Red Blood Cell Morphological Abnormalities
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- เผยแพร่เมื่อ 25 ก.ค. 2024
- This is a video describing various morphological abnormalities found in red blood cells, including changes in red cell size, shape, color, and distribution.
I created this presentation with Google Slides.
Image were created or taken from Wikimedia Commons
I created this video with the TH-cam Video Editor.
ADDITIONAL TAGS:
Macrocytosis
Large
As measured with MCV
altered DNA synthesis
MCV,
things that alter DNA synthesis , B12/folate deficiency
Liver disease
Thyroid disease
Chemotherapy
Anti-retrovirals (AZT)
Microcytosis
Small
Measured with MCV
iron deficiency, thalassemia, lead poisoning
measured with MCV,
Iron deficiency, Thalassemias, Lead poisoning, Sideroblastic anemia
Anisocytosis
Wide range of RBC sizes
High red cell distribution width (RDW)
Hypochromasia
with too little hemoglobin
Measured with mean corpuscular Hb (MCH)
hypochromic cells, central cell diameter
caused by lack of hemoglob (iron defiiciency, thalassemia, liver problems)
Polychromasia
that are shaded grayish blue
often reticulocytes (immature )
Anisocytosis, large RDW
Poikilocytosis
that vary widely shape
Analogous anisocytosis
anisocytosis - vary size
poikilocytosis - vary shape
Target cells
codocytes
Related liver disease, thalassemias, hemoglob C, post-splenectomy
Normal RBC
cross section
Target cell
Anisocytosis, large RDW
Spherocytes
Spherical (instead of biconcave disk-shaped
Appears on blood smear as loss of central pallor
Hereditary spherocytosis
Autoimmune hemolysis
Normal RBC Spherocyte
cross section cross section
(biconcave disk) (more spherical)
Ab attack membrane of RBC, if you pull out chunks of membrane, surface area of RBC membrane decreases
Schistocytes
fragments
Sharp edges
Can be caused by plaque on arterial walls that shear
Also Microangiopathic Hemolytic Anemia (MAHA)
Sickle cells
fragments
sickle cell anemia
Hemoglob molecules with
Point mutation that changes glutamic acid valine
Polymerization of Hb at low pH, low pO2, high temperature
Anisocytosis, large RDW
Echinocytes
burr cells
Projections that are regular
renal disease
Acanthocytes
spur cells
Projections that are irregular large
liver disease
Teardrop cells
dacrocytes
Caused by infiltration of bone marrow (myelophthisic processes)
Something body ( lymphocytes, scar tissue, cancer) enters grows bone marrow
Linear aggregations or “stacks” of
are high levels of immunoglobulins
usually have similar surfaces charges that keep them from sticking together
Immunoglobulins neutralize these charges, allow attract with charge-charge interactions
a normal patient, you might see this on dense side of a blood smear, bc RBC conc is more concentrated
Agglutination
collect clumps
Less orderly than rouleaux
are coated with IgM, which bridge together cause aggregation
Howell-Jolly Bodies
Remnants of nucleic acids that found postsplenectomy
Look like little purple dots
Reticulocytes can only be seen with certain stains such as new methylene blue and Romanowsky stain(which turns all RBCs blue and main purpose is to only see retics). You can not see retics on a peripheral smear which uses Wright stain.
Isn't wright stain=romanwsky though? And using Romanowsky you only see polychromatophilic erythrocytes that are early or immature and not the more mature reticulocytes, so you end up counting only the early rather than late reticulocytes. If you don't get this then you probably don't learn everything, which is fine
This video needs more views, this is very good thank you
Awesome video. Very helpful.
looking forward to more videos from you
Fantastic! This really helped me prepare for my hematology practical. Thank you.
Thank you so much.
Brilliant brilliant video!!! I'm a lay person, I just got a live blood analysis done, and after watching this I can explain it better than the guy who explained the LBA to me :P THANK YOU! Great job!!!
Thank You so very much. I have a big exam tomorrow and this video has taught me all I needed to know for RBC morphology. #highlyappreciated
Thank you so much for helping me understand my condition.
Awesome presentation. Thank you.
Excellent video, Help me a lot in my Haematology course
Terrific video. Thank you.
Thank you so much. Love from India😊
Amazing video, this is better than what they gave me in class. Thank you!
Very good video, thanks
it helped me understand anisocytosis, hypochromacic, which I have. thank you
Important presentations
thank you very much 👍
Lol. This video has been shared by my professor and will be tested on our exam
I hope i'll ace my quiz tommorow thank you!
very helpful thank you !!!!
Aside from Howell-Jolly Bodies, there are actually more RBC inclusions to be included like Heinz Bodies, Cabot Rings, and Basophilic Stipplings :)
Helpful for my hematology course!!
Thank you so much sir this helped me alot!
Thank you sir,this is really help ful for pathology
very well. thanxxxxxxxx for uploading
Wasif Haider The
Thank youuuu
nice lecture
thank you for summarizing these for me
Well explain 💕
good job
Thanks alot 😍😍
nice really
Amazing video😚
Thank u😢💊
hi. good morning. how are u. Very excellent performance. we hope more. thanks.
Hartono Budiono hadir
I understand it now
do you have an email address for us to communicate with you to understand further on RBC? how can one improve the shapes of RBC?
Which program do you use for videolectures? Thx a lot :)
So which RBC would be considered "jagged"? And what causes "jagged" RBCs? What does speckled pattern mean?
My blood work showed I had tear drop & oval shaped cells, what can that mean?
Hello sir
Hb - 14.5
Rbc - 5.12
MCV - 85.8
MCH - 28.3
MCHC - 32.9
RDW - 16%
Report says anisocytosis. Is there anything to worry?
rbc normal speak good
10:46
I didn't understand this point 😥
Hi I got 2+ Schisto , 2+ Poikilo , 2+ Ellipto, 1+, Targets, 3+ Hypochrom , 2+ Microcyto..what does this mean...i also had low iron n feriitin
2+ schistocytes is pretty diagnostic for a lot of things by itself. Low iron and B12 can cause those other shape changes.
@@benwearne542 Nice :)
Why would hypoxemia lead to sickling of RBCs? I mean hypoxemia caused by acidemia maybe but isolated hypoxemia should cause polycythemia, not sickling.
nice lecture