Sandmeyer Reaction - experimental procedure and set up.

I set up a Sandmeyer reaction. The Sandmeyer reaction is often used to prepare aryl halides from aryldiazonium salts using copper salts.
Aryldiazonium salts are usually prepared from the corresponding arylamines via diazotization, a process that involves sodium nitrite under acidic conditions. The most commonly employed Sandmeyer reactions are used for chlorination, bromination, cyanation, and hydroxylation. Also, the formation of aryl iodides can be achieved by adding potassium or sodium iodide, without the need for copper salts.
The Chemists' Cookbook: nrochemistry.c...
This essential reference book arranges reactions alphabetically and by type, highlighting target molecules, reaction conditions, isomer ratios, reported yields, references to source articles, and experimental procedures. Additional notes discuss the practical scope and utility of each reaction, covering modifications, intermediate structures, and, in some cases, reaction mechanisms. These entries not only demonstrate the chemistry involved but also clarify its real-world applications, making it an invaluable resource for chemists at every level.
The Chemists' Cookbook includes an introduction by Professor Erick Carreira and a foreword by Professor Phil Baran, underscoring its significance to the field of synthetic organic chemistry.
This video was recorded at Selvita Laboratories. We thank Selvita for providing the facilities and support for this project.
Disclaimer: All chemical reactions demonstrated in this video are performed by trained professionals in a controlled laboratory environment. Do not attempt to replicate these experiments without appropriate training and supervision. Always use personal protective equipment (PPE) including lab coats, safety goggles, and gloves when handling chemicals. Be aware of the specific hazards associated with each chemical used, such as toxicity, flammability, and reactivity. For detailed information on each chemical refer to Material Safety Data Sheets (MSDS) or Safety Data Sheets (SDS). The creators of this video are not responsible for any harm or injury resulting from the misuse of the information provided. This video is for educational purposes only.

[@chemdelic]

Please keep these videos going. Goldmines of information

[@user-mp4bc9qp2x]

yes sandmeyer is one of those classic reactions with so many conditions to try. i've had good luck with aq. NaNO2 in MeCN, with some xs HBr and catalytic CuBr. always worth trying Cu(II) salts or organic nitrites as you've done here.

[@NROChemistry]

Totally agree

[@datdude3327]

Great video as always Lluiś, keep it up

[@NROChemistry]

Thanks, will do!

[@symphos5684]

It is worth to note that the aqueous solution of phenyl diazomium bromide is clear almost colorless and stable below +5 C for at least an hour. So it looks the yield was not good because an issue with the diazotation may have a place (yellow precipitate)?

[@NROChemistry]

Agree, this is a very useful way to monitor the formation of the aryl diazonium salt, when the aqueous solution becomes clear.

[@ICCPL0355]

this is an interesting video. could you please record the flash chromatography process and purification procedure. this will help the beginners

[@HindIsmaeel]

Thanks ,could you record reaction with CuCN if possible