Ken's corporation analogy for discriminate vs indiscriminate weight loss is up there with Arthur's sun tan analogy for teaching the relationships between intensity, stimulus, volume, and overtraining.
I would argue more relevant to more individuals in this day and age of atrophied skeletal muscle systems. I love the simplistic genius of the HIT community :)
I apologize if you spoke to this already. What are the negative / (projected) long term side effects of these drugs? And if taken for weight loss and properly applying resistance training as described? Thank you
Its crazy the things people will try and do to look better while overlooking the simplest and most effective one...resistance training. Its really quite mind-boggling, especially when you consider how small the minimum effective dose can be in most cases.
Thanks Dr. McGuff...looking big💪 Just this week realized how maintaining stimulus in exercise, while eating just enough creates the optimal dynamic balance to lose fat☺. Here is the title to a video on the channel called: 'Kurzgesagt - In a Nutshell' which helps explain the catch 22 in weight loss: 'We Need to Rethink Exercise (Updated Version)' - It also really helped me understand why losing fat and exercise have such a counterintuitive/asymmetric relationship. As you explained in your video it's about the conditioning of our metabolism(in the metabolically active tissues which are resistant to change due to the energy demand they would necessitate in the first place) and not about burning off the calories when training... because the important caloric burn happens when we are not training, ironically... So losing fat is basically an indirect and not a direct response to the catalyst of training. Also figured out last month that eating twice a day may be the best in terms of balancing out nutritional variation, insulin sensitivity and caloric restriction... I imagined were we to be a hunter gatherers, going to look for food first thing in the morning would be the main thing to then have a late breakfast and then any kind of opportunistic meal for a second meal in the afternoon... Also makes sense to me that a big initial meal would have time to digest so that nutrients would be available in time to rebuild during sleep. Anyway, just thought I'd share that maybe it's useful... Thanks Dr. McGuff - keep safe🙏
Great presentation as always Dr Mcguff... Prompted me to review some of your other, videos which the reference flags in my head. Would've had me guess 1 yr ago, 3 years 4 years etc.....wild under estimation in all cases......big shock with the back training video I would have guessed 5 or 6 years, nope......14 years!
Thank you dearly for this video Dr. McGuff. I shall put this parable to great use with my clients looking to lose FAT and gain MUSCLE, simply brilliant :)
I believe this is true under the assumption you’re getting enough sleep. Without proper sleep your body will drop muscle in a deficit no matter how much you train.
Good stuff. It is always good to have a reinforcement on HIT. How about this for simple, but challenging, overall approach: Avoid the ultra damaging stuff like smoking, drugs, heavy alcohol, eat whole foods, do intense strength training.
Yup. GLP agonist are only trying to replicate what exercise does. You can get the body to stimulate muscle growth by eating enough (30g or so) at once. It’s a separate pathway. Save the $1200 a month on the prescription, and buy steak and a the fresh organic vegetables instead.
Doug--could you elaborate on the "nervous tissue" loss? What exactly is lost, and what are the (objective and subjective or "felt") ramifications of that?
In the periphery, there is evidence for motor unit loss, axonal atrophy, demyelination caused by oxidative damage to proteins and lipids, and modified transmission of the electrical signal through the neuromuscular junction. Quote from: Aging and muscle a neuron's perspective Manini, Todd M.a; Hong, S. Leeb; Clark, Brian C.b Author Information Current Opinion in Clinical Nutrition and Metabolic Care 16(1):p 21-26, January 2013. | DOI: 10.1097/MCO.0b013e32835b5880 When motor units are shut down the nerves (axons) along with their insulating material (myelin) is deconstructed as well.
@@dr.dougmcguff282 So...if people take Wegovy, Ozempic, etc. and do not exercise (or ingest sufficient protein) they will not only lose large amounts of muscle, but they will be less able to use the muscle they have left?
Our bodies break down and build up about 300 grams of protein each day, regardless of what we eat. Having enough amino acids, in the right combination, ensures they are built back up. Fortunately, all animal products have these amino acids in the combinations we need to build muscle.
Ageing Research Reviews Volume 21, May 2015, Pages 55-70 Ageing Research Reviews Review Muscle and bone, two interconnected tissues Aging and muscle a neuron's perspective Manini, Todd M.a; Hong, S. Leeb; Clark, Brian C.b Author Information Current Opinion in Clinical Nutrition and Metabolic Care 16(1):p 21-26, January 2013. | DOI: 10.1097/MCO.0b013e32835b5880 Physiologists have discovered that when people lose weight, about 25-30% of their weight loss is lean muscle mass, and the remainder is a reduction in fat mass. In the STEP-1 study, patients treated with semaglutide lost nearly 14 kg in total, with 8.5 kg (60%) being fat loss and 5 kg (38%) being lean mass loss, which exceeds normal physiological expectations. Just a brief cruise through Google Scholar will show the evidence, particularly with regard to GLP-1 Agonists.
Ken's corporation analogy for discriminate vs indiscriminate weight loss is up there with Arthur's sun tan analogy for teaching the relationships between intensity, stimulus, volume, and overtraining.
I would argue more relevant to more individuals in this day and age of atrophied skeletal muscle systems. I love the simplistic genius of the HIT community :)
I apologize if you spoke to this already. What are the negative / (projected) long term side effects of these drugs? And if taken for weight loss and properly applying resistance training as described?
Thank you
Its crazy the things people will try and do to look better while overlooking the simplest and most effective one...resistance training. Its really quite mind-boggling, especially when you consider how small the minimum effective dose can be in most cases.
I always look forward to your videos. Great stuff!
Very useful! Thank you Doug!
So well spoken. Never leave one of your videos wondering "what did he just say?" Thank you .
Thanks Dr. McGuff...looking big💪 Just this week realized how maintaining stimulus in exercise, while eating just enough creates the optimal dynamic balance to lose fat☺.
Here is the title to a video on the channel called: 'Kurzgesagt - In a Nutshell' which helps explain the catch 22 in weight loss: 'We Need to Rethink Exercise (Updated Version)' - It also really helped me understand why losing fat and exercise have such a counterintuitive/asymmetric relationship. As you explained in your video it's about the conditioning of our metabolism(in the metabolically active tissues which are resistant to change due to the energy demand they would necessitate in the first place) and not about burning off the calories when training... because the important caloric burn happens when we are not training, ironically... So losing fat is basically an indirect and not a direct response to the catalyst of training. Also figured out last month that eating twice a day may be the best in terms of balancing out nutritional variation, insulin sensitivity and caloric restriction... I imagined were we to be a hunter gatherers, going to look for food first thing in the morning would be the main thing to then have a late breakfast and then any kind of opportunistic meal for a second meal in the afternoon... Also makes sense to me that a big initial meal would have time to digest so that nutrients would be available in time to rebuild during sleep. Anyway, just thought I'd share that maybe it's useful... Thanks Dr. McGuff - keep safe🙏
Great presentation as always Dr Mcguff...
Prompted me to review some of your other, videos which the reference flags in my head. Would've had me guess 1 yr ago, 3 years 4 years etc.....wild under estimation in all cases......big shock with the back training video I would have guessed 5 or 6 years, nope......14 years!
Thank you dearly for this video Dr. McGuff. I shall put this parable to great use with my clients looking to lose FAT and gain MUSCLE, simply brilliant :)
Good parable teaching
I believe this is true under the assumption you’re getting enough sleep. Without proper sleep your body will drop muscle in a deficit no matter how much you train.
Sleep is the least important aspect
I've dieted for contests with sleep averaging 5hrs with no change in muscle loss
@@goodman_1955 well I’ve had the opposite happen. Are you enhanced?
What a great analogy
Hi would you consider short hill sprints done at max intensity an order for muscle?
Fasting also has a muscle sparing effect. I did a 30 days waterfast and lost no strength in the Gym.
I was a beginner 60 years old.
Good stuff. It is always good to have a reinforcement on HIT. How about this for simple, but challenging, overall approach: Avoid the ultra damaging stuff like smoking, drugs, heavy alcohol, eat whole foods, do intense strength training.
I wish you'd make more videos and online content, longer than 5 minutes...
Interesting but hard to understand for people who might not get these fancy terms.
And the same can be said for those who are resistance training without taking any weight loss medication, right?
Yup. GLP agonist are only trying to replicate what exercise does.
You can get the body to stimulate muscle growth by eating enough (30g or so) at once. It’s a separate pathway.
Save the $1200 a month on the prescription, and buy steak and a the fresh organic vegetables instead.
Yes. That is the scenario the parable was made for.
Doug--could you elaborate on the "nervous tissue" loss? What exactly is lost, and what are the (objective and subjective or "felt") ramifications of that?
In the periphery, there is evidence for motor unit loss, axonal atrophy, demyelination caused by oxidative damage to proteins and lipids, and modified transmission of the electrical signal through the neuromuscular junction.
Quote from:
Aging and muscle
a neuron's perspective
Manini, Todd M.a; Hong, S. Leeb; Clark, Brian C.b
Author Information
Current Opinion in Clinical Nutrition and Metabolic Care 16(1):p 21-26, January 2013. | DOI: 10.1097/MCO.0b013e32835b5880
When motor units are shut down the nerves (axons) along with their insulating material (myelin) is deconstructed as well.
@@dr.dougmcguff282 So...if people take Wegovy, Ozempic, etc. and do not exercise (or ingest sufficient protein) they will not only lose large amounts of muscle, but they will be less able to use the muscle they have left?
DR DUGG BACC!
Hello doc, your message is great, yound quality is very poor.
Your spelling is worse.... Seriously, I apologize as I keep forgetting my external mic and UE is very echoey.
@@dr.dougmcguff282 haha, great response
Wassup, doc? JK. Nice vid, doc.
It's important that you eat enough protein and carbs to spare your bodies need to cannibalise muscle.
Our bodies break down and build up about 300 grams of protein each day, regardless of what we eat. Having enough amino acids, in the right combination, ensures they are built back up.
Fortunately, all animal products have these amino acids in the combinations we need to build muscle.
Is there scientific evidence for the MBNF weight loss scenario though? Sounds good but empirical science is the real story.
Ageing Research Reviews
Volume 21, May 2015, Pages 55-70
Ageing Research Reviews
Review
Muscle and bone, two interconnected tissues
Aging and muscle
a neuron's perspective
Manini, Todd M.a; Hong, S. Leeb; Clark, Brian C.b
Author Information
Current Opinion in Clinical Nutrition and Metabolic Care 16(1):p 21-26, January 2013. | DOI: 10.1097/MCO.0b013e32835b5880
Physiologists have discovered that when people lose weight, about 25-30% of their weight loss is lean muscle mass, and the remainder is a reduction in fat mass. In the STEP-1 study, patients treated with semaglutide lost nearly 14 kg in total, with 8.5 kg (60%) being fat loss and 5 kg (38%) being lean mass loss, which exceeds normal physiological expectations.
Just a brief cruise through Google Scholar will show the evidence, particularly with regard to GLP-1 Agonists.