Cell Biology | Zellweger Syndrome, Refsum's Disease, Adrenoleukodystrophy

Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be teaching you about the structure and function of peroxisomes. After discussing the normal function of peroxisomes, we will go into USMLE step 1 disorders related to peroxisomal deficiencies. These will include Zellweger syndrome, Refsum's disease, and Adrenoleukodystrophy. We hope you enjoy this lecture and be sure to support us below!
Thanks to NN Community Friend @123awesome321 for the time stamps!
0:14 - Overview
0:32 - VLCFA, BCFA, & Peroxisome's ABCD1 Transporters
1:59 - F1: Beta-Oxidation of VLCFA Pathway (OHOT)
3:39 - F2: Alpha-Oxidation of BCFA Pathway
4:36 - F3: Ethanol Metabolism
5:49 - F4: Bile Acid Activation & Metabolism
6:37 - F5: Cholesterol Synthesis
8:11 - F6: Plasmalogen Synthesis
9:30 - F7: Catalase Activity for Reducing H2O2 Buildup
12:07 - Zellweger Syndrome
14:45 - Refssum's Disease
17:06 - Adrenoleukodystrophy (ALD)
19:12 - Comment, Like, SUBSCRIBE!
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#ninjanerd #Peroxisomes #CellBiology

[@F22_Raptors]

If there is a nobel prize for education, you are definitely the no.1 candidate

[@abrarkhan9674]

Zach, I was a cab driver u turned me into a doctor. Thank you zach

[@alih6953]

congratz mate on becoming a doctor!

[@arizonablossom8635]

Preparing for usmle step1 and all your lec are amazing this topic is high yield for step 1 usmle,thanks a lot for your great work.

[@MEZ4RCI]

finally an explanation of this disorders. I had searched for them two years ago but couldn't find a good resource back then

[@drfutoonkhaled5798]

One of the best videos I have ever seen for explaining such a complex topic . Special thanks we appreciate you so much

[@fadeskywards1245]

Wow, I love how you were willing to make a video on diseases with intracellular organelle dysfunctions as their etyologies. Make a video on different types of dyslipidemia if you already haven't. Thanks again for being awesome!

[@ginaaponte8893]

Very informative in an easy to follow format!! Great job Zach

[@carlospelaez2866]

Mate! i have a project on peroxisomes, and im mexican so i read 5 articles, consulted 3 books, watched like 5 videos all in spanish, and your video is AMAZING, putting EVERYTHING together beautifully.
NEW SUB

[@BloxWorldTV]

This was the most amazing explanation of PBD. My daughter is 10 and was diagnosed with zellweger may 2016. The resources parents have to learn about the disease are trash compared to this. You definitely have a gift

[@tashahollander9121]

Hey Robin. My son has a single enzyme disorder. (AMACR deficiency ) He does explain it all so well.

[@ranadam5568]

Already know these but will always watch your vids to refresh my memory ♥️

[@maureenonyango8198]

the best teacher ever ...am really grateful for your assistance and simplifying issues

[@MinhNguyen-we9cl]

Dude you re just an amazing teacher. You help me a lot going through medical years. Thank you so much for your great work!!!

[@deepaktripathy4930]

amazing sir, you are the machine that make the complex thing to so simple,not only understandable but last in memory for ever.🙏🙏

[@pridemhlanga6950]

viewing this all the way from zimbabwe!!!!thanks alot ......really helps

[@abwaankhadar9659]

Expert in medico lessons and professional teacher 🙏

[@michaelbraccia4556]

I love learning about these diseases. Thank you

[@salaheddinehouache1015]

I really appreciate your work Ninja crew, I'm waiting to watch your videos of every single organel... Good luck

[@bluedolphin4574]

Great video. Thank you. Please make more videos about diseases. They are highly appreciated.

[@m.ziauddin14]

Excellent sir. You are a hero of medical

[@ThatGuy_Biscuit]

I love this topic! Thank you sir zach! ❤️

[@diligesoderunt380]

Thank you so much Zach. You’re my hero

[@mrsamandabernier]

You're the most underrated channel on TH-cam. Amazing.

[@samisadeq]

EXCELLENT EXPLANATION! THANK YOU.

[@granola1210]

Thank you so much for all your videos❤️❤️🥰

[@eilianejad9178]

This channel is a gold mine.

[@alibekaltay631]

Don't stop man, you are doing great thing

[@abdelgadireshaq3990]

We can't thank you enough guys for this amazing work
Thank you so much ✨

[@NinjaNerdOfficial]

Thanks for the support

[@binshx5774]

I love ur clarifying!

[@thebest-yi3ro]

ufff!!! I don't know whenever u r video pops up I feel blessed... u amazing man.. 🌹

[@NinjaNerdOfficial]

Thanks for the support

[@akhtarparas3238]

Amazing sir please keep making videos on molecular biology ❤❤lots of love and respect ❤

[@Maryam-zx6iw]

Perfect explanation

[@tutututi8299]

i cant believe that boring stuff wold appear so simple nd it actually did make sense :). THANKS A LOT :)

[@zahraaamjad2952]

You make medschool SOOOOOO much easier, ZACH!!!!!

[@farisomran1892]

I loveed this topic thanks 😊

[@ashujha5154]

Love you BRO-TEACHER

[@guna7558]

Zach,your videos r very much helpful....thank you so much for being our mentor.I have a request....please make video on apoptosis n cancer,protein sorting.

[@m.s.e.4192]

Simply excellent!!!

[@nanaokonsam4805]

You made things super easy

[@simpleliving4049]

I love you sir for marking topic easy. LOVE 💕 FROM INDIA 🇮🇳

[@userkotoriyusitetotpsevdonim]

Thank you very much 😃❤🙏🏻

[@solij9961]

Thank you 🙏

[@jannmikoingelrabagogamingc6012]

Zach you are amazing!

[@xaaboopinkly]

Huge thanks sir!

[@Praise_ye_Yahweh]

Thank you.

[@GopalKumar-wn6ns]

Thanks a lot 🙏

[@bushrajamil1443]

LOVE YOUR VIDEOS! MAY GOD BLESS YOU!

[@deekshithbangera779]

Amazing sir love you✨💖

[@niyadeo7970]

Amazing!

[@SunilVerma-sj8fx]

Excellent sir

[@sarahaseeb3839]

The best explanation (HERE)❤

[@kennethdaniella-ab7963]

Best teacher ever

[@abdullahabdullah3722]

God bless you and your team man !

[@user-sm5zq7cp7n]

You are amazing guys !!

[@linaviolon4105]

Even if we study medecin in french in my country but you are helping us so much thank you

[@jamalabdinasir3697]

thanks Dr

[@kairananda8330]

your videos are great,

[@melissalanigan6221]

Thanks Gain ur a genius amazing info

[@prasenjitdas7694]

Nice explanation ❤️

[@dorcasb2194]

Kindly do a video series on how to read and interpret X-rays and other radiographs. Thanks

[@18bhavyanchandrach18]

Please do videos on neoplasia it will be very helpful can't thank u enough u help us go through toughest phase from covid. Pandemic with out much effect by helping us through these videos love from India ninja nerd

[@aliamer2868]

Great job

[@TheUlumpa]

Zach is love ❤

[@hawraaalhilali1092]

thank you!!!!

[@atulsinghtech52]

Amazing

[@buthainafazza836]

thank youu!!

[@immy0119]

Name something that Zach can't ..I can wait forever!!!

[@CLICK_SUBSCRIBE_BUTTON]

Thumbs up for zach hardworking ✌️

[@arfaaamer1707]

Amazing 👌
Extremely helpful & Awesome 👍

[@NinjaNerdOfficial]

Thanks!!

[@artworld2720]

Love you ninga nerds team

[@sadiqahmad988]

i am from pakistan .you are the first doctor easiest my way for mbbs

[@victorias1839]

omg, your t-shirt! got me laughing so much when I realized it's Schrutes Farms! Lmao!
but seriously, thank you so much for the lecture

[@thefrancesco502]

thank you very mutch

[@chikeagbo3531]

Beautiful

[@BruinChang]

Much appreciations from Taiwan!!

[@ikramshehzad6936]

Lov u man.. plz makes vedios on microbiology

[@nenelach4473]

ช่วยชีวิตผมมาก thank you very much ❤🙏

[@easyenglish1415]

first thank you siencehero and then please upload biology video more and rapid like this i have cell biology exam 3 mounth later and i really need your help.
your ninja fan🙏🌹

[@user-gh4nt4ve6l]

thanks

[@ayushtanwar6074]

Zach I I am jealous of your skills man amazing....if I got a chance I'll steal them from yours

[@rohanhittalamani7028]

when teaching is a passion 🙂

[@riyastodaily]

Excellent explanation...

[@NinjaNerdOfficial]

Thank you!!

[@abdelgadireshaq3990]

Can you please make video about necrosis and apoptosis and differences between them?

[@prabhatipanda6365]

Ty sir

[@soltanahaddad1545]

The BEST💥❤️

[@Chandra-tw2bp]

We are following you sir

[@RobertSelig]

Dr Zach, you are the best! That acetyl aldehyde that the body makes is still very toxic(brain fog, candida, alcohol) so to break acetaldehyde down into acetate, Mo the most unpronounceable element on the table is needed for this enzyme aldehyde dehydrogenase to work or we get the symptoms of acetaldehyde symptoms. Can you talk about the metal cofactors on how they are critical for these enzymes to work since Mo is the most deficient mineral I see on Hair tissue mineral analysis?

[@hamzenouh4911]

first year medical exam. thank you

[@JK-md4or]

bangin my man

[@Victor20041]

Thanks sir....
One request,
If you can give a moment after completing video when only board seen.
So we can take screenshot....

[@nandembarane8862]

Thanks man from 🇿🇦🇿🇦

[@sudikshachopra1936]

you are awesome!!

[@123Iamawesome321]

Table of Contents:
@0:14 Overview
@0:32 VLCFA, BCFA, & Peroxisome's ABCD1 Transporters
@1:59 F1: Beta-Oxidation of VLCFA Pathway (OHOT)
@3:39 F2: Alpha-Oxidation of BCFA Pathway
@4:36 F3: Ethanol Metabolism
@5:49 F4: Bile Acid Activation & Metabolism
@6:37 F5: Cholesterol Synthesis
@8:11 F6: Plasmalogen Synthesis
@9:30 F7: Catalase Activity for Reducing H2O2 Buildup
@12:07 Zellweger Syndrome
@14:45 Refssum's Disease
@17:06 Adrenoleukodystrophy (ALD)
@19:12 Comment, Like, SUBSCRIBE!

[@tavataniyapramote2689]

didnt know anyone could explain things this well

[@farisomran1892]

Thanks u 🔥🎉✨

[@evadesc]

there seems to be a rising trend and interest in life extension, anti-aging, cell reprogramming, etc., what would be the best way to get a career in that field?

[@rn3333]

Zach thank you so much for your presentation, I am a pediatrician and this is an excellent review this is not only for students of USMLE but also for those of us in practice for some time.

[@NinjaNerdOfficial]

That’s awesome thanks for saying that!

[@chaimaa4303]

fantasticc❤❤❤

[@Mohammad-xe2qw]

Best Of The Best

[@michaellee6079]

You should do an explicit MCAT prep course

[@Alper-ut2cg]

perfect.