Keynote Presentation: The NIH Microphysiological Systems Program: Tissue on Chips for Safety...
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- เผยแพร่เมื่อ 5 ก.ย. 2024
- Presented By: Danilo A. Tagle, PhD
Speaker Biography: Danilo Tagle is currently Director, Office of Special Initiatives at the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH) where he leads efforts in developing innovative tools and technologies that can greatly accelerate development of disagnostics and therapeutics. These programs involve interdisciplinary collaborations between intramural and extramural components of NIH, and entail partnerships with other agencies, such as FDA, NASA and DARPA, as well as with private sector. Some of the programs include tissue chips, 3D bioprinting, automated chemistry, electronic nose technology for disease diagnosis, and the isolation and analyses of exosomes for biomarker and therapy development. He has served on numerous advisory and review committees and editorial boards....
Webinar: Keynote Presentation: The NIH Microphysiological Systems Program: Tissue on Chips for Safety, Efficacy, and Precision Medicine Studies with Live Q&A
Webinar Abstract: Current methods used to predict safety and efficacy of candidate drugs accounts for as much as 90% failure rate. Approximately 30% of drugs have failed in human clinical trials due to adverse reactions, and another 60% fail due to lack of efficacy. A number of these failures can be attributed to poor predictability of human response from animal and 2D in vitro models currently being used in drug development. Recent systematic studies on the predictive value of animal models have demonstrated a poor correlation between animal data and human outcomes owing to substantial interspecies differences in key disease pathways and disease-induced changes in gene expression profiles, highlighting the critical need for alternative methods to model complex human-relevant conditions....
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