I have been hyper sensitive to histamine for long time and have had HB with swelling feet your Vedio makes a lot of sense to me Thanks again for your support
clarified butter(desi gee) with bread& chapati used in morning and get rid off this anti hestime i swear i use it’s beneficial It’s just dry blood issue.
In relation to the Histamine flush from Niacin B3 vitamin, how would you classify histamine intolerance ?? Prolonged high Histamine levels is causing depression , in my opinion ; More of a question than the statement it is ?? Maybe by using Niacin causing small histamine flush can increase the tolerance for food related histamine release ?? Which receptors for Histamine are involved , H1 , H2 , H3 , H4 at the time of Niacin flush ?? DAO involvement etc. Please get it addressed in following presentations.
Can you answer how does the stimulation of H1 receptors (which are Gq coupled) lead to vasodilation ( since any smooth muscle contracts when it is stimulated via a Gq coupled receptor)?
H1 receptors are typically coupled to Gq proteins and can mediate smooth muscle contraction, the overall effect of H1 receptor activation on vascular tone involves a complex interplay of various signaling pathways, including the release of vasodilatory factors like nitric oxide and prostacyclin, modulation of calcium signaling, and indirect effects on other vasoactive substances.
yes! because there is H1 receptors for histamine on skin.. so when histamine is released and bind to this receptor it stimulate sensory nerve endings and cause itching and pain.
Sir, you say that Histamine receptors are found on "small blood vessels" and their activation causes vasodilation. But surely vasodilation can only be caused by contraction of their smooth muscle, and this cannot occur in capillaries (which don't have smooth muscle)?
I have been hyper sensitive to histamine for long time and have had HB with swelling feet your Vedio makes a lot of sense to me
Thanks again for your support
Which begger dislike the vedio..if u have doubts just ask him.its not the way by dislikeing his efforts and hard work...
At 4:16 what meaning Direct action,i mean what's the mechanism.plz tell me. thnxs for lecture
EXCELLENT CONCEPT SIR,THANK YOU SIR!
Thank you, sir! It really helped me a lot - from Korea
A lot of love and thanks from Lahore Pakistan.
Pakistan ki maa ka bhosda nikl gandu
Very simple and ease to remember. Excellent sir
Unspeakable 💛💛💛
Thank u
Best explanation big big thumbs up 👍
Great video man, studying for a pharmacology exam this helped
Mst
THANK YOU SIR 🙂
Sir it's really a good explanation but need more detail plezz sir
What a good explanation
I am grateful for your lectures Sir
It's my pleasure
Bahot Good Sirji 👍
Excellent sir...👏👏👏👏👏
Chemical classifications of antibiotics
Watching from uganda 🇺🇬
Simple and easy to understand
clarified butter(desi gee) with bread& chapati used in morning and get rid off this anti hestime i swear i use it’s beneficial
It’s just dry blood issue.
In relation to the Histamine flush from Niacin B3 vitamin, how would you classify histamine intolerance ??
Prolonged high Histamine levels is causing depression , in my opinion ; More of a question than the statement it is ??
Maybe by using Niacin causing small histamine flush can increase the tolerance for food related histamine release ??
Which receptors for Histamine are involved , H1 , H2 , H3 , H4 at the time of Niacin flush ??
DAO involvement etc. Please get it addressed in following presentations.
I think, both H1 and H2
Need drugs effect GIT and endocrine system lectures 😢
Nice explanation and easy understanding 🤗
Can you answer how does the stimulation of H1 receptors (which are Gq coupled) lead to vasodilation ( since any smooth muscle contracts when it is stimulated via a Gq coupled receptor)?
H1 receptors are typically coupled to Gq proteins and can mediate smooth muscle contraction, the overall effect of H1 receptor activation on vascular tone involves a complex interplay of various signaling pathways, including the release of vasodilatory factors like nitric oxide and prostacyclin, modulation of calcium signaling, and indirect effects on other vasoactive substances.
Sir you left some points like enzyme between histamin and histidin
Histidine decarboxylase
L-histidine decarboxylase in presence of pyridine phosphate
Thankyou well explained
Great sir g
Sir I want anti histamine drug explaination... Sir 🙏
Is itching response due to histamine action , kindly clarify?
yes! because there is H1 receptors for histamine on skin.. so when histamine is released and bind to this receptor it stimulate sensory nerve endings and cause itching and pain.
Thank you sir it is really helpfull
Doctor, What is the reason NO is released by Histamine action and subsequent fall in BP? What is the reason for this design?
Sir, upload all topics of pharmacology.
Thank you
Sir can u mention D link of next video in ur description . It ll b easy for many.. TQ
sir making more video on. pharmacology
Sir, Is histidine also stored in mast cell
And from where NO released
Stored in mast cells and released when req
maybe NO is released from endothelial cells
Sir one question
Why histamine has two basic center?
thank u so much sir..
According to you histamine dialate smooth muscle,,what's about bronchial contraction in asthama caused by histamine,,
Please when I get pdf of this lecture
Sir pls share the link anti cancer drug topic
Sir there is some selective videos of pharma by U why?
You can avail full subscription on Www.medvizz.com
Thanks dear sir
Very helpful sir, thank you👍
Most welcome
Good sir
Triptan mnemonic...... is SUMA & ZOLI FEAR
flare due to axon reflex .. is not clear ... please clear it to me sir
Sir there is no anti histamine videos?
Histamine is good Or bad human body?
Why antagonists are more when compare to agonist drug which is bad for body
Veeru Veeruyadav depends
Synthesis of histamine
Sir, you say that Histamine receptors are found on "small blood vessels" and their activation causes vasodilation. But surely vasodilation can only be caused by contraction of their smooth muscle, and this cannot occur in capillaries (which don't have smooth muscle)?
Vasodilation is by relaxation of smooth muscle
capillaries have h1 receptors .release of NO causes relaxation
dilatation nahi dilation hota ha
Good
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Ｗｅｌｌ ｄｏｎｅ
Tysm
Sir please speak in hindi
Covid 19 thinking of
😊😊👌
Sir hindi english
Tari english k hal b moye moye ki terha h😅
💖
Good
Nice