Do inverse agonists cause the opposite biological cell function to be activated compared to antagonists? Or do they rather cause a more pronounced neutralization of the receptor?
basically.. an antagonist blocks the function of a receptor so no effect is exerted whereas an inverse agonist does exert an effect but the opposite effect of an agonist. So antihistamine H1 1st generation eg. Diphenhydramine inverse agonist binds to the H1 receptor but it doesn't inhibit the receptor's effect. It actually causes the opposite effect for example instead of normal effect of wakefulness in brain H1 receptor it causes sedation effect. Hope it makes sense :) As I was just revising this. Partial agonist is when it it produces agonist effect but only partially, not fully.
As far as I know MDMA is a powerful serotonin releasing agent. (It's related to Methamphetamine, however, with MDMA being the abbreviation for methylenedioxy-methamphetamine.)
Mam what about , 5HT 4 agonist like -cisapride (not used now a days), mosapride,renzapride and tegaserod ( not used now a days because of MI and stroke)
Very informative presentation , but I'm surprised that you didn't mention anxiety , addiction and depression .Or maybe I missed the focus or purpose of the lecture .
Here is a drug with the drug mechanism that works so that it accelerates the transporter that returns serotonin back from the pre-synaptic space, what is right? A. The drug acts as an indirect antagonist B. The drug acts as a direct agonist c. The drug acts as an indirect agonist D. The drug acts as a partial agonist Plz help ?
indirect antagonist. Because it's "antagonizing" serotonin by removing it from the synapse back to the axon terminal. But it does this "indirectly" because it's not actually binding to or blocking the serotonin receptors.
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No doubt great work ♥️👍
great work. it is very helpful 👌
well done.. its a good lecture
Lubz...on lecture and handwritings ...keeps going❤️😍😍
Bwautiful video. Thanks a lot ✨
Good one.keep it up.
4 years ago but this still works! Thank you so much!!!
Glad it helped!
Thank you so much Dear Mam!
Thanks...
Very helpful
Your videos are so wholesome ma'am. Thank you so so so much🌻💕
She's awesome🎉
nice video mam it is very help fully🙂
MY GOD GUIDE YOU AND BLESS YOU
Thanku for such an video 🙏🏼
From which books u had written all these notes..plz reply
Thank You
Thank you ❤️
Great work
Also make some videos for 2nd year
Really good 😍😍😍
MAM Triptans group are contraindicated in ICH or Ischemic Heart Disease. In this video you told Ischemic Heart disease but you wrote ICH.
Wow!..❤❤
Thaaanks alot 💜💜💜💜💜💜
Do inverse agonists cause the opposite biological cell function to be activated compared to antagonists? Or do they rather cause a more pronounced neutralization of the receptor?
basically.. an antagonist blocks the function of a receptor so no effect is exerted whereas an inverse agonist does exert an effect but the opposite effect of an agonist. So antihistamine H1 1st generation eg. Diphenhydramine inverse agonist binds to the H1 receptor but it doesn't inhibit the receptor's effect. It actually causes the opposite effect for example instead of normal effect of wakefulness in brain H1 receptor it causes sedation effect. Hope it makes sense :) As I was just revising this. Partial agonist is when it it produces agonist effect but only partially, not fully.
Apne 5HT ka agonist or antagonist ka same role kasey bataya .?
Alag hoga role to.
Thanks a lot
Bhut khoob kya bat h Maja a gya.
Best pharma videos i found .. thank u
Really? You might want to search TH-cam again.
You don't know who speed is
@@reubenjandroh7452but I like her videos more than speed
Can you use little bit larger sheet some words are not visible?!! thanks 🧬🧬
Thank you so much it was very helpful 👍👌👏
nice
Good
How both agonist and antagonist is used as drug for migraine?
Only agonist used in migrane, ergotamine is also partial agonist
Any serotonin releasing agents though? Only one I can really find is Methamphetamine. Releasing agents need to be made.
As far as I know MDMA is a powerful serotonin releasing agent. (It's related to Methamphetamine, however, with MDMA being the abbreviation for methylenedioxy-methamphetamine.)
So 5ht2a has no agonist drugs?
Mam what about , 5HT 4 agonist like -cisapride (not used now a days), mosapride,renzapride and tegaserod ( not used now a days because of MI and stroke)
Agonist; Use: Management of Irritable Bowel Syndrome with constipation.
I got this from my pharmacy notes. :)
Please correct me if i am wrong.
@@jenniemharserrana2855 can u tell me which agonist r u saying , like i want to know drug name
Please, can you explain why antagonist and agonist receptors have the same result with is serotonin re uptake? Thank you very much
they dont have same effects
agonist enhances uptake while antagonist blocks. However it depends on the receptor
Very informative presentation , but I'm surprised that you didn't mention anxiety , addiction and depression .Or maybe I missed the focus or purpose of the lecture .
She talked about buspirone that acts on 5HTA receptors as an anxiolytic
@@miknelltech221 Yes , she did indeed . I missed it the first time . Thanks for the correction .
SAMJAYE BOHT AXHA HAI LKN Words k size thora bara rakhan tk banda ss ly kr chat k khyen aty jty phar sky ya jaldi sy revise kr sky . 😜😜👍👍
5ht4 is not metoclopramide it's cisapride and mosapride etc
Metoclopramide is dopamine antagonist
I thought 5HT 1 came in 1a and 1b?
DISTRIBUTION
5HT1a: Raphe nuclei, hippocampus
5HT1b: Substantia nigra, globus pallidus and basal ganglia
ref: Basic clinical pharmacology 13th edition page 280
Here is a drug with the drug mechanism that works so that it accelerates the transporter that returns serotonin back from the pre-synaptic space, what is right?
A. The drug acts as an indirect antagonist
B. The drug acts as a direct agonist
c. The drug acts as an indirect agonist
D. The drug acts as a partial agonist
Plz help ?
indirect antagonist.
Because it's "antagonizing" serotonin by removing it from the synapse back to the axon terminal.
But it does this "indirectly" because it's not actually binding to or blocking the serotonin receptors.
Are you from India
No I’m from Pakistan.
@@MedMadeSiriuslyeasy tell me about tegaserod
@@MedMadeSiriuslyeasy due to difiecency of tegaserod cause ibs????
Why is there a hippie in the thumbnail when she doesn't even discuss psychedelics with regards to the 5HT2A-receptor? ;)
AUTACOIDS not AUT(O)COIDS
Hint aksanı ingilizce dinleyemiyorum çok gıcık ediyor