💭 Do you think the concept of “microdosing” medications like Ozempic is helpful, or is it mostly a marketing tactic? - 🚨 Your opinion matters! Help us make a difference! We’re expanding our services to better support YOU on your health journey, and we need your input! We’re developing a number of new resources, and creating more impactful TH-cam content-all focused on practical support for weight management and wellness. ✨ Want to help shape these resources? ✨ Please take just a few minutes to fill out our quick survey! Thank you for making a difference! 🙌 🔗forms.gle/drfN5oE7Wewvxz7Z6 If you need assistance in your journey to reach your weight loss goals, book a consultation with me: calendly.com/drdanburton/weight-loss-consult Thanks for watching!
I'll be honest. I microdose Compound Tirzepatide. And I'm still losing the weight. I was losing weight too fast as prescribed, and started finding the right dose for me. i even seen a Hospital Surgery Doctor on TH-cam recommending it because he was on it and it worked from him. Like he said, no clinical studies on this. I agree with your video. Ppl need to find the right dose for them
I think microdosing and low dosing are 2 different things..Micro dosing for most legit providers is for people who want to use the meds for other purposes other than weight loss
Qeustion can i take saxenda on a lower dosse like 0.25 or less? Do i need to start at 0.60? Why is this higher start then ozimpic? Thank you Also with ones is best to buy saxenda or ozempic. I need to loss like 30kg
Interesting discussion. If (say) Mounjaro at 5.0 mg/week is divided into 1.0 mg/day, would the latter dosing regime have the same effect as the weekly dosing? From what I've heard, it's supposed to smooth out the effect so that there are less ups and downs during the week. Not sure if this is true, but I think maybe guys are applying what's true of testosterone to the GLP1s.
If you want to do a daily dose then take Saxenda, which is a daily injection, rather than Mounjaro which is a weekly medication. As Dr Dan said, there are other medications out there that can fit the bill for different medication uses but to not follow the recommendations of the manufacturers, who designed the drugs to be used in a certain way is, IMO, a silly thing to do. Specifically, if you dosed MJ at one mg daily, each 1 mg shot would still break down in your body (half life is 5-7 days for Ozempic and Mounjaro) so the first day you would have 1 mg on board, the second day most of that first dose would still be on board and you would be adding another so would have maybe 1.9 on board and every day you would be adding in a little bit more and a little bit would be breaking down.But each molecule of the MJ takes that 5-7 days to break down to half effectiveness so your levels would go up over the weeks. If you were exquisitely sensitive to the medication this might work to help you to build up tolerance but it also might delay your body getting used to the medication, and so cause more side effects for longer. With Saxenda, which is a daily med that breaks down over a day you would be on a safer bet. You would get the correct appetite suppression and it the half life is 12 hours so it would be gone by the time you took your next shot. It is horses for courses here.
@@gablovesplantssydney The starting dose of Mounjaro is actually 2.5 mg/wk. It is not at a sufficient concentration to get into the therapeutic range. It's just an introductory dose, to get patients used to the drug. Because, of that would a 1 mg/day even get into the therapeutic range? As you note, each dose is at a certain level of concentration and loses half its effectiveness over the half life. Mounjaro 5.0 mg/wk divided into 1 mg microdoses per day would be: 1 mg + 1.5 mg + 1.75 mg + 1.88 ,mg + 1.94 mg. That dosing schedule doesn't get it into the therapeutic range. So, that's why I wonder if "microdosing" makes any sense.
no, a daily shot of 1mg leaves you with 7mg per week. You also want your body to NOt always have the same level but to keep its facility to adjust on its own to more or less GLP-1 arriving at receptors.
@@VernCrisler try different sort order, newest first should show all undeleted c9mments.. it probably was not deleted, just considered to be irrelevant. My initial comment is totally gone though. Was a bit contrary though
I know you're not asking me, but what are your options for? Type 2 Diabetes or weight loss? If it's for diabetes, Rybelsus lowers HbA1c by between 0.6 and 1.4 percent. Mounjaro lowers A1c by 1.8% to 2.1% for the 5-mg dose, 1.7% to 2.4% for the 10-mg dose, and 1.7% to 2.4% for the 15-mg dose. For weight loss, Rybelsus shows about a 5 lb. weight loss. Mounjaro, 25-26% of the starting body weight. Rybelsus is a pill, which has its benefits over a weekly shot, but Mounjaro's injections are negligible (to me, as I have lost 260 lbs on Mounjaro and my HbA1c has gone from a 9.0 to a 5.0, all in 2.5 years). Research both and see which one fits for you... keep talking to your doctor, too. Harmful? In the long-term? Immediately? Check the package inserts on both to read what they have found out so far. For me, the possible risks of the medication are FAR less than the damaging real life illnesses I had from obesity... the ones that are completely GONE now. I hope this helps a little. Dr. Dan might surely have more to say!
@HealthAtAnyCost thanks. For sharing your experience and thoughts. Appreciate it a lot. Weight loss is the goal at this moment. The doctor's thoughts over messages were from cost point of view when I initially reached out about Monjauro. As per what I'm finding on TH-cam and Reddit user experiences, Rybelsus works but definitely not as effective as Monjauro. Some are definitely taking Rybelsus improperly like not in empty stomach or not waiting at least 30 mins to eat after taking it and so on. I have my appointment day after tomorrow so let's see how it goes. Thanks again for sharing your thoughts.
The is just one persons opinion and everyone’s body chemistry is different but I personally like the weekly injection part of MJ because you cannot “skip” a day or two and go out to dinner and have a blowout. You would need to skip a whole week in order to do that. I was taking Saxenda, which is a daily injection and is effective (and it is now off patent so generic versions can be made which should bring the price way down) but I prefer the weekly Ozempic and Mounjaro. They are also working on a monthly shot so stay tuned in the next few years for that day if it comes off. I already take enough pills daily for my chronic migraines and reflux and HRT so the injection is great for me.
Interesting topic, but I’m not so happy that that you don’t really name or explain the issues or Problems which Can come with the Microdosing. I am Missing as Well the possible Advantages or possible Benefits. Please give a Little More in depths Information.
Agree it could’ve been more in-depth… but the problems part is pretty Captain Obvious. As in, insufficient dosage for any significant therapeutic benefits… whether weight-loss, anti-inflammation, or in being cardioprotective. 🤷🏽 Though I suppose if one is a super-responder, then even a microdose could be sufficient for those effects. Or for maintenance. 🔧 Also, microdoses could be beneficial for ppl starting on the meds who are having bad side effects. Always thought Lilly should’ve offered an optional 1.25mg starter dose. 💉 There are some less-common use cases, sure. But as a general thing for most ppl? Nah, probably not. Does appeal to ppl who want to be on the least-possible amount of meds as a general rule though. Can’t argue with it as a clever bit of marketing/positioning.💡
You’re right, It would be interesting if there are arguments besides these obvious aspects. I am a very good responder as far as I can see, and I would like to know, if there were further insights about using the very small doses over a long time. Considering I will be using this medicine for the rest of my life, perhaps 30 years, and considering that some kind of habituation will happen, I think staying at the lowest dose possible might be the only solution to keep the weight off for the rest of my life… at least until more potent medicines like for example, Retatrutide or others will be available. These are my considerations, but perhaps I’m wrong?
@susanne There honestly doesn’t seem to habituation with GLP-1s. Despite what some ppl say, GLP-1s do not seem to suddenly ‘stop working’. They are not like say opioids or alcohol in that you build up a ‘tolerance’ over time or something. What seems to be happening is, ppl define ‘stopped working’ as they eventually stop losing weight. But, they forget or don’t know that your body ‘fights back’ against weight loss. And the more weight you lose, the HARDER the body fights back (long story short: caveman/cavewoman genes, and your body sees major weight loss as you starving to death, so it attempts to slow, stop, and eventually reverse it). Your body fights back multiple ways: - Increases your hunger hormones - Decreases your satiety hormones - Slows your metabolism But to the patient, none of that hormone-causation is obvious. They just know that the scale stopped moving, and that they feel hungrier. AKA, “OMG, my GLP-1 STOPPED WORKING!!” 😱 Makes sense? What can you do? Well, if you haven’t got to goal weight yet, it’s generally a case of titrate up and keep doing so as needed until you either hit the top dose or your goal weight (whichever comes first) - plus make sure your nutrition, exercise, stress and sleep are all optimal. But, some ppl don’t like that path, so they hope for another one. And there’s always a demand for well-marketed solutions to distressing or poorly understood problems. Sometimes even if said solutions don’t really work particularly well for the majority of ppl. 🤷🏻♂️
Problem is that there are no studies to give us evidence based research on what microdosing the meds would do. It is all just supposition by the quacks in the space. Dr Dan is all about evidence when he talks to us so if there is no research he cannot say what might be the benefits or he would be as bad as the quacks who promote this stuff.
Most of the Docs pushing Micro dosing are chiropractors which have absolutely nothing to do with internal medicine... this Micro dosing protocol has absolutely nothing to do with loosing a good amount of weight..if you want to consider on trizepitide that they started the trial test at 5mg but prescribe 2.5 mg then you are already starting at a Micro dose level 😆 but as you stated if you can't handle the 2.5 then maybe work your way to that..but this Micro dosing pushed by these chiropractors is kinda funny to me and they making waves off people 😆
Thank the Universe for you, Dr. Dan. I have been hollering into the void about "Functional Medicine 'Doctors.'" Chiropractors are NOT MDs even if they are called "Doctors." People also call "microdosing" anything less than the standard dosages. "I microdose with 7.0 mg. instead of 7.5 mg." Ummm, no, that isn't even remotely the definition of microdosing. Microdosing is the buzz word of the moment and that "Functional Doctor" touting to know how and what to do will rake in her cash and then vanish into the night eventually, leaving people without the health gain and weight loss they were looking for and needing. Keep speaking up, but also put on your asbestos suit because that "doctor's" fans are rabid and are sure to come for your head. I've got your back!
All true. ‘Microdosing’ is REALLY trendy right now, but the benefits seem minimal at best - and confined to super-responders or ppl who have not much weight to lose. And yes, everyone seems to misuse the term too. 🤦🏼♂️ At least split-dosing (another trend/fad) seems to have *some* possible utility. But microdosing? A whole lotta noise over not much. 🤷🏻♂️
To be fair on the person I think you are referring to (Tyna Moore), her micro dosing regimen is for people who are metabolically sound, NOT for weight loss but to treat other inflammatory conditions, in combination with other peptides. I think there is a bit of misunderstanding. She also has repeatedly refused to give a specific amount to dose with. She just says micro dosing is less than the therapeutic dose. Again, her application is NOT for weight loss but for the alleged neuro- and cardio protective and antiinflammatory properties of GLP 1 peptides and encouraged weight lifting to combat muscle loss. She has also told everyone to work with their physicians and does not encourage you doing your own thing at home..please let's be honest before beating down on people.
@@msparkz11 The thing with that is, is a micro-dose really going to be cardio-protective or anti-inflammatory… to any meaningful extent? 🤔 And do we have any good clinical trial data on that either? My guess is, probably not.
@@msparkz11 Thanks for that information. I know it's helpful to many. There are a LOT of other people besides Tyna Moore talking about microdosing. I'm glad you clarified what you know about her style and method of taking care of people's health issues. Thank you!
Absolutely agree. A functional doctor is just the new term for a naturopath (ie, not a real doctor). Stick your medical team of experts like Dr Dan who work in the obesity management space and are backed up by evidence based scientific research.
Useless video that does nothing but appeal to authority. You have not presented a single scientific argument against the practice of microdosing which has shown many benefits in many different drugs for decades.
💭 Do you think the concept of “microdosing” medications like Ozempic is helpful, or is it mostly a marketing tactic?
-
🚨 Your opinion matters! Help us make a difference!
We’re expanding our services to better support YOU on your health journey, and we need your input! We’re developing a number of new resources, and creating more impactful TH-cam content-all focused on practical support for weight management and wellness.
✨ Want to help shape these resources? ✨ Please take just a few minutes to fill out our quick survey! Thank you for making a difference! 🙌
🔗forms.gle/drfN5oE7Wewvxz7Z6
If you need assistance in your journey to reach your weight loss goals, book a consultation with me: calendly.com/drdanburton/weight-loss-consult
Thanks for watching!
some people are sensitive to the smallest dose so yes it would make sense to microdose
I'll be honest. I microdose Compound Tirzepatide. And I'm still losing the weight. I was losing weight too fast as prescribed, and started finding the right dose for me. i even seen a Hospital Surgery Doctor on TH-cam recommending it because he was on it and it worked from him. Like he said, no clinical studies on this. I agree with your video. Ppl need to find the right dose for them
people need to eat good and get up and move no quick fix
Agreed - if this works better for you, perfect!
If only it were that easy, everyone would be slim.@@sammyocgirl7411
What dose did you start with in Tirzeptide? I am going to chat with my doc in a few weeks.
I think microdosing and low dosing are 2 different things..Micro dosing for most legit providers is for people who want to use the meds for other purposes other than weight loss
Key is "legit providers" - I agree!
What are the other options other than weight loss?
Try Drunk Doctor Dan at half speed 😂
LOL! 😆
Yeah, it is *really* funny like that.
Half speed is 💯 accurate lol
I lost tons of weight on 1.5 mg tirzepatide. The dose that works for each person is the dose you need.
Another useful video. Thank you
Thank you for watching!
will ozempic side effects be mitigated if you eat supplements or foods rich in probiotics/prebiotics?
Qeustion can i take saxenda on a lower dosse like 0.25 or less?
Do i need to start at 0.60? Why is this higher start then ozimpic? Thank you
Also with ones is best to buy saxenda or ozempic. I need to loss like 30kg
Interesting discussion. If (say) Mounjaro at 5.0 mg/week is divided into 1.0 mg/day, would the latter dosing regime have the same effect as the weekly dosing? From what I've heard, it's supposed to smooth out the effect so that there are less ups and downs during the week. Not sure if this is true, but I think maybe guys are applying what's true of testosterone to the GLP1s.
If you want to do a daily dose then take Saxenda, which is a daily injection, rather than Mounjaro which is a weekly medication.
As Dr Dan said, there are other medications out there that can fit the bill for different medication uses but to not follow the recommendations of the manufacturers, who designed the drugs to be used in a certain way is, IMO, a silly thing to do.
Specifically, if you dosed MJ at one mg daily, each 1 mg shot would still break down in your body (half life is 5-7 days for Ozempic and Mounjaro) so the first day you would have 1 mg on board, the second day most of that first dose would still be on board and you would be adding another so would have maybe 1.9 on board and every day you would be adding in a little bit more and a little bit would be breaking down.But each molecule of the MJ takes that 5-7 days to break down to half effectiveness so your levels would go up over the weeks.
If you were exquisitely sensitive to the medication this might work to help you to build up tolerance but it also might delay your body getting used to the medication, and so cause more side effects for longer.
With Saxenda, which is a daily med that breaks down over a day you would be on a safer bet. You would get the correct appetite suppression and it the half life is 12 hours so it would be gone by the time you took your next shot.
It is horses for courses here.
@@gablovesplantssydney The starting dose of Mounjaro is actually 2.5 mg/wk. It is not at a sufficient concentration to get into the therapeutic range. It's just an introductory dose, to get patients used to the drug.
Because, of that would a 1 mg/day even get into the therapeutic range? As you note, each dose is at a certain level of concentration and loses half its effectiveness over the half life.
Mounjaro 5.0 mg/wk divided into 1 mg microdoses per day would be: 1 mg + 1.5 mg + 1.75 mg + 1.88 ,mg + 1.94 mg. That dosing schedule doesn't get it into the therapeutic range. So, that's why I wonder if "microdosing" makes any sense.
no, a daily shot of 1mg leaves you with 7mg per week. You also want your body to NOt always have the same level but to keep its facility to adjust on its own to more or less GLP-1 arriving at receptors.
@@sabineacahaya2980 Why did YT delete my comment?
@@VernCrisler try different sort order, newest first should show all undeleted c9mments.. it probably was not deleted, just considered to be irrelevant. My initial comment is totally gone though. Was a bit contrary though
Thanks for this. My options are now between Mounaro and Rybelsus. My GPs aren't saying either of these are harmful. What are your thoughts?
I know you're not asking me, but what are your options for? Type 2 Diabetes or weight loss? If it's for diabetes, Rybelsus lowers HbA1c by between 0.6 and 1.4 percent. Mounjaro lowers A1c by 1.8% to 2.1% for the 5-mg dose, 1.7% to 2.4% for the 10-mg dose, and 1.7% to 2.4% for the 15-mg dose. For weight loss, Rybelsus shows about a 5 lb. weight loss. Mounjaro, 25-26% of the starting body weight. Rybelsus is a pill, which has its benefits over a weekly shot, but Mounjaro's injections are negligible (to me, as I have lost 260 lbs on Mounjaro and my HbA1c has gone from a 9.0 to a 5.0, all in 2.5 years). Research both and see which one fits for you... keep talking to your doctor, too.
Harmful? In the long-term? Immediately? Check the package inserts on both to read what they have found out so far. For me, the possible risks of the medication are FAR less than the damaging real life illnesses I had from obesity... the ones that are completely GONE now.
I hope this helps a little. Dr. Dan might surely have more to say!
@HealthAtAnyCost thanks. For sharing your experience and thoughts. Appreciate it a lot.
Weight loss is the goal at this moment.
The doctor's thoughts over messages were from cost point of view when I initially reached out about Monjauro.
As per what I'm finding on TH-cam and Reddit user experiences, Rybelsus works but definitely not as effective as Monjauro. Some are definitely taking Rybelsus improperly like not in empty stomach or not waiting at least 30 mins to eat after taking it and so on.
I have my appointment day after tomorrow so let's see how it goes.
Thanks again for sharing your thoughts.
@@mojjammil Good luck and let us know what you choose!
The is just one persons opinion and everyone’s body chemistry is different but I personally like the weekly injection part of MJ because you cannot “skip” a day or two and go out to dinner and have a blowout. You would need to skip a whole week in order to do that.
I was taking Saxenda, which is a daily injection and is effective (and it is now off patent so generic versions can be made which should bring the price way down) but I prefer the weekly Ozempic and Mounjaro.
They are also working on a monthly shot so stay tuned in the next few years for that day if it comes off.
I already take enough pills daily for my chronic migraines and reflux and HRT so the injection is great for me.
@@HealthAtAnyCost thanks. Will do hopefully.
I don't see how it matters, if there's 5-7 day half life it'll be the same amount in your body after awhile
Incorrect
Interesting topic, but I’m not so happy that that you don’t really name or explain the issues or Problems which Can come with the Microdosing. I am Missing as Well the possible Advantages or possible Benefits. Please give a Little More in depths Information.
Agree it could’ve been more in-depth… but the problems part is pretty Captain Obvious.
As in, insufficient dosage for any significant therapeutic benefits… whether weight-loss, anti-inflammation, or in being cardioprotective. 🤷🏽
Though I suppose if one is a super-responder, then even a microdose could be sufficient for those effects. Or for maintenance. 🔧
Also, microdoses could be beneficial for ppl starting on the meds who are having bad side effects. Always thought Lilly should’ve offered an optional 1.25mg starter dose. 💉
There are some less-common use cases, sure. But as a general thing for most ppl? Nah, probably not.
Does appeal to ppl who want to be on the least-possible amount of meds as a general rule though. Can’t argue with it as a clever bit of marketing/positioning.💡
You’re right, It would be interesting if there are arguments besides these obvious aspects. I am a very good responder as far as I can see, and I would like to know, if there were further insights about using the very small doses over a long time.
Considering I will be using this medicine for the rest of my life, perhaps 30 years, and considering that some kind of habituation will happen, I think staying at the lowest dose possible might be the only solution to keep the weight off for the rest of my life… at least until more potent medicines like for example, Retatrutide or others will be available. These are my considerations, but perhaps I’m wrong?
@susanne There honestly doesn’t seem to habituation with GLP-1s. Despite what some ppl say, GLP-1s do not seem to suddenly ‘stop working’. They are not like say opioids or alcohol in that you build up a ‘tolerance’ over time or something.
What seems to be happening is, ppl define ‘stopped working’ as they eventually stop losing weight.
But, they forget or don’t know that your body ‘fights back’ against weight loss. And the more weight you lose, the HARDER the body fights back (long story short: caveman/cavewoman genes, and your body sees major weight loss as you starving to death, so it attempts to slow, stop, and eventually reverse it).
Your body fights back multiple ways:
- Increases your hunger hormones
- Decreases your satiety hormones
- Slows your metabolism
But to the patient, none of that hormone-causation is obvious. They just know that the scale stopped moving, and that they feel hungrier. AKA, “OMG, my GLP-1 STOPPED WORKING!!” 😱
Makes sense?
What can you do? Well, if you haven’t got to goal weight yet, it’s generally a case of titrate up and keep doing so as needed until you either hit the top dose or your goal weight (whichever comes first) - plus make sure your nutrition, exercise, stress and sleep are all optimal.
But, some ppl don’t like that path, so they hope for another one. And there’s always a demand for well-marketed solutions to distressing or poorly understood problems.
Sometimes even if said solutions don’t really work particularly well for the majority of ppl. 🤷🏻♂️
Problem is that there are no studies to give us evidence based research on what microdosing the meds would do. It is all just supposition by the quacks in the space.
Dr Dan is all about evidence when he talks to us so if there is no research he cannot say what might be the benefits or he would be as bad as the quacks who promote this stuff.
@susanne6938 - Note taken! I will continue to work on sharing the right amount of science and general information.
Microdosing would be around 0.5ml
Thxxx
Thank you for watching!
Most of the Docs pushing Micro dosing are chiropractors which have absolutely nothing to do with internal medicine... this Micro dosing protocol has absolutely nothing to do with loosing a good amount of weight..if you want to consider on trizepitide that they started the trial test at 5mg but prescribe 2.5 mg then you are already starting at a Micro dose level 😆 but as you stated if you can't handle the 2.5 then maybe work your way to that..but this Micro dosing pushed by these chiropractors is kinda funny to me and they making waves off people 😆
The wording has become wordy and advice can come from anywhere, myself included! I can only hope that people know when red flags are flagging 🤞🤞
Thank the Universe for you, Dr. Dan. I have been hollering into the void about "Functional Medicine 'Doctors.'" Chiropractors are NOT MDs even if they are called "Doctors." People also call "microdosing" anything less than the standard dosages. "I microdose with 7.0 mg. instead of 7.5 mg." Ummm, no, that isn't even remotely the definition of microdosing. Microdosing is the buzz word of the moment and that "Functional Doctor" touting to know how and what to do will rake in her cash and then vanish into the night eventually, leaving people without the health gain and weight loss they were looking for and needing. Keep speaking up, but also put on your asbestos suit because that "doctor's" fans are rabid and are sure to come for your head. I've got your back!
All true. ‘Microdosing’ is REALLY trendy right now, but the benefits seem minimal at best - and confined to super-responders or ppl who have not much weight to lose.
And yes, everyone seems to misuse the term too. 🤦🏼♂️
At least split-dosing (another trend/fad) seems to have *some* possible utility. But microdosing? A whole lotta noise over not much. 🤷🏻♂️
To be fair on the person I think you are referring to (Tyna Moore), her micro dosing regimen is for people who are metabolically sound, NOT for weight loss but to treat other inflammatory conditions, in combination with other peptides. I think there is a bit of misunderstanding. She also has repeatedly refused to give a specific amount to dose with. She just says micro dosing is less than the therapeutic dose. Again, her application is NOT for weight loss but for the alleged neuro- and cardio protective and antiinflammatory properties of GLP 1 peptides and encouraged weight lifting to combat muscle loss.
She has also told everyone to work with their physicians and does not encourage you doing your own thing at home..please let's be honest before beating down on people.
@@msparkz11 The thing with that is, is a micro-dose really going to be cardio-protective or anti-inflammatory… to any meaningful extent? 🤔
And do we have any good clinical trial data on that either? My guess is, probably not.
@@msparkz11 Thanks for that information. I know it's helpful to many. There are a LOT of other people besides Tyna Moore talking about microdosing. I'm glad you clarified what you know about her style and method of taking care of people's health issues. Thank you!
Absolutely agree. A functional doctor is just the new term for a naturopath (ie, not a real doctor). Stick your medical team of experts like Dr Dan who work in the obesity management space and are backed up by evidence based scientific research.
Love u
Useless video that does nothing but appeal to authority. You have not presented a single scientific argument against the practice of microdosing which has shown many benefits in many different drugs for decades.
Did I not satisfy your confirmation bias with enough personal anecdotes or stories reddit forums?