I learned about this combo, read the original papers and have been using it for ~ 2 years. My health has never been better. I dance in and out ketosis effortlessly, like a young child. So, I eat carbs, and I still generate ketones. Meaning, to me, I get access to all 3 major fuel sources all the time. One interesting thing I have noticed is that my caffeine sensitivity seems to remain/reset at the caffeine naive user level.
Side effects? NAC &FDA? Glycine and low pressure/weak hearts?
Me too!!! I’be been taking 12 grams of each a day split into a morning and evening dose for the past 2 years…. I weigh 190 pounds with approx 10% body fat and I am 52 years old - What dosage are you taking
@@RichardSchefren u take 12 grams of nac?
80 here still running take NAC NAD+ NMN glycine…..nothing but supplements. I do Fast 72 hrs each week. I live off Ribeyes and sardines. Female
@@lynnwilliams5432 The science seems to show that for longevity it pays to eat protein on one exercise day per week, or even every two weeks which is how long it takes to lose the benefits of a day of exercise. But then go low protein the rest of the week and fast for at least 36 hours once a week. Also, HIIT is good for autophagy, not sustained exercise. Not advice, just what I'm learning.
I'm a nutrition and body hacking nerd. Thank you for taking the time to analyze all this data. You earned a new subscriber 😎. I've been using NAC since early covid.
I stocked up on it. Luckily because the scumbags in the government stopped letting people buy it
What are you going to do if and when they ban all vitamin supplements, etc?
@@warrencurtis7442 You could use BioAcoustics as pioneered by Sharry Edwards to listen to the frequency equivalents.
This stuff is so interesting. Im just a regular person but ive been researching how to get healthier after having my gall bladder removed 3 yrs ago. Its caused so many issues. These detailed videos going over studies and results really help lay people like myself make informed choices on what to take. I started NAC, Glycine, Taurine and 3 other supplements and Im finally feeling better. Thank you for doing these deep dive videos.
I got to the "nerd out" point. I appreciate the in-depth explanation. At 49 and in excellent health, but starting to learn all I can on increasing longevity and reversing age. I can tell you as an avid surfer for the past 15 years, I contribute this to looking much younger than my age. Trying to live stress free, giving up alcohol 12 years ago and trying to eat as healthy as possible have also been contributing factors. Trying to do everything to avoid Alzheimer's Disease that my dad has and his mom had. Thank you for this video.
The orthosilicic acid form of silica found in Fiji water is known to help detox aluminum from the brain; aluminum toxicity leads to Alzheimer's. To save money you can make the equivalent of Fiji water via Dr. Dennis Crousse's "silicade" recipe.
😂
Made it to DNA repair and have been taking NAC/Glycine for a few months plus DMG. I intermittent fast daily, am physically active, and have never been in better health on all levels. Im a 25yr cert. Nutritionist, been studying health and nutrition mainly as a passion and personal health, but give suggestions to others almost daily. I really enjoy the breaking down of the processes because it helps me articulate my knowledge to ppl. For example, yesterday in the grocery store, trying to educate someone on nutrient inhibitors in certain vegetables; even though I understand, its good to have proper understanding on all levels before introducing to others.
@M.C. Who should not eat oxalates?
For most people, oxalate is completely harmless, and they simply pee it out in their urine. But for people who have a tendency to form certain types of kidney stones, eating a diet high in oxalate can increase the risk of another kidney stone.May 4, 2022
DMG?
@ladydrgnfly921 Dimethyglycine: A naturally occurring derivative of the amino acid glycine which supports the bodies metabolic processes and promotes neurological and brain function.
How much of the supplements are you taking, definitely interested in trying dimethyglicine too. Any help with how much would be great help.
Hi, what doses do you take of NAC, Glycine & DMG?
Dear professor, your words are a gift and your desire to educate people that wish to help themselves is beyond generous. I am a high school dropout and I can understand you 😉.
I have been taking many supplements and generally I have a very healthy unprocessed veg diet. After 2 weeks of supplementing with NAC at 600mg 1st week to 1200 mg 2nd week I have felt physically better, at 48 years old I have noticed my energy is improving, less tiredness and greater muscle energy and less stiffness. 💪 To note I have noticed less bloating from food at the 1200mg per day, I am losing weight, fat, not muscle, it appears.
Hi, so i also made it to the DNA repair section. And actually i am a big fan of the detailed explanations, of understanding the mechanism in general. There are to many of those, who tell us the conclusions alone, and to few of those, who, like you, take us through the entire journey of „how“. Great job, thanks!
Thank you, Galina!
Thank you for your analysis of these foods. I usually combine Glycine, NAC and Glutamic Acid every night before bed. I knew that combination was a great way to clean the cells. You gave me a lot more information about the underlying mechanisms. I appreciate your time. By the way, I don't think it's a good idea to eat NAC without also eating B-Complex. Otherwise you increase the risk of increasing Homocysteine in the blood vessels. I think homocysteine is one of the leading causes of diminished metabolic capacity as we age.
no problems with adding fluids before sleep?
Thanks!
What brands do you take ?
@@laptopdoc Chiming in here... Jarrow B-Right is a good one I've taken. Reminds me, I need to reorder some.
@@razoraz thanks!
"Hey! I got to the DNA repair proteins!" :)
As a 69.9-year-old UK man, I've experienced firsthand the transformative power of changing my diet. This led me to explore biochemistry. After struggling with numerous health issues for over 25 years, adopting a keto/carnivore diet has freed me from conditions like nodular scerising Hodgkin's lymphoma, type 2 diabetes, and more. This led me to explore biochemistry. As a former electronics/computer engineer, I find your videos fascinating and appreciate how they allow me to "nerd out" while expanding my biochemistry knowledge. Although I may not grasp everything, I can follow your explanations, and I'm grateful for your efforts. Thank you for sharing your knowledge and helping me broaden my understanding!
Thank you!
I found this very interesting. Thank you for the in depth information. It would be interesting if a similar study was done with varying dosages of GlyNAC to determine if there is a dose dependent benefit of this supplement.
Hey, I got to the DNA repair protein section! Although I have to confess that a lot of it is over my head, but that's why I like it when individuals like yourself break information down for the rest of us.
Watched the WHOLE video. Thank you for taking the extra time explaining everything 😊
Thank you for this presentation. Have been listening to podcasts about mitochondria/ oxidative stress/ autophagy/ Glutathione/ NAC/ glycine etc, for years. Cannot say, that I fully understand it however am familiar with all the jargon. I feel you have explained this study sooo well. Will pass this video to friends as it gives a very clear explanation of the possible benefits from supplementation and it's connection to oxidative stress.
I do sometimes wonder whether it might not be necessary to supplement daily but rather a couple of times per week, to get the same effect but studies don't seem to attempt this. Need more "groups" in these studies.
Made it to the DNA analytics. Tried it myself: Sinuses opened, lungs opened, and energy increased significantly over time. 3.5 weeks in now. I've had no headaches in 3.5 weeks.
How much are you taking of it? I'd do anything to help with bad sinuses and the sinus 😩 headaches.
@Pamela Tabachak 1800 mg. per day. 1 first thing in the morning, 1 at 2:30, and 1 before bed.
I made it to the halfway point. My reason for watching this is because I have been supplementing with glycine and NAC every day(since 3 months ago). It's not an easy routine to upkeep unless I have a strong conviction for doing it. I put my body through a lot of stress(exercise, 22% incline, tredmill HIIT's, 1min sprints/30-60min), and I experience a lot of inflammation. I love the workout, but my heart hurts after a good one. I do everything I can to downplay the inflammation and take glycine, and NAC is one of my ways. I appreciate finding out why glycine and NAC supplementation works backed by real evidence. I don't really have time to properly research the subject or have the necessary background to understand this kind of material. I gotta say that I couldn't have understood this without physionic's thorough explanation. Thanks, brother.
Thanks for the kind words!
I watch the whole thing and enjoy it very much. I am 78 years old former scientist trying to figure out if my quality of life can be improved. You really left me in suspense regarding study 119 which I will read for myself.
Thank you! Enjoy!
Just discovered your channel. Am older white male; 6ft 3in, 205lbs. Recently learned abt autophagy via cardiologist in FL. Was eating in time restricted window already. Changed to 6 hr window a few months ago. Have been taking NAC, Quercetin, Vit C, Vit D, and others thru-out the pandemic. Vit D blood level is at 70 ng/ml. Watched all of video. Found it very interesting. May look into Glycine. Have been a distance swimmer for decades. With time limited eating & much less sugar, think autophagy is wrkng.
My blood pressure is at normal levels. Sleeping pulse rate was in low 50s. Recently is consistently going down to 48 to 44, on most nights.
Very well done video. Many thanks. 🤔🤔😁
How old are you pal. If you don't mind me asking?
Careful with the fasting - will slow your metabolism over time. Cycle on/off to protect metabolic flexibility
I’m 73. Healthy and thin. Very active. Watched the entire video. Very fascinating. I’m definitely not a nerd! But great job explaining this to a non nerd. Began supplementing recently.
Hi Nicolas, I saw the whole video, it's not new to me as I already saw much other vids before here on TH-cam. That said, I found your presentation relaxed and easy to understand 👍 I'm personally taking those supplements since arround one year, NAC = 1800mg and Glycine = +/- 5gr every day and don't feel any side effects. But, I've to confess that I'm taking also a big numbers of supplements like fisetin, AAKG, CoQ10, glucosamine + MSM + chrondroitine, lithium orotate 10mg, spermidine, citicoline, piracetam, sulforaphane, lutein, zeoxanthin, tumeric, quercetin, NMN, resveratrol, creatine, magnesium, zinc, b-complex, vitamin C slow release, etc... and doing some power lifting and love to walk. I'm 61 and freshly retired, so the stress factor is also down. I'm taking glucosamine since my 38y because of a knee pain and never stopped taking that, the pain only came back if I stopped for 3 weeks or so... I think this supplement do make me look much younger than my age, people are always surprised when I say my real age. My 3 sisters are just a bit older (1-2y), no one took that supplement and they all look their age (we have the same parents)... Hope this can help other people looking for healthspan/lifespan.
Thanks for sharing, Pierre!
I literally just took a screen shot of your comment to order some products for my mum. Taken together you must experience a great synergy of effect with a supplement regimen as comprehensive as that. It must be v.expensive on a monthly basis though, do you recommend anywhere in particular I imagine you source them from multiple places but I’d love to hear if you’ve found a way to cut costs? Thank you in advance 😃
@@AS-gz8oe Hi, I'm from Belgium, yes indeed this is at all not cheap, you've to look for the best price you can get into your country ! 12y ago I was a smoker and when I decided to stop with that costly addiction, I tought it was better to invest the same amount in "healthier plants" ! So I became interessed in all that "longevity" stuff. I'm not as smart as Mister Physionic but there is much information on the Internet, you've to read much about it and view much video content on YT. Then, you've to make your own opinion, choices and trials, all in function of your (or your mum) health condition and also your budget. If I had to limit the numbers I would stick with Glucosamine (Kirkland with MSM is excellent and cheap), GlyNac, Taurine 3-6gr, Creatine, Magnésium Taurate, Vit C slow release, Vit B complex, Melatonin < 3mg and Lithium Orotate. For mental aid: Piracetam and Citicoline.
I will watch the full video, because this subject is very interesting.
I'm currently supplementing with a low dose of NAC and Glycine.
(2 times a day of 500 mg NAC and 1000 mg of Glycine).
What I remember from the research, is that they utilized much more!
I speculate that keeping up the Glutathion level high will also help NAD+. Because that would reduce some NAD+ consumers.
So I don't do anything extreme for that, just enough of B3, in the form of Nicotinamide.
There are many who talk about precursors of NAD. But I think that we should focus more on reducing its consumers.
I would also suggest that Taurin would keep the mitocondria from producing excessive ROS. So, some synergy there?
David Sinclair has Nad+ sirtuon +health supplement (vids)notes worth review,,,
Thank you for the explanation. I never take the “conclusion “ as an information before listening to the explanation. And I apply that logic to everything in my life. Thank you again!
Watched entire video. Really interesting results in the human studies. A little saddened that the health benefits begin quickly reversing shortly after supplementation ceases but it’s good to know. GlyNac is a lifelong supplement
Got to the DNA repair proteins, I have no science background but as a previous cancer survivor ( bladder) and a heart attack survivor (2 of), I've been attempting to assist my body in its repair, never to late hopefully. Thank you for your efforts to explain in basic terms.
Add magnesium taurate and Ubiquinol for heart health.
God bless you
@@Нфт-ц8и Thank you for that.
@@tendr247 A Pharmacist advised me to take CoQ10 ( CoEnzyme Q10) to assist in muscle recovery after my heart attack when I was left with 20% damage, as it took Paramedics an hour to reach me, then an hour to hospital. After 10 years on the CoQ10 there is no sign of damage reported at my regular checkups. The Pharmacist/Researcher was convinced that the heart can recover from damage but very slowly ( 2% per year), it seems he was correct.
I got to the DNA repair section. Fascinating and very informative. I became interested in GlyNAC not because of anti-ageing, initially but because of the restorative benefits of NAC for so many other issues. I am amazed, seriously. I initially took it *with* glutathione and at high dose when I didn’t know any better a few years ago. I stopped.
Now there are so many videos since the FDA issues, I am now amazed by the information available and the possibilities. Thanks again, and you have a new subscriber🚀
I reached the DNA repair section, and looking forward to the remainder of the breakdown on GlyNAC. Thanks, my dude! I have learned a lot from your channel.
Thanks, John!
Hey! I got there to the DNA analysis too! It's heavy going for me as someone considered an arts person but I'm enjoying it and totally appreciate your detailed presentation. Ty!
I appreciate the dedication, then, J. Thanks!
I watched two of your videos from start to finish. I enjoyed watching you explain the meaning of the studies and comments. I did not skip any of your lecture.
Thank you!
I’ve been taking GlyNAC for 6 months and I’ve definitely noticed anecdotal improvements in my exercise performance, my skin, and overall well being. What is your opinion on the daily intake? I’m 50 years old and I’ve read that as you age, the more GlyNAC you should take. I’m currently taking 3 grams of each. Anyway, appreciate this!
Thanks for sharing your own experience, Sean. Always nice to see it from the people using it.
I discuss dosages in the full version of the analysis!
Does NAC cause break down of the mucus lining ?I ask because I was prescribed Acetyl Cysteine for breaking up phlegm during a month long respiratory illness. But I also read it breaks down the mucus lining in the digestive track as well.
Being Nerd #4, enjoy your presentation and explanation. What makes your discussion is you lay it out, not only for the medical community but explain such that the general population can comprehend your findings., implications.
Thank you spending the time to make this public.
Made it to the DNA repair section, fascinating. Love the presentation and explanation!
AMAZING channel! Thank you for this analysis. I'm in AI, but so interesting to hear these long science papers from the aging field.
Thank you!
I watch your video mainly to work on my English. But indeed, I spent 1 hour listening to you ;)
Wow. I'm blown away by the content depth, illustrative graphics, pacing, and clear explanations of this video. Thoroughly enjoyed the entire video. How has GlyNAC been off my radar till now? Will research further. Thanks Nic. Can you do a video on mitichondrial uncoupling - mechanisms and agents?
Thank you, Luc. I deeply appreciate the kind words. I'd love to do that for you - I have a few videos that have discussed mitochondrial uncoupling, but not in any great detail. Unfortunately, I have a huge backlog of requests and videos already releasing, so it'll be many weeks. One day, when Physionic grows larger and I can have a team helping me, I hope to get content out faster - right now its just me!
Yep, I do watch your videos start to end, sometimes a month after you post them 😅
Damn, the results for gait speed and grip strength are incredible, literally, it seems to good to be true.
Let's hope it is true this cheap supplement has much greater effects than the much more expensive NMN, NR, stem cell therapy, hormone replacement, etc.
Thanks, Mario!
I was especially blown away by that, as well. It does seem too good to be true, but at least its been replicated once. I'm curious what other research groups will find.
I greatly appreciate the detailed explanations and your views on what can and cannot be inferred from the studies.
I got to the DNA repair part. Having said that, I do listen at 1.75x so that helps. Also, I'm taking glyNAC (plus a bunch of other stuff) so its not just an academic discussion for me. I'd like to get sense of ideal dosage per kg. I'm leaning toward the 50-100mg/kg range but that is still rather large. Any info on this would be helpful.
Wo what's the right dosage in your opinion?
Yes, I made it through to the DNA Repair Protein repair graphs, but only with 6 bites at your podcast. I am 72 and not a nerd, but I had bought Glycine, and then NAC, and then started taking both together after doing some research, a few weeks before seeing this amazingly detailed podcast.
Excellent explanation, Nicholas! I'm a medical doctor, but as you probably know, even MDs often jump to conclusions or just read the abstract. Instead, I wouldn't be able to really get the topic if I hadn't watched the entire video. Thank you for this insightful review. Congratulations!
Claudio, UCSC University of Rome, IT
Fascinating! I wonder what the influence on telomere lengths is and, could you also research carnosine, taken pure or as precursor beta-alanine, related to this same subject? It's very much affecting the glycation process in the mitochondria. In this same league, it's also very interesting to research Melatonin production in the mitochondria as function of optical stimulation by infrared light and other wavelengths as well.
I definitely got to the DNA repair. I’m very interested in this for my 69 year old father who suffers from chronic pain, arthritis, and suffered a heart murmur after the Moderna vaccine.
If GlyNAC can help him, I want him to get on it ASAP.
Glycine with nothing added is calming. Add NAC and magnesium taurate all at bedtime. Start low...I only take 600 mg of NAC and 2,000 of glycine. Probably will up Nac. Also with a meal I take methylated b- complex. Selenium. D3 , K in mornings.
🇬🇧57 yr old, 2 month long carnivore. Better collectively on overall health already! I've just ordered a supply of NAC. I was on the fence, but your fascinating info made me take the leap. 👍