Synthetic Biology: Realizing synthetic carbon dioxide fixation - Tobias Erb
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- เผยแพร่เมื่อ 28 พ.ค. 2024
- www.ibiology.org/bioengineeri...
Tobias Erb outlines the principles of building synthetic metabolism using, as an example, work in his lab to engineer bacteria to undergo synthetic carbon dioxide fixation.
Talk Overview:
The conversion of atmospheric carbon dioxide (CO2) to biomass via photosynthesis is the foundation for all of our food and energy. Tobias Erb explains how his lab is working to design, build and optimize pathways for synthetic CO2 fixation. By combining enzymes from multiple organisms with “re-engineered” enzymes and optimizing the processes, Erb and his lab generated a synthetic cycle that fixes CO2 more energy efficiently than photosynthesis. In the future, they plan to test the system in artificial cells and to transplant it into bacteria and chloroplasts. The video exemplifies the general rules and principles of building synthetic metabolism.
Speaker Biography:
Tobias Erb studied biology and chemistry at the University of Freiburg and Ohio State University. He was a postdoctoral fellow at the University of Illinois before starting his own group at the Swiss Federal Institute of Technology (ETH) in Zurich, Switzerland. In 2014, Erb moved to the Max Planck Institute for Terrestrial Microbiology in Marburg, Germany where he became Director and Head of the Department of Biochemistry and Synthetic Metabolism in 2017. Erb’s lab studies the principles of natural metabolism with the aim of using this knowledge to build, from basics, novel synthetic metabolic processes. Erb is particularly interested in the enzymes and pathways of bacteria that capture and convert carbon dioxide.
In 2015, Erb was named one of 12 up-and-coming-scientists by the American Chemical Society and in 2016 he received the Heinz-Maier-Leibniz prize of the German Research Foundation.
Learn more about Erb’s research here:
www.mpi-marburg.mpg.de/erb - วิทยาศาสตร์และเทคโนโลยี
This has to be the absolute best video I've ever seen in my life. The picture of scientists sitting down, each writing their own little cycles and comparing them to see which one's the best, is exactly what I consider fun. Then, making this a reality by using libraries of discovered enzymes, followed by engineering them to work efficiently. and... you know... help solve a global crisis. One day, after my degrees, I will be a scientist which uses this type of enthusiasm to solve problems using interdisciplinary approaches, engaging in very much relevant research, and look back at this, and probably wonder what drugs I was on.
Also real smooth execution at 17:07, made me cry of laughter
Amazing and very detailed explanation. TH-cam is so great
What an incredible POC, will be following to see what comes of this
Better than plants. (7:55,21:21)
15:15 Building a pathway.
I am a few months from graduating an Engineering education in Biotechnology in Sweden and would really much want to work with this type of projects. Any suggestions on how to precede?
Respect. I learned a lot today.
Fantastic
All of the advantages that you list for biological systems, such as 'self optimizing' are disadvatanges when trying to get biology to actually do any work as they will often reject your modifactatuon if they can find a way to survive without it.
That’s what I was thinking too. Gotta go beyond sounding cool.
While the idea of synthetic CO2 fixation using ECRs is intreguing, it is still going to take energy to grow and incubate these cells. When you compair that to the energy needed to pump a fossil file out of the ground (nearly free), why would industry ever adopt the synthetic CO2 fixation process?
The CETCH cycle is in vitro though. You simply need the enzymes. The physical extraction process is somewhat "free" but that is only one step in a huge distribution chain that also involves its own political (eg. OPEC, state and federal taxes/regulations) and technological hurdles. The advantage that this could provide would be to massively simplify distribution chains because CO2 is available everywhere. It also has the upside of being a net carbon loss to the atmosphere. The tipping point however will be when the price point of energy produced per dollar spent reaches the price point of current methods.
Jordan Gentges To me, this technology seems more likely to be the kind of technology one needs to colinize Mars, but less likely to be competitive with converting CO2 using Thorium Salt reactors on Earth. Either way, I wish you the best of luck.
I don't know how the system work. Actually you are spending more energy in the form of (NADPH/ATP) to just fix CO2. You are still heavily dependent on TCA cycle
Pardon me but I have a question. I do not understand some of the jargon or the patterns of initials. But I would like to know if this could be used to make plants grow more efficiently? Or whether or not it would require additional modification? Thank. 😊
Microphone creates a sound like dripping water. There must be some way to edit this out. Really annoying.
Thumb down for silly writing hand trick.