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- เผยแพร่เมื่อ 9 ก.พ. 2025
- View full lesson: ed.ted.com/less...
Within every cell in our body, two copies of a tumor suppressor gene called BRCA1 are tasked with regulating the speed at which cells divide. Michael Windelspecht explains how these genes can sometimes mutate, making those cells less specialized and more likely to develop into cancer.
Lesson by Michael Windelspecht, animation by Zedem Media.
I read an article years ago that said that the first multicellular organism on earth were almost identical to cancer cells, and that modern cells turning into cancer may be caused by a gene going missing or inactive, causing them to revert to an earlier evolutionary state.
WOW, actually I'm korean, and I saw this video through korean version. I think the translation of this is veryveryvery wonderful. Maybe translator is amazing person. I will give him a big hand.
thank your lucky stars every morning waking up with no cancer.
I woke up with cancer
@@gloobstermcstinkwad3741 damn, sorry to hear that
@@gloobstermcstinkwad3741 damn bro, i hope you get cured soon😔
Everybody who's ever checked their symptoms online, has feared one time or another that he might have cancer. I guess those medical sites were right. We all might have cancer.
Actually brca1 has much less effect in cell cycle control/reparation/cancer suppression than p53, cyclin dependent kinase genes such as CDK1-3, CDKL5 or p21 etc. But brca1 was selected as a sample to demonstrate how the system actually works...though the video is for general public and mentions not even 5% of the processes which take place in cells both on genetic and cellular levels.
5% is pretty generous. I’d argue it’s not even 0.01%. And by the way - no such thing as a “genetic” level - that simply refers to on a molecular level, which includes nucleic acids and proteins.
I thought this was going to be more difficult to understand, it turned out to be pretty easy.
Dammit! I lost my sandwich again!
infernalthing
I will get it back for you.
That is the idea.
I'll take care of this personally.
WAS I THE ONLY ONE WHO THOUGHT MY SCREEN WAS DIRTY?
yes LoL
ANNIE ZHAO no I did
You are not alone...
Such useful information.
Both my mum and brother died from cancer
wow! What a sweet video! Keep it up ted
I had an exam to day of biology molecular/Cytogenetic, and there was 2 question about that.
Gatekeeprs (p53), and caretakers.
Thanks TED-Ed, I really could use that info, and apparently I´m smarter than 3 minutes ago :D
well, that was kind of depressing, yet reasonably informative
thanks
This is a very complicated topic to cover in 3mins, BRAVO! ted-ed...conceptualize!
I like to think of it like computer networking. The sum check is used for error detection when transferring data, there is a low chance of it not catching an error but there are a few cases where the error won't be caught and the file being transferred becomes corrupted like it got cancer when copying itself from the host computer.
awesome video and channel and teaching was very nice
Very good and funny videos bring a great sense of entertainment!
Great video. Viva Ted and Co.!
How does crashing turn a car into a monster truck and how exactly is BRCA1 involved in regulating the progression through the cell cycle? But mainly how the monster truck got there
There is BRCA 1 and BRCA 2.
well done!
wait question vsauce just made a video on cancer.....
I noticed that too when I was checking my subscriptions. I guess cancer is just the topic of the day in the educational part of TH-cam.
YouShouldRepeatThat but it also happened last week...... vsauce made a video on the web and then so did ted ...... but that is another story
Damn I was gonna ask the same question ted and vsauce uploading videos on the same topic
Hilarious! We love Vsauce. And they're both named Michael! Great educators think alike.
I guess there’s only so many things to talk about, and it had to happen eventually.
p53?
Are there also other genes that have a connection with cancer? Or is the BRCA1 gene the only one?
Technically all genes can cause cancer, because if there is a malignant mutation in any gene, it can lead to cancer. Mutations happen since we are born until we die, but most of these mutations are silent and have no effect. Mutations in our genes give us diversity and some even help us evolve and adapt to our environment. Mutations are not all bad, but there are some very bad ones. But, mutations might happens spontaneously by a mistake during DNA replication or by factors that affect us every day like: UV light, Radiation, Water, Pollution and many other things. Our body is constantly fighting off bad mutations, our cells have mechanisms that clone or cells and evaluate those cells if they are 100% correct and are mutation free. If a cell gets cloned and there is a mutation in it, our own body gets rid of that malignant cell, but there are always mistakes, and anything can happen, so that is why we should love our bodies and take care of ourselves, because every cell in our body fights for us everyday until they die and we must not take that for granted. We have amazing bodies and we must be proud of them.
There is tp53 gene. I have it.
WHEN DID MY SCREEN GET SO DIRTY??--- Oh, wait...
G. Edward Griffin a world without cancer
GREAT
NOW, teach us why some foods, radiation, magnetism, and stuff can increase chances of having cancer please!
We find it interesting and useful, therefore we have translated it to Hungarian language.
I would like to inquire whether it is possible to add the text file to the video?
If so, I would like to send you the text file in order to attach it to the video.
Thank you in advance for your reply!
Vsauce just uploaded: Why don't we all have cancer?
I got a ted ad for this
Take the BRCA test to find out if you have a mutation.
We have two copies in each cell (one from the father, and one from the mother), but do we need both of them, or does only one suffice?
We need both of them as a cell needs to maintain the same number of chromosomes (i think we receive half number of chromosomes from father and the other half from mother) but in a cell, only one gene from a pair is dominant (that means it shows its function) while the other is recessive (its function is masked by the other dominant gene). It is in nature's hand which gene will be dominant and which gene will be recessive
الله يجيرنا ويجير المسلمين
Great vid and all but... why is every man in the vid in his underwear??
Becuz this is TedEd. What do you expect? They made you cringe every single day
so if failed tumor suppressors are hereditary does that mean (with all technicality aside) that if both parents had a weak one, their child would be more susceptible to cancer?
I guess so, yeah... because either of the Brca1 gene needs to be dominant and the other recessive... if both of the inherited tumour supressing genes are weak, then the child will be more prone to cancer.
Added to "Watch Later". Looking forward xd
This will make some nightmares!
Thanks for the death anxiety.
Question 1) what causes the "cancer to cut the break lines"?
my grandmother died of breast tumour at the age of 29. Maybe she had a faulty breast cancer susceptibility gene 1.
Uhhhhh..... grandmother at 29? So if you wrote that at 10, your mom had you at 13, and your grandmother had her at 13 then 3 years and she is dead. I don’t think that makes a lot of sense. I don’t think that is true
@@armoredpumpkin8840 bro r u ok ?
His grandma died long a go not now
I heard that cancer is caused by dysfunction of cell apoptosis, not over speed of cell division? So which true is true then?
Both are true. If an increase in rate of division (through mutations in specific genes like brca1) is compounded with the cells losing their ability to undergo apoptosis (through additional mutations in other genes) you're on your way to developing some real bad cancer.
The truth of the matter is 5-7 things need to go wrong in the cell for an aggressive cancer to develop. If interested on what these are look up "hallmarks of cancer" by Wineberg. Here they mention but one.
Banana Boy Thx for answer. Now I get it its more complex than I thought. I didn knew there is bad cancer and less bad etc...
But how do we know the rate of a mutation, the chances of it occurring? Plz do tell
Why did it become a monster truck?
Vraiment très intéressant. Par contre ça va trop vite avec les sous-titres et j'ai dû regarder la vidéo 2 fois.
i now know that i'm dangerous
I'm scared now.
Great information by the way!
I wish my moms brca1 didn't fail :(
Good vid
Can you please do Video on why we can't cure it and why it costs so much ? Thank you
I'm no doctor/scientist but i think the problem has always been effectively targeting the cancer cells without harming the rest of the body. We can target bacteria pretty effectively because they have completely different/unique cell mechanisms that we can exploit. The best solution we got at the moment for cancer is to introduce poison into our bodies in the hopes that it kills the cancer cells faster than it kills the healthy ones - which sucks a lot
Potentially? More like commonly. :(
So gimme more of that geeeeeeeeeeeeeeeeeen!
Why are the dudes only partially dressed, while the gals are fully dressed?
if a dress is considered fully dressed than i dknt know life
Cuz this is TedEd. What do you expect? They made you cringe every single day
Dam how many times did she say brca1?
Shouldn't there be some sort of steroid to make all BRCA1 cells detect cancer cell at the start of their growth and never have one slip by and create a tumor
Ted - Ed, lessons for the peasant indisde us.
Who said that i want to be a doctor?
So... last week Vsauce made a video about the web and TED-Ed followed with a similar video on that very same day. Today Vsauce made a video about cancer and you are doing the same video on the same day aswell? Coincidence? I THINK NOT!
Can this really be a coincidence? Vsauce does a video about the web, you make a video about the web, Vsauce makes a video about cancer, you make a video about cancer. I'm trusting you right now, but if this happens again, I'm going to call copying on you.
So, cells conforming to the majority is great while someone conforming to the majority is sometimes not good
Can you do more Nordic mythology vids
Why are vsauce and ted doing the same topics now?
Just need better nanotech to combat genetic insuperiorities.
And high alkalinity is suppose to erraticate, disable, or stop these mutations. But we are more acidic with our diets... and almost every thing we create nowadays is toxic or radiated.
onco genes
I'm scared now :(
why do the boys have to be in underwere
Anybody watching this should stop and watch b17 cancer cure, or listen to Rick Simpson story run from the cure.
Watch G. Edward Griffin world without cancer, it's a lot more in depth with how cells work, great film if you're Interested this. Maybe you will learn something that's my aim.
This is not what I like to see
i dont like it ether but it is interesting
What do mean by that? elaborate, I don't want to misunderstand you.
i mean that i am sincerely interested in the way healthy cells change into cancer cells
ps.by the way is it not possible to genetically modify a virus that attacks these mutated cancer cells
So where's the cure!?
***** You don't know me, but I wish you'd feel better and get well. As we Asians say, Aja aja fighting!
be vegan don't put crap in your body
Hope you beat the cancer dude, wich in turn means beating your own cells, wich mean beating yourself... MASOCHISM FTW.
But seriously best wishes.
+Drazen Jankovic you beat cancer?
@@TheHaillstorm that wont eliminate the risk of cancer and there arent god plants that can cure cancer sorry
Hiiiiiiii
I wish that every cell with cancer would just die in an instant and no one would have it
A girl can prey
*pray
Not prey.
ok video but i cant stand her voice omg
on my life this is the ugliest animation i have seen
gay analogies, you don't need them
I like to think of it like computer networking. The sum check is used for error detection when transferring data, there is a low chance of it not catching an error but there are a few cases where the error won't be caught and the file being transferred becomes corrupted like it got cancer when copying itself from the host computer.
Very good and funny videos bring a great sense of entertainment!
G. Edward Griffin a world without cancer