@@penguinlieo4723 I have been applying for a lot of time as well, and it's really hard indeed. But I think it's even harder when you start working. So don't give up man. Not now and not later when you are accepted in a good place inshaAllah :)
Thank you very much for preparing this great webinar which could help me out to appreciate more precisely. I am very interested in immunotherapy and I also am going to present my project in this significant field. As you have mentioned TME is able to produce molecular and cellular barriers for decreasing CAR T cells’ efficiency and preventing from CAR T cells’ entrance in solid tumors. Many thanks once again.
Dear Colleagues. Thank you for very informative and helpful information. I am agree that this like therapy will be useful in cancer treatment. How I can apply for investigation in the this field. I have some ideas for fighting against cancer.
Have any clinical trials been conducted with CAR-T cells targeting solid tumours such as Osteosarcoma? My son was diagnosed with Osteosarcoma in June 2018, and since then he has had limb salvage surgery & multiple rounds of aggressive pre- and post-surgery chemotherapy. Sadly he has had a few relapses since his treatment finished earlier this year, and his recent PET scan in November 2019 has detected multiple tumours throughout his body, including in his lungs. He is now back on chemotherapy, and we are now resigned to the fact that the chemotherapy is just a short term solution. We have read up on CAR-T cell immunotherapy, which seems to be quite effective, and would be very grateful if you could advise whether this may be an option in treating our son's diagnosis. If not, are you aware of any other treatments available? Thanking you very much in advance.
Hi Ritesh. You can find current immunotherapy treatment options and clinical trials on our website here: www.cancerresearch.org/immunotherapy/cancer-types/childhood-cancer www.cancerresearch.org/immunotherapy/cancer-types/sarcoma
There are adoptive cell therapies in clinical trials for all those cancers. Learn more: liver cancer - www.cancerresearch.org/immunotherapy/cancer-types/liver-cancer pancreatic cancer - www.cancerresearch.org/immunotherapy/cancer-types/pancreatic-cancer stomach cancer - www.cancerresearch.org/immunotherapy/cancer-types/stomach-cancer colorectal cancer - www.cancerresearch.org/immunotherapy/cancer-types/colorectal-cancer
@@zhexu1727 The answer to the micoenvironment situation is to destroy it. High dose IV vitamin C and even a healthy diet largley consisting of vegetables, does a great job at unraveling the microenvironment. Chemotherapy only kills the tumors and by doing that, it creates a debris and collection of dead cells which adds onto the cancer microenvironment, highly acidic and anerobic area.
Outstanding
Thankyou for posting this info . My son has acute lymphoblastic t cell leukaemia .
Great talk .
I am writing my cover letter to join a research group that works in Immunotherapy! Your work is inspiring and bringing hope :)
Ahmed El-Molla I will give up if I cannot find a new team to join this year. Very hard due to my age.
@@penguinlieo4723 I have been applying for a lot of time as well, and it's really hard indeed. But I think it's even harder when you start working. So don't give up man. Not now and not later when you are accepted in a good place inshaAllah :)
That was exceptionally well explained.
Thank you very much for preparing this great webinar which could help me out to appreciate more precisely. I am very interested in immunotherapy and I also am going to present my project in this significant field. As you have mentioned TME is able to produce molecular and cellular barriers for decreasing CAR T cells’ efficiency and preventing from CAR T cells’ entrance in solid tumors.
Many thanks once again.
Wow, thank you for the feedback, Parvin :)
Great webinair guys!
Dear Colleagues. Thank you for very informative and helpful information. I am agree that this like therapy will be useful in cancer treatment.
How I can apply for investigation in the this field. I have some ideas for fighting against cancer.
Can CAR T-cell therapy be used to treat thalassemia and sickle cell anemia?
Have any clinical trials been conducted with CAR-T cells targeting solid tumours such as Osteosarcoma? My son was diagnosed with Osteosarcoma in June 2018, and since then he has had limb salvage surgery & multiple rounds of aggressive pre- and post-surgery chemotherapy. Sadly he has had a few relapses since his treatment finished earlier this year, and his recent PET scan in November 2019 has detected multiple tumours throughout his body, including in his lungs. He is now back on chemotherapy, and we are now resigned to the fact that the chemotherapy is just a short term solution. We have read up on CAR-T cell immunotherapy, which seems to be quite effective, and would be very grateful if you could advise whether this may be an option in treating our son's diagnosis. If not, are you aware of any other treatments available? Thanking you very much in advance.
Hi Ritesh. You can find current immunotherapy treatment options and clinical trials on our website here:
www.cancerresearch.org/immunotherapy/cancer-types/childhood-cancer
www.cancerresearch.org/immunotherapy/cancer-types/sarcoma
When can we expect car t for liver, pancreas, stomach and colon cancer?
There are adoptive cell therapies in clinical trials for all those cancers. Learn more:
liver cancer - www.cancerresearch.org/immunotherapy/cancer-types/liver-cancer
pancreatic cancer - www.cancerresearch.org/immunotherapy/cancer-types/pancreatic-cancer
stomach cancer - www.cancerresearch.org/immunotherapy/cancer-types/stomach-cancer
colorectal cancer - www.cancerresearch.org/immunotherapy/cancer-types/colorectal-cancer
many ongoing trials, but its very hard to do car t on solid tumor due to many microenvironment limitations.
@@zhexu1727 The answer to the micoenvironment situation is to destroy it. High dose IV vitamin C and even a healthy diet largley consisting of vegetables, does a great job at unraveling the microenvironment. Chemotherapy only kills the tumors and by doing that, it creates a debris and collection of dead cells which adds onto the cancer microenvironment, highly acidic and anerobic area.
14:27 CAR-T cells are capable of multiplying when activated. Are they capable of uncontrolled growth?
Hi Pankti, to learn more about CAR T cell therapy: www.cancerresearch.org/immunotherapy/treatment-types/adoptive-cell-therapy#cart