2023 Dupuytren Disease and Research for a Cure
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- เผยแพร่เมื่อ 16 ก.ย. 2024
- This recording is Dr. Eaton's presentation for the Dupuytren Research Group on Saturday, June 3, 2023 in New York City. A very special thanks to the Hospital for Special Surgery in New York City for supplying the event facility and presentation recording. For privacy, post-presentation discussions were not recorded. See below for summaries of some of the topics discussed.
What is Dupuytren?
A chronic medical disease that affects the hands and sometimes elsewhere. It causes lumps in the palm and sometimes bent fingers. Sometimes it causes bumps on the back of finger knuckles (“knuckle pads”). Sometimes it causes lumps on the instep of the foot (“Ledderhose disease”). Named after the 1800s French surgeon who invented surgery for it.
Who is most likely to develop Dupuytren?
Seniors with European ancestry and with affected family members.
Some additional risks from injury, diabetes, smoking, drinking, and heavy hand work.
How common is it?
10 million Americans have it, most with the mild version and no bent fingers.
What is the timeline?
One in five people will develop bent fingers within ten years of diagnosis.
What can slow down or stop fingers from bending over the long term?
No current treatment has been statistically proven to prevent finger bending.
How do Doctors treat it?
The only effective treatments are procedures to unbend fingers. Open surgery (fasciectomy) removes affected tissue inside the palm. Minimally invasive (Xiaflex; needle release) lengthens affected tissue. Knuckle pads and Ledderhose don’t contract and rarely need treatment.
What is the biggest problem with Dupuytren disease?
Recurrence after treatment is the critical unsolved problem.
What is diathesis?
A way to guess the risk of recurrence after surgery using three factors: Relatives with Dupuytren, Diagnosis before age 50, and Ledderhose. It’s not clear that it is reliable. Recent studies suggest it isn’t. It doesn’t predict any more rapid progression in those with vs. those without.
Why aren’t medicines proven to prevent progression and recurrence?
Preventive medical research is impractical if the only test is finger angles.
How can we find a cure?
We need a blood biomarker test to develop and test preventive treatments. We need significant funding for research to make a blood biomarker test.
Who is doing research for a cure?
Only the Dupuytren Research Group is conducting large-scale dynamic biomarker discovery research.
How can I help the mission of the Dupuytren Research Group?
Enroll in research: DupStudy.com
Share your expertise in research, nonprofit management, and fundraising
Spread the word about Dupuytren and DRG research
Support DRG research through charitable giving
Contact the DRG to discuss more: info@dupuytrens.org
I found the beginning interesting, where the chance of having Dupuytren are higher for europeans then for all the other ethnics. But those people also have something else in common: they consume a lot of milk products (butter/cheese/etc..) all calcium rich foods. We also saw in the presentation that magnesium might help slow down the progression, because the cells in the cords are mainly calcium-dependent pathway involved in the activation of MLCK in the nodes. So I'm starting to think that magnesium helps because magnesium and calcium compete for body absorption. So if we take magnesium, we can absorb less calcium, and therfore the MLCK activation slows down. It's also important to consider that magnesium can act as a natural calcium channel blocker, which might influence cellular activities that are calcium-dependent
Wonder if K2-Mk7/4 would help?
I have released these contractions with slow intense pressure at small point moving along the lines of thicening.
Thank you for this, Dr. Eaton.
I manage FB group of some 4,000 sufferers and many have gotten good results adding magnesium (both oral and topical).
What is the name of your group?
Adding how much magnesium to what? And how much what to who? Michael that is not science, nor would a couple wee drops, which might be more efficacious.
Make sure you get the recommended daily allowance. Check with your doctor.
I am 69 and have taken 1000 mg of mag at night, 500 mid day for years. While it helps with regularity, relaxing etc. I will be scheduling surgery this week.
@@bluedragonfly5 dupuytrens disease science and diet.
Great video and passion for helping and finding a cure. Yes! I'll donate to the research. Thank you!!
Thanks. There are so many others outside the group's you describe as those at risk. Something just speed up the weakening of the tendons, then something must mutate that cause the lumpies.
When you spoke about the intellectual effect of the change of manual dexterity, I got very excited. I experienced this just today working g with my dog in obedience class. I count I kept dropping the treats until the instructor suggested I tried using my other hand. I am now walking my dog on the opposite side of the one I was.
Thank you. I have injury based dupuytrens and after two years nothing has changed except that it hurts less.
This is great stuff, please keep up the good work - we need it!
Thank you, Dr. Eaton, for sharing this video, for being an advocate, for your exceptional work 🙏
Being that I have applied pressure that has released these contractions I suggest that experiment with ultrasound, cold Lazer, stem cell serums.
Mason Williams, who wrote and performed Classical Gas, has Dupuytrens. This was reported to me some years back by Nokie Edwards of The Ventures. He and Mason were acquaintances. I told Nokie to advise Mason to seek out a Dupuytren's expert. Whether he ever did or not, I don't know.
I have been struggling with this disease since 1995 as a 21 year old. I believe trauma was my trigger, In 95 my right hand was affected and it was never apparent until I was ran over and slammed in-between two cars breaking my arm and impacting my hand. Two or three weeks later I immediately formed lumps in my hand and my fingers started to twist and pull in. I had went 15+ years before having the surgery. Fast forward to 2014 I got into a motorcycle accident that crushed my collar bone, shoulder blade, vertebrae extensive damage to left side and hand, a few weeks later I got those lumps in my left hand and started to distort my fingers and pull them in. Since to date I have had 5 surgeries on each hand. My last surgery was on 12/27/2023 on my right hand. I firmly believe DRs know squat about this disease.
I would like to know if this is considered an autoimmune issue.
I'm booked in for surgery shortly, they asked if it hurt, when the cords started thickening, I felt as though I wanted to cut it out myself, pain was excruciating and I have a high pain threshold.
Thank you so much for your work on this condition.
I just learned about this and was diagnosed with it. I though it was my Rheumatoid Arthritis and am excited there is a name and maybe help!
Thank you!
Thank you for this video!
A big thank you. You’re a champion of the cause.
I've just developed Dupytrens after a wrist fracture. My hand and forearm was put into a cast and my hand felt cramped in the cast. After two weeks I noticed the sore nodule in my hand and it felt like the cast wasn't on properly.
When I had the cast off they said I have Dupytrens and that it's hereditary and not as a result of the cast being put on incorrectly. I'm at a loss and now a week after having my cast removed,a cord is developing.
I got the same .... I had a hamate fracture and after I took my cast off, I was diagnosed with dupuytrens a few months later. I m not of Northern European heritage but a full bloodied Southern European/Balkan ... 26 years old male
Since I have dupytrens on my right little finger, I thought it odd that after a break in my left wrist I developed it rather quickly in my left hand. Started out with knots in my palm to seeing the tendons on all fingers but the thumb. In 2 years. My Uncle on my Mom's side has had it for years, no one else, large family. Grandmother from Ireland.
Great explanation, thank you!
I have it for ten years now, sometimes i wake up cause of the pain, than i have to stretch the hand and put it flat under my pillow to ease the pain , i climb, and always thought that was the reaseon why i can still sttetch my hands, but now i started looking this video, it seems that maybe the climbing started this, i onley climb on my fingers now, cause the palms hurt to much
Thank you for this great video. My wife works on her PC 9 hours per day. Is there any recommendation for a more friendly mouse that would minimizes continued finger motion? Any recommendations from patients? Thank you.
I use a Logitech MX Master 3. It’s very comfortable for long sessions. I am a software developer so use it A LOT!
The Logitech vertical mouses are also quite good as well. Takes a bit getting used to it but I swear by them.
It seems that there is a connection between Cholinergic Urticaria and Dupuytren's. ☝
Can you look at the potential of mesenchymal stem cell injections as possible treatments? Looking at the mechanisms of treatment such as immunomodulation, anti inflammatory, tissue regeneration?
I've never smoked, but I drink alcohol moderately. If I stop drinking all alcohol, will it go away? My mother had it and she refinished furniture. I have been a massage therapist for 37 years. Could it be related to our activity?
I doubt it. I never smoked & drink very moderately, to me there’s no relation.
I do cycle a lot, but the I would expect all fingers having it, not just my middle fingers.
Diabetic might correlate, but then I’m not diagnosed as such, and I’m sure my mother isn’t diabetic at all.
I’m so so so so tired of the pain in both hands and both feet, that I’ve actually looked up bionic feet and hands…help!!!
Sorry about the rant…this was an absolutely fabulous wealth of info…that’s hard to find!!! Thank you!!
Thank you! . Does light stretching of the hand with the disease help delay or accelerate the symptoms ? I am
In the early stages (pinky and ring finger) and want to stretch mine in hopes it slows down the curling of the fingers.
It seems like Peyronnies is part of the problem and a cure would possibly treat that as well. Probably get a lot more funding going down that road.
I do push ups every day. 20 years, Could this cause it? Pressure on my palms.
my dupuytrens hurts sometimes. like a cramp i play scales on the piano to get relief
That's how mine feels often. Much like the pain just before or after a Charlie Horse. Similar anyway with excess fatigue
My brother has had three surgeries, so I have been watching. I am 62 and had no symptoms until I took Cipro. I ended up with torn Achilles tendons and a year later a hard cyst in my hand and hard thick tendon and drawing slightly of pinky finger.
I'm wondering if this is a reoccurring situation with floxins triggering this to happen in people's hands.?
I have it in both hands..my right hand middle finger is painful at the nerve area feel ..doctor just wants to operate. ....any advice please.
get a second opinion from a doctor who is familiar with alternative dupuytrens treatments. The more info you have the better the decision will be that you make.
My Dupuytren growed after a surgery massively and started to grow on the healthy other hand. Meanwhile both hands are in a very severy situation.
I encourage you to seek out a dupuytren's expert in your area, if you've not already done so.
THOUGHTS PLEASE .
High or med more frequent focussed extracirporeal Shock wave therapy this seems ideally suited bothe in disintegration or breaking down collagen and in promoting healing and much less damaging than surgery ,one might combine this with adenilub re Oxfird trial or with collegenaze which should facilitate uptake of drugs ,maybe longer term ultrasound or micro current to encourage full cycle mrna dna signalling regeneration back into the correct liminal pattern and collagen 1 from 3,6 reversion.
TH😢OUGHTS PLEASE
I'm planning using systemic enzyme therapy ..lumbrokinease, serrapetease, and or nattokinease for other reasons, but thinking it may help with the DC. I'm also thinking that dmso, mixed with lugols iodine, or cds (chlorine dioxide solution), or just by itself, may have an effect. If anyone has tried these things, leave a post!
Do you use the International Dupuytren Society Forum? Maybe a good place to ask a question or two!
@@azr1453link to the forum?
Let me know if it helps you. I have tried all but it has not seemed to help me.
I first used Oil of Magnesium only and it helped a lot. I would spray it in my palm and massage it in and go to bed with it. I also take a magnesium supplement from Dr. Berg. Then a couple of months ago the pain came back with a vengeance but this time it was attacking my middle finger’s knuckle. So in addition to the oil of oregano I also used DMSO. Again I sprayed the oil of oregano in the palm of my hand but also on the middle finger’s knuckle and then I put a few drops of the DMSO on top of everything. You can feel the skin getting warm for a few seconds. I did this at night before bed. After a couple of times the pain dissipated to almost nothing. Also my nodules have flattened quite a bit. I also do a hand exercise with my hand flat on a table lifting my fingers and also hands together and pushing the fingers backward to stretch them. I did try the DMSO by itself, in my case it didn’t help at all.
Šta mi vredi kad na srpskom nemogu pročitati ništa a ne razumem engl.jezik. imam kontrakture obostrano - na obema rukama.
Google translate!
Is it possible to get dupytrens via fingertip amputation ?
I’m not sure if it is dupytrens or my intrinsic muscles & faschia
Physical trauma in the hand can trigger dupruytens. I had a knife kitchen accident and developed dupruytens between my thumb and first finger (while there’s no ligament there originally, now there is. This developed slowly, 30 years back)
One case I read about, was a Dutch designer who had a soccer ball hit his hand which triggered dupruytens.
So what is the cure?
as of this writing, 6/7/23 there is no cure. Treatment is the only option. Dr. Eaton devoted over 20 years of his hand surgery career to successfully using non-invasive Dupuytren's treatments and is now using his retirement years to help find a cure. That's difficult to do with self or crowd-sourced contributions which is the purpose of his foundation.
@@wstagner Thank you very much. I am experimenting on myself and I tried almost everything I found on the internet, but it only is getting worse.
@@davecopp9356 True, that is the reality. I don´t think that there is a cure actually.
Try listening to the video! He literally says they still don’t know enough yet!
I m currently trying my own cure. Soaking my hand in warm water and add dead sea salt (high in magnesium) and adding a few drops of organic castor oil & vitamin E oil. Before sleeping I apply a few drops of castor oil and sleep overnight. Also I make sure to streth my hands everyday and do some light training/stretching. Also got a hand gripper which I think might help strenghten your hands
PLEASE 1:18 in even a decent graduate student can see this the only really significant thing said at this stage it is an adaptive ir overactive resp to damage common in mechanics in people who routinely use tools probably 90% more ar risk or once bones broken etc the bodies production of collegenaze compromised healing cycle partil ..Your missing the point
You are missing alot context or circumstance ,ie my bike accident and surgeries initiated mine ,collagen 3》6 rather the comp C 1 and thus as you say genetically prone to this phase shift ,then we have seeding ie nutrition on going inflamaftion growth factors snd so forthe ,the reason the surgery is so successfull is that no damage tissue doesn't trigger more myoblasts to release specific growth factors the body is saying my hand is still being damaged to be successfull the collagen must be totally disrupted broken down move back into circulation thus shock wave targeted therapy is intuitively correct then use hherapeutics to help normal healing cycle ,the true treatment gets rid of the diseases tissue and reinstates healthy tissue this way the signalling mrna dna changes .
Please answer my questions re shockwave treatment ,let's just use our intelligence intuition shall we More money waisted ,I see ! All this says to me let me do endless research and pay me rather than find and use treatments sounds as iv you dont really care rather let's play eround in a lab ,there ard psychological names for this sorry but you are insulting people research ISNT as imp as treatment .