J'ai moi-même été opérée pour un mélanome au stade 4. en 1980 J'ai ensuite été traitée par immunothérapie avec des comprimés sur une période de 5 ans. On m'avait avertie que je serais traitée par immunothérapie à titre d'expérience, et j'ai accepté. Tous les mois j'avais des prises de sang et j,étais surveillée de très près par la Société Canadienne du Cancer. On ne connaissait pas cependant les effets secondaires du médicaments. Tout s'est très bien passé et ça fait maintenant 45 ans. Merci à la Société Canadienne du Cancer.
Great lecture,- thank you for making available! I wonder, if the mechanistic effect of IL-2 therapy for cancers is due to the IL-2-induced STAT5 activation, which results in upregulation of IL12RB2 mRNA and protein expression, before the well studied role of IL12RB2 during the clonal expansion of T-cells, where it is necessary for the differentiation of TH1 and cytotoxic T-cells via the IL-12p70/ IL12RB1&2/ STAT4/ IFN-gamma circuit. This early transcription of IL12RB2 functions as a possible interface for molecular and cellular mechanisms during T-cell activation due to the binding of JMJD3 to three locations on the intronic regions of IL12RB2, which initiates the JMJD3-mediated demethylation of H3K27me3 on cell type-specific genes, resulting in chromatin opening and elongation, thereby providing chromatin accessability for binding of and interaction between multiple transcription factors necesssary for tumor control. JMJD3 also regulates Brg1 in the SWI/SNF complex, where it cooperates with T-bet-mediated H3K4me3. IL12RB2 is therefore a target gene for the superenhancer STAT5, which is characterized by the positive markers H3K27ac and H3K4me3,- possibly regulated by a stepwise mechanism beginning with the IL12RB2-induced JMJD3-mediated demethylation of H3K27me3 on PRC2 target genes. Furthermore, IL-2-induced upregulation of CD25 works in concert with IL12RB2 to enhance T-cell proliferation in a p38 mapk-dependent manner, which is necessary for the IL-12-induced IFN-gamma production. This demonstrates an activation-induced, T-cell-mediated maturation of the DC (or APC), which is necessary for the regulation of high level IL-12p35 production snd adaptive immunity. Given that anti-PD-1 immunotherapy has been shown to work synergistically with an EZH2 inhibitor in some cancers, could the above mentioned epigenetic mechanisms, resulting from an intracellular IL12RB2 signaling pathway, help to deliever a mechanistic explanation for the synergistic effect of simultaneous use of cancer therapies such as IL-2, EZH2 inhibitor and anti-PD-1 in terms of tumor control?
Immune checkpoint inhibitors relies on the mechanism explained in the video to boost the immune system and fight against tumor cells. Thanks for the detailed explanation laid a good foundation on the understanding of immune system.
Tumor cells have many influencers . Suppressor cells T cells Immune cells check point proteins. Antigens are expressed on tumors. Viral antigens please express the treatment modality. What role do INTERFERON’S play ? Interleukins 1 -2 IL 10 IMmunoglobins express their interactions in tumor necrosis.
I have bladder cancer, I took chemo which was not successful doc put on keytruda immunotherapy treatment ,tumors shrunk after 20 treatment 1 tumor swelled up ,Please advise
Hi there, Please visit our website for more information regarding immunotherapy treatments for bladder cancer: www.cancerresearch.org/immunotherapy/cancer-types/bladder-cancer
Is something happening to the T & B cells long before a tumor appears? Maybe a foreign invasion like some bad cancer infection blood that activates the immune system. Maybe it changes the immune cells. Just wondering. I had a very strange neurologist do an unscheduled emg on me in a very remote room in a hospital. That was in 1995. He stuck the needle into the palm of my thumb. When I got back to the office the gauss was full of dark blackish blood. Today 2021 I have adenocarcinoma hhs. My ascending colon was removed. They also found the cancer in my lymph nodes. I'll be starting chemo in July.
Hi there, We are constantly updating our website and our social media with the latest immunotherapy news! Visit our website to take a look: www.cancerresearch.org
NEO-antigens CDA T cells passenger cells. Blocking PDL AAMD PDL1 head to head trials can I Google clinical studies ? Where can I find this data. Growing TIL cells sounds promising for tumor receptors.
Can cancer cells ever reverse some of their mutations? Do they just turn faulty genes on/off? How do they change back and forth from being a differentiated cancer cell to being a cancer stem cell. I don't understand some points.
Hi! While immunotherapy is an effective treatment for many cancers and many patients, it is not yet an effective treatment for everyone. Oncologists make treatment recommendations based on the latest data and results from various studies, factoring in multiple variables about the patient and their cancer (genomic testing, biomarkers, progression, metastases, etc.). The field is changing rapidly and there are new studies coming out every week. Guidelines for treatment are revised continuously and adapted to each individual patient. We're excited about the future, including combination therapies that may combine chemotherapy and immunotherapy or surgery and immunotherapy. Learn more on our website: www.cancerresearch.org
Sir my mother detect cancer in 2015 as liver cancer sprade in left lung and ascites Dr said approximately she live one month but I found some hearb and I started to give my mother now she is fine and healthy. I wish to discuss with you more with medical reports of my mother petscan I wish to send you
Check wikipedia/youtube, this video is long enough, if it started with what is a human, and what is DNA, and what is a cell.... He is presenting results of leading studies.
As a person diagnosed with the disease and chose to use natural therapy instead of conventional therapies, I learned that cancer is series of viruses that mutate and overwhelm the immune system. When those viruses grow every 120 days. Kill the virus by trying to maintain a ketogenic diet that promote the accelerators and limit the suppressor during the natural process called apotosis.
This is brilliant! Thank you so much. I watched it some time ago and will definitely watch again to remember things. Thanks.
Glad you enjoyed it!
J'ai moi-même été opérée pour un mélanome au stade 4. en 1980 J'ai ensuite été traitée par immunothérapie avec des comprimés sur une période de 5 ans. On m'avait avertie que je serais traitée par immunothérapie à titre d'expérience, et j'ai accepté. Tous les mois j'avais des prises de sang et j,étais surveillée de très près par la Société Canadienne du Cancer. On ne connaissait pas cependant les effets secondaires du médicaments. Tout s'est très bien passé et ça fait maintenant 45 ans. Merci à la Société Canadienne du Cancer.
Any progress? This was 8 years ago
Superb resource. Excellent clear and concise presentation.
Great lecture,- thank you for making available!
I wonder, if the mechanistic effect of IL-2 therapy for cancers is due to the IL-2-induced STAT5 activation, which results in upregulation of IL12RB2 mRNA and protein expression, before the well studied role of IL12RB2 during the clonal expansion of T-cells, where it is necessary for the differentiation of TH1 and cytotoxic T-cells via the IL-12p70/ IL12RB1&2/ STAT4/ IFN-gamma circuit.
This early transcription of IL12RB2 functions as a possible interface for molecular and cellular mechanisms during T-cell activation due to the binding of JMJD3 to three locations on the intronic regions of IL12RB2, which initiates the JMJD3-mediated demethylation of H3K27me3 on cell type-specific genes, resulting in chromatin opening and elongation, thereby providing chromatin accessability for binding of and interaction between multiple transcription factors necesssary for tumor control.
JMJD3 also regulates Brg1 in the SWI/SNF complex, where it cooperates with T-bet-mediated H3K4me3.
IL12RB2 is therefore a target gene for the superenhancer STAT5, which is characterized by the positive markers H3K27ac and H3K4me3,- possibly regulated by a stepwise mechanism beginning with the IL12RB2-induced JMJD3-mediated demethylation of H3K27me3 on PRC2 target genes.
Furthermore, IL-2-induced upregulation of CD25 works in concert with IL12RB2 to enhance T-cell proliferation in a p38 mapk-dependent manner, which is necessary for the IL-12-induced IFN-gamma production.
This demonstrates an activation-induced, T-cell-mediated maturation of the DC (or APC), which is necessary for the regulation of high level IL-12p35 production snd adaptive immunity.
Given that anti-PD-1 immunotherapy has been shown to work synergistically with an EZH2 inhibitor in some cancers, could the above mentioned epigenetic mechanisms, resulting from an intracellular IL12RB2 signaling pathway, help to deliever a mechanistic explanation for the synergistic effect of simultaneous use of cancer therapies such as IL-2, EZH2 inhibitor and anti-PD-1 in terms of tumor control?
Brilliant. Thanks!
Great video...
Thanks for watching!
Very nice and through presentation.....thank you.
Very well explained....thanks a lot sir.
Immune checkpoint inhibitors relies on the mechanism explained in the video to boost the immune system and fight against tumor cells. Thanks for the detailed explanation laid a good foundation on the understanding of immune system.
Thank You very much for Explanations I appreciate that Sir
Thanks for watching, Nahid!
if the combination treatment can shorten the course of the treatment dramatically, then hopefully the cost will be the same or less..
Thank you for making this, very clear.
Tumor cells have many influencers . Suppressor cells T cells Immune cells check point proteins. Antigens are expressed on tumors. Viral antigens please express the treatment modality. What role do INTERFERON’S play ? Interleukins 1 -2 IL 10 IMmunoglobins express their interactions in tumor necrosis.
dr.Weber, would you mind explain how the NY-ESO-1 works as an immune based therapy?
Thanks Professor
I have bladder cancer, I took chemo which was not successful doc put on keytruda immunotherapy treatment ,tumors shrunk after 20 treatment 1 tumor swelled up ,Please advise
Hi there, Please visit our website for more information regarding immunotherapy treatments for bladder cancer: www.cancerresearch.org/immunotherapy/cancer-types/bladder-cancer
Is something happening to the T & B cells long before a tumor appears? Maybe a foreign invasion like some bad cancer infection blood that activates the immune system. Maybe it changes the immune cells. Just wondering. I had a very strange neurologist do an unscheduled emg on me in a very remote room in a hospital. That was in 1995. He stuck the needle into the palm of my thumb. When I got back to the office the gauss was full of dark blackish blood. Today 2021 I have adenocarcinoma hhs. My ascending colon was removed. They also found the cancer in my lymph nodes. I'll be starting chemo in July.
Any new Information in 2023?! Any new discoveries that has potential?!
Hi there, We are constantly updating our website and our social media with the latest immunotherapy news! Visit our website to take a look: www.cancerresearch.org
NEO-antigens CDA T cells passenger cells. Blocking PDL AAMD PDL1 head to head trials can I Google clinical studies ? Where can I find this data. Growing TIL cells sounds promising for tumor receptors.
Hi there- you can learn more about immunotherapy by visiting our website! www.cancerresearch.org/en-us/immunotherapy/what-is-immunotherapy
which immune cell is first to appear against cancer cells NK cells or cytotoxic T cells ? thanks
Z cells
According to en.m.wikipedia.org/wiki/Natural_killer_cell
If the cancers projects MHC1 than the answer is T cells
Well great you asked two years ago... Ups
About car t cell therapy: the nasty cytokine, are they released by t-cell or by killed neoplastic lymphocytes?
20:00 so interesting !
Can cancer cells ever reverse some of their mutations? Do they just turn faulty genes on/off? How do they change back and forth from being a differentiated cancer cell to being a cancer stem cell. I don't understand some points.
Then why do doctors recommend chemotherapy?
Hi! While immunotherapy is an effective treatment for many cancers and many patients, it is not yet an effective treatment for everyone. Oncologists make treatment recommendations based on the latest data and results from various studies, factoring in multiple variables about the patient and their cancer (genomic testing, biomarkers, progression, metastases, etc.). The field is changing rapidly and there are new studies coming out every week. Guidelines for treatment are revised continuously and adapted to each individual patient. We're excited about the future, including combination therapies that may combine chemotherapy and immunotherapy or surgery and immunotherapy. Learn more on our website: www.cancerresearch.org
new cancer patient share Cancer Revealed: How the Immune System Sees and Destroys Tumors, with Jeffrey Weber
Sir my mother detect cancer in 2015 as liver cancer sprade in left lung and ascites Dr said approximately she live one month but I found some hearb and I started to give my mother now she is fine and healthy.
I wish to discuss with you more with medical reports of my mother petscan I wish to send you
May I ask what herb?
In the book Leviticus 🐝God says we are to detest shell fish🦉maybe this is why
What causes cancer? What is cancer? That's what you need to talk about first. You don't know the cause you can't heal it.
Body rot and white verses red blood cell war.
Check wikipedia/youtube, this video is long enough, if it started with what is a human, and what is DNA, and what is a cell....
He is presenting results of leading studies.
As a person diagnosed with the disease and chose to use natural therapy instead of conventional therapies, I learned that cancer is series of viruses that mutate and overwhelm the immune system. When those viruses grow every 120 days. Kill the virus by trying to maintain a ketogenic diet that promote the accelerators and limit the suppressor during the natural process called apotosis.
what causes liver?
Cancer is caused by cells that divide to much or uncontrollable.Cancer can be caused by smoking or radiation or uvray
QUE FUE ES ESE HORRIBLE RUIDO AL CAMBIAR DIAPOSITIVA???