Making Ethoxypillar[6]arene - The Future of Drug Delivery?
ฝัง
- เผยแพร่เมื่อ 6 ส.ค. 2022
- In this video I'm tackling another cool looking molecule called ethoxypillar[6]arene, belonging to the class of pillararenes. Pillararenes have only been in the picture since 2008 and are therefore a very new class of molecules with few applications. Yet, there is interest in using it for drug delivery, especially pillar[6]arenes which can hold large molecules (like many drugs are) inside their structure. The whole complex has a different polarity than a drug alone, therefore the complex could pass into parts of the body the drug wouldn't be able to go alone.
Procedure that i followed:
www.orgsyn.org/demo.aspx?prep=...
Much praise to the scientists who developed this method and made pillar[6]arenes accessible. I'll be following with curiosity if pillar[6]arenes will be applied in any drug delivery methods.
Support my channel with patreon:
/ chemiolis
Support my channel by becoming a member
/ @chemiolis - วิทยาศาสตร์และเทคโนโลยี
That's something new, I've heard only about calixarenes
These look really promising for future medicine and pharmacology; I think it's fascinating that we'll be able to hide "stowaway" drugs within the pillararene to sneak it through the blood brain barrier, like some kind of chemical Trojan horse lol
yeah its an odd thought. the only usage i can think of though is like when you have something like loperamide which is known to be a full mu-opioid agonist in the myenteric plexus in the gut which makes it effective for incontinence but it cant cross the BBB. So if put in a pillararene, which isnt swept away by enzymes like P-glycoproteins or monoamine oxidase, it could be used in a different way than normal. But obviously used with something more practical and useful.
@@redphoenix120 i feel kind of guilty that i had the same thought instantly.. well phenethylamine maybe 2
@@redphoenix120 loperamide which makes you really high is something practical and useful i would say
Loving that !!!
Trojan horse :))
man, i've seen heaps of papers about novel drug delivery methods, but i've never seen them used in actual drugs
Well done, mate! first time hearing about pillararenes!
Although I'm an inorganic chemist, I can see a great potential in these
its basically a "simplified" cyclodextrin, which are used in drug delivery and food processing already for quite some time. And you can also modify them very intensively.
If it's for drug delivery, could it be called a pillararene pillbox?
A pillarbox
3:42 Ah yes, forbidden cookie dough
Maybe I'm just blessed with NileRed but it's hard to imagine the undergoing reactions without showing the chemical equations. 😅
Also, pings >:/
There’s a lil equation in the link but it’s very simple, unfortunately couldn’t find exact mechanism since it’s so new so didn’t want to butcher it 🥲
go back there then. or maybe make some of your own content :)
@@kid_missive Meanie ;w;
I hate when people say that there is not such thing as magic. Uh chemistry! That is real life magic.
Man I found this Channel today and watched all videos. What a piece of art for chemistrys.
Wow this is actually amazing, thank you for showcasing the synthesis and bringing it to our attention as the chemistry community! 😎
3:40 forbidden cookies and cream
Stracciatella! 😆
I thought the same.
DCM is a really good low-pressure refrigerant which we may start seeing used again in large centrifugal chillers.
Nice! I would have liked to see some demonstrations of the properties and/or reactions of the final product.
Wow, what a nice channel. I really like true chemistry. Is it possible to add NMR or/and other spectrum, where u could show assignment of signals directly from ur product?
Unfortunately don’t have access to it now, but since this is an orgsyn procedure it is very reliable even without doing any analysis. Hopefully in the future I can run some NMR for these types of vids to verify.
@@Chemiolis So why exactly can you guarantee that your product is what you think it is? I'm new to organic chemistry.
@@lazyman114 OrgSyn refers to an online chemistry journal where procedures (developed by a team of chemists) to make a molecule are submitted for consideration by a separate team of 'checkers'. These checkers duplicate the procedures independently of the submitters, perform chemical analysis on each molecule in the synthesis and confirm the purity and identity of the final product. In this way one can be sure that any procedure in Org Syn will yield high quality material. However, in general chemists use a variety of methods to identify the things they use in the laboratory including NMR, HPLC, abscorption spectroscopy and mass spectrometry etc.
That's so cool, never heard of pillararenes before!
Just when I thought I knew a lot about chem. You humbled me. This sounds very promosing.
Educating, and entertaining. Good video
Interesting AF! I wonder if you could use a metal with the right size to "build" the pillararene around it; maybe get higher yields of the desired [6] product?
Excellent Video!
Nice work! Looking forward to more interesting content 🙂👋
Cool synthesis. I wish I could do that...
Nice work, well done. But I think you should provide melting point analysis or sth like that (if NMR is out of reach) to prove the final product. Because directly writing pillar[6]ene was seemed a little bit self-righteous.
What if he did and didn't post it because THAT would be self ritious, you do the chemistry and test it, let him make videos with retention and click through rate to pay his bills.
that stirbar reminds me of the fundip sticks
You make it look easy!
Nice work.
Super great video, love for supramolecular hosts
Woah, so you can possibly get medicine that doesn't cross the blood brain barrier to cross the blood brain barrier 🧠👍🏻 that can be very beneficial for medication use.
I don't know if it is just because of the camera or whatever, but that is definitely blue on my screen:P nice video though:DD
Nice video!
Very nice!
Really interesting.
That was so cool!!!!
Awesome!
Really great video :)
Incredible !
The green is so pretty
Well done!👍
However, the solvent consumption for the procedure is quite high.
I’d be awesome if you could test the purity of your product. Do you have any access to analytic equipment? I’d love to k ow how well this chemistry actually worked without any chromatography.
Very very intresting .... is the mechanism known;
Nice video
Do you have work on cyanoacrylate adhesive?
For the mechanism, isn’t it some sort of friedel crafts reaction followed by a dehydration ? Idk about the template effet though bc no pi stacking is possible
Looked into it a bit looks like it’s just inclusion of chlorohexane (during the closing of the ring) that yields the 6 over the 5. I suppose the polarity of ClCy is key bc to have the pillar5arene they use 1,2-dichloroethane
Thank you for the synthesis demonstration. I have quires that, if we use bromocyclohexan instead of chlorocyclohexane then its work? What do you think? please reply
I think it only works with chloro
Ice cold dcm looks oddly refreshing
3:41 forbidden cookies and cream ice cream
Why are the larger pillararenes more strained than pillar[5]?
What's that bluish green thing?
Nice vid! Do you have an oil-free vac pump? I would be worried for your pump oil if not
I don't mean to be negative, it's a great synthesis and taught me a lot. I just have PTSD from my first couple syntheses and oil changes. I once tried similarly pulling off water from sieves, but it ended up being more water than oil by the end
Yes I have a membrane pump
I need a reaction diagram!!! Otherwise you're just adding reagents to a flask for me 😢😢
"whole bottle" chemistry is relaxing!
Pillararenes, the joy of every Chinese organic chemist.
How does this differ from fulvic acid?
0:39 makes me think of hemeglobin
cool!!!
Have you had it analyzed?
Are the pillar[6]arenes safely metabolized?
i don't have any idea of what that is but i want to make some
nice
Bold to use BF3 etherate with exposed wrists
Are you sucking DCM through your pump? This ruins the membranes super fast if you use membrane pumps, and even though they are disposables, they are expensive as frick to replace for a hobbyist
It would be better to add a possible scheme and explain it at the beginning of the vid. Thank you.
I always like to see 2,5 di(m)ethoxyphenyl moieties get used in non-illegal applications
Do you have work on cyanoacrylate adhesive?
woah
Why did they add the extra ar
Now make the Alzheimer’s medicine and test wether your product really works /j
I liked
3:42 delicious oreo ice cream
Damn! How can I like it a second time? Can’t find the button.
It seems to me as some Covalent organic framework which i am making. Cool video though
cool
3:57
I must have skipped over the point that you said you were acetylating morphine.
it look like some gooood diamorphine
Legendary comment.
Yeahs I'm cool with putting DMT through my BBB, but I'll stay away from having to Trojan anything in, holy loose ends I messed my body up just with what was natural.
DCM through the pump???
It’s a membrane pump, they are made to handle it. Inside is all PTFE, no oil.
Cool science bro! I hope I’m not on a watch list now-
What glassware is best for anal insertion? Can you recommend advanced stuff as well as something for beginners ?
beginner: NS14 straight vacuum adapter
advanced: NS29 dimroth condenser
np
Wow to both: what kind of (brown) humor!
For all viewers who don't take this as a joke -
only use massive glass devices that are specially made for this purpose, if you don't want to bleed to death internally before you reach the emergency room... 😱💀
Reporting to the emergency room. HK is someone that wanted to have a little too much fun with their chemistry equipment. “Best of both worlds”, they thought.
They didn't shorten the name to pillarene, that is just disappointing.
But since the nomenclature is free, I propose pillarenes be actual pillars, like at least two layers of pillar[n]arene rings on top of each other. Kinda like a shitty short carbon nanotube. Then if we close the tubes with a flat top like a benzene ring we can have pillar-pillarenes. If we close them with "rounder" caps like a trialkylamine we can have pill-pillarenes.
In a general case I propose pillarenes to be relatives of carbon nanotubes which lack conjugation along and/or around the tube.
IUPAC, get on it! Make it canon.
why does the residue look like cookie & cream?
It looked like cookies and cream at one point
It is really disappointing that you get such low yields.
Wow, so this is how new businesses can be created. I'll be sure to never take notes about it.
(I am joking)
Boop
pls condense dcm not just evap so much
I have no idea what going on. I just watch those videos to hear people say those ridiculous names.
Appalachia 🤝 Netherlands
“warsh”
Hopefully it doesnt make you deaf like HPBCD? :p
I‘m actually amazed how you get your hands on all those chemicals. In Germany a swat team will knock on your door when you call politicians „1 Pimmel/ one dick“. I don’t want to know what happens when you try buy this stuff on the internet. 😄
> 50 years old
> New