Id really like to hear Simon do a dive into the new studies on lean body mass responders. My understanding is that the 2 researchers (sorry can’t remember their names, but Physionic just did an interview with them). It sounds like they think further investigation may revise the lipid hypothesis or add nuance to it.
There are so many variables involved with health (food, exercise, sleep, stress, etc) and trying to determine the best diet for the average person (and there are precious few of them) it is extremely difficult to prove anything. LMHRs are just one example that doesn't seem to fit the consensus. There is so much more to learn about nutrition and we have only just scratched the surface of knowledge.
@@dennisward43It is not reconciled by the prevailing paradigm, because that paradigm is erroneous. Excess oxidation of lipoproteins should be the focus, the primary levers to tip the balance in our favor being 1. Increased antioxidant intake and 2. Decreased industrial seed oils.
@@JasonActualization Increased antioxidant intake is important when what you are consuming is pro-oxidative. However Vitamin C is an example of something that can be both anti-oxidant and pro-oxidant. So foods touted as high in antioxidants may not always be the best. Decreasing industrial plant oils should certainly be high on everyone's agenda.
@@dennisward43 Yes, I would submit that step 1 is addition via subtraction, and subtracting the highly prone to oxidation industrial seed oils that are unbelievably pervasive nowadays, would be my first move. Smoking cessation, if applicable, and avoiding vehicle exhaust fumes would be prudent as well (I use the air recycling mode function in my Civic when I am trailing another vehicle). All that said, adding a potent source of antioxidants such as from pomegranate juice, (my personal choice) wild blueberries, or dark chocolate for example, will be instrumental, as will supplementing vitamin C and E (ascorbic acid is only pro oxidative when injected intravenously to levels not normally feasible, so I would advise just taking 500mg at a time by mouth).
- question for Simon: could you make a video like this but about saturated fat? some people claim that we need to eat saturated fat because it is important for cell structure, including in the brain. 12:12 the observational studies that report a correlation between low cholesterol and increased mortality are explained by reverse causality. 13:20 every cell in ur body produces all the cholesterol it needs. the function of lipoproteins is not to deliver cholesterol to ur cells: they deliver triglycerides to cells for energy: they contain cholesterol in order to be spherical and to flow through the blood. people with very low cholesterol (due to genetics or cholesterol-lowering drugs) are completely fine, also in terms of hormones. infact, most of the cells in our body manufacture Excess cholesterol, which is then taken by lipoproteins to the liver. the brain is independent from the body in terms of cholesterol, due to the blood-brain barrier [bbb].
We have had lots of studies on the link between saturated fat consumption, LDL and CVD but very few on the link between sugar consumption and mental illness. Given both of them have risen sharply over the last 60 years or so why is this? Especiallly ilnesses like autism, ADHD and Alzheimers.
Good question. What else has risen in the last 100 years? Aluminum is directly linked to the conditions you mention. Read Exley's book. Mercury in people's mouths. Both of these are in the stabbies.
It's not native cholesterol, but rather, lipoproteins that have been oxidatively modified that are recognized as foreign and elicit the immune system response necessary for net plaque deposition. LDL and ApoB are not causal, but the higher they are, the more oxidizable substrate there is in circulation. The appropriate response is to 1. Augment ones antioxidant capacity and 2. Eliminate industrial seed oils.
At low levels < 160mg/dl or ldlc, my apoB is almost exactly the same as my ldlc. Plant based no drugs apoB:84, ldlc:80, plant based + drugs apoB:35, ldlc:30, plant based + drugs. - fish apoB:40, ldlc:40. I wonder if I still need to pay extra for apoB assuming no life style changes ? Seems I. Just wasting money. I look at a lot of my friends blood work and they also have apoB that tracks with ldlc. How common is a discordant apib from ldlc ?
Low carb high fat is the only successful way ive been able to maintain a lower body weight but it did send my LDL through the roof i had mild coronary artery disease which forced me to re evaluate and get on statins and i have my APO B down to 65. Can you eat low carb high fat if you control lipids with medication?
Certainly one option! You could also swap the type of fat you’re eating (less saturated fats) and add some unrefined carbs - you’ll see LDL-C come down
@TheProofWithSimonHill I've noticed swapping the fat out doesn't seem to offer the same level of satiety as saturated fat. I will try upping the unrefined carbs before converting back to low carb high fat. It's basically my last resort. Love your work sir. Thank you.
You do have another alternative, A diet of whole plant foods (not refined carbs) has been demonstrated to result in weight loss. So, along the lines of an Ornish/Esselstyn type diet, no meat, no dairy, no eggs, no oil. It's also VASTLY better for heart health, lowering LDL greatly. I did this myself 10 years ago, reversed cvd after a heart attack, still going. Quite easy, actually.
That doesn't sound easy at all. Lol adherence is the number 1 predictor of weight loss when it comes to diet. I've done a diet similar to what you were suggesting and it gave me terrible gastric distress and I got sick constantly after hard workout days. I was also always hungry. Nothing has been easier than just don't eat carbohydrates. So swapping out the fat for healthier fats along with increasing non refined carbohydrates seems to be the most achievable long term solution for myself. To each their own.
@@LAallday941 Well, if you were hungry all the time and feeling sick after hard workouts, it's a pretty clear indication you weren't eating enough volume. One point of eating whole plant foods is that they're less calorie dense than fattier foods, so a greater volume needs to be consumed. Many people find it quite easy, check out the BROAD study, where the whole plant foods group had a very high compliance rate and lost an average of 25 pounds over 6 months. It was made certain that the participants understood the what, how, and why of following the eating pattern, which seems important for compliance. Or, there's the plain old potato diet- Penn Gillette, of Penn and Teller fame, lost 100 pounds in a few months eating nothing but potatoes. Others have done the same. Then transition from that to a workable variety of whole plant foods. Just takes a little gumption, until one gets used to it. :) We do the best we can, and we do what we do ... the point is there are choices.
I'm assuming you mean because your body produces and needs cholesterol then high cholesterol is fine, if not, what is your point? I can say your body needs blood pressure or you're going to die, that does not mean high blood pressure is good
So, in theory, according to your current knowledge about where cholesterol acts in the body, if medication didn't have any side effects, it would be okay to use them to lower blood cholesterol to 0 ? Like what I understood is that cholesterol is only acting inside cells and there's no benefits to it being in the blood?
The genetic studies show that if you have ldl below 50 or something you dont have atherosclerosis at all. But your ldl can never be 0 cuz your own body produces it. Also, not having plaque building up in your artheries does not mean you cant have a heart attack or other type of cardiologic problems.
Broda Barnes always claimed that elevated cholesterol was due to low thyroid, ie, hypothyroidism, since cholesterol is very necessarily converted to androgens in the presence of active thyroid hormone, see Ray Peat’s work
People spreading misinformation often do so around a kernel of truth. The kernel here is that yes, some people with hypothyroidism do have elevated LDL caused by the thyroid disregulation. However, most people with high LDL have a thyroid that's fine. Also, for most people with hypothyroidism, their LDL levels are not changed by their hypothyroidism.
Wow, Ray Peat and Broda Barnes are misinformed, probably cannot find anyone more informed than they on topics of nutrition and physiology, note that TSH is not a sufficient marker to determine thyroid function, if someone has elevated cholesterol and their TSH is in "normal range", poor thyroid function can certainly still be the cause of their elevated cholesterol, need to also evaluate pulse and temperature, T4 and T3 levels @@k.h.6991
In his book Simon looks at hundreds of studies and eliminates many for their imperfections. He boils it down to the Lyon Diet Heart and PREDIMED study. He is right that even the flawed studies point in the same direction. 'Flawed' meaning confounded with other interventions like exercise or poorly controlled. In simple language: 'Mediterranean' with low saturated fat and primarily plant based. I will just add my own observation that overall oil intake should be minimum since it may trigger rheumatoid arthritis in some people (depending on how the original toxic insult occurred to the gut e.g antibiotics used to control skin disease in adolescents). Simon might not agree but check with Clint Paddison on TH-cam.
Id really like to hear Simon do a dive into the new studies on lean body mass responders. My understanding is that the 2 researchers (sorry can’t remember their names, but Physionic just did an interview with them). It sounds like they think further investigation may revise the lipid hypothesis or add nuance to it.
There are so many variables involved with health (food, exercise, sleep, stress, etc) and trying to determine the best diet for the average person (and there are precious few of them) it is extremely difficult to prove anything. LMHRs are just one example that doesn't seem to fit the consensus. There is so much more to learn about nutrition and we have only just scratched the surface of knowledge.
@@dennisward43It is not reconciled by the prevailing paradigm, because that paradigm is erroneous. Excess oxidation of lipoproteins should be the focus, the primary levers to tip the balance in our favor being 1. Increased antioxidant intake and 2. Decreased industrial seed oils.
@@JasonActualization Increased antioxidant intake is important when what you are consuming is pro-oxidative. However Vitamin C is an example of something that can be both anti-oxidant and pro-oxidant. So foods touted as high in antioxidants may not always be the best. Decreasing industrial plant oils should certainly be high on everyone's agenda.
@@dennisward43 Yes, I would submit that step 1 is addition via subtraction, and subtracting the highly prone to oxidation industrial seed oils that are unbelievably pervasive nowadays, would be my first move. Smoking cessation, if applicable, and avoiding vehicle exhaust fumes would be prudent as well (I use the air recycling mode function in my Civic when I am trailing another vehicle). All that said, adding a potent source of antioxidants such as from pomegranate juice, (my personal choice) wild blueberries, or dark chocolate for example, will be instrumental, as will supplementing vitamin C and E (ascorbic acid is only pro oxidative when injected intravenously to levels not normally feasible, so I would advise just taking 500mg at a time by mouth).
- question for Simon: could you make a video like this but about saturated fat? some people claim that we need to eat saturated fat because it is important for cell structure, including in the brain.
12:12 the observational studies that report a correlation between low cholesterol and increased mortality are explained by reverse causality.
13:20 every cell in ur body produces all the cholesterol it needs. the function of lipoproteins is not to deliver cholesterol to ur cells: they deliver triglycerides to cells for energy: they contain cholesterol in order to be spherical and to flow through the blood. people with very low cholesterol (due to genetics or cholesterol-lowering drugs) are completely fine, also in terms of hormones. infact, most of the cells in our body manufacture Excess cholesterol, which is then taken by lipoproteins to the liver. the brain is independent from the body in terms of cholesterol, due to the blood-brain barrier [bbb].
Hey Simon, do you put any importance on
apo e 3/4 or mthfr?
Yes Apoe4 for sure when it comes to cognition. Upcoming eps on this
We have had lots of studies on the link between saturated fat consumption, LDL and CVD but very few on the link between sugar consumption and mental illness. Given both of them have risen sharply over the last 60 years or so why is this? Especiallly ilnesses like autism, ADHD and Alzheimers.
Good question. What else has risen in the last 100 years? Aluminum is directly linked to the conditions you mention. Read Exley's book. Mercury in people's mouths. Both of these are in the stabbies.
damn, learnt a lot from this! thanks Simon
Cholesterol deniers are the flat earthers of the nutri world.
It's not native cholesterol, but rather, lipoproteins that have been oxidatively modified that are recognized as foreign and elicit the immune system response necessary for net plaque deposition. LDL and ApoB are not causal, but the higher they are, the more oxidizable substrate there is in circulation. The appropriate response is to 1. Augment ones antioxidant capacity and 2. Eliminate industrial seed oils.
At low levels < 160mg/dl or ldlc, my apoB is almost exactly the same as my ldlc. Plant based no drugs apoB:84, ldlc:80, plant based + drugs apoB:35, ldlc:30, plant based + drugs. - fish apoB:40, ldlc:40. I wonder if I still need to pay extra for apoB assuming no life style changes ? Seems I. Just wasting money. I look at a lot of my friends blood work and they also have apoB that tracks with ldlc. How common is a discordant apib from ldlc ?
Low carb high fat is the only successful way ive been able to maintain a lower body weight but it did send my LDL through the roof i had mild coronary artery disease which forced me to re evaluate and get on statins and i have my APO B down to 65. Can you eat low carb high fat if you control lipids with medication?
Certainly one option! You could also swap the type of fat you’re eating (less saturated fats) and add some unrefined carbs - you’ll see LDL-C come down
@TheProofWithSimonHill I've noticed swapping the fat out doesn't seem to offer the same level of satiety as saturated fat. I will try upping the unrefined carbs before converting back to low carb high fat. It's basically my last resort. Love your work sir. Thank you.
You do have another alternative, A diet of whole plant foods (not refined carbs) has been demonstrated to result in weight loss. So, along the lines of an Ornish/Esselstyn type diet, no meat, no dairy, no eggs, no oil. It's also VASTLY better for heart health, lowering LDL greatly. I did this myself 10 years ago, reversed cvd after a heart attack, still going. Quite easy, actually.
That doesn't sound easy at all. Lol adherence is the number 1 predictor of weight loss when it comes to diet. I've done a diet similar to what you were suggesting and it gave me terrible gastric distress and I got sick constantly after hard workout days. I was also always hungry. Nothing has been easier than just don't eat carbohydrates. So swapping out the fat for healthier fats along with increasing non refined carbohydrates seems to be the most achievable long term solution for myself. To each their own.
@@LAallday941 Well, if you were hungry all the time and feeling sick after hard workouts, it's a pretty clear indication you weren't eating enough volume. One point of eating whole plant foods is that they're less calorie dense than fattier foods, so a greater volume needs to be consumed. Many people find it quite easy, check out the BROAD study, where the whole plant foods group had a very high compliance rate and lost an average of 25 pounds over 6 months. It was made certain that the participants understood the what, how, and why of following the eating pattern, which seems important for compliance.
Or, there's the plain old potato diet- Penn Gillette, of Penn and Teller fame, lost 100 pounds in a few months eating nothing but potatoes. Others have done the same. Then transition from that to a workable variety of whole plant foods. Just takes a little gumption, until one gets used to it. :)
We do the best we can, and we do what we do ... the point is there are choices.
If I had a dollar for every time I had to tell someone that every cell including the brain produces its own cholesterol I'd be very well off
Wow, that’s really STUPID but, as we know, vegans are STUPID, our brain needs meat to produce neurons. Sorry, you should talk to not longer vegans.
I'm assuming you mean because your body produces and needs cholesterol then high cholesterol is fine, if not, what is your point?
I can say your body needs blood pressure or you're going to die, that does not mean high blood pressure is good
@@MrGarystanislawski That was just stupid. Watch this video maybe.
So, in theory, according to your current knowledge about where cholesterol acts in the body, if medication didn't have any side effects, it would be okay to use them to lower blood cholesterol to 0 ?
Like what I understood is that cholesterol is only acting inside cells and there's no benefits to it being in the blood?
The genetic studies show that if you have ldl below 50 or something you dont have atherosclerosis at all. But your ldl can never be 0 cuz your own body produces it.
Also, not having plaque building up in your artheries does not mean you cant have a heart attack or other type of cardiologic problems.
There are few case studies, one comes to mind where a guy had an LDL of 4mg/dL and he had no adverse effects, normal markers for everything.
Broda Barnes always claimed that elevated cholesterol was due to low thyroid, ie, hypothyroidism, since cholesterol is very necessarily converted to androgens in the presence of active thyroid hormone, see Ray Peat’s work
People spreading misinformation often do so around a kernel of truth. The kernel here is that yes, some people with hypothyroidism do have elevated LDL caused by the thyroid disregulation. However, most people with high LDL have a thyroid that's fine. Also, for most people with hypothyroidism, their LDL levels are not changed by their hypothyroidism.
Wow, Ray Peat and Broda Barnes are misinformed, probably cannot find anyone more informed than they on topics of nutrition and physiology, note that TSH is not a sufficient marker to determine thyroid function, if someone has elevated cholesterol and their TSH is in "normal range", poor thyroid function can certainly still be the cause of their elevated cholesterol, need to also evaluate pulse and temperature, T4 and T3 levels @@k.h.6991
@4:00 so a newborn with genetics pre-disposing to high LDL will have the same LDL level at birth as someone without the genetics?
Nope. The baby with the genetic predisposition to high LDL, will have a higher LDL than a baby that doesn't have that predisposition.
Excellent, thanks for cutting through the BS all over over the internet.
PS - cholesterol is a protectant - a symptom - not to be covered up with statins.
I tuned out as soon as he said "the entire body of literature".
Yeah, he should have said the overwhelming abundance xD truth hurts huh, look at the average life span of meat eater influencers over the decades
Legit literature, not poorly designed studies, bloggers, and social media influencers
You are already tuned out of your mind buddy, nothing he says will change that. Stick to 300ldl.
@@ladagspa2008 🤣
In his book Simon looks at hundreds of studies and eliminates many for their imperfections. He boils it down to the Lyon Diet Heart and PREDIMED study. He is right that even the flawed studies point in the same direction. 'Flawed' meaning confounded with other interventions like exercise or poorly controlled. In simple language: 'Mediterranean' with low saturated fat and primarily plant based. I will just add my own observation that overall oil intake should be minimum since it may trigger rheumatoid arthritis in some people (depending on how the original toxic insult occurred to the gut e.g antibiotics used to control skin disease in adolescents). Simon might not agree but check with Clint Paddison on TH-cam.
really getting the hotties on the podcast lately