Ion Detectors in Mass Spectrometry | Faraday Cup| Electron Multipliers| Dr. Nagendra Singh | PENS#73

#Massspectrometery #faradaycup #electronmultipliers
Ion Detectors in Mass Spectrometry | Faraday Cup| Electron Multipliers| Dr. Nagendra Singh | PENS#73
MS, detectors are the “eyes” of the instrument. New detectors and technologies
are needed to correct, improve, and extend
ion detection and, hence, our “chemical vision”. This report reviews current MS detector
technology and provides a glimpse of what we
hope future detectors will be capable of.
The technology of MS can be divided into
three processes: ion generation, ion separation, and ion detection. Ion generation and
separation have received significant and focused attention. The first prevalent MS ionization source, the electron impact (EI) source,
has given way to a variety of other specialized
ionization sources, for example, spark source
(SS), thermal ionization, chemical ionization,
fast-atom bombardment, secondary ion, glow
discharge, inductively coupled plasma (ICP),
ESI, and MALDI. Similarly, a variety of ion
(mass/charge) separators have been developed, including the seminal sector-field or
magnetic MS, electrodynamic techniques (2-
D quadrupoles, 3-D quadrupole ion traps),
combined magnetic and electrodynamic techniques (FT ion cyclotron resonance [ICR]),
and drift-tube or TOF devices
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The Lectures are given by Dr. Nagendra Singh aiming to spread basic understanding and awareness of biological molecules and reactions. Dr. Nagendra Singh finished his Doctoral and Post Doctoral studies from "All India Institute of Medical Sciences" (AIIMS) New Delhi. Dr. Singh has a vast experience of research and Teaching in the fields of Structure & Molecular Biology and Biochemistry, which also include Biomolecules, Proteomics, Protein Engineering and Drug Design.
Dr. Nagendra Singh currently works at the School of Biotechnology, Gautam Buddha University, Greater Noida, INDIA (www.gbu.ac.in/FacultyProfiles/.... He does research in Molecular Biology, Structural Biology and Biotechnology. His current research interest include 'Structural and functional characterization of proteins involved in RNA metabolism from human and microbial origin. Dr Singh has published over 70 research articles in intentional Journals of good repute. He has over 20 awards and honors on his name. Few of the awards include "National Academy of Sciences of India (NASI, Allahabad) young scientist award", UGC-NET, CSIR-JRF, GATE, Best Research Awards etc. Dr. Singh has participated and presented research work at over 50 national and International conferences world wide.

[@emilynischwitz5371]

This is the best description of mass spec detectors I've been able to fine. Thank you for taking the time to put it together.

[@proteinengineering007]

@Emily Nischwitz ... I am glad it helped ...Thank you

[@leezat3598]

The textbook I was using didn't explain this thoroughly. This was very helpful, thank you😌❤

[@proteinengineering007]

its my pleasure @lee zat

[@ahmedakawy1284]

Thank you very much Dr. Nagendra for your remarakamble and beneficial explaination

[@proteinengineering007]

I am glad it helped you @Ahmed Akawy

[@felipesaltao7378]

this is just what i was looking for, thank you very much!

[@proteinengineering007]

@Felipe Saltão
My pleasure.

[@suhanamishra3685]

Really informative Sir🙌🏻 Thankyou so much Sir

[@proteinengineering007]

Thanks dear @Suhana Mishra

[@vikki10pavam25]

Sir can you please explain how we know charge to mass ratio of ions from the current coming out of detector

[@proteinengineering007]

th-cam.com/video/nKimCwkoljs/w-d-xo.htmlsi=XEgWTrNxyIOqDk42
hope it will help

[@proteinengineering007]

Analyzer is generally pre-calibrated . eg it is known for a n analyzer what m/z ions will be collected at detector with a given magnetic field.

[@attahussain2643]

On what basis we use different detectors

[@proteinengineering007]

depending on nature of analyte and cost available.