Gene regulation and the epigenome

With around 20-25,000 genes in the human genome, how do our body cells make sure genes work in the right place at the right time?
2015 Francis Crick prize lecture on 'Gene regulation and the epigenome' by Professor Rob Klose, at the Royal Society, London, on 2 December 2015.
royalsociety.org/events/2015/...
TH-cam thumbnail image: Genetic information winding out of a cell by Professor Rob Klose.

[@ayushmishra3468]

A nice presentation.
Great professor.

[@Markolio95]

Great presentation for a deeply interesting topic! Well done

[@issong23]

So easily explained, very impressive

[@Stop-and-listen]

Indeed it was a wonderful presentation

[@araida36]

Enviado por Profa. Teresa da Costa

[@kipling1957]

But what controls the CG reading systems themselves, e.g., during development?

[@gregorypellar1555]

Complex answer, but during development you get spacio-temporal expression cascades of proteins like wnt, nog, flag ect. that set up anterior-posterior and dorso-ventral gradients (french flag hypothesis of development) which alter expression of the genes so that the right gene is expressed at the right time and in the right place. These CG reading system help to accentuate the binary switch of feedback loops form positive to negative and vise versa. The egg itself already has gradients and pattern elements (cytoplasmic centers) to direct development

[@CandidDate]

The neutrino is NOT made of quarks, while the proton and the neutron are. There are two types of quarks, up and down.

[@BattlecamBrent]

I just want to know what kind of water they're drinking.. whether it be the brand of filter or brand of bottle lol

[@aivanm.vaughn1576]

2:45, who can spot the only person not clapping?

[@braintree7502]

i can spot your evil ugly face tho Hitler

[@biostaples]

@@braintree7502 That's Guy Fawkes, dude.

[@johnmelvinhamilton]

First comment!

[@grayarcana]

Gee! Did your genes cause you to make these comments?