U should have also touched on the hyperawareness, impulsitivity, and compulsitivity that comes along with it doc. Always nervous, on edge, brain never shuts off, and especially anticipated triggers or presenting triggers activating or arousing the HPA. I'd like to see you.
But the COMT mutation is what made us smart civilised people. Without the COMT met allele we would still be in the jungle, hunting and climbing the trees
I posted a link to a company that does some of them in a video and blog post with title MTHFR testing. The comprehensive testing for genetics are only available through doctors office, as far as I know.
This first link is an affiliate link to a company that does it. www.mthfrdoctors.com/health-reports/?ref=88ylvtzj If you have done 23andme.com or ancestry.com reports you can also get the information from there.
I was recently diagnosed with comt v158 homozygous positive. My body is unable to break down estrogen. I would go crazier everytime it was prescribed to me. I have tests showing i have zero testosterone which is causing me female menopausal issues. Does having this gene mutation mean I cannot take testosterone or DHEA either since these are androgens? Any reply would greatly be appreciated.
Hi Mina, This particular SNP will slow down your bodies ability to breakdown estrogens but there are back up pathways. If you got worse from birth control (which are not estradiol but synthetic forms of estrogen), it could be related. However since they are synthetic forms of estrogen and some also have synthetic progesterones, it would be hard to say without having the exact formula. If it was bioidentical estradiol then your back up pathways may also be compromised. To your question about testosterone and DHEA, you may be fine. It is true that some of the testosterone will turn into estradiol but not all will. It will really depend on how your back up pathways for estrogen breakdown are working, how much testosterone you take, and how much aromatizes to estradiol. I hope this helps, you may want to also check out my video "3 reasons hormones cause anxiety" as I think it will help as well.
Southwest Integrative Medicine thank you for your reply. Since being diagnosed I've been scouring the web trying to learn about this. It's super hard to understand the dynamics when it comes to medical terms and what not. I have tried all hormones( estrogen and progesterone synthetic pills and bio identical creams. I have tried the estrogen patch, the estrogen vaginal cream estrace.)All these were the lowest dose possible) and all have caused me more anxiety and depression. What's weird is that everyone i would take any type of estrogen, i would immediately feel great but only to feel anxiety crying and depression a few hours later. I have never tried testosterone or dhea tho. But my specialist won't start me On these until i try all these natural supplements first. I am currently on a 12 supplement plan via a specialist, such as magnesium glycinate (gave me headaches), methylated b complex, Sam-e, Panax ginseng, ldl, DIM cq10 absorb, to name a few. I'm supposed to start these slowly and introduce each one every 3 days, I've only done probiotic sachets 5billion, the magnesium and the b complex. Tonight I will try and Introduce either Sam-e or DIM. One thing I should mention is that about 2.5 years ago, I woke up one morning with weird adrenaline type rushes starting from my lower pelvic area all the way up my chest and sometimes my head. I almost feel like a lit up Christmas tree. To date I still wake up each and every morning with these and no doctor has been able to tell me what it is. I feel these rushes are going to be part of my life forever. Any thoughts?
Well that is interesting and it sounds like it may not be just one thing. I can't say for sure what it is or what to do but I would focus on detoxification (specifically amine elimination).
@@leannsanchez9716 sure. I will make a video on that topic. The basic idea is that amines can build up in your system when you have COMT. As a result other stimulating neurotransmitters (amines) stay in your system longer. I would be curious how much research there is on this topic.
Hi doc. Is it really true that methyl-B12 and Methyl Folate can cause anxiety in people with COMT. And the should prefer other forms of this vitamines?
Hi Thomas, val/val is normal so typically this is not associated with anxiety. In combination with other genetics, though it could be a contributing factor.
@@Nietskii that's about enough for me. I think it takes time to top up the body supply, so more than that, at one time, I don't suppose gets absorbed. Try the other channels, like Epsom salt bath.
@@swintegrative I use Natural Calm magnesium citrate to keep me regular. I'm not sure I can take additional magnesium on top of that. Why do you say that Mag Citrate is not the way to go for Slow comt folks?
Hi Mark, you mean if you have slow COMT function can you take clonidine? There would be no absolute contraindication there. Clonidine is decreasing the binding of catecholamines (in specific tissues) but does not change the actual levels.
U should have also touched on the hyperawareness, impulsitivity, and compulsitivity that comes along with it doc. Always nervous, on edge, brain never shuts off, and especially anticipated triggers or presenting triggers activating or arousing the HPA. I'd like to see you.
Is exercise bad if you have this problem. I found out I have it. I was given one handout that mentioned to avoiding strenous exercise.
How can u get into deep rem without bruxism?
But the COMT mutation is what made us smart civilised people. Without the COMT met allele we would still be in the jungle, hunting and climbing the trees
Never heard that interpretation
I have a fast COMT gene G/G and C/C. Believe this is the warrior. What are some things I can do to increase my dopamine?
Catechol foods and drinks. Google. Mucuna pruriens too
How do you address if you have MTHFR and COMT both?
Great video doc! Is there one single gene test which would test for all of these or do i need to test for it specifically?
I posted a link to a company that does some of them in a video and blog post with title MTHFR testing. The comprehensive testing for genetics are only available through doctors office, as far as I know.
What can be done to relieve anxiety without meds?
what are the alternative genes ....im a train wreck mess ....damaged by anti depressants and benoziapines
Hi LAM, what do you mean alternative genes, like other genetics that contribute to anxiety?
@@swintegrative YES
Is magnesium oil spray good?
Hi Maaike, I am not a fan of the spray. It might work but hard to know who will absorb it or not.
How do I get tested? Where can I get a test done by mail it directly to lab?
This first link is an affiliate link to a company that does it. www.mthfrdoctors.com/health-reports/?ref=88ylvtzj
If you have done 23andme.com or ancestry.com reports you can also get the information from there.
Could the palpitations be because of the comt?
A contributing factor
I was recently diagnosed with comt v158 homozygous positive. My body is unable to break down estrogen. I would go crazier everytime it was prescribed to me. I have tests showing i have zero testosterone which is causing me female menopausal issues. Does having this gene mutation mean I cannot take testosterone or DHEA either since these are androgens? Any reply would greatly be appreciated.
Hi Mina, This particular SNP will slow down your bodies ability to breakdown estrogens but there are back up pathways. If you got worse from birth control (which are not estradiol but synthetic forms of estrogen), it could be related. However since they are synthetic forms of estrogen and some also have synthetic progesterones, it would be hard to say without having the exact formula. If it was bioidentical estradiol then your back up pathways may also be compromised. To your question about testosterone and DHEA, you may be fine. It is true that some of the testosterone will turn into estradiol but not all will. It will really depend on how your back up pathways for estrogen breakdown are working, how much testosterone you take, and how much aromatizes to estradiol. I hope this helps, you may want to also check out my video "3 reasons hormones cause anxiety" as I think it will help as well.
Southwest Integrative Medicine thank you for your reply. Since being diagnosed I've been scouring the web trying to learn about this. It's super hard to understand the dynamics when it comes to medical terms and what not. I have tried all hormones( estrogen and progesterone synthetic pills and bio identical creams. I have tried the estrogen patch, the estrogen vaginal cream estrace.)All these were the lowest dose possible) and all have caused me more anxiety and depression. What's weird is that everyone i would take any type of estrogen, i would immediately feel great but only to feel anxiety crying and depression a few hours later. I have never tried testosterone or dhea tho. But my specialist won't start me On these until i try all these natural supplements first. I am currently on a 12 supplement plan via a specialist, such as magnesium glycinate (gave me headaches), methylated b complex, Sam-e, Panax ginseng, ldl, DIM cq10 absorb, to name a few. I'm supposed to start these slowly and introduce each one every 3 days, I've only done probiotic sachets 5billion, the magnesium and the b complex. Tonight I will try and Introduce either Sam-e or DIM. One thing I should mention is that about 2.5 years ago, I woke up one morning with weird adrenaline type rushes starting from my lower pelvic area all the way up my chest and sometimes my head. I almost feel like a lit up Christmas tree. To date I still wake up each and every morning with these and no doctor has been able to tell me what it is. I feel these rushes are going to be part of my life forever. Any thoughts?
Well that is interesting and it sounds like it may not be just one thing. I can't say for sure what it is or what to do but I would focus on detoxification (specifically amine elimination).
@@swintegrative Can you explain the importance of amine elimination?
@@leannsanchez9716 sure. I will make a video on that topic. The basic idea is that amines can build up in your system when you have COMT. As a result other stimulating neurotransmitters (amines) stay in your system longer. I would be curious how much research there is on this topic.
Hi doc. Is it really true that methyl-B12 and Methyl Folate can cause anxiety in people with COMT. And the should prefer other forms of this vitamines?
That is common but not in an absolute sense. I certainly have people that have come that take both
what about val/val?
Hi Thomas, val/val is normal so typically this is not associated with anxiety. In combination with other genetics, though it could be a contributing factor.
@@swintegrative Thanks!
Mag glycinate and threonate didn’t do much for me, wasn’t effective
Dose up dude. It's unstoppable.
@@wizardatmathtake more then 400mg?
@@Nietskii that's about enough for me. I think it takes time to top up the body supply, so more than that, at one time, I don't suppose gets absorbed. Try the other channels, like Epsom salt bath.
What form of magnesium for comt
Hi Jordan, Any kind except oxide or citrate. We use this one amzn.to/3k7oxBx
Generally people take between 200-800mg/d.
@@swintegrative I take magnesium oxide to get the bowels moving, and magnesium glycinate to sleep. Life changing!
@@swintegrative I use Natural Calm magnesium citrate to keep me regular. I'm not sure I can take additional magnesium on top of that. Why do you say that Mag Citrate is not the way to go for Slow comt folks?
@@swintegrative I used threonate and glycinate didn’t feel any different I was even told I have low magnesium I was taking about 800mg a day
can you take clonidine if have problems with comt?
Hi Mark, you mean if you have slow COMT function can you take clonidine? There would be no absolute contraindication there. Clonidine is decreasing the binding of catecholamines (in specific tissues) but does not change the actual levels.