The first half of this course, taught by Prof. Yaffe, is available on the MITx platform as 7.05x Biochemistry: Biomolecules, Methods, and Mechanisms. The videos below are from the second half of the course with Prof. Vander Heiden, which focuses on metabolism. The exception is Lecture 12, which is in the first half of the course and was taught by Prof. Vander Heiden. See ocw.mit.edu/7-05S20 for more information.
(On Sunday of March 12, 2023). On the Matter of PhD Heiden and MIT OpenCourseWare on the Subject Matter of Lipids and Fatty Acid Oxidation (Metabolism and Biochemistry): 1) Fatty Acids are Storage of the Potential of Carbon (Carbon Oxidation Potential And/or Voltage Capacity Therein); 2) Triglycerides and Lipids are even more Polymers of Fatty Acid Molecules and/or Nature's Storage Molecular Mechanism. Therefore, Biomolecules of Energy Potential Storage; 3) Carnitine Shuttle the most Reduced For of Carbon is Fatty Acid; 4) Fatty Acid Oxidation generates Acetyl-CoA to Fuel Tricarboxylation of the Tricarboxylic Acid Cycle (TCA Cycle); 5) Accounting Glucose and Fatty Acids making the Total Ergonomics of these Carbon Molecular Mechanism of Oxidation of Carbon into Electron Carriers yields a greater Potential Storage and/or Yield by Fatty Acids than Glucose Monosaccharide; 6) Standard Reduction Potentials is ultimately the Favorable Chemical Circumstance of Electron Transfer depending on Concentration Ratio of Reactants and Products in the System (In Biochemistry this is Carbon Oxidation via Enzymatic Action on to a Synthate-Product, ATP, ADP or NAD+ to NADH or the Reverse is the System Input/Outputs); It is a wonderful World when one delves into the intricacies of Bioenergetics and even Grander when one contemplates Proteomics therein; and utmost when Nucleic Acid And/or Genetic Expression therein (One Example the Daithesis of Pyruvate Dehydrogenase Deficiency [X-Linked Dominant Disease of Rare Incidence but Grave Consequences]). PhD Matthew Vander Heiden, das Natur fast nur Perfekt ist, aber wir auch haben die Tod order Krankheit oder Entropy welche Energie niemals kann Immer sein Aktive (Bose-Enstein Condensate und Teilchenphysiks zeigen Dass. Heil!
@26:44 - Prof. Vander Heiden's explanation of trans fats is just wrong. Quote: "Trans fats are basically taking animal fat and introducing chemically double bonds into them such that you have this solid that is now a liquid at room temperature ... and this leads to these unnatural trans fatty acids, which lead to health issues and are now banned." Trans fats were never a result of converting solid animal fats to liquid (why would you want to?), but rather of food companies converting liquid vegetable oils to solid (e.g. Crisco, margerine) to make them more like animal fats (i.e. more stable, longer shelf life). The motivation was money - vegetable oils were cheap industrial by-products that could be repurposed for human food. This became even more widespread later on as people were (wrongly) convinced these products were healthier than naturally saturated animal fats.
Lot of mis information unfortunately because of industry lobby and because eating animals is discouraged. You get junk science to show that eating vegetables is somehow a good thing
Not stearate, it is stearic acid, Not palmitate, it is palmitic acid .... I feel the professor has a poor background in organic chemistry ....In fact, I checked his CV, He is a biologist ... :(
No wonder why the world is so damned... It seems to be full of biologically cloned interbreeds that have been specifically nested to hit the messenger, rather than understanding the message.
Stearate is the salt form of stearic acid and in our body acidic or basic environment is not preferred that's why the body prefers the acids in the salt form like stearic acid reacted with sodium can form sodium stearate and generally in biology we call it as stearate
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The first half of this course, taught by Prof. Yaffe, is available on the MITx platform as 7.05x Biochemistry: Biomolecules, Methods, and Mechanisms. The videos below are from the second half of the course with Prof. Vander Heiden, which focuses on metabolism. The exception is Lecture 12, which is in the first half of the course and was taught by Prof. Vander Heiden. See ocw.mit.edu/7-05S20 for more information.
(On Sunday of March 12, 2023). On the Matter of PhD Heiden and MIT OpenCourseWare on the Subject Matter of Lipids and Fatty Acid Oxidation (Metabolism and Biochemistry): 1) Fatty Acids are Storage of the Potential of Carbon (Carbon Oxidation Potential And/or Voltage Capacity Therein); 2) Triglycerides and Lipids are even more Polymers of Fatty Acid Molecules and/or Nature's Storage Molecular Mechanism. Therefore, Biomolecules of Energy Potential Storage; 3) Carnitine Shuttle the most Reduced For of Carbon is Fatty Acid; 4) Fatty Acid Oxidation generates Acetyl-CoA to Fuel Tricarboxylation of the Tricarboxylic Acid Cycle (TCA Cycle); 5) Accounting Glucose and Fatty Acids making the Total Ergonomics of these Carbon Molecular Mechanism of Oxidation of Carbon into Electron Carriers yields a greater Potential Storage and/or Yield by Fatty Acids than Glucose Monosaccharide; 6) Standard Reduction Potentials is ultimately the Favorable Chemical Circumstance of Electron Transfer depending on Concentration Ratio of Reactants and Products in the System (In Biochemistry this is Carbon Oxidation via Enzymatic Action on to a Synthate-Product, ATP, ADP or NAD+ to NADH or the Reverse is the System Input/Outputs); It is a wonderful World when one delves into the intricacies of Bioenergetics and even Grander when one contemplates Proteomics therein; and utmost when Nucleic Acid And/or Genetic Expression therein (One Example the Daithesis of Pyruvate Dehydrogenase Deficiency [X-Linked Dominant Disease of Rare Incidence but Grave Consequences]). PhD Matthew Vander Heiden, das Natur fast nur Perfekt ist, aber wir auch haben die Tod order Krankheit oder Entropy welche Energie niemals kann Immer sein Aktive (Bose-Enstein Condensate und Teilchenphysiks zeigen Dass. Heil!
Brilliant lecture, loved the overall perspective given and the elements of thermochemistry
@26:44 - Prof. Vander Heiden's explanation of trans fats is just wrong.
Quote: "Trans fats are basically taking animal fat and introducing chemically double bonds into them such that you have this solid that is now a liquid at room temperature ... and this leads to these unnatural trans fatty acids, which lead to health issues and are now banned."
Trans fats were never a result of converting solid animal fats to liquid (why would you want to?), but rather of food companies converting liquid vegetable oils to solid (e.g. Crisco, margerine) to make them more like animal fats (i.e. more stable, longer shelf life). The motivation was money - vegetable oils were cheap industrial by-products that could be repurposed for human food. This became even more widespread later on as people were (wrongly) convinced these products were healthier than naturally saturated animal fats.
how can liquid oils be converted to solid by unsaturation, that's not possible
Lot of mis information unfortunately because of industry lobby and because eating animals is discouraged.
You get junk science to show that eating vegetables is somehow a good thing
Very helpful lecture, thank u so much.
Not stearate, it is stearic acid, Not palmitate, it is palmitic acid .... I feel the professor has a poor background in organic chemistry ....In fact, I checked his CV, He is a biologist ... :(
No wonder why the world is so damned...
It seems to be full of biologically cloned interbreeds that have been specifically nested to hit the messenger, rather than understanding the message.
He makes mistakes sometimes but he literally addresses this at 6 minutes.
Stearate is the salt form of stearic acid and in our body acidic or basic environment is not preferred that's why the body prefers the acids in the salt form like stearic acid reacted with sodium can form sodium stearate and generally in biology we call it as stearate
He calls Olive oil a plant oil, i mean this is a big mistake honestly when discussing fats
At Ph 7 the COOH is deprotonated (look at the Pka) so his use of the ionic form palmitate is a more correct form, from a biochemical point of view