Computational Optical Bioimaging | CCS, Univ. Tsukuba

Recent years, the technology of optical imaging is extraordinarily developing, and thereby molecular processes in live cells and tissues can be pursued. At present, the imaging methods such as X-ray CT or MRI are widely applied, and mainly detect the alteration of morphology at a level of organs and tissues. However, these methods are subject to the risk of significant exposure and require a large-scale apparatus or a specialized measurement room. On the other hand, the optical imaging can dynamically visualize multi-level function and morphological alteration in molecules and organs, and possesses a lot of advantages such as no exposure, non-invasion, bed side inspection, low cost, low restraint, and high time -resolution. Thus, it allows us to make automatic and remote diagnosis, monitoring, and screening and is applicable to new-born babies and infants without side effects like CT or MRI. Since biological tissues are strong scattering media, a sophisticated technology of computational science is required to extract the local information from scattered light. The study for the practical realization at clinical settings has not been thitherto sufficient. In this project, we aim at developing a safe technology of CT with near-infrared imaging under the cooperation among the construction of light propagation models based on radiative transfer equation (RTE), the inverse-problem analysis based on mathematical methodology, and the experiments of medical optics for biological tissues.
日本語字幕版： • 計算光バイオイメージング | 筑波大学計算科...
Movie production year: 2021