Named Reactions in Organic Chemistry
Named Reactions in Organic Chemistry
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Wittig Olefination Reaction - reaction mechanism, experimental procedure and how to get rid of TPPO.
In this video I set up a Wittig olefination reaction. The Wittig olefination involves the reaction between carbonyl compounds, such as aldehydes or ketones, and phosphorus ylides to form C=C double bonds.
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The video describes the Wittig reaction, explains the reaction mechanism, and provides an experimental procedure to show how to set up the reaction in the lab.
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This video was recorded at Selvita Laboratories. We thank Selvita for providing the facilities and support for this project.
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The Chemists' Cookbook: nrochemistry.com/the-chemists-cookbook/
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Disclaimer: All chemical reactions demonstrated in this video are performed by trained professionals in a controlled laboratory environment. Do not attempt to replicate these experiments without appropriate training and supervision. Always use personal protective equipment (PPE) including lab coats, safety goggles, and gloves when handling chemicals. Be aware of the specific hazards associated with each chemical used, such as toxicity, flammability, and reactivity. For detailed information on each chemical refer to Material Safety Data Sheets (MSDS) or Safety Data Sheets (SDS). The creators of this video are not responsible for any harm or injury resulting from the misuse of the information provided. This video is for educational purposes only.
มุมมอง: 674

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Hydrogenation Reaction Set up - Reduction of a Nitro group
มุมมอง 1.2K21 วันที่ผ่านมา
In this video I set up a Hydrogenation reaction to reduce a nitrobenzene to the corresponding aniline. . This video was recorded at Selvita Laboratories. We thank Selvita for providing the facilities and support for this project. . The Chemists' Cookbook: nrochemistry.com/the-chemists-cookbook/ . Disclaimer: All chemical reactions demonstrated in this video are performed by trained professional...
Mitsunobu Reaction - reaction mechanism and experimental procedure
มุมมอง 8842 หลายเดือนก่อน
A Mitsunobu reaction: Description, reaction mechanism, and experimental procedure. . The Chemists' Cookbook: nrochemistry.com/the-chemists-cookbook/ . Disclaimer: All chemical reactions demonstrated in this video are performed by trained professionals in a controlled laboratory environment. Do not attempt to replicate these experiments without appropriate training and supervision. Always use pe...
A saponification Reaction.
มุมมอง 4536 หลายเดือนก่อน
A saponification reaction. . Disclaimer: All chemical reactions demonstrated in this video are performed by trained professionals in a controlled laboratory environment. Do not attempt to replicate these experiments without appropriate training and supervision. Always use personal protective equipment (PPE) including lab coats, safety goggles, and gloves when handling chemicals. Be aware of the...
Total Synthesis of Phomopsene
มุมมอง 8818 หลายเดือนก่อน
This video is about the first total syntheses of polycyclic diterpene phomopsene, which has been achieved using a unique cascade reorganization of carbon-carbon single bonds. The method involves: A novel Nazarov cyclization/double ring expansion developed by the authors, enabling rapid and stereospecific construction of the 5/5/5/5 tetraquinane scaffold with contiguous quaternary centers; and a...
Total Synthesis of (+)-Incargranine A
มุมมอง 1.1K11 หลายเดือนก่อน
In this video I talk about the synthesis of incargranine A, an alkaloid that features a [2,2,2]-bicyclooctane core with six contiguous stereocenters. To synthesize this natural product, the authors took advantage of a previously proposed biosynthetic pathway from a hemiaminal intermediate. This pathway consists of a retro-oxa-Mannich, oxa-Michael, keto-enol tautomerization, and Mannich cascade....
Total Synthesis of (+)-Aberrarone
มุมมอง 1.2Kปีที่แล้ว
In this video I talk about the synthesis of aberrarone, a natural product that bears a unique 6/5/5/5 tetracyclic ring system, four ketones, seven stereocenters, and three quaternary carbon centers. . For the synthesis of this diterpene, the authors envisioned the possibility of constructing the carboskeleton via a manganese-mediated intramolecular 5-exo/5-exo/5-exo radical cascade reaction. . ...
DMP Oxidation
มุมมอง 833ปีที่แล้ว
I set up an oxidation reaction. In this transformation, I wanted to oxidize my primary alcohol to the corresponding aldehyde. One of the easiest and mildest ways to effect this transformation is through the action of Dess-Martin periodinane, DMP. Disclaimer: All chemical reactions demonstrated in this video are performed by trained professionals in a controlled laboratory environment. Do not at...
Adagrasib - Mechanism of Action and Synthesis
มุมมอง 1.7Kปีที่แล้ว
Adagrasib is a pharmaceutical approved by the FDA in 2022 for the treatment of non-small cell lung cancer. . Therapeutic area: oncology Disease: NSCLC Target: KRASG12C Mechanism of Action: Covalent inhibitor, allosteric inhibitor. RoA: PO Chemistry section: Retrosynthesis & Forward Synthesis . References: Mechanism of Action: 1. J Exp Clin Cancer Res 41, 27 (2022). doi.org/10.1186/s13046-021-02...
Amidation Reaction
มุมมอง 920ปีที่แล้ว
I set up an amidation reaction. In this transformation I wanted to prepare an amide from the corresponding carboxylic acid. First I prepared the acid chloride and reacted it with the amine and a base to obtain the desired amide. Disclaimer: All chemical reactions demonstrated in this video are performed by trained professionals in a controlled laboratory environment. Do not attempt to replicate...
Sotorasib - Mechanism of Action and Synthesis
มุมมอง 2.1Kปีที่แล้ว
Sotorasib is a KRAS inhibitor that was approved by the FDA and the European Medicines Agency for the treatment of adult patients with KRAS G12C mutant non-small cell lung cancer. In this video, I am going to talk about the mechanism of action and the scale-up synthesis of sotorasib. Therapeutic area: oncology Disease: NSCLC Target: KRASG12C Mechanism of Action: Covalent inhibitor, allosteric in...
Delgocitinib - Mechanism of Action and Synthesis
มุมมอง 1.2Kปีที่แล้ว
Atopic dermatitis is a chronic disease that causes inflammation, redness, and irritation of the skin. Delgocitinib is a pharmaceutical drug that was approved in Japan for the treatment of atopic dermatitis. In this video, I talk about the mechanism of action and the scale-up synthesis of delgocitinib. Disease: Inflammation. Target: pan-JAK - Tyrosine Kinase. Mechanism of Action: Reversible inhi...
Pemigatinib - Mechanism of Action and Synthesis
มุมมอง 1.2Kปีที่แล้ว
Pemigatinib is a medication that was approved by the FDA for the treatment of cholangiocarcinoma in 2020. Disease: Oncology. Target: FGFR - Tyrosine Kinase. Mechanism of Action: Reversible inhibitor. Chemistry section: Retrosynthesis & Forward Synthesis. References: Mechanism of Action: 1. J. Clin. Med. 2019, 8(1), 7. https-//doi.org/10.3390/jcm8010007 2. doi.org/10.3389/fonc.2022.860453 Chemis...
Deoxofluorination
มุมมอง 952ปีที่แล้ว
I set up a deoxofluorination reaction. In this transformation, I wanted to convert an aldehyde to the corresponding geminal difluoride using diethylaminosulfur trifluoride, also known as DAST. Disclaimer: All chemical reactions demonstrated in this video are performed by trained professionals in a controlled laboratory environment. Do not attempt to replicate these experiments without appropria...
Oliceridine - Mechanism of Action and Synthesis
มุมมอง 1.4Kปีที่แล้ว
Oliceridine is an opioid medication that was approved by the FDA for the treatment of moderate to severe acute pain in adults. The medication is indicated for short-term intravenous use in hospitals and other controlled clinical settings. Disease: CNS Target: μ-opioid receptor (MOR). Mechanism of Action: G protein-biased μ-opioid receptor agonist. Chemistry section: Retrosynthesis & Forward Syn...
Discovery of Futibatinib
มุมมอง 1.2Kปีที่แล้ว
Discovery of Futibatinib
Cyanation Reaction
มุมมอง 974ปีที่แล้ว
Cyanation Reaction
Lenacapavir - HIV capsid protein
มุมมอง 1.3Kปีที่แล้ว
Lenacapavir - HIV capsid protein
Synthesis of Bempedoic acid
มุมมอง 1.5Kปีที่แล้ว
Synthesis of Bempedoic acid
Alpha-Keto Halogenation
มุมมอง 688ปีที่แล้ว
Alpha-Keto Halogenation
Reductive Amination
มุมมอง 2.2Kปีที่แล้ว
Reductive Amination
Strecker Reaction
มุมมอง 966ปีที่แล้ว
Strecker Reaction
Synthesis of Enarodustat
มุมมอง 1.8Kปีที่แล้ว
Synthesis of Enarodustat
Hantzsch-type reaction - Dean Stark
มุมมอง 1.1Kปีที่แล้ว
Hantzsch-type reaction - Dean Stark
Hydrogenation Reaction Set up - Reduction of a Nitrile group using Raney Nickel
มุมมอง 4.3Kปีที่แล้ว
Hydrogenation Reaction Set up - Reduction of a Nitrile group using Raney Nickel
Synthesis of Drugs: Lumateperone
มุมมอง 3.7Kปีที่แล้ว
Synthesis of Drugs: Lumateperone
Synthesis of Drugs: Avatrombopag
มุมมอง 2.4Kปีที่แล้ว
Synthesis of Drugs: Avatrombopag
Krapcho Decarboxylation
มุมมอง 1.9K2 ปีที่แล้ว
Krapcho Decarboxylation
Hofmann-Löffler Cyclization
มุมมอง 1.8K2 ปีที่แล้ว
Hofmann-Löffler Cyclization
Synthesis of Drugs: Lasmiditan
มุมมอง 1.6K2 ปีที่แล้ว
Synthesis of Drugs: Lasmiditan