Thank you for watching. If you enjoyed this topic and episode, please click the "like" button and subscribe to our channel here on TH-cam. Thank you for your interest in science! -- Andrew
Thank you for hosting me on your amazing podcast! I am excited to engage with your audience. Looking forward to lots of questions and wanting to be resourceful to answer.
Dr. H- you have an incredibly accessible manner about you. 😊This is my favorite series. The mix of hard science with a humble, direct and truth-seeking demeanor is highly magnetic. I’m what I call a slacker hacker- former trainer and yoga instructor - gym rat. I’m at the point where exercising “harder” is not going to be helpful getting through menopause so understanding different paths to vitality is highly valuable. ❤
@@craigkonivermdyour interview and discussion with Dr. Huberman was so detailed and helpful, I’ll need to re-listen! Thank you both for having a brain, a heart, and the desire to share! 🤩
As a biologist, I've been a big fan of Hubermanlab for years now and I have almost listened to all episodes and I can sincerely say that THIS EPISODE IS THE BEST!!! So informative and it spiked my curiosity on peptides even more. Now Dr Craig Koniver has gained a new fan! Not only is he super knowledgeable but he is compassionate and I can see that he is truly living his purpose. Thank you for taking the time to teach all of us nerds!
@@craigkonivermdAs a physician who is totally new to this but open to learn in other to know more for may be improve my assistance to mi patients, i want to truly acknowledge you and Dr Andrew for this top 1 episode, hope you can one day come to Spain because i would love to assist a seminar or something to improve even more my knowl❤ also if you know somewhere to learn more i would be very grateful if you can tell me your best tips ❤ ( sorry if my English is bad hahaha)
A book that changed my life in ways that I never could imagine is "Secret Testosterone Nexus of Evolution".Drop whatever you're doing right now and go find that book. Trust me after I implemented things from the book my testosterone levels went beast mode
Trizepatide has changed my life for the better. Best decision I could have made. The change in my mood alone has had a huge impact on my life. I’m no longer anxious or stressed. My mind is relax. My inflammation gone. And of course the lbs coming off and feeling awesome 🤩
Started Tirzepatide in March after decades of my weight yo-yo’ing and dealing with difficult to treat hypertension and NA Fatty Liver Disease. I’m now down 45lbs to my goal weight, am on maintenance dose, and my FLD is reversed and BP has never been so well controlled. I’ve gone from two high dose BP meds to only one med, and at half the dose I was on. Hope that I’ll soon be off of it, too. It’s important to do resistance training, drink plenty of water, eat plenty of of fiber and protein. I believe these peptides are the future of proactive health care.
I’m an integrative nurse practitioner and cannot thank you enough for sharing all of this vital information! The majority of what was shared I practice on a regular basis with my clients and feel that not enough people know about these modalities and it’s such a fresh breath of air to see the good word spreading. I also greatly appreciate the sharing of details surrounding mechanism of actions and dosing ❤
And this is one of the reasons why I subscribed to Andrew humerman's channel is because he interviews quality people who are giving truthful information to the public
You can find them where first you will be asked to pay $200 for consultation. And then you will be charged tens of thousands of dollars for unnecessary treatment
To me this is a very bittersweet episode. It's not an easy realization that mainstream medicine has failed except in keeping people alive and sick. The alive part is obviously amazing, the sick part is not. Most medical research is also now very close to useless, only synthetic (patentable) pharma products are studied in incredibly biased ways. Bioidentical hormones, peptides and molecules (biologics) are largely left out in the cold or outright banned where they compete. Then we have amazing clinicians like Dr Koniver who have wealths of clinical knowledge using mostly biologics but it's siloed, hidden and extremely expensive thus very few can access this kind of care. I love the part about positivity though, somehow we need to have a medical revolution. Vote for your health freedom!
Andrew, your podcasts have been a game-changer for me! Unfortunately, the paradox is that the more I learn and implement your protocols, the less time I have to catch up on the latest episodes. I'm currently staring at a list of about 20 episodes I haven't been able to get to. I guess that's a good problem to have!
I have been using peptide therapy for the past 5 years and they have been absolute game changers in perimenopause. No Dr was helpful so I just did my own thing and could not be happier. No HRT
I am one example of someone andrew huberman saved, From releasing my self destructive behavior and armed me with the tools to make health and wellness a top priority in life so thank you for helping so many poeple!
I’ve listened to this podcast twice. This was one of the most outstanding speakers you’ve had on and I’ve loved most of them. I think you summed it up in the end, his humanity Was so apparent in his approach to his patients and the practice of medicine along with his breadth of knowledge and approach to what health actually is for patients. Your mutual admiration was truly beautiful and well expressed. I’ve got to go meet this man! Thank you again for your thoughtful choice of guests.
Andrew, you keep making it difficult for me to have a favorite episode!!! You have the best discussions with your guests 🎙️ Thank you for your service to humanity 🙏🏾
I have been following Huberman postcast since day 1, it's been so amazing, grateful and inspiring themes and guest's. 🙏. Dr Craig koniver beets another level... the knowledge, the expertise, the work in the field and most of all the humanity and empathy for the ones that suffer its beyond words! Thanks for sharing 🙏🙏🙏
This is one of the best episodes I’ve listened to, for multiple reasons. Thank you both for doing this. There is so much more I want to learn. There is so much that sickens me about the treatment of chronic illness in the USA.
Thank you for finally discussing Methylene Blue! My recommendation is to heat up 4oz of water (45 sec in microwave). Put the Methylene Blue in the warm water and add about a tablespoon of vitamin C powder. Stir and it becomes clear and won't stain. It also allows the vitamin C to pass the blood/brain barrier.
Oh, this episode was like Christmas morning! I love my peptides, they're the only thing that's moved the dial on my multiple autoimmune disorders. NAD has now been moved up on my to-do. Thank you Dr Huberman and Dr Koniver!
Dr. Koniver’s approach can be seen as both innovative and cautious in this respect. He is leveraging newer therapies that seem to have low risk of harm, but their full efficacy or potential risks may not be fully understood. This makes his methods more exploratory, appealing to those looking for cutting-edge solutions in health optimization but requiring a degree of trust in treatments that are not yet mainstream.
00:03 Dr. Craig Koniver specializes in performance medicine using peptides for mental and physical health. 02:12 Peptides and hormone therapies offer a middle ground between supplementation and prescription drugs for health augmentation. 06:19 Discussion on the importance and benefits of therapy for overall health 08:19 Peptides are gaining popularity for health and performance benefits. 12:45 Focus on achieving goals first to motivate individuals for long-term health improvements. 14:39 Peptide and hormone therapies can positively impact health and longevity. 18:18 Peptides like GP1 and BPC 157 are being used to address inflammation and immune system health. 20:18 BPC helps reduce inflammation and improve overall health 23:47 BPC157 has a general anti-inflammatory response with better efficacy through injection. 25:21 Peptide BPC157 benefits joints and promotes repair systemically 28:56 Concerns about obtaining bpc 157 from gray market sources 30:47 Nandrolone combined with testosterone can benefit long-term users. 34:10 Having a knowledgeable physician is crucial when considering peptide therapies 36:01 Compounding pharmacies face restrictions due to FDA regulations. 39:19 Peptides for performance medicine and health 41:01 Purchasing peptides from gray or black markets can be dangerous 44:35 Concerns about FDA regulations impacting peptide use 46:24 Prefer using peptides over direct hormone manipulations 49:47 Proper dosing of peptides is crucial for avoiding adverse effects 51:26 Peptides like ghrp6 have specific benefits for health and performance 54:38 Searon and Tesone work on growth hormone releasing hormone for health benefits. 56:25 Peptides can enhance health and longevity 59:43 Detoxification and mercury levels are important for health. 1:01:19 Benefits of taking CoQ10 for mitochondrial health 1:04:44 Co-enzyme Q10 supports electron flow at cytochrome C 1:06:21 Repurposing drugs for various medical conditions is a common practice in healthcare. 1:10:06 Importance of trustworthy health information 1:11:53 Focus on holistic health beyond just prescriptions. 1:15:23 Importance of surrender and creating space for flow state 1:17:01 Peptide therapies help with muscle mass and overall health. 1:20:31 Hormone release is highest in the early morning 1:22:17 Homocysteine levels indicate cardiovascular risk. 1:25:47 Pinealon improves rapid eye movement sleep 1:27:27 Pinealon may impact circadian rhythm and melatonin production 1:31:01 Glycine helps improve sleep and aids in liver detoxification. 1:32:42 Liver's role in making fat-soluble substances water-soluble for excretion. 1:35:55 Bioavailability of peptides in oral versus injectable form 1:37:43 Concerns about access to compounded peptides due to potential removal by pharmaceutical companies 1:41:26 Thymosin Alpha 1 was used for immune modulation 1:43:17 Peptide and hormone therapies have been used for decades in certain medical settings. 1:46:37 Methylene blue is a cognitive stimulant and can be combined with other agents for brain function. 1:48:10 Methylene blue can impact urine color and mitochondrial efficiency 1:51:59 NAD therapy effectiveness in combating inflammation 1:53:50 NAD therapies can lead to rapid transformation to a super well state. 1:57:23 Nutritional deficiencies may contribute to mental illness 1:59:11 NAD infusions have a transformative effect on various biological processes. 2:02:28 Monthly maintenance dose is recommended for optimal results. 2:04:11 Peptide infusion can cause empathetic response to pain. 2:07:40 Peptide PT-41 stimulates libido and hormonal pathways in both men and women 2:09:32 Peptides can have a narrow therapeutic window in humans. 2:13:08 Peptides have immense beneficial uses but face regulatory challenges 2:15:07 Take control of your health by being your own advocate 2:18:31 Discussion on pharmaceutical companies and government oversight 2:20:17 Positive thoughts can enhance immune system function 2:24:06 Discovering our unique purpose brings magic to life 2:26:02 Dr. Craig Koniver's work focuses on peptide and hormone therapies. Putting in the work for you guys has been a pleasure. Kindly like and subscribe to show your love❤ buymeacoffee.com/gmdavid
18:00 - when I lost weight a huge (ha, pun) help was when everyone stopped treating me like I was sub-human. The constant low level poor treatment, dismissive attitudes, and occasional outright bullying have an accumulative effect on a person. Once that lifted EVERYTHING felt easier.
Totally real, I get treated like crap while shopping, unless I am fresh out of the gym, ripped, and swole in a TShirt....The same young women crapping on me, are all too friendly and helpful...lol...and I am 54
I was eating zero processed foods, super clean, fasting, training 4 times a week and detoxing regularly... I was not losing the 10 pounds I gained from perimenopause. NOTHING was working. I was miserable because I was literally doing everything. Tirzepatide has changed my life in no time. I microdose. I still feel hungry and eat but it's just melted the fat off. My hormones are even more balanced than they were from the bioregulators. I have gained muscle as I train three times a week - hard. I was the last person I'd ever thought would go on these but geez.... it's changed my life and I have had ZERO side effects. My digestion has never been better!
That’s amazing! Io e hearing this. Are you saying the Tirzepatide helped you gain muscle ? Of course I understand that it was in combination with hard training.
Thank you Drs. Koniver and Huberman for this podcast (vodcast?) episode. I have listened to 47 minutes, and will continue to the end. I added peptides, isolate whey protein, and creatine from Momentous about three months ago to my diet, based on other Huberman Lab broadcasts. It is intriguing to read the comments below claiming that this is the BEST episode EVER. My opinion of the BEST episode EVER is about the quevedoces (sp?) -- how clearly the role of hormones in sexual development was articulated by Dr. Huberman! I can't wait to finish this episode. Again, thank y'all!
I would go through BioFusion Peptides if you are looking for a good source, used their BPC-157 & TB-500 for my Grade II rotator cuff tear and they helped me out with protocol as well so that stood out to me. Also I believe their peptides are all HPLC tested and verified for purity, don't really see any other companies doing that
Great discussion. I was “hooked” on antidepressants (SSRI’s) for 12 years, couldn’t get off them as hard as I tried, the withdrawals were horrific. I started taking NAD injections for general health and coincidentally tried to taper off my SSRI’s and noticed I have zero withdrawal. I got off them within a month and never looked back. NAD is truly an amazing compound.
I couldn't agree more regarding taking agency for my own health. Dealing with a couple of auto immune conditions and just trusting my Dr was getting me nowhere. Finding a Dr to work with has been transformative for me. My Dr follows you too!
Be careful with BPC 157. It accelerates cancer. I was using it along with TB 500 and IPA/CJC for about two months and then I noticed my piss stream is getting really weak. Went in for a prostate exam and sure enough I got a lump in there. Due for a biopsy in a few weeks. I’ve stopped the peptides and going to try a few things to see if I can shrink it and then getting a second opinion.
I have been an avid follower of your platform and your real life approach to health and vitality. This is one of the most impactful episode of how out traditional medical system and educational system is outdated and antiquated . The most profound way to live your best life is to take it into your own hands and not rely on all the existing system that is in place.
I’ve always listen to your podcast. And this one is one of the books.. This episode is sooooooo goood!! Felt like i ate a food that i’ve never had! The knowledge and open intellectual conversation is breath of fresh air.. just speechless esp. the closing message❤❤❤
Can I say. This is the only episode whereby you haven’t covered the topic as in depth as I would like. We need an episode on each peptide, side effects, long term, short term, duration of use etc etc. I am concerned you only covered benefits and for those without a good understanding of all the other aspects. This episode really peaked my interest though. Thank you, Andrew!
Thank you to both Dr. Andrew Huberman and Dr. Craig Koniver for this awesome discussion and a belated Happy Birthday to Dr. Huberman. This topic naturally gravitates attention and I definitely aspire to work towards lean yet strong. I call it "lean and mean".
The microdose discussion is so important. Dr. Tyna Moore has researched this extensively and is well recognized expert on this specifically, in combination with her metabolic health and regenerative medicine expertise. What I learned from her in this arena has totally changed my mind on GLP1s in particularly. Would love to see her on the show!
Agreed!! I recently listened to her “Ozempic Done Right” episodes (parts 1, 2, and 3) and my fascination w/ peptides after listening to her - led me to this podcast. Highly recommend these 3 podcast episodes on “The Dr. Tyna Show”. And others…
I found that BPC157 and TB5 from Swisschems were super helpful during my recovery from a knee injury caused by a motorcycle accident. It really seems to speed up my healing process post-surgery.
How is your recovery so far? Any update? I also just recently got in a motorcycle accident. Low sided into a mountain. Knee is banged up and all swollen and bruised with a seroma. Nothing broken luckily. Just ordered some BPC and TB
¡Hola Profe!Just wanted to express my gratitude for the education in a form of conversation on such a cutting-edge subject from such a knowledgeable source.Thank You for all Your hard work and care for all of us.
Thank you Andrew, it's great to have you sharing these vital information and experience. People really need to learn more about how peptide can help their health. I recently tried tirzepatide and I'm genuinely impressed with the results! The GLP-1 is amazing for weight management!😀
This has been one of the best podcasts. So much good information. I wish I was a little smarter so I could digest it all. I took some notes so I can catch up. Thank you!
I cannot stop saying thank you for all great sources of scientific information. I really appreciate your help to understand how works our bodies and all the amino acids in the system. Would be great if you do a podcast of epigenetics with reference between nature vrs nurture. Thanks again!!!
Andrew, I love your podcasts - they're consistently outstanding! While listening, I noticed something I thought you might find interesting: there's a subtle but meaningful distinction between initialisms and acronyms that even expert communicators sometimes mix up. When we use abbreviations like BPC, FDA, NFL, or NBA, these are actually initialisms - where we pronounce each letter individually (F-D-A). Acronyms, on the other hand, are abbreviations we pronounce as complete words, like NASA or SCUBA. This distinction is close to my heart since my own name, T.J., is an initialism. As someone who values precise communication, I thought you'd appreciate knowing this nuance! Keep up the fantastic work - your content is making a real impact!
Dr. Huberman proceeds to spend remainder of day in a manic investigation of abbreviation/acronym/initialism, followed by petition to Cambridge to change it so that he is correct.
One issue with injectable peptides that looms large for someone striving to avoid toxins is that they all use toxic preservatives, such as benzyl alcohol. They'll tell you it's a tiny amount and your liver will detoxify it but it can't be good.
I've been watching this podcast for a while now but then i got recommended to this channel from both my psychologist and psychiatrist and I was like I already know about this channel and I love it too ❤
Dr. Huberman,, I'm a huge fan of your work on neuroscience. I’ve been using your Neuroplasticity Super Protocol and NSDR practices rigorously, especially during 5-6 hour study sessions and daily workouts. It often adds up to 2.5-3 hours of NSDR per day. My question is: Could this frequent use of NSDR be beneficial, or could it lead to dopamine crashes from too many spikes?..If anyone else is curious about this question, feel free to like so Dr. Huberman might see it! 😊
Hey, can i ask you a quick question about your experience with regular NSDR practice? Have you noticed any impact on your sleep due to engaging in the protocol so frequently and for extended durations?
@@moab_gaming1239 Hey! I’ve actually noticed deeper and more consistent sleep since I started using NSDR regularly. It’s been a game-changer for me, especially in helping me wind down and recover.
@@moab_gaming1239 Hey! I’ve actually noticed deeper and more consistent sleep since I started using NSDR regularly. It’s been a game-changer for me, especially in helping me wind down and recover.
This was the first full podcast of yours that I listened to and I loved every minute. I have been totally into peptides since learning about them at A4M. Thank you!
Dr. Craig brings up a very important point (several times) that gets missed/ignored by a lot of fitness influencers... The act, and effort, of working out, is massively different between people who are fit, and people who are significantly unfit. For fitness influencers, for fit people, for Andrew, working out is enjoyable, and there is "good difficulty" - all the resilience, willpower, commitment, pushing yourself, making PRs, all those are ultimately enjoyable during or after-the-fact. For overweight or very unfit people, working out is a *different kind of difficult* - the machines never fit; the weights do not move well; joints hurt; bodyweight and shape is messing up a lot of movements; you're too weak to do X, Y or Z, you get out of breath too fast... quite simply, *exercise is not enjoyable if you are under a certain level of fitness* and it's very demoralizing and difficult to get to that level, where you can perform well enough to start enjoying it. And this mostly gets ignored (or is just not internalized/understood) by all the fit youtube people who tell unfit people to go to gym and grind.
I felt the same way when I started training 7 years ago. The reality is that you need to change the way you think about working out. Consistency is way more important than how hard you work out. Start easy, you should never be sore. The way to do that is to monitor your heart rate and build your aerobic base. Focus on zone 2 training which is a lot easier than you think. Check out “the maffetone method”. It’s a game changer. It will make working out fun because it feels easy and you will see results as you are able to run/bike faster at the same low heart rate. Once you build your aerobic base you can start adding light weight lifting and you will have established that habit pattern of working out. Good Luck!
I was super excited when you spoke about methylene blue. I have Hashimotos and started using Methylene blue. Basically only 5 drops in my protein shake in the morning. I want to support my mitochondria. I have been blown away at the difference in my cognition, my skin is even in better health. It’s exciting to hear more info! Thanks so much!!!
im curious, how old are u ? and I also wanna ask for opinions, Im 20, im a powerlifter and studying for engineering and i would love to enhance my performance in any way possible. So i have been searching and its not expensive to buy methylene blue, + its a good thing that it works when taken orally. I also wanted to ask would u recommend taking other peptides such as bpc157 ?
This is the first time I hear of methylene blue since the days my mom used to put it in our mouths as kids to heal mouth sores. Worked well, and I haven't seen it anywhere since!
2:19:15 I would argue (as a long-time advocate [unpaid lobbyist in my context]) that it’s not necessarily that the government’s erroneously going too far. It’s just that lawmakers are forced into coming up with solutions that have to be, “one size fits all”. The motivation for this fairly pointless pontification, just so you know, is to help “you” (aka Huberman et al) because this is EXCEEDINGLY helpful (in addition to intellectually stimulating and entertaining) content. Content, for which I’m more than grateful.
@@craigkonivermd my functional medicine doc recommended it a few years ago- I took it for a while then went off and I *think* I noticed a big difference with joint pain so went back on last year, I'm just surprised there's not any discussion around it. How high do you usually taper up?
Can’t wait for the new book. I don’t have time to watch 200 hours of shows to learn protocols. This will put it all in one spot for me. Pre ordering now.
Wow fascinating information! Thank you so much for sharing this with us. I can’t help but be shocked by the FDA’s actions. Sure seems like their motives aren’t in the right place.
Great insights! Emphasizing that NAD therapy is a long-term investment is key. A short infusion window of under 2.5-3 hours often results in faster NAD metabolism into AMP, reducing efficacy. Dr. Ross Grant’s work supports that sustained NAD administration over longer sessions is vital for maximizing benefits and cellular longevity. For anyone considering NAD, understanding that it’s not a one-time fix but rather a “long game” is crucial for achieving meaningful results. It saved my life over the course of a few years once a month. 5 days at 750-1000 mg really helped my TBI
I love this podcast. It is very helpful for finding automomy. Which is my jam. I have always taken my health in my own hands. And I believe it's something everyone should do. I've made numerous changes to my health regime as recommended and highlighted by Huberman, and they have helped a lot. Daytime light was obvious to me, (and yes necessary) but viewing sunset light has changed the sleep game for me. I take NAC currently. I make sure to floss at night (something I overlooked). And I use the physiological sigh during high stress times. As well as stop hiccups when I want! lol. Really great podcast!!!
Great great episode. So much information and truly appreciated the candor at the end regarding the FDA and questioning of their intentions. I am curious about the results seen in men v. women with some of these peptides, including BPC157, specifically, women in perimenopause - even if just a small sampling of Dr. Koniver's patients. Are the results the same? The end of the episode on mindset.... Mic Drop! Great way to end it. And so so true.
I have to say Andrew, this was an amazing episode. But always, shout out to you and what you do. I've been listening to you for a while now, and want to echo Dr Koniver's (and every one else's) comments about the value you bring to everyone. It's now a joke around my friends, family and colleagues ... "what, you heard it on the Huberman Podcast!". Always interesting, insightful and always helps me make positive changes in many aspects of life.
it is the timeline snippet equivalent of "let me guess: you heard it from Nikola Tesla....you heard it from Carl Jung?!....you heard it from Isaac Newton?!"
Rating: 6.1/10 In Short: Peptides as a supplement (whiteout mechanism) Notes: Huberman and Craig discuss many peptides, with a lot of info on dosing and effects and discussion on their efficacy and approval. But this is really it. Hardley any mechanism, neuroscience, or 'fun' detial regarding how these work. Felt this kind of episode feeds right into a common critism of the pod where huberman 'just sells supplements'. Would have liked much more nuance, more stories, and more relation to previous guests and epiosdes (although did a little with deisseroth and attia). Felt this was redundant with a lot of previous pods and not really good for a general audience, only good for aficionado supplement users.
In this episode Dr. Koniver mentions methylene blue as a treatment for carbon monoxide poisoning. It is not typically used to treat carbon monoxide poisoning. The primary treatment for carbon monoxide poisoning is 100% oxygen therapy or hyperbaric oxygen therapy in more severe cases. These methods help to rapidly displace carbon monoxide from hemoglobin, thereby restoring oxygen delivery to the body’s tissues. Methylene blue, on the other hand, is primarily used in cases of methemoglobinemia, a condition where an abnormal amount of methemoglobin is present in the blood, impairing the blood’s ability to carry oxygen. In methemoglobinemia, methylene blue helps by reducing methemoglobin back to its functional form, hemoglobin, allowing normal oxygen transport. As a provider in an emergency department I think it is important to correct these mistakes as we have plenty of patients that demand treatments they hear on TH-cam. I do enjoy the show and want to keep it as credible as possible
I’d love it if you did an episode on derealisation/depersonalisation, the causes of it, treatment, and what it actually is. I’ve been struggling for over 15 years of chronic derealisation - possibly due to a diagnosis of epilepsy 15 years ago, or depression.
Previously Huberman has says that BPC-157 shouldn't be taken unless needed, as it can provoke/encourage cancer growth. I've taken it with TB previously, and felt positive effects - but stopped it due to the concerns here... No mention of being a cancer risk here... So which is it?
I’ve been taking glycine 25 years ago, it was popular in Russia among students, teenagers and sometimes recommended even for infants. Pinealon is a new thing and somehow you didn’t explain much how it works and what are the effects. A.H.: I like Pinealon, what do think?” - “ it’s good”. And that’s it?!
I'm sure, this is a wonderful episode like others.❤ I would love to listen an entire episode on Lipedema, which is quite common in women but still many of them are not even aware of it. 🌸🙏❤
Thank you, Dr. Huberman and Dr. Konniver for opening a new avenue for possible treatment options for my husband and I. As a former immunological research scientist, I would appreciate any good scientific references for low-dose GLP-1 and other peptides as relates to type 2 diabetes. I would also really appreciate any papers relating to peptides reducing inflammation in autoimmune diseases such as RA. I did review your show notes and found a couple of articles of interest, but they only made me more curious. Thank you again.
Thank you very much, Dr. Huberman. I have type 2 diabetes, which developed after having gestational diabetes during all three of my pregnancies. After my third pregnancy at 39 years old, the diabetes remained. Despite my efforts to eat mostly vegetables and meat twice a day, my morning sugar levels were consistently high, ranging from 8 to 10. I started taking Ozempic, and it has been wonderful for me. I've been on it for a year, taken a break for a year, and then used it again for another year, followed by another break. Now, I’ve been back on it for six months. I'm afraid I will have some side effects if I use it all the time, for 30 years (if I live that long). I don’t know what’s better, to die from the side effects of Ozempic or from side effects of diabetes? : )))
Amazing information and insightful conversation Andrew, thanks! Can I ask, would you ever consider making an episode on optimizing vascular health in the head and neck region as a means to deal with complex headaches and migraines and potentially have a deep dive into new research concerning the longevity of vasculature within the brain region and more anti-headache protocols? As a sufferer of long-term headaches this would be really interesting to learn.
cerebrolysin is the best brain repairing peptide mix. i never noticed that you come to a dark place with thoughts it feels like a little sunburn in the brain and when you have to work you will have a bit of trouble with coordination tasks and you will feel dumb because of it but it goes away after some time. i have more capacity in terms of thinking and my add got alot less problemlematic. i will definetly do it again there is a chance to cure these kind of conditions with it.
Thanks for sharing I cannot endure suffering for the balance of this miserable life with adhd or whatever the hell keeps me from thinking efficiently or at all
@@capgainsI'm a retired educator , 31 years, HS + college, team taught differently abled students w ashd, autism, Ms, etc, and now w long COVID have great empathy, as I experience similar symptoms🙏💞
You mentioned some of the "steroids" you can obtain legally through a Dr. And named test and deca. You can also legally get pharmacy grade dht derivatives. Anavar, andralone and winstrol. Unfortunately you can't get masterone
Terrific pod, currently subcutaneous injecting bpc/tb500 obtained through a local hormone performance doctor via compound pharmacy, expensive but I wanted the boost for recovery after spine fusion surgery. 2 weeks have passed and 2 days, and I just finished a few sets of weight lifting and light squats with yoga bar over my shoulders. F Big pharma
Ur lucky to have source for that,iam battling mentally because of injury and can’t seem to win,I can’t find any source of bpc ,where did u get it from,I can’t workout now I feel like have lost my purpose in life
This has been a GAME changer for me! Thank you and cannot wait to try all these. Totally got the point to not buy online. I am in Texas and called Compounding Pharmacies and they said I need a perscription. I called my PCP and they said they do not prescribe these things. I called my sister's clinic where she gets semi-glutide and they said they do not deal with the types of peptides I am looking for. PLEASE HELP - what type of company/clinic/business do I need to look for to start these injections? thanks so much
Great episode so far -still listening- but wondering how to find a physician who is knowledgeable about peptide use! Brought BPC 157 up with my teenage son's gastroenterologist and he had no idea and did not embrace looking into it. Doc wanted to keep him on the medicines (i.e. corticosteroids, balsalazide, immunosuppressive drugs) that cause worse side effects than the actual autoimmune disease. Now how to get the Pentadeca Arginate for him?? Grateful you share your knowledge and conversations in your podcasts!
@@craigkonivermd@craigkonivermd Awesome conversation. I was a youth Olympian/national champion sailor and randomly lost the ability to stand and hold any weight on my feet. 5 years later after hell I got diagnosed with Crohn's but seemingly no connection; it acts like greirson gopalan syndrome but surely it's an associative problem to the crohns. Regardless, I second the comment above; hard to find a physician who understands. Hence why I'm on immunosuppressants and lyrica, some nexium. I live off grid in Tasmania so I'm healthy-ish but it's undulating. Obviously this isn't your fight but any advice would be greatly appreciated. BPC - 157 sounds like it has great potential.
Dr Koniver, PLEASE READ! What is your opinion on the field of bioactive precision peptides which have sparked a transformative dialogue around their natural sources and potential for ingestion, proposing a shift from synthetic compounds typically administered via injection to naturally occurring peptides identified through AI panels. The argument is that these panels have ingeniously isolated specific peptides in nature that may provide the same therapeutic benefits as their synthetic counterparts. What is the feasibility of harnessing these bioactive compounds through dietary means? Can ingestible forms deliver comparable efficacy without the need for invasive treatment
watch out for dental staining with the methylene blue, if you have dental work on the front side of your teeth, it will stain them blue for much longer than an hour. for days. I do capsules just because of that and they work!
Thank you for watching. If you enjoyed this topic and episode, please click the "like" button and subscribe to our channel here on TH-cam.
Thank you for your interest in science! -- Andrew
Happy birthday 🎂
Thank you for hosting me on your amazing podcast! I am excited to engage with your audience. Looking forward to lots of questions and wanting to be resourceful to answer.
Dr. H- you have an incredibly accessible manner about you. 😊This is my favorite series. The mix of hard science with a humble, direct and truth-seeking demeanor is highly magnetic. I’m what I call a slacker hacker- former trainer and yoga instructor - gym rat. I’m at the point where exercising “harder” is not going to be helpful getting through menopause so understanding different paths to vitality is highly valuable. ❤
@@craigkonivermdyour interview and discussion with Dr. Huberman was so detailed and helpful, I’ll need to re-listen! Thank you both for having a brain, a heart, and the desire to share! 🤩
@craigkonivermd. Greig is very interesting and informative. Great interview. Do you take out of state patients? Let me know please
As a biologist, I've been a big fan of Hubermanlab for years now and I have almost listened to all episodes and I can sincerely say that THIS EPISODE IS THE BEST!!! So informative and it spiked my curiosity on peptides even more. Now Dr Craig Koniver has gained a new fan! Not only is he super knowledgeable but he is compassionate and I can see that he is truly living his purpose. Thank you for taking the time to teach all of us nerds!
Thank you so much!
@@craigkonivermdAs a physician who is totally new to this but open to learn in other to know more for may be improve my assistance to mi patients, i want to truly acknowledge you and Dr Andrew for this top 1 episode, hope you can one day come to Spain because i would love to assist a seminar or something to improve even more my knowl❤ also if you know somewhere to learn more i would be very grateful if you can tell me your best tips ❤ ( sorry if my English is bad hahaha)
A book that changed my life in ways that I never could imagine is "Secret Testosterone Nexus of Evolution".Drop whatever you're doing right now and go find that book. Trust me after I implemented things from the book my testosterone levels went beast mode
I don't tend to trust obvious bots.
Trizepatide has changed my life for the better. Best decision I could have made. The change in my mood alone has had a huge impact on my life. I’m no longer anxious or stressed. My mind is relax. My inflammation gone. And of course the lbs coming off and feeling awesome 🤩
Where did you get the Tripepatide?
Dr. Craig Koniver is the best guest Dr. Huberman has had, and this was one of the best -- and most informative -- podcasts I have ever listened to.
Thank you!
U must not have listened to Matt Walker
why he didn't mention mk677 dosing then
Started Tirzepatide in March after decades of my weight yo-yo’ing and dealing with difficult to treat hypertension and NA Fatty Liver Disease. I’m now down 45lbs to my goal weight, am on maintenance dose, and my FLD is reversed and BP has never been so well controlled. I’ve gone from two high dose BP meds to only one med, and at half the dose I was on. Hope that I’ll soon be off of it, too. It’s important to do resistance training, drink plenty of water, eat plenty of of fiber and protein. I believe these peptides are the future of proactive health care.
I’m an integrative nurse practitioner and cannot thank you enough for sharing all of this vital information! The majority of what was shared I practice on a regular basis with my clients and feel that not enough people know about these modalities and it’s such a fresh breath of air to see the good word spreading. I also greatly appreciate the sharing of details surrounding mechanism of actions and dosing ❤
And this is one of the reasons why I subscribed to Andrew humerman's channel is because he interviews quality people who are giving truthful information to the public
Now the real questions where we can find trusted physicians and Drs near us that are honest and have the best products.
You can find them where first you will be asked to pay $200 for consultation. And then you will be charged tens of thousands of dollars for unnecessary treatment
@@lilyameleshko3096truth!!!!
The Wellness Way of Appleton. They specialize in using natural supplements to heal. I love them.
@@lilyameleshko3096which pushes us into The gray market, right?
To me this is a very bittersweet episode. It's not an easy realization that mainstream medicine has failed except in keeping people alive and sick. The alive part is obviously amazing, the sick part is not. Most medical research is also now very close to useless, only synthetic (patentable) pharma products are studied in incredibly biased ways. Bioidentical hormones, peptides and molecules (biologics) are largely left out in the cold or outright banned where they compete. Then we have amazing clinicians like Dr Koniver who have wealths of clinical knowledge using mostly biologics but it's siloed, hidden and extremely expensive thus very few can access this kind of care.
I love the part about positivity though, somehow we need to have a medical revolution. Vote for your health freedom!
One of the best podcast on peptides! Andrew continues to lead the way on anti-aging and longevity! 💯
I shall stay listening to these at work forever
It makes Mondays not suck
Andrew, your podcasts have been a game-changer for me! Unfortunately, the paradox is that the more I learn and implement your protocols, the less time I have to catch up on the latest episodes. I'm currently staring at a list of about 20 episodes I haven't been able to get to. I guess that's a good problem to have!
same here
Me too!
Put it on at 1.25x speed
I have been using peptide therapy for the past 5 years and they have been absolute game changers in perimenopause. No Dr was helpful so I just did my own thing and could not be happier. No HRT
If you’re doing this for research purposes only… do you have a recommendation on where to go to conduct my own research?
Please share your protocols
Where can I buy them?
Hi I’m sure you’ ve been swamped with requests but would you share your protocol of peptide therapy and where to buy them from? Thank you
@@tanyal6331 biotech peptides is where I get mine very good company
I am one example of someone andrew huberman saved, From releasing my self destructive behavior and armed me with the tools to make health and wellness a top priority in life so thank you for helping so many poeple!
I’ve listened to this podcast twice. This was one of the most outstanding speakers you’ve had on and I’ve loved most of them. I think you summed it up in the end, his humanity Was so apparent in his approach to his patients and the practice of medicine along with his breadth of knowledge and approach to what health actually is for patients. Your mutual admiration was truly beautiful and well expressed. I’ve got to go meet this man! Thank you again for your thoughtful choice of guests.
My thoughts exactly. What a beautiful ending.
Andrew, you keep making it difficult for me to have a favorite episode!!!
You have the best discussions with your guests 🎙️
Thank you for your service to humanity 🙏🏾
I have been following Huberman postcast since day 1, it's been so amazing, grateful and inspiring themes and guest's. 🙏. Dr Craig koniver beets another level... the knowledge, the expertise, the work in the field and most of all the humanity and empathy for the ones that suffer its beyond words! Thanks for sharing 🙏🙏🙏
This is one of the best episodes I’ve listened to, for multiple reasons. Thank you both for doing this. There is so much more I want to learn. There is so much that sickens me about the treatment of chronic illness in the USA.
Thank you for finally discussing Methylene Blue! My recommendation is to heat up 4oz of water (45 sec in microwave). Put the Methylene Blue in the warm water and add about a tablespoon of vitamin C powder. Stir and it becomes clear and won't stain. It also allows the vitamin C to pass the blood/brain barrier.
@@b.alix3 365 Labs is excellent
@@b.alix3a source would be great
We pair it with peptides 🔓👆🏽
What a way to denaturalize vitamin C.
Oh, this episode was like Christmas morning! I love my peptides, they're the only thing that's moved the dial on my multiple autoimmune disorders. NAD has now been moved up on my to-do. Thank you Dr Huberman and Dr Koniver!
I too have autoimmune diseases. Do you mind if I ask which peptides have been most successful for you?
Great to hear…are you taking bpc157?…orally?
Dr. Koniver’s approach can be seen as both innovative and cautious in this respect. He is leveraging newer therapies that seem to have low risk of harm, but their full efficacy or potential risks may not be fully understood. This makes his methods more exploratory, appealing to those looking for cutting-edge solutions in health optimization but requiring a degree of trust in treatments that are not yet mainstream.
00:03 Dr. Craig Koniver specializes in performance medicine using peptides for mental and physical health.
02:12 Peptides and hormone therapies offer a middle ground between supplementation and prescription drugs for health augmentation.
06:19 Discussion on the importance and benefits of therapy for overall health
08:19 Peptides are gaining popularity for health and performance benefits.
12:45 Focus on achieving goals first to motivate individuals for long-term health improvements.
14:39 Peptide and hormone therapies can positively impact health and longevity.
18:18 Peptides like GP1 and BPC 157 are being used to address inflammation and immune system health.
20:18 BPC helps reduce inflammation and improve overall health
23:47 BPC157 has a general anti-inflammatory response with better efficacy through injection.
25:21 Peptide BPC157 benefits joints and promotes repair systemically
28:56 Concerns about obtaining bpc 157 from gray market sources
30:47 Nandrolone combined with testosterone can benefit long-term users.
34:10 Having a knowledgeable physician is crucial when considering peptide therapies
36:01 Compounding pharmacies face restrictions due to FDA regulations.
39:19 Peptides for performance medicine and health
41:01 Purchasing peptides from gray or black markets can be dangerous
44:35 Concerns about FDA regulations impacting peptide use
46:24 Prefer using peptides over direct hormone manipulations
49:47 Proper dosing of peptides is crucial for avoiding adverse effects
51:26 Peptides like ghrp6 have specific benefits for health and performance
54:38 Searon and Tesone work on growth hormone releasing hormone for health benefits.
56:25 Peptides can enhance health and longevity
59:43 Detoxification and mercury levels are important for health.
1:01:19 Benefits of taking CoQ10 for mitochondrial health
1:04:44 Co-enzyme Q10 supports electron flow at cytochrome C
1:06:21 Repurposing drugs for various medical conditions is a common practice in healthcare.
1:10:06 Importance of trustworthy health information
1:11:53 Focus on holistic health beyond just prescriptions.
1:15:23 Importance of surrender and creating space for flow state
1:17:01 Peptide therapies help with muscle mass and overall health.
1:20:31 Hormone release is highest in the early morning
1:22:17 Homocysteine levels indicate cardiovascular risk.
1:25:47 Pinealon improves rapid eye movement sleep
1:27:27 Pinealon may impact circadian rhythm and melatonin production
1:31:01 Glycine helps improve sleep and aids in liver detoxification.
1:32:42 Liver's role in making fat-soluble substances water-soluble for excretion.
1:35:55 Bioavailability of peptides in oral versus injectable form
1:37:43 Concerns about access to compounded peptides due to potential removal by pharmaceutical companies
1:41:26 Thymosin Alpha 1 was used for immune modulation
1:43:17 Peptide and hormone therapies have been used for decades in certain medical settings.
1:46:37 Methylene blue is a cognitive stimulant and can be combined with other agents for brain function.
1:48:10 Methylene blue can impact urine color and mitochondrial efficiency
1:51:59 NAD therapy effectiveness in combating inflammation
1:53:50 NAD therapies can lead to rapid transformation to a super well state.
1:57:23 Nutritional deficiencies may contribute to mental illness
1:59:11 NAD infusions have a transformative effect on various biological processes.
2:02:28 Monthly maintenance dose is recommended for optimal results.
2:04:11 Peptide infusion can cause empathetic response to pain.
2:07:40 Peptide PT-41 stimulates libido and hormonal pathways in both men and women
2:09:32 Peptides can have a narrow therapeutic window in humans.
2:13:08 Peptides have immense beneficial uses but face regulatory challenges
2:15:07 Take control of your health by being your own advocate
2:18:31 Discussion on pharmaceutical companies and government oversight
2:20:17 Positive thoughts can enhance immune system function
2:24:06 Discovering our unique purpose brings magic to life
2:26:02 Dr. Craig Koniver's work focuses on peptide and hormone therapies.
Putting in the work for you guys has been a pleasure. Kindly like and subscribe to show your love❤
buymeacoffee.com/gmdavid
18:00 - when I lost weight a huge (ha, pun) help was when everyone stopped treating me like I was sub-human. The constant low level poor treatment, dismissive attitudes, and occasional outright bullying have an accumulative effect on a person. Once that lifted EVERYTHING felt easier.
Totally real, I get treated like crap while shopping, unless I am fresh out of the gym, ripped, and swole in a TShirt....The same young women crapping on me, are all too friendly and helpful...lol...and I am 54
I was eating zero processed foods, super clean, fasting, training 4 times a week and detoxing regularly... I was not losing the 10 pounds I gained from perimenopause. NOTHING was working. I was miserable because I was literally doing everything. Tirzepatide has changed my life in no time. I microdose. I still feel hungry and eat but it's just melted the fat off. My hormones are even more balanced than they were from the bioregulators. I have gained muscle as I train three times a week - hard. I was the last person I'd ever thought would go on these but geez.... it's changed my life and I have had ZERO side effects. My digestion has never been better!
Love this for you!! Same for me. And a lot of our clients at Peptide Courses 🔓
That’s amazing! Io e hearing this.
Are you saying the Tirzepatide helped you gain muscle ? Of course I understand that it was in combination with hard training.
@@annab5090 yep, certainly not losing muscle
Thank you for this comment, it's very inspiring. What's your microdose? I was doing 1.5mg a week, now I wonder if I can go even lower.
Would you mind sharing where you get your peptides? Is it compounded? Thanks!
Thank you Drs. Koniver and Huberman for this podcast (vodcast?) episode. I have listened to 47 minutes, and will continue to the end. I added peptides, isolate whey protein, and creatine from Momentous about three months ago to my diet, based on other Huberman Lab broadcasts. It is intriguing to read the comments below claiming that this is the BEST episode EVER. My opinion of the BEST episode EVER is about the quevedoces (sp?) -- how clearly the role of hormones in sexual development was articulated by Dr. Huberman! I can't wait to finish this episode. Again, thank y'all!
One of the best podcasts you’ve had. This man seems like such a light in health. Love it! Thank you both ❤
It would be great to get some recommendations regarding compound pharmacies , so we can have some reliable source for buying peptides.
I would go through BioFusion Peptides if you are looking for a good source, used their BPC-157 & TB-500 for my Grade II rotator cuff tear and they helped me out with protocol as well so that stood out to me. Also I believe their peptides are all HPLC tested and verified for purity, don't really see any other companies doing that
not a compound pharmac, but i trust limitless life
wizard peptides
Life link Research is the best I have found
@AdonisJohnson-n4i This commentor only joined YT basically the same time video was dropped - beware the post trying to push you to a certain place.
Great discussion. I was “hooked” on antidepressants (SSRI’s) for 12 years, couldn’t get off them as hard as I tried, the withdrawals were horrific. I started taking NAD injections for general health and coincidentally tried to taper off my SSRI’s and noticed I have zero withdrawal. I got off them within a month and never looked back. NAD is truly an amazing compound.
I couldn't agree more regarding taking agency for my own health. Dealing with a couple of auto immune conditions and just trusting my Dr was getting me nowhere. Finding a Dr to work with has been transformative for me. My Dr follows you too!
Be careful with BPC 157. It accelerates cancer. I was using it along with TB 500 and IPA/CJC for about two months and then I noticed my piss stream is getting really weak. Went in for a prostate exam and sure enough I got a lump in there. Due for a biopsy in a few weeks. I’ve stopped the peptides and going to try a few things to see if I can shrink it and then getting a second opinion.
I'm sure I've read somewhere this peptides increase risk. But they are all saying safe.
@@TheSibolovin yeah kind of surprised there was no mention of it on this podcast.
Get ivermectin
@@jumpman1113 i’ve honestly been wondering if ivm with help. I’m on a Facebook group about Fenben and ivermectin for cancer. seems promising
@@atlskyline1He mentioned it on one of his other podcast about peptides
I have been an avid follower of your platform and your real life approach to health and vitality. This is one of the most impactful episode of how out traditional medical system and educational system is outdated and antiquated .
The most profound way to live your best life is to take it into your own hands and not rely on all the existing system that is in place.
I’ve always listen to your podcast. And this one is one of the books.. This episode is sooooooo goood!! Felt like i ate a food that i’ve never had! The knowledge and open intellectual conversation is breath of fresh air.. just speechless esp. the closing message❤❤❤
Can I say. This is the only episode whereby you haven’t covered the topic as in depth as I would like. We need an episode on each peptide, side effects, long term, short term, duration of use etc etc.
I am concerned you only covered benefits and for those without a good understanding of all the other aspects.
This episode really peaked my interest though.
Thank you, Andrew!
Agree 💯
Thank you to both Dr. Andrew Huberman and Dr. Craig Koniver for this awesome discussion and a belated Happy Birthday to Dr. Huberman. This topic naturally gravitates attention and I definitely aspire to work towards lean yet strong. I call it "lean and mean".
The microdose discussion is so important. Dr. Tyna Moore has researched this extensively and is well recognized expert on this specifically, in combination with her metabolic health and regenerative medicine expertise. What I learned from her in this arena has totally changed my mind on GLP1s in particularly. Would love to see her on the show!
Agreed!! I recently listened to her “Ozempic Done Right” episodes (parts 1, 2, and 3) and my fascination w/ peptides after listening to her - led me to this podcast. Highly recommend these 3 podcast episodes on “The Dr. Tyna Show”. And others…
I found that BPC157 and TB5 from Swisschems were super helpful during my recovery from a knee injury caused by a motorcycle accident. It really seems to speed up my healing process post-surgery.
I got BPC157 from them and it works wonders in healing from bull riding.
How is your recovery so far? Any update?
I also just recently got in a motorcycle accident. Low sided into a mountain. Knee is banged up and all swollen and bruised with a seroma. Nothing broken luckily. Just ordered some BPC and TB
Train by day Intellectual dark web by night. All day
Bruh
Its from joe rogan podcast
Do you even read bruh?
@@dingosmith9932Bruh.
@@dingosmith9932bruh
This is one of the best programs on an already lready great channel
¡Hola Profe!Just wanted to express my gratitude for the education in a form of conversation on such a cutting-edge subject from such a knowledgeable source.Thank You for all Your hard work and care for all of us.
Hubie, one of the best episodes, you're the man!
Thank you Andrew, it's great to have you sharing these vital information and experience. People really need to learn more about how peptide can help their health. I recently tried tirzepatide and I'm genuinely impressed with the results! The GLP-1 is amazing for weight management!😀
This has been one of the best podcasts. So much good information. I wish I was a little smarter so I could digest it all. I took some notes so I can catch up. Thank you!
I cannot stop saying thank you for all great sources of scientific information. I really appreciate your help to understand how works our bodies and all the amino acids in the system.
Would be great if you do a podcast of epigenetics with reference between nature vrs nurture.
Thanks again!!!
Where does one get these peptides? MD has to prescribe? Do we need to find a integrative medicine or functional medicine practitioner ?
I'm curious too.
Andrew, I love your podcasts - they're consistently outstanding! While listening, I noticed something I thought you might find interesting: there's a subtle but meaningful distinction between initialisms and acronyms that even expert communicators sometimes mix up.
When we use abbreviations like BPC, FDA, NFL, or NBA, these are actually initialisms - where we pronounce each letter individually (F-D-A). Acronyms, on the other hand, are abbreviations we pronounce as complete words, like NASA or SCUBA.
This distinction is close to my heart since my own name, T.J., is an initialism. As someone who values precise communication, I thought you'd appreciate knowing this nuance! Keep up the fantastic work - your content is making a real impact!
Dr. Huberman proceeds to spend remainder of day in a manic investigation of abbreviation/acronym/initialism, followed by petition to Cambridge to change it so that he is correct.
One issue with injectable peptides that looms large for someone striving to avoid toxins is that they all use toxic preservatives, such as benzyl alcohol. They'll tell you it's a tiny amount and your liver will detoxify it but it can't be good.
Really enjoyed this episode. Love the work that Huberman and Dr Koniver are doing.
I've been watching this podcast for a while now but then i got recommended to this channel from both my psychologist and psychiatrist and I was like I already know about this channel and I love it too ❤
Dr. Huberman,, I'm a huge fan of your work on neuroscience.
I’ve been using your Neuroplasticity Super Protocol and NSDR practices rigorously, especially during 5-6 hour study sessions and daily workouts. It often adds up to 2.5-3 hours of NSDR per day. My question is: Could this frequent use of NSDR be beneficial, or could it lead to dopamine crashes from too many spikes?..If anyone else is curious about this question, feel free to like so Dr. Huberman might see it! 😊
Hey, can i ask you a quick question about your experience with regular NSDR practice? Have you noticed any impact on your sleep due to engaging in the protocol so frequently and for extended durations?
@@moab_gaming1239 Hey! I’ve actually noticed deeper and more consistent sleep since I started using NSDR regularly. It’s been a game-changer for me, especially in helping me wind down and recover.
@@moab_gaming1239 Hey! I’ve actually noticed deeper and more consistent sleep since I started using NSDR regularly. It’s been a game-changer for me, especially in helping me wind down and recover.
I have been prescribing huberman podcast & thrilled when my patients quote his reference to re- enforce facts I shared . Thank you Dr
The man of the people ! Thank you Huberman, you’re the best !
Great episode! Loved Dr. Koniver's stressing the importance of positivity. Thanks to both of you.
This was the first full podcast of yours that I listened to and I loved every minute. I have been totally into peptides since learning about them at A4M. Thank you!
Really enjoyed this episode. Keep up the good work to both doctors and keep spreading education and positivity!
Simply wow 🤩!! You’re inspiring Prof. Huberman 🙏🙏
加油，hubermab博士，我是来自中国的年轻人，在我学习了你所传播的内容，大大提高了我的生活质量，非常感谢您❤
Dr. Craig brings up a very important point (several times) that gets missed/ignored by a lot of fitness influencers... The act, and effort, of working out, is massively different between people who are fit, and people who are significantly unfit. For fitness influencers, for fit people, for Andrew, working out is enjoyable, and there is "good difficulty" - all the resilience, willpower, commitment, pushing yourself, making PRs, all those are ultimately enjoyable during or after-the-fact. For overweight or very unfit people, working out is a *different kind of difficult* - the machines never fit; the weights do not move well; joints hurt; bodyweight and shape is messing up a lot of movements; you're too weak to do X, Y or Z, you get out of breath too fast... quite simply, *exercise is not enjoyable if you are under a certain level of fitness* and it's very demoralizing and difficult to get to that level, where you can perform well enough to start enjoying it. And this mostly gets ignored (or is just not internalized/understood) by all the fit youtube people who tell unfit people to go to gym and grind.
which may necessitate the customized "primer" that physicians like Dr. Koniver can offer.
I felt the same way when I started training 7 years ago. The reality is that you need to change the way you think about working out. Consistency is way more important than how hard you work out. Start easy, you should never be sore. The way to do that is to monitor your heart rate and build your aerobic base. Focus on zone 2 training which is a lot easier than you think. Check out “the maffetone method”. It’s a game changer. It will make working out fun because it feels easy and you will see results as you are able to run/bike faster at the same low heart rate. Once you build your aerobic base you can start adding light weight lifting and you will have established that habit pattern of working out. Good Luck!
I was super excited when you spoke about methylene blue. I have Hashimotos and started using Methylene blue. Basically only 5 drops in my protein shake in the morning. I want to support my mitochondria. I have been blown away at the difference in my cognition, my skin is even in better health. It’s exciting to hear more info! Thanks so much!!!
im curious, how old are u ? and I also wanna ask for opinions, Im 20, im a powerlifter and studying for engineering and i would love to enhance my performance in any way possible. So i have been searching and its not expensive to buy methylene blue, + its a good thing that it works when taken orally. I also wanted to ask would u recommend taking other peptides such as bpc157 ?
This is the first time I hear of methylene blue since the days my mom used to put it in our mouths as kids to heal mouth sores. Worked well, and I haven't seen it anywhere since!
2:19:15 I would argue (as a long-time advocate [unpaid lobbyist in my context]) that it’s not necessarily that the government’s erroneously going too far. It’s just that lawmakers are forced into coming up with solutions that have to be, “one size fits all”.
The motivation for this fairly pointless pontification, just so you know, is to help “you” (aka Huberman et al) because this is EXCEEDINGLY helpful (in addition to intellectually stimulating and entertaining) content. Content, for which I’m more than grateful.
Thank God for the existence of these men.
Thoughts on off label use of low dose Naltrexone for inflammation/autoimmune condition?
We use Low Dose Naltrexone for autoimmune conditions and have a lot of success. We generally start with a dose of 1.5mg at bedtime
@@craigkonivermdcan this be purchased through your service, I'm long COVID w cormobidities, + would start lower, to forvgreat podcast💞
@@craigkonivermd my functional medicine doc recommended it a few years ago- I took it for a while then went off and I *think* I noticed a big difference with joint pain so went back on last year, I'm just surprised there's not any discussion around it. How high do you usually taper up?
Can’t wait for the new book. I don’t have time to watch 200 hours of shows to learn protocols. This will put it all in one spot for me. Pre ordering now.
53:35 happy Birthday Good Doctor!
One of the best episodes.
Wow fascinating information! Thank you so much for sharing this with us. I can’t help but be shocked by the FDA’s actions. Sure seems like their motives aren’t in the right place.
Great insights! Emphasizing that NAD therapy is a long-term investment is key. A short infusion window of under 2.5-3 hours often results in faster NAD metabolism into AMP, reducing efficacy. Dr. Ross Grant’s work supports that sustained NAD administration over longer sessions is vital for maximizing benefits and cellular longevity. For anyone considering NAD, understanding that it’s not a one-time fix but rather a “long game” is crucial for achieving meaningful results.
It saved my life over the course of a few years once a month. 5 days at 750-1000 mg really helped my TBI
I love this podcast. It is very helpful for finding automomy. Which is my jam. I have always taken my health in my own hands. And I believe it's something everyone should do. I've made numerous changes to my health regime as recommended and highlighted by Huberman, and they have helped a lot. Daytime light was obvious to me, (and yes necessary) but viewing sunset light has changed the sleep game for me. I take NAC currently. I make sure to floss at night (something I overlooked). And I use the physiological sigh during high stress times. As well as stop hiccups when I want! lol. Really great podcast!!!
Thank you Dr. Huberman, team, sponsors and supporters. ☀️ THANK YOU DR. CRAIG KONIVER!
Great great episode. So much information and truly appreciated the candor at the end regarding the FDA and questioning of their intentions. I am curious about the results seen in men v. women with some of these peptides, including BPC157, specifically, women in perimenopause - even if just a small sampling of Dr. Koniver's patients. Are the results the same? The end of the episode on mindset.... Mic Drop! Great way to end it. And so so true.
I have to say Andrew, this was an amazing episode. But always, shout out to you and what you do. I've been listening to you for a while now, and want to echo Dr Koniver's (and every one else's) comments about the value you bring to everyone. It's now a joke around my friends, family and colleagues ... "what, you heard it on the Huberman Podcast!". Always interesting, insightful and always helps me make positive changes in many aspects of life.
it is the timeline snippet equivalent of "let me guess: you heard it from Nikola Tesla....you heard it from Carl Jung?!....you heard it from Isaac Newton?!"
Huge value in this episode compared to the previous ones. I love practical episodes. Thank you!
I’m halfway through the interview. Great information! I’m learning something new and oh so helpful. Thank you! 👏🏼
Rating: 6.1/10
In Short: Peptides as a supplement (whiteout mechanism)
Notes: Huberman and Craig discuss many peptides, with a lot of info on dosing and effects and discussion on their efficacy and approval. But this is really it. Hardley any mechanism, neuroscience, or 'fun' detial regarding how these work. Felt this kind of episode feeds right into a common critism of the pod where huberman 'just sells supplements'. Would have liked much more nuance, more stories, and more relation to previous guests and epiosdes (although did a little with deisseroth and attia). Felt this was redundant with a lot of previous pods and not really good for a general audience, only good for aficionado supplement users.
Was waiting for this podcast for ages ❤
In this episode Dr. Koniver mentions methylene blue as a treatment for carbon monoxide poisoning. It is not typically used to treat carbon monoxide poisoning. The primary treatment for carbon monoxide poisoning is 100% oxygen therapy or hyperbaric oxygen therapy in more severe cases. These methods help to rapidly displace carbon monoxide from hemoglobin, thereby restoring oxygen delivery to the body’s tissues.
Methylene blue, on the other hand, is primarily used in cases of methemoglobinemia, a condition where an abnormal amount of methemoglobin is present in the blood, impairing the blood’s ability to carry oxygen. In methemoglobinemia, methylene blue helps by reducing methemoglobin back to its functional form, hemoglobin, allowing normal oxygen transport.
As a provider in an emergency department I think it is important to correct these mistakes as we have plenty of patients that demand treatments they hear on TH-cam. I do enjoy the show and want to keep it as credible as possible
I’d love it if you did an episode on derealisation/depersonalisation, the causes of it, treatment, and what it actually is. I’ve been struggling for over 15 years of chronic derealisation - possibly due to a diagnosis of epilepsy 15 years ago, or depression.
Hi Andrew! (waves vigorously at phone screen)
Hi. Waves back in comments to say hello.
Previously Huberman has says that BPC-157 shouldn't be taken unless needed, as it can provoke/encourage cancer growth. I've taken it with TB previously, and felt positive effects - but stopped it due to the concerns here...
No mention of being a cancer risk here... So which is it?
I’ve been taking glycine 25 years ago, it was popular in Russia among students, teenagers and sometimes recommended even for infants.
Pinealon is a new thing and somehow you didn’t explain much how it works and what are the effects.
A.H.: I like Pinealon, what do think?” - “ it’s good”. And that’s it?!
I'm sure, this is a wonderful episode like others.❤ I would love to listen an entire episode on Lipedema, which is quite common in women but still many of them are not even aware of it. 🌸🙏❤
I contril mine with low carb, compound trizepatide and b1. Good luck
Same here. Having the best results with pure carnivore, but falling off the vagon from time to time. 😊
Thank you, Dr. Huberman and Dr. Konniver for opening a new avenue for possible treatment options for my husband and I. As a former immunological research scientist, I would appreciate any good scientific references for low-dose GLP-1 and other peptides as relates to type 2 diabetes. I would also really appreciate any papers relating to peptides reducing inflammation in autoimmune diseases such as RA. I did review your show notes and found a couple of articles of interest, but they only made me more curious. Thank you again.
Not sure if what Dr Tyna Moore does would assist you. Her channel is growing, but she also has additional courses on her website.
Dr Tyna promotes micro dosing
I need to listen to this again and take notes
I've been waiting for this one!🎉
Thank you very much, Dr. Huberman. I have type 2 diabetes, which developed after having gestational diabetes during all three of my pregnancies. After my third pregnancy at 39 years old, the diabetes remained. Despite my efforts to eat mostly vegetables and meat twice a day, my morning sugar levels were consistently high, ranging from 8 to 10.
I started taking Ozempic, and it has been wonderful for me. I've been on it for a year, taken a break for a year, and then used it again for another year, followed by another break. Now, I’ve been back on it for six months. I'm afraid I will have some side effects if I use it all the time, for 30 years (if I live that long). I don’t know what’s better, to die from the side effects of Ozempic or from side effects of diabetes? : )))
This was an amazing episodes! Super educational. Love HubermanLab and all your work. Thank you!
Where can I find a good Dr to help me? Any recommendations? I want to get BPC 157.
You won't find one for BPC 157 since the FDA banned it.
Amazing information and insightful conversation Andrew, thanks! Can I ask, would you ever consider making an episode on optimizing vascular health in the head and neck region as a means to deal with complex headaches and migraines and potentially have a deep dive into new research concerning the longevity of vasculature within the brain region and more anti-headache protocols? As a sufferer of long-term headaches this would be really interesting to learn.
Great suggestion
cerebrolysin is the best brain repairing peptide mix. i never noticed that you come to a dark place with thoughts it feels like a little sunburn in the brain and when you have to work you will have a bit of trouble with coordination tasks and you will feel dumb because of it but it goes away after some time. i have more capacity in terms of thinking and my add got alot less problemlematic. i will definetly do it again there is a chance to cure these kind of conditions with it.
Thanks for sharing
I cannot endure suffering for the balance of this miserable life with adhd or whatever the hell keeps me from thinking efficiently or at all
@@capgainsI'm a retired educator , 31 years, HS + college, team taught differently abled students w ashd, autism, Ms, etc, and now w long COVID have great empathy, as I experience similar symptoms🙏💞
You mentioned some of the "steroids" you can obtain legally through a Dr. And named test and deca. You can also legally get pharmacy grade dht derivatives. Anavar, andralone and winstrol. Unfortunately you can't get masterone
How do I best find my “local version” of Dr Koniver that can help guide and monitor use of peptides like he describes?
Could you please talking about the pituitary gland and Tumor’s relating to it
Thanks In Advance
Great pod, but no talk of dose of Pinealon? Does anyone know of the dosing protocol?
Topic suggestion: How to protect brain when young for better quality of life in old age.
Terrific pod, currently subcutaneous injecting bpc/tb500 obtained through a local hormone performance doctor via compound pharmacy, expensive but I wanted the boost for recovery after spine fusion surgery. 2 weeks have passed and 2 days, and I just finished a few sets of weight lifting and light squats with yoga bar over my shoulders. F Big pharma
Ur lucky to have source for that,iam battling mentally because of injury and can’t seem to win,I can’t find any source of bpc ,where did u get it from,I can’t workout now I feel like have lost my purpose in life
This has been a GAME changer for me! Thank you and cannot wait to try all these. Totally got the point to not buy online. I am in Texas and called Compounding Pharmacies and they said I need a perscription. I called my PCP and they said they do not prescribe these things. I called my sister's clinic where she gets semi-glutide and they said they do not deal with the types of peptides I am looking for. PLEASE HELP - what type of company/clinic/business do I need to look for to start these injections? thanks so much
China
Great episode so far -still listening- but wondering how to find a physician who is knowledgeable about peptide use! Brought BPC 157 up with my teenage son's gastroenterologist and he had no idea and did not embrace looking into it. Doc wanted to keep him on the medicines (i.e. corticosteroids, balsalazide, immunosuppressive drugs) that cause worse side effects than the actual autoimmune disease. Now how to get the Pentadeca Arginate for him??
Grateful you share your knowledge and conversations in your podcasts!
Many pharmacies will be carrying and the ones we utilize certainly do
@@craigkonivermd@craigkonivermd Awesome conversation. I was a youth Olympian/national champion sailor and randomly lost the ability to stand and hold any weight on my feet. 5 years later after hell I got diagnosed with Crohn's but seemingly no connection; it acts like greirson gopalan syndrome but surely it's an associative problem to the crohns. Regardless, I second the comment above; hard to find a physician who understands. Hence why I'm on immunosuppressants and lyrica, some nexium. I live off grid in Tasmania so I'm healthy-ish but it's undulating. Obviously this isn't your fight but any advice would be greatly appreciated. BPC - 157 sounds like it has great potential.
Dr Koniver, PLEASE READ! What is your opinion on the field of bioactive precision peptides which have sparked a transformative dialogue around their natural sources and potential for ingestion, proposing a shift from synthetic compounds typically administered via injection to naturally occurring peptides identified through AI panels.
The argument is that these panels have ingeniously isolated specific peptides in nature that may provide the same therapeutic benefits as their synthetic counterparts.
What is the feasibility of harnessing these bioactive compounds through dietary means? Can ingestible forms deliver comparable efficacy without the need for invasive treatment
What brand of sublingual NMN do you use? I only ask because as a lay person I find it difficult to know that it is quality with a reasonable price?
Love this episode. Question: How do I find the right physician that is knowledgeable and willing to work with patients to explore peptides?
watch out for dental staining with the methylene blue, if you have dental work on the front side of your teeth, it will stain them blue for much longer than an hour. for days. I do capsules just because of that and they work!
U can use half glass water, stir ketchup sit, use straw, no staining💞