The Membrane Potential: Ionic Basis of the Resting Membrane Potential
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- เผยแพร่เมื่อ 7 ก.ย. 2024
- This video discusses the role of potassium ion (K+) in producing a membrane potential. All cells have a membrane potential--it is a fundamental feature of being a living cell. For most cells, the membrane potential arises from two main features: 1) a K+ concentration gradient (produced by the Na+/K+ pump); and 2) selective permeability of K+ ion for the plasma membrane. Understanding how the membrane potential occurs is essential to understanding a variety of physiological processes and pathophysiological conditions.
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Wow--very cool. I'm happy that you plan on recommending my videos to your students! I'll be producing more videos this summer, and into the Fall semester. Thank you for the kind words!
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I'm really glad it was helpful and sincerely appreciate the positive comment. Thank you!
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Your efforts for making this explanation video are appreciated!
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Thank you for the kind and encouraging words!
This was so helpful! 😭 I just came from a mathematical derivation of the Nernst equation via the Boltzmann distribution, and I think everything makes sense now. Lol I’m not even a med student, I’m just trying to help me gf (who is) 😂
Glad it helped!
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Great video pete. Thanku
But i have a doubt. Its said that an increase in sodium conc outside the cell doesnot affect resting membrane potential bcos at rest permeability of sodium is very low.
I have a small doubt here. Eventhough sodium is not much permeable, wont an increase in sodium outside increase the positive charge outside inturn indirectly making it more repelling to the movement of pottasium outwards? And wont this indirect effect on pottasium movement (which is permeable) affect the RMP ??
Thats a really good question. But increasing the extracellular Na+ concentration won't directly affect the charge outside the membrane. This is because any increase in the Na+ concentration will be balanced, by mass action, with a corresponding increase in the extracellular anion concentration (mostly Cl-, but also HCO3-, PO4- etc...). This is in accordance with the law of electrical neutrality. Therefore no change in the net charge will occur.
@@PeteMeighan Thanku so much pete.... But cant the same apply to pottasium also ?
Hi, I have a question. When the cations and anions interact across the membrane, do they actually stick to it? And if they do stick to the membrane, would that affect their concentration, considering that they’re not free anymore but stuck to the membrane.
Great question! I wouldn't necessarily consider them "stuck". You can think of them as a population of anions (inside) and cations (outside) that continually associate with the membrane (via those electrostatic interactions) and disassociate from the membrane (due to thermal energy) occurring at an equilibrium (i.e., equal rate). Nevertheless, the ions that are associated with the membrane are, indeed, not in solution (i.e., does not contribute to the ionic concentration). So in theory the presence of a membrane potential would decrease the ionic concentrations. However, the number of ions that associate with the membrane (as a membrane potential is produced) is Infinitesimally small (compared to the number of ions in solution). Therefore, the presence of a membrane potential has a negligible effect on the ionic concentrations. Hope that helps!
@@PeteMeighan Whoa that makes a lot of sense! The course I’m taking did mention both the clustering of the ions at the lipid bilayer and the negligible, but I failed to put two and two together. Much thanks sir!
very helpful!
Legend
i finally know how we keep the electroneutralité rule ahahaha thanks alot all love
Happy to help! Thank you!