The Electron Transport Chain: Complex IV

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[@maukachauka8793]

Complex I or II shutting down does not stop the whole respiratory system, it says so in my textbook 'Biochemistry' by Voet-Voet

[@piesl8842]

really amazing explanation!
I just had one of the "woaaah-moments" and I really needed that.
Everyone knows oxygen is important - duh, but now I finally understood the reason why -> ATP production!

[@wellnesspathforme6236]

Except that ATP is worthless in and of itself. The body can't use it. Oh, now the plot thickens! The true energy currency of the cell is... Mg-ATP. A magnesium electron is required to activate the ATP so the body can use it! Technically, and Mg2++. Search "magnesium in biology wikipedia" -- hidden in plain sight.
Now, go to your grocery store and look for the word "magnesium" on any of the nutrition labels. The plot just thickened to the point of cement.
And then there is the pesky little enzyme pathway required to deliver copper to the mitochondria to split that oxygen... try looking for "copper" on a "nutrition" label.
No worries, only your quality of life, and eventually your life, depends on getting this right. ;-)

[@jjangtan]

You are just so good at teaching! Thank you so much. Your ETC videos helped me a lot

[@mommyfeifei]

Thank you, that was really good!

[@kobedierckx2918]

Great video!

[@milanbhattarai3396]

Can anyone tell me how and why the two proton gets pumped to the inter membrane space?

[@CatalystUniversity]

The simplest answer is that 2 moving protons are required to elicit the appropriate conformational changes in the proteins.

[@erikhenze2339]

how does the pumping of the protons relate to mechanism of O2 reduction by this complex? Is it coupled to the O2 reduction, or is it a seperate activity?

[@comfortablyad2164]

The transport of electrons through the complex provides the energy necessary to pump the protons from the matrix to the Intermembrane space against their electrochemical gradient

[@Reir.Rodriguez]

uhm can you please point out the image that you are talking about, so it will be more understanding and clear

[@cicerorules7826]

Thanks for this excellent video - I would not say that the water produced by complex 4 is a waste product. There is increasing evidence that this water is in the from of H2O3 and is incredibly important for energy production in the cell. The work of Gerald Pollock demonstrates this very well. Thanks again

[@michaelsmith6420]

This video needs proper editing. Should tell the viewer that Cu_A is really a 2-Cu center even though it typically transfers one electron at a time. This diagram also hints that cytochrome a receives and donated electrons 2 at a time, which is not true. Finally, this slide states that CcO is strongly inhibited by N_3. There is no evidence for this statement. I once worked beside a fellow who attempted for 3 years to find evidence for N_3 inhibiting mammalian CcO, without any luck. There is some evidence that chronic delivery of N_3 may be deleterious to mitochondria, but this actually bolsters my opinion that N_3 is not a strong inhibitor of CcO. PMID: 11346134 DOI: 10.1080/152873901750128380