Energy Toxicity and Insulin Resistance with Dr. Ben Bikman
ฝัง
- เผยแพร่เมื่อ 5 มิ.ย. 2024
- In this episode of The Metabolic Classroom, Dr. Bikman, a biomedical scientist and professor of cell biology, delves into the concept of energy toxicity.
He begins by explaining that energy toxicity attempts to explain why certain cells, particularly those capable of storing energy like muscle and liver cells, become insulin resistant. The primary idea is that when these cells accumulate excess energy, particularly in the form of triglycerides, they become resistant to further energy storage by becoming insulin resistant. He clarifies that this is closely related to lipotoxicity, where the stored fat itself, rather than glycogen, is seen as the main culprit for this condition.
Ben notes that while the notion of energy toxicity encompasses both glucose and fats, triglycerides, a type of fat stored in muscle and liver cells, play a significant role. However, studies, such as one on endurance athletes, have shown that muscle triglycerides alone do not cause insulin resistance, leading to the concept of the “athlete’s paradox.”
Dr. Bikman further explores the biochemical pathways involved in insulin resistance, emphasizing that specific lipid intermediates, particularly diacylglycerols (DAGs) and ceramides, are more relevant than triglycerides in causing insulin resistance. DAGs disrupt the insulin signaling pathway by activating protein kinase C, while ceramides inhibit insulin signaling and affect mitochondrial function, increasing reactive oxygen species and contributing to insulin resistance.
Ben challenges the notion of energy toxicity as a primary cause of insulin resistance, advocating instead for a focus on lipotoxicity and its mediators. He concludes that chronically elevated insulin levels, rather than the stored energy itself, are the main drivers of insulin resistance, suggesting that the term “insulin toxicity” might be more appropriate. This understanding is crucial for addressing what he identifies as the most common health issue worldwide-insulin resistance.
01:16: Defining Energy Toxicity
02:58: Lipotoxicity vs. Energy Toxicity
06:20: Ectopic Fat Storage
08:20: Triglycerides in Muscle Cells
13:57: The Athlete's Paradox
17:11: DAGs and Insulin Resistance
19:26: Ceramides and Mitochondrial Function
29:21: Insulin and Lipolysis
33:59: High Insulin and Insulin Resistance
Studies Referenced:
A phenomenon known as the “athlete’s paradox”:
academic.oup.com/jcem/article...
www.sciencedirect.com/science...
www.sciencedirect.com/science...
www.jci.org/articles/view/43378
pubmed.ncbi.nlm.nih.gov/24073...
www.jbc.org/article/S0021-925...
#MetabolicHealth #InsulinResistance #EnergyToxicity #Lipotoxicity #BenBikman #CellBiology #Triglycerides #DiabetesResearch #FatMetabolism #EctopicFat #KetogenicDiet #InsulinSensitivity #MitochondrialFunction #MetabolicClassroom #HealthScience #BiomedicalResearch #Endocrinology #Metabolism #HealthEducation #Type2Diabetes
www.insuliniq.com - วิทยาศาสตร์และเทคโนโลยี
You are such an excellent teacher. I'm a musician and college professor with no science background other than an intense interest in health for both my family and my career longevity. Not only could I follow this, but it beautifully connected and added depth to so many concepts I've been exploring. I can't thank you enough for your intellectual generosity and public service.
You mean you don't learn great science learning music theory?
😂😂
@@ianstuart5660 Ha! I know laryngeal anatomy, but my math tops out at a major 15th!😂
@rhshrimpton
Lol! Thanks for that and I'm glad you knew I was just joking around! Have a Majorly splendid day!..
👍😺❤️
So simple to understand even for a non-science major. Thank you for your service to mankind!
Ben Bikman is a living legend and living god for worldwide human race...who will share this knowledge free of cost and why is ben doing it free of cost... because deep inside he is a good human being born to beautiful mother and father who instilled these values of sharing and helping fellow humans since he was a child ...I'm sure Ben has immense gratitude for his upbringing and his mother and father guidance throughout his childhood and adulthood which has shaped him to be what he is now ...love hearing your classroom sir ...God bless you
if I had a teacher like Dr. Bikman, I would have persued and enjoyed biology!
True👍🏻
When you look in the dictionary for the word CLARITY you will find Dr. B's picture next to it. Well done, ooooh soooo well done. Thank you
It’s thinking how awesome it must be for Dr Bikman to teach over two hundred thousand of us who just want to know more about health, take control of our bodies and be well. No other reason, not to get a grade, a degree, get credits. You’re amazing Professor, and I am so grateful.
Dear Dr. Bikman I really appreciate and enjoy these classroom videos!
When I think energy toxicity I immediately think seed oil poisoning.
And I remember my mother…
and Thomas Delauer is blaming saturated fats😂
@@powerguiller no he is not.
which is a wrong association. They are poisonous for other reasons than their energy. you may revise your pavlovian reflex.
Thomas Delauer is a clown.
You are a wonderful teacher. I could listen to you for hours. Thank you so much for sharing your vast knowledge so articulately!
It’s great to see someone who LOVES teaching & helping people change their life!!!! Thank you! 🙏🏻 ❤
Thank you Dr. Bickman, you are a masive contributor to my carnivore journey back to health. Please keep up your excellent work. Stuart from Melbourne AU.
I heard a alleged medical expert on fat metabolism on Dr. Berry's channel this week and was horrified at the incorrect information she spewed and that Dr. Berry would give her a voice. I'm so THANKFUL for your generosity in educating me so I know when I hear WRONG information, half truths and theories based on just a notion instead of the real hard researched science.
Is that the "Dark Calories." Video?
Yep saw that. I think she’s spot on about seed oil toxicity but nothing trumps chronic high insulin as a metabolism killer. However seed oil consumption and the inflammatory state it causes should not be overlooked.
@@MelzCarnivoreJourney yes. She's only partially understanding this complex subject and got a lot of it wrong, unfortunately.
@@lindarichmond7814 I agree, but she does not have any knowledge of fat as being an endocrin organ.
I turned that one off too, alarm bells went off to me
The only time the general public hears about ceramides is regarding cosmetics, that it softens and plumps up your skin.
I agree and sent Dr. Bikman a question regarding this. Especially the relationship between topically applying this and their effects on the body's production of ceramides since the skin is the largest organ and toxins are absorbed through our skin.
@@meatdog Did you get a response? I had the same question and I would be very interested in the answer.
This makes the idea of low carb style of eating all the more important. Thank you Dr. Bickman👍🏻
Absolutely Excellent! I’m understanding how my body built up the fat and what I’m actively doing now within the cell… Burning it!! I’ve listened 3 times at 25 minutes in… You are the best teacher and guide. I have been looking for you 20 years! SOOO happy to be apart of InsulinIQ! Can’t wait for the next year to unfold thanks to you changing my life! Cyndee
You've got a great working brain and it's a privilege to learn from you. Thank You
Wow! You manage so well to explain it to “common” people! So interesting! Thank you 🙂
Listen to this lesson as I performed my daily resistance exercise. What a glorious way to start my day.!
I would like to see Prof Bikman and Prof Kay have a discussion, they make their points so clear.
Will be revisiting this episode frequently to insure that I've taken it in thoroughly. As a linguist, I appreciate your precision with the definition and use of words, closing doors and windows to possible confusion and conflation. As a T2D in remission, I am both grateful for the deep, "owner's manual" level of education you offer and for how this piques my curiosity to keep learning and to dive deeper. Most of all, thank you for your time and willingness to share your expertise.
I have only a very limited science background, but I could follow you all the way, with only the odd bit here and there I had to stop and go back over. I'm so glad you explain things so well, Ben, it must be an honour to be one of your students.
Beautiful talk!
I have CLARITY now!
Thank you so much!
I’ll need to listen 4-5 more times. This is dense 😊
Dr. Sean O'Mara advises sprints and max intensity exercises instead of endurance to get rid of visceral fat.
Is it possible to use diagrams, pictures and slides in these clips? I am sure they would help clarify a lot of things.
This is a breathtaking lecture and high-level, invaluable information most influencer and TH-cam metabolic-informed channels do not explain. Dr. Bikman should be charging money for this kind of information. God bless him.
If he starts doing that, we'll know who to blame!
😂😂
Shut Yo Mouth! LOL He is a truly valuable individual in today's world of misinformation and agendas.
@@Metqa
IKR, even the Agendas have Agendas!
😢😢
My favorite metabolic scientist
Great teaching skills
Thank you
OK, you opened another rabbit hole for me, one that sounds near and dear to you. Ceramides and sphingolipid family. I want to know more details as it this appears to be a primary key holder! Pathway interactions, how and where they fit! Sounds like you would be the perfect one to lead the way in informing us.
I'll have to listen to this one a few times to take in everything... Thank you!
Oh I love your Metabolic Classes. Finally a resource I can rely on.
Thank you Professor Ben Bikman!! Love your content and I’ve learned so much from you 🎉
Great great great, it took me back to school. It also clinically makes so much sense. Thank you Dr Bikman! 😊
QUESTION TO YOU DR. BIKMAN: Here is my take away. You are saying in a nutshell that high insulin over long periods of time leads to insulin resistance. The inference is that insulin resistance IS ALSO a problem. But I am confused. Ultimately, it is high BLOOD GLUCOSE that defines a person as a diabetic and causes the body to, basically rot. In my understanding, insulin resistance is a FABULOUS PROTECTIVE MECHANISM for each cell - the bouncer so to speak. If the cell is keeping out a fuel source, be it glucose or fat, it is because the cell is either FULL and taking in more would be damaging, OR the cell is not yet ready to take in more fuel. Why a cell may keep out fuel even though it has room to store more stems from complications based on eating a mixed diet of carbs and fat together. As I understand that complication, it is that a cell needs to control the composition of the fuel source inside the cell. At one end of the spectrum, if there is only fat inside the cell, and a fat cell is knocking at the door wanting to get in, PLUS there is room in the cell for more fuel, the bouncer lets the fat in, no problem. If there is glucose in a cell and glucose is at the door knocking to get in, sure, plenty of room, the bouncer lets it in. NO INSULIN RESISTANCE in these examples. BUT if the cell is using fat and glucose is at the door, the bouncer will keep out the glucose until the cell is drained of fat, THEN it will let the glucose in. And the waiting game, all the time it takes to drain a cell of one fuel source before the other can enter, this leads to degeneration, fatigue, AND because there still exists the problem of high blood glucose, the body is basically slowly embalming itself as the sugar dehydrates everything it comes in contact with. I am a Korean Natural Farming - we make farming inputs by mixing equal parts brown sugar to plant material in order to extract the liquid from the plant material; this works based on the principle of osmotic pressure, and this is what diabetes is to my understanding. What artificial insulin injections do is arm all the glucose in the blood with a battering ram so glucose can FORCE its way into cells, REGARDLESS of whether or not the cell is full, REGARDLESS of what fuel source is already occupying the cell. For cells containing fat, the mixture of fat and glucose is like mixing diesel and ethanol fuel in the same fuel tank - it's very very bad - IT'S INFLAMATION (cell damage) - it's early cell death. Artificial insulin DOES keep down blood glucose but the tradeoff seems to be a slow degenerative death spiral. My conclusion is that a 100% carnivore diet IS our species specific diet. I am so novice to this subject. Please, if it is not too much trouble, correct me where I am misunderstanding.
Thank you so much, Doctor. Yes this is very deep. As a complete layperson, I can grasp most of it if I really pay attention and listen a second time on another day. I appreciate this information so much. Myself, my family and even three generations back have struggled with obesity. It is good to understand the mechanisms. I have completely reversed pre diabetes, fatty liver, high BP, but the excess 50 lbs of fat defy me at every turn. 63 yr old female, 5'3". I would love to eliminate the excess fat. I am working at increasing insulin sensitivity.
Good job 👏! Keep going. Good for you for breaking out of your family obesity trend.
Great explanation! Thanks Dr. Bikman! Now I'm able to find errors in texts I'm reading, like this sentence: "Dietary intake of saturated fat has been shown to increase serum ceramide and increase insulin resistance." in Wiki article about ceramides.
This is incredible. As how easily understandable you've made it. lets share and continue to get this message out there.
These are sooo good and informative.
Thank you!
Dear Dr. Bikman I really enjoy yours classroom videos!
Fascinating! Thank you for this episode, which I found particularly enlightening. I appreciate that imaging is not your field, but I found myself asking whether the difference between triglycerides, diglycerides and ceramides would be apparent on MRI images. The difference between athletes and obese people is readily apparent, as the muscle and fat appear (more or less) as black and white, and the sarcopaenia in diabetes and obesity is also clear. Sadly, such incidental findings are not documented in radiology reporting.
And yet, I wonder how much more could be interpreted from an image, in terms of the tissue composition, ratio of muscle to fat, or, even more specifically, the types of fat, and what that tells us about metabolic health. Are we missing an opportunity here?
Great lecture! Thank you, Professor!😊
Thank you sir for sharing the information well done 👍
Great info. Thank you
Thank you Dr Ben, very informative as usual.
I appreciate your videos, very helpful. Thanks
BB, good vid, thanks for the lesson.
Thank you for another great session!
Thank you
Awesome presentation
(~28m) Nice explanation of ketone generation: liver buring fat because insulin in low. This also makes home monitoring of insulin level (or sorts) obvious: if you are generating endogenous ketones, insulin is low enough for fat cells to release. Also really understandable following explanation of high fat high insulin harm!
Thank you very much!
Excellent and very interesting overview.
I have been watching you for about 7 or 8 months now. I give recommendations to everyone I interact with who has diabetes as I do. I have been eating a carnivore diet for almost 11 months. My last fasting insulin was 5.3😍. However , I still am very insulin resistant. I was having improvement but after a recent colonoscopy my sugars have elevated into the 200-300 range and stay there and my inflammation is through the roof (again). I know that my diet is low enough in carbs that it should not be elevated like this. I am also exploring the MTHFR gene mutation theory but I am wondering if this has to do with my gut. Both parents are/were T2D and my son is also and one daughter is prediabetic. Could you please give me suggestions? Maybe links to more videos? I have been on this journey since having a bad experience with Ozempic it left me with optic neuropathy in both eyes so I am low vision (legally blind). So I am taking back control of my own health. Thank you so much for your generosity in educating the masses ❤️
Such a great teacher, thank you very much !!
Thank you so much for sharing
Thanks a lot, marvellous explanation!
You are amazing!
This is a big one!
Thanks Ben
You sure were able to teach me new insights! Thanks again for these wonderful explanations (although it is bedtime over-here right now I just had to watch the whole video because of it's content and your excellent way of explaining all this.Thanks the Lord for internet and the new technologies. Greetings from the low lands on the north seacoast (i.e. The Netherlands)
Thank you for these great and informative videos. I really appreciate your lectures. I learn so much from them.
Very interesting discussion, Dr. Bikman. Thank you! It sounds to me that the culprit here is what Daniel Trevor calls CCOD - Corporate Carbohydrate Overdose Disorder.
Thank you!!!!
I left a comment or question for Dr Bikman about TG and was hoping to hear his take on TG. Also expressed my observation about some people that burn fat or lose fat mass very well but deal with high or very high TG. And here it makes more sense when Dr Bikman explains what could be going wrong. My history is 30 year very high stress job, 5’ 11 200 lb for years, steady weight but drop pounds quick with food restriction, TG 350 to 450 with meds, today its 85 with only Vasepa and no statin or fenofibrate. I stoped all sugar, limit carbs greatly to 20 or 50g maybe, time restricted 16:8 with random extended fast 1 to 3 days in duration. The random fasts are just that, whenever i feel well enough to handle, no plan just dive into it. Never compensate in food mass just out of a fast and eat high protein first and then a little carbs.
Have to add, lost 30 lb however at 200 lb you would wonder where i put it since i carried the weight very well.
yep, stress, snacking carbs, too much fructose ingestion, where the first two result in endogenous fructose production, then leading to high TG.
So, please correct me if I am wrong, to summarize:
Feeding on carbs every 3 hours sustains a high insulin level throughout the day. Extended high insulin is toxic as it prevents the use of fat as a fuel and promotes the conversion of carbs to fat for storage. You therefore can't use your fat, get repeatedly hungry and store yet more of what you eat.
If the fat cells have maxed out and become insulin resistant due to the presence of ceramides then the new fat is stored in muscle cells and the liver.
This metabolic imbalance leads to T2D and fatty liver disease. Annedotally, this condition also appears to be implicated as the root cause of CVD, cancer, mental illness from anxiety and depression through to the psychoses as well as the range of neurodegenerative diseases. ( Perhaps seed oils, oxalates and plant sterols are in there as well?)
The cure is to keep the consumption of carbs to a minimum and then to allow long gaps, perhaps 5 or 6 hours, between such consumption to allow insulin to fall and the burning of fat as a fuel to resume.
I am guessing that snacking on protein throughout the day would also cause insulin toxicity as it will lead to sustained gluconeogenesis and raised blood sugar levels/insulin.
Perhaps eat one protein rich meal in the evening and otherwise focus on fat rich food for breakfast and lunch such as bacon, eggs, butter, cream and cheese?
To much eating spikes insulin continuously
Good morning
Thanks!
Hi Lisa. That is so kind of you. Certainly not expected, but appreciated. Thank you.
"Inflammation as a cause..." Question:
What about the effects of chronic and intermittent systemic inflammation from Rheumatoid Arthritis?
These classes are great. Have you ever thought about developing a metabolic health specialist certification?
So how do you block the ceramides? 25:34
That’s what I want to know as well 😊
👍👍👍👍👍👍👍
Because the 👍 must be like resistant.
Isn't the concept of high insulin plus high free fatty acids at the same time pretty much explained by the Randle cycle? The consumption of carbs and fats at the same meal would activate two separate biochemical pathways that inhibit one another, so when the fatty acid one "wins", one would end up with high blood sugar that would require high insulin to get rid of it. The cells would appear to be glucose-intolerant and the insulin would store the glucose as fat at the adipose tissues. Isn't this the cause of chronically elevated insulin?
What about the Randle cycle, and excess citrate blocking GLUT4? And does dietary intake of citrate contribute?
I had the exact same questions!☺️
Thank you for your very informative videos. I don’t normally comment but I enjoy them a lot.
One question regarding the Athlete paradox:
How do they store fat in their muscles in a low insulin context?
Thank you, Dr. Bikman!
QUESTION/REQUEST: Would you please address how long it takes to reverse insulin resistance? I guess it will be a range as people are different, but many people struggle with feeling like their efforts are not moving the needle much- despite going very low carb. I think it is fairly slow compared to lowering hyperinsulinemia and glucose- which is already 3-6 months. Needing some perspective!
We need a meter that can measure insulin but unfortunately they haven’t come up with one yet. All we can do at this point is get a fasting insulin test at a lab and check our blood glucose levels at home. It’s frustrating not to know. But if your BP is good, your A1C is good etc that’s an indicator that you’re getting better. It took me about six months of weight loss to get off meds. I had to lose a good amount of weight before I started getting results. No sugar, no alcohol and very low carb plus intermittent fasting worked for me. No processed food and no seed oils will cure a lot of problems.
Keep doing fasting insulin tests half yearly and measure it by that. I also think I heard someone comment that if you don't do a fasting insulin test that the triglycerides and HDL numbers will show the insulin levels coming down. Triglycerides are an inflammation marker so if they are coming down that's a good sign. 😊
Thanks. How are the ceramides blocked?
Struggled with this one Ben
I’ve been on the carnivore diet for three months. It is working, absolute wonders, but now I want to understand why and that’s when I come to your channel.. thank you very much
I'm curious about the lesser hormones that have an influence on insulin resistance and energy toxicity. Do we have influence on these?
I think Dave Feldman would generalize the idea of energy toxicity to include energy in blood, rather than just energy in cells. I think I recall a talk of his where he mentioned that it's bad to have energy parked in your blood.
This was excellent and I could follow along most of the time. However, I am a very visual learner. Where could a find your information in a more visual way please? Thank you so much!
Bedankt
Thank you very much. That is kind of you and I appreciate it.
@insuliniq Ben: I beg you to read these research articles. They match perfectly with what you're saying about the dangers of high carb/ high sugar/ frequent booze. I agree we're getting more insulin resistant, BUT those "manmade carbs" & sugars or frequency of alcohol are actually depleting our B1 thiamin during krebbs cycle! Actually very common mimicking other diseases as the first article says.
-"Hiding in Plain Sight: Modern Thiamine Deficiency"
-"Sugar intake and thiamine"
BY DERRICK LONSDALE MD, FACN, CNS
-"Thiamin Deficiency (Beriberi; Vitamin B1 Deficiency)"
By Larry E. Johnson, MD, PhD
-"A Patient With Thiamine Deficiency Exhibiting Muscle Edema Suggested by MRI"
-"Wet Beriberi Associated with Hikikomori Syndrome"
QUESTION: Do ceramides in topical skin cosmetics have any effect upon this info?
This is a great explanation if you're familiar with Dr Sean O'Mara's work and MRI scans.
When talking about energy models and mitochondria I respect Dr. Sean O’Mara; however, I remain intrigued by the Reiter and Zimmer publication on photo bio modulation published nearly five and a half years ago and promoted by Dr Roger Sehuelt in his award winning TH-cam channel : MedCram
Block them ceramides! 😎👍🛴🎵
@@denniswilliamson6899 But how? Dr. Bikman doesn't elaborate on that. My thoughts go to nutritional ketosis, and Dr. Bikman seems to indicate that as well, but the NIH hypothesizes, like they always do, more fruits & veggies. We need clarity to battle the misinformation and confusion.
Did Ben talk about the Randle cacle at some point in any of his videos?
You did not use the term Lean Mass Hyper Responder, perhaps because they have low triglycerides and high LDL? Does your explanation apply to them?
Are the ceramides in meat and dairy also contributing to insulin resistance..or just the ceramides produced by liver because of insulin resistance ? (Sorry i don't have a background in biology)
02:30 How about "glucotoxicity"? After all, glucose is the molecule that the body will do anything to get out of the blood stream, and even when it has entered a cell, as I understand it, it more or less immediately gets phosphorylated to glucose 6-phosphate.
first, not anything. he body keeps producing glucose, even if i is in small amounts.The brain likes to run on at leas10..20% of its energy consumption on glucose. Second, glucose is weakly toxic, as it causes glycation, mainly of proteins. I s reflected in the hbA1c. It cause stiff connective tissue, from eyes, to arteries, and tendons. These processes are extracellular, hence it is not a classic toxin in the more narrow sense. Those are working intracellular, causing the death of cells
Just wonder:What autoimnun issue do you have?
I can see that your imunsystem are little upset.
Dr. Bikman, please explain, why is there zero ketonuria after a 20-hour fast in a fast-adapted and well-exercised middle aged person with a fasting insulin of less than 5( quest diagnostics units) ?
Hago una pregunta.
Entonces la acumulación de grasa visceral que en principio suponemos que es perjudicial en atletas de largas distancias no tiene relación con la lipotoxicidad?
Quiero decir que en ese caso, esa marmolización en el musculo del atleta de larga distancia no es perjudicial?
Muchas gracias y no deje usted su labor informativa.
How does one block, or control, ceremides?
Why does the Liver even make these ceremides?
Dr bikman, can our body absorb and store dietary fat in our adipose tissue (gain weight) without involving influence of insulin by eating very low/ zero carbs diet?
The body is so absolutely beautiful and amazing.
Is fasted insulin level of 2 too low if a person is lean mass responder and have a1c of 6 triglycerides 64 and very high cholesterol?
Also, MAF proponents claim the muscles burn fat during "maximum aerobic function". I take it the intramyocellular lipid droplets are used in the fatty acid oxidation cycle to provide immediate ATP after the glycogen has been consumed. So wouldn't high insulin levels prevent the lipolysis and use of these lipid droplets (as well as adipose tissue generally) and curtail aerobic endurance activity (even if you fat-loaded before an ultramarathon, as one study examined)?
Ectopic = Εκτοπιζω comes from "εκ" (from/ουτ) and "τόπος " (place).
Out of a place. It means also exile.
What creates seramides?
Two question, sir: First, If we inject insulin intramuscularly, does it bind to that muscle's IR more than it would bind to the IR on adipocytes?
Second: Bodybuilders sometimes use insulin while cutting, Is it the case that due to their number and size of adipocytes with respect to their skeletal myocytes, the insulin would help their muscles to consume the carbohydrates available in the blood much more than the adipocytes storing them?
Eating fat also raises basal insulin, but it is much slower and longer-acting. I just found this out.
🔥🔥 🔥
How does one "block the ceramides"? 😊
Stop eating carbs 24x7, eat non-inflammatory foods, take care of your leaky gut, reduce stress and stress hormones.