Cell and Molecular Biology: Protein Insertion into the ER Membrane

Learn how transmembrane proteins import into the endoplasmic reticulum (ER) and embed themselves in the ER bilayer.
Visit www.drawittoknowit.com to find more tutorials, quiz questions and an interactive drawing pad!

[@kayliamiller5489]

Thank you so much! This was EXTREMELY helpful to understanding the topology, especially the multipass membrane-spanning domains.

[@paturulekharamani9710]

The best explanation i ever had on this topic

[@DownSouth954]

Clear and concise. Thank you for you time and effort!

[@mikiahstorm8138]

Thank you! This was difficult to understand in my lecture, as diagrams and explanation weren't as clear as here. I appreciate this :)

[@김밍뭉]

Thank you! I was in difficulty to study this part because my professor had... VERY SAD lecture skill. Now I can help other friends in study group :D

[@ecthescientist]

This was sooo helpful! Thank you very much!

[@zhenzipeng5056]

Thanks very much！Extremely helpful for me to understanding. The drawing is outstanding.

[@virens16]

Oh sir at last find someone who guide me to understanding anatomy thank you very much sir
Sir why not you upload development biology ,and biochemistry video once again thank you very much sir
God bless you 🤗

[@avalonp6469]

I love the drawings!! thank you for a great explanation!

[@ibz2836]

very helpful video thanks

[@flight-at-the-speed-of-light]

Such clear explanation ! Thanks a lot ❤

[@juandiegodistefano335]

That analogy was so accurate

[@foggy551]

Finally a great explanation! :)

[@aidanmcf]

Rarely comment on these types of videos but wow, great explanation. My textbook was quite confusing but this made it really easy to understand.

[@pigeonlove]

That's a really original comment...for someone who takes the effort to say they rarely comment on these types of videos

[@nichapatp1928]

Thank you soooo much! This helps me a lot

[@nelsonayre8651]

Finally makes sense. Thanks!

[@lf8737]

Great visuals. Thank you.

[@gingertea659]

You're a genius that was a helpful method thank you now i get it

[@ayesha7404]

Is it the same process for when the protein is inserted into the plasma membrane?

[@kajalpandey6071]

thank you very much. helped a lot

[@arijitbiswas6478]

Thank you so much.

[@amanpreetkaur1533]

thank you very much!!! it was so well explained

[@zainabkhanzainab296]

Plz clear poly topic integral membrane protein in detail

[@khadija500]

Thank you so much ! This is really well explained !

[@drawittoknowit]

Many thanks for the kind words!

[@monurajput-od5qz]

Zzzzzhuuhh

[@peachlife5118]

GOD BLESS YOU

[@Kevinsu1997]

Really helpful, thanks

[@laur_bk]

For multipass proteins - does the c terminus always end up at the cytosol side?

[@sandalbasotra5765]

This is the best.

[@animelover8801]

is there a difference between type I and type III MPs? The textbook seems to define Type I as single pass cytoplasmic C terminal, Type II as single pass cytoplasmic N terminus, Type III as single chain multipass and Type IV as assembly of multiple chains

[@Ps3COD4Fan]

Amazing!

[@lifewithanime2192]

In step 2, why internal signal sequence did not stop transfer of nascent peptide through translocon ?

[@girikowshik3724]

Thank you Sir

[@keerthireddy01]

❤️❤️

[@ZezimaTruth]

confused :(