I just started study medicine one week ago and already, I do nothing else. These videos are probably going to be the reason, I pass my exams properly and going to be a knowledgeable doctor. Thank you very much for all you've done and all the videos to come!
This channel is changing my life, no joke. 🙏🏻 I would be SO HAPPY if you did a lecture all about the Lymphatic system - especially how it works in conjunction with blood vessels - because I have lymphoedema and there is NO good information about this disorder out there. Thank you just a million thanks for what you guys do. So excellent 🏆
Zach you are amazing! So close to 900K subs mate! Whenever I see your videos, I am so grateful. 3 Videos in 3 Days . In Soccer you would be Hat Trick Hero. In Basketball you would be MVP
Please make video on some tips for studying and How to make effective notes and how to keep maintain focus.. I know there is a lot on videos on TH-cam but you are deep explainer so it will be helpful.. Thanks in advance 😇
Best thing is to make notes form videos lecture or you can do another thing you can also make notes form the different books material and also from google and makes different diagram and writes in your own words as it will be easy for your revision.
Zach I want to say from the bottom of my heart you represent the best of humanity! You are giving so much and asking for so little. You are an angel mate! (Have tears in my eyes)
I love all of your videos, Zach! So helpful in all my courses I’ve taken thus far and I’m just 2 semesters away from graduating, then onto graduate school 😃 you’ve made learning an enjoyable experience. Do you think you could make a video series of ways that YOU study? Since you clearly have retained so much information 😃 thank you!
I memorized a chart for this section because I didn't understand the purpose of these enzymes in lysosomes. So basically what I think I'm getting from this video is that all the sphingolipidoses are due to defects in lipid metabolism. These lipids are all derivatives of sphingosine and are part of the cell membrane whether they are sphingomylelins, ceramides, cerebrosides, or gangliosides. They are not the same as TG that undergo beta oxidation, they are broken down in lysosomes and are either released in the cytoplasm or ECM via secondary lysosomes. They are used in the liver for LDL degradation, in all cells that undergo autophagocytoses, and in the WBC for pathogen degradation. Fabry is the only XR disease the rest is AR, Fabry and Gaucher usually present in adulthood whereas the other diseases present during childhood. Only gaucher disease may present with increased risk of infection due to pancytopenia, differentiating Tay Sach from Niemann Pick via hyperreflexia vs hyptonia and no hepatosplenomegaly vs hepatosplenomegaly.
Thank you so much You make my knowledge concrete! I have been studying biology with you. I hope you feel our happy 😊 Be safe from Covid19! Be always happy!
As an old engineer I had a brain freeze about 1:00 in. Then about 10:00 when you talk about Receptor Mediated Endocytosis a few brain cells came out of hibernation connecting stress analysis and vibrations and I nearly had a stroke. I couldn’t even relate to nonlinear optics. Holey-Moley I guess I better start with basic biology. However, after a third go of it some synapses are forming.
Don't often see anything on LSDs like this. Thanks for raising the profile. Woild like to see something on lysosomal membrane proteins especially NPC1 (Niemann-Pick 1 protein. Amazing small writing!
I’m currently taking a paramedic class thank you for your videos. Tremendous help! For a future video topic can you do a video on med math . We were learning about IV piggybacks with dopamine drips of different Concentrations. Some of your clear explanation would really be helpful!
Hi Zach, Thank you so much for the amazing explanation, I have a question to share with you regarding the NPC disease (Niemann pick type c)! Out of this explanation, what is the possible consequences of following a low carb & high fat diet and Intermittent fasting on NPC cells and how consuming different kind of fat can increase or slow down the process of the disease in the cell level?
Thank you so much for the video, such a clear concise explanation. However, does anyone know why Tay Sachs and Nieman Picks present so similarly besides the hepatomegaly while Gaucher and Fabry dont. Also why does gaucher seem to affect the bone (is it because the enzyme that its deficient in is only found in that bone?)? What is the reason behind Fabry causing Angiokeratomas while the others are less likely? These might all be moot points, but Im just curious to know if there is an actual answer or if its just by experience that these are the most common presentations?
Really,u r awesome n your videos r also awesome n very much helpful....thank you so much zach....lots of love (India)😍😍😍....please upload videos of all the cell organelles🙏
I hope you be successful in your entire life and you worth it for all your dedication and your perseverance. I know you're work is not so easy but it worth.
If everyone in the world were like Zach, the world would be heaven! Thank you for making 3 videos in 3 days!
But... We can't have good things
I agree 🧘🏻♀️🤍
I just started study medicine one week ago and already, I do nothing else.
These videos are probably going to be the reason, I pass my exams properly and going to be a knowledgeable doctor.
Thank you very much for all you've done and all the videos to come!
This channel is changing my life, no joke. 🙏🏻 I would be SO HAPPY if you did a lecture all about the Lymphatic system - especially how it works in conjunction with blood vessels - because I have lymphoedema and there is NO good information about this disorder out there. Thank you just a million thanks for what you guys do. So excellent 🏆
i can't believe this man is actually real!!! a genius indeed
Zach you are amazing! So close to 900K subs mate! Whenever I see your videos, I am so grateful. 3 Videos in 3 Days . In Soccer you would be Hat Trick Hero. In Basketball you would be MVP
I clap after each video. Thank you so much for doing this, you're a blessing on this app! Virtual hugs
Please make video on some tips for studying and How to make effective notes and how to keep maintain focus.. I know there is a lot on videos on TH-cam but you are deep explainer so it will be helpful.. Thanks in advance 😇
Yessss please 🙏🙏
Best thing is to make notes form videos lecture or you can do another thing you can also make notes form the different books material and also from google and makes different diagram and writes in your own words as it will be easy for your revision.
@@drirfan72941 thanks you! 😊❤️
he already did a studying video on his channel 2-3 weeks ago
Making STEP 1 studying so much easier. Thank you so much!
I would have never made it through my first year of med school without your help. Thank you for all of the great videos.
20 years after biology semester, recapitulation with Zach.Thank you Ninja Nerd🙏
Zach I want to say from the bottom of my heart you represent the best of humanity! You are giving so much and asking for so little. You are an angel mate! (Have tears in my eyes)
This is the first video I've seen on TH-cam without a dislike! Thanks Ninja!
This man is a Angel for medical students.
Thank you so much.
Keep it up.
I’m a third year phd student at Notre dame working on npc disease. Loved the video, and it was really impressive.
I love all of your videos, Zach! So helpful in all my courses I’ve taken thus far and I’m just 2 semesters away from graduating, then onto graduate school 😃 you’ve made learning an enjoyable experience. Do you think you could make a video series of ways that YOU study? Since you clearly have retained so much information 😃 thank you!
I will say only one sentence "you are amazing zach"❤️❤️❤️
I memorized a chart for this section because I didn't understand the purpose of these enzymes in lysosomes. So basically what I think I'm getting from this video is that all the sphingolipidoses are due to defects in lipid metabolism. These lipids are all derivatives of sphingosine and are part of the cell membrane whether they are sphingomylelins, ceramides, cerebrosides, or gangliosides. They are not the same as TG that undergo beta oxidation, they are broken down in lysosomes and are either released in the cytoplasm or ECM via secondary lysosomes. They are used in the liver for LDL degradation, in all cells that undergo autophagocytoses, and in the WBC for pathogen degradation. Fabry is the only XR disease the rest is AR, Fabry and Gaucher usually present in adulthood whereas the other diseases present during childhood. Only gaucher disease may present with increased risk of infection due to pancytopenia, differentiating Tay Sach from Niemann Pick via hyperreflexia vs hyptonia and no hepatosplenomegaly vs hepatosplenomegaly.
Thank you so much
You make my knowledge concrete!
I have been studying biology with you.
I hope you feel our happy 😊
Be safe from Covid19! Be always happy!
Such a simple, to the point, awesome video!!! You make learning fun. Keep going
you saved my many hours of reading
God Bless you Zach
Thank you so much for this wonderful video❤
This is wonderful. Everything I wanted to know and understand about the lysosome, I found it here. Thank you very much😊
This helped a lot sir.... Thank you so much...
Congrats zach bro you are near to 1million
As an old engineer I had a brain freeze about 1:00 in. Then about 10:00 when you talk about Receptor Mediated Endocytosis a few brain cells came out of hibernation connecting stress analysis and vibrations and I nearly had a stroke. I couldn’t even relate to nonlinear optics. Holey-Moley I guess I better start with basic biology. However, after a third go of it some synapses are forming.
Don't often see anything on LSDs like this. Thanks for raising the profile. Woild like to see something on lysosomal membrane proteins especially NPC1 (Niemann-Pick 1 protein. Amazing small writing!
Thank you so much for this knowledge🙂
Je parle pas anglais et j'ai quand même trouver son cours super
U are just AMAZING Professor !
Thank you for making it easy for me to understand 🙏🏾💞
I’m currently taking a paramedic class thank you for your videos. Tremendous help!
For a future video topic can you do a video on med math . We were learning about IV piggybacks with dopamine drips of different Concentrations. Some of your clear explanation would really be helpful!
You make the lesson very easy.
Dude, you are a hero! We all love you!
Thanks to you and your team!
OMG you are simply amazing, i enjoyed the full lecture. Thank you very much for this!
Thanks you ninja nerd for the best you have done.
Best up and coming rapper!!!
The best lecture I've ever seen! Thank you so much!
Brilliant video
stunning!! Love all the lectures. Bless you all.
you are so awesome to watch!! Thank you for making and sharing your super personality with us!! love ur videos!!
Loved it! Thank you, Zach, appreciate your contribution!
Thank you for this amazing video
Thank you for making this video.. you make things simplier.
YOU ALL ROCK THANK YOU
only 100k away from the million lets do this ninja nerds!
I love how you are repeating facts with having these little breaks, so one has a change to suggest frist
Thank you so much for being just the way u r
Loves your teaching style...❤️❤️🙏🙏
Amazing sir keep making videos on cell biology lots of love from Pakistan ❤❤
great video! I like you explained end to end process
it was an awesome lecture but I wished that you explained other sphingolipidoses. like krabbe farber etc. still was a nice roundup video. loved it.
Hi Zach,
Thank you so much for the amazing explanation, I have a question to share with you regarding the NPC disease (Niemann pick type c)!
Out of this explanation, what is the possible consequences of following a low carb & high fat diet and Intermittent fasting on NPC cells
and how consuming different kind of fat can increase or slow down the process of the disease in the cell level?
You are a blessing
Wow extraordinary it's makes me feel better understanding thankyou so much sir
bro your energy while explaining is different!
You are a good teacher, thank you.
god damn i love you guys so, so, so much
Thank you so much for the video, such a clear concise explanation. However, does anyone know why Tay Sachs and Nieman Picks present so similarly besides the hepatomegaly while Gaucher and Fabry dont. Also why does gaucher seem to affect the bone (is it because the enzyme that its deficient in is only found in that bone?)? What is the reason behind Fabry causing Angiokeratomas while the others are less likely? These might all be moot points, but Im just curious to know if there is an actual answer or if its just by experience that these are the most common presentations?
can never thank you enough for this !
Wow Zach you are explaining stuff that we used to think that they are non-doable in medschool and never understand 😂 lysosomal storage diseases are 💀💀
Thank you very much
Thanks zack sensi
Sir also deliver lectures on remaining cytology such as details description on nucleus . Cell membrane. And so on👍👍👍👍👍👍👍
Kindly do a video series on how to read and interpret X-rays and other radiographs. Thanks
thank you so much !!
Thank you
Many thanks. It was really helpful.
Sir I am ur biggest fan sir 😌💓
Thanks
Thank you sir for making amazing lactures
Excellent Lecture! Please provide me with the links for all of your biochemistry and molecular biology lectures
His liiitttlle bit deeper is very deep😌
Amazing!
Amazing explanation as always
Excellent informative vedio
Please make a video on Tuberculosis...Thanks
thank you so much
Sir pls post more videos on pathology , pharmacology and microbiology....
We r waiting....🙏🙏❤️
Danke!
Nice information
Wey neta que te amo, explicas super bien todo
Very useful
We want more video on organells of cell I mean on ribosome on golgi aperatus etc
Very nice content.
1 st video on yt ..likes are more than 1k without dislike ❤️ I think 🤔
Great as usual... good job !
a hero
Really,u r awesome n your videos r also awesome n very much helpful....thank you so much zach....lots of love (India)😍😍😍....please upload videos of all the cell organelles🙏
Thank you Zach
I hope you be successful in your entire life and you worth it for all your dedication and your perseverance. I know you're work is not so easy but it worth.
Thank you, Sensei
Thanks a lot for your hard work👍🙏
Thank you zach bro!! 😊
can’t wait to watch this!
Nice
Great video!! As always
thanks.
Very good explanation..
Superhero of medical students Zach🦸🏻♂️
You r amazing.. plaease can explain the hormone and its role on immunity