Yeah, Derek lost a lot of fans. The non-cucks like me know Derek didn't care, he just wants money. Cucks like you apologize for Derek all the time. So sad.
I've been on semaglutide for 5 months, it's been one year total of exercise, weight lifting and dietary changes, and as of today I'm down 105lbs! I've been obese since 5th grade, this is the first time (at 35) that I've been under 300lbs in 25 years... Can't tell you how much this shit changed my life. Hard work, weight training, and protein intake make sure you lose fat but not muscle. It's working for me! Good luck everyone!
If you have only been exercising for the last year. You added fitness, you cleaned your diet. Get off the drug. You have the rest of your life to keep exercising and maintaining a healthy lifestyle with good healthy habits. Exercise is the life time sentence, not this crappy drug. 💪💪#mindset
@@FitnessSheriff absolutely brother, this was about a lifestyle change that before I couldn't do on my own, I was 410lbs and was sure set for an early death, now under 300 I've made the changes Ive needed and dropped most of the weight I needed, so I'll drop the drug and continue on, I just needed that extra push in the beginning to help me fight the hunger that was so damn hard to fight as an obese person, so damn hard.
@@FitnessSheriff I doubt you've been morbidly obese ever in your life or struggled to stop eating. Please leave your bs for people that have just decided to start losing weight. For those that have struggled to keep the weight off and are still struggling to learn self-control when it comes to eating this could be saving lives if it works out.
At my heaviest I weighed 605; I'm down to 540 since April. I gained and lost the same 50 pounds for three years because I had become so insulin resistant; Ozempic has been key to my success. I've had side-effects: you definitely have to "behave" when you're taking it. You can't eat fatty or sugary foods, nor can you overeat, or you WILL experience intestinal discomfort. Before I found Ozempic, I was going to trying to get to 500 so I could have the gastric sleeve surgery. However, I've been so successful with Ozempic,I really don't see the need to surgically remove 80% of my stomach. But I haven't been relying solely on Ozempic: I hired a personal trainer, and I've been building up my stamina to walk longer and longer distances. I'll ask my doctor for that test. Here's what it boils down to: I'd rather be "skinny fat" than dead. As my personal trainer said, "You don't see too many old fat people." Why no, no you don't.
You are certainly the person Ozempic should be used on. I think the biggest problem is with people who are 20-50 pounds overweight and use Ozempic rather than exercise, let alone people who are already below the obese line using this drug.
Look at getting on TRT as well, it helps preserve and even build muscle mass while on GLP-1 agonists. You're old enough that it is likely applicable, and will make your later years a lot more enjoyable.
Derek was on Tirzepatide like 2 months (and might still be). I agree this stuff isn’t sunshine but a more interesting video would be on its dopaminergic effects and possible addiction-resistance effect. People have quit alcohol, cigs, drugs, etc. while on this by accident.
You can modify the dosages in the pens by calculating "clicks". The spring mechanism works similarily in all the pens and each "click" corresponds to a certain dosage. For example, on a 1mg pen the full 1mg is 72 clicks while 36-37 is 0.5mg. Buying more needles allows you to customize how much you want to use as well as how often. I personally have had huge GI issues when going up to 1mg and will be testing splitting the dosages in two 0.5mg weekly doses to see if it works based on your recommendation. I was luckily smart enough to extensively research the drug and have kept up with resistance training and a proper diet, had a BMI of almost 40 and am now down 10kg in the last 4 months. I have deliberately been taking it slow and the effectiveness for the drug has not been as massive for me as for some other people.
Thanks Derek for making this video. I just started on Wegovy 2 weeks ago, and have already noticed a crazy decrease in appetite. And you hit the nail on the head, your appetite can get suppressed in such a way that it's so easy to forget to eat quality, nutrition-rich foods. Seriously, thanks for sharing this very pertinent take 👍
Can I ask how much weight you’ve dropped? And if you’ve noticed a drop off in gym performance (assuming you’re still eating nutritional meals and with supplements like protein/multi vitamins to make up for decreased intake)
There is a rebound effect btw, it’s called tolerance , you will gain the weight back after 6 months and even the max dose will not reduce appetite anymore,
@@dandylion968 If you properly lose weight at a safe rate and do a maintenance period you'll be fine. Stop spreading misinformation and start working on yourself.
@@ElAndresRodriguez i dispense this and take it , how about you take some yourself for a year then see what happens , not all info online is true especially when they want to make money off you
MD here with quite some experience prescribing GLP1s for some years now. Great video as usual but I wanted to provide 2 comments bc there are a couple of misleading messages here: -I am not sure what was the whole answer from Attia, but what is shown in the bit here it’s just not what good data shows. From the 2 main cohorts (sub-studies from Phase 3 trials) with DXA data, it’s clear that patients lose more fat mass than lean mass. In all studies available, body composition IMPROVES in these patients. So it’s just not true that they get fatter. It’s the opposite (I would need to see Dr. Attia’s data: baseline metabolic status, what GLP1, what dose, for how long, etc. - but the data available so far with GLP1s is pretty solid). Agree in any case that results will be even better with the diet+exercise adjustments described here, but the net benefit on body composition is already there. -Increase in HR: good discussion on a well-known adverse effect of this class of drugs. Agree that mechanism is still unclear (probably autonomous-mediated). But the most important thing I believe is there are a solid number of studies (and meta-analysis) with a huge number of patients showing that these drugs have a spectacular benefit on CV as well as all-cause survival. This means that despite the increase in HR, thr average patient on GLP1 should expect a 20-30% reduction in risk of CV mortality rather than be concerned by this well-known AE. Please do not overlook that the main benefit of GLP1s is that they are able to improve SURVIVAL in the populations tested so far, beyond the obvious and much hyped results on WL. And that’s probably why Elon made a good decision to get on them… 2 minor comments: -The problem of the limitation of just one Wegovy 2.4 mg dose is right on point, but the company also relies on the use of lower doses of ozempic already on the market… -tolerability remains the biggest point of improvement of this drug class. We all feel this is just the beginning, and the upcoming new treatments will be even better wrt to these issues (nausea, sarcopenia, etc.). But I doubt they’ll be able to improve the already great benefit on survival/CV outcomes…
its nice to see dr's who actually know what theyre talking about with respect to research/data. Most drs suck at this. Here in the UK most GPs dont even know anything about semaglutide and how important it is (its not even available on the NHS to most people even if they are extremely obese and have a history of CVD)
Semaglutide makes me feel like a normal person at the dinner table. I actually feel full in the middle of my meal and can easily stop, and when I am stressed and want gorge I eat a little bit of something that makes me feel better and stop after a normal amount.
But-and this is no hate, really-if you served yourself an appropriate portion you should be able to eat all of it and feel full. If it’s an appropriate portion, then you’re under eating, if it’s not an appropriate portion and you feel full midway, why serve yourself that much? Again no hate, just confused
Also eating cause you’re stressed-while I do it myself and is something I’m aware of and working on-even if you only eat a little bit to take the edge off is not necessarily reinforcing good eating patterns. I do get it though, I do the same; eat only a few potato chips (always have done this though, I’m not on semiglutide, so I can see how it could help w true binging)
I’m just excited to have these long mpmd videos. I was so excited yesterday that I actually used the affiliate link to place my first magic spoon order.😅
Guaranteed we’ll see major effects emerging over the next 2-3 years. The sheer volume of people taking these drugs vs. 12 months ago is stunning. Much like surgery if we’re talking about people who are 100lbs overweight who simply refuse to lose weight on other ways then it’s a net positive. In everyone else it’s more complex.
I mean it's like using cocaine to lose weight... I'm obviously no scientist but it's completely the wrong way to do it. I don't think we'll discover anything we didn't already know
Semiglutide has been used for literally decades. It's not a new drug. It's only "new" when being used for fat loss. Not saying there won't be newer side effects discovered but one of the benefits is that it's been around for a long time
I tried it before and it was a trip. Won’t stop stress eating/your grocery shopping. But it absolutely makes eating less super easy. Probably won’t use it again, because I don’t need it but it absolutely makes you not hungry lol.
This stuff was a miracle for me. Years of zigzag dieting and I decided to hop on ozempic. Lost 110lbs of mostly fat from what I can tell and 2 years off the drug it’s still gone. Basically zero side effects and I took between 0.25-0.5mg most of the time.
@@TheFaro2011 lol, I’d wager to say losing 110lbs and keeping it off naturally after is WAY healthier in the long run. The medicine was made with the intention of longterm use from the beginning, people using it short-term to literally get their life back on track and learn healthy habits aren’t going to be in anymore danger than anyone who watches Dericks vids and takes supplements and is a gym rat. What Derick has done has more risk associated than people taking this drug properly.
@@mikel6090 Have a big genetic predisposition to obesity. I was well aware of what a healthy lifestyle looked like but the drug gave me breathing room to be able to control those calories. I learned how to count calories while on it yes, but the drug was invaluable for me. Weight loss is simple but not easy and we shouldn’t dismiss anything that could help fight the obesity epidemic.
Isn't the lean body mass loss just the result of drastic weight loss with no resistance training? Would love to see a study where calorie deficit and exercise is equated between semaglutide and non semaglutide groups
@@LumemDH he didn’t ask “what is lean mass” he asked if the lean mass loss was as a result of a lack of resistance training. In other terms, if you’re training and have enough protein intake, will you still have this loss of lean mass?
@@lastactionhero7541 unlikely, but the point is that the people who are using this drug are clearly not doing that, otherwise they wouldn’t need this drug
I’m a pharmacist and Derek did a great job explaining all the injectable GLP1/GIP medications. I have personally managed diabetic patients on these injectables too and it’s about 50/50 for tolerability. Usually the worse side effects occur in the first 2-3 days after injection and they have a long half life so it takes about a month before reaching steady state (side effects become most tolerable at this point). Another thing is this medication has been responsible for causing pancreatitis and we will see an uptick or these cases as the years go on and more individuals are on them. Some studies are showing long-term side effects relating to metabolism, such as hair loss and an overall lower metabolism baseline.
What do you do as a pharmacists in the practice you work at to help these people that suffer from the side effects of GLP1- agonists and still continue taking the drugs to lose weight?
@@zikrullahkafa7132 with a collaborative practice agreement, I have authority to work with specific patients on their disease states. Most commonly hypertension and diabetes. I’ve also dealt with patient needing pain relief with chronic opiate use and manage their dosing on that. Essentially I see patients and can change/prescribe the medications I have a collaborative practice for. If they’re suffering from side effects, it’s most commonly nausea and that is mainly due to the delay gastric emptying. They are overeating usually.
I am scared shitless of this semaglutide shit i just got talked into taking with my testosterone shots weekly.... I have about 15 lbs of fat on lower stomach and the formation of manboobs coming..which is main reason i agreed to it and already paid for the month for it....but stupid ole me , i should have done research first...but anyway. I hear this stuff has addiction and compulsion benefits as well...for people who smoke, drink etc I also am currently weaning down on suboxone for the tenth time and am almost off...but when i dont take it, i have no energy at all!!! I currently do HIT 3 times a week and its been a nice change from constantly having tendonitis from trying to outrun/outwork my diet in the gym,.. Also i sometimes have GERD and i will sometimes wake up unable to breath from reflux... Its like this inability to breathe for about 5-10 seconds that feels like hours...its very frightening. I literally am having an anxiety attack thinking about it...fuck. I wish i could get a straight answer from anyone.
Hair loss can be explained by people unintentionally going into too large of a caloric deficit for a prolonged time while using this drug. It's easy for this to happen when you don’t feel hunger. I didn’t use this drug but lost 30kg over the course of 8 months, lost practically all my hairline and hair on the front of my head, fully regrown once I went into a surplus for my bulk.
What is about meth and losing teeth? Why does it happen? Ah, I ask ChatGPT, here's the response. "Methamphetamine abuse is associated with a phenomenon commonly referred to as "meth mouth," which involves severe dental problems, including tooth decay, gum disease, and tooth loss. There are several reasons why methamphetamine use is linked to dental issues: Dry Mouth (Xerostomia): Methamphetamine use often leads to a decrease in saliva production, resulting in dry mouth. Saliva plays a crucial role in neutralizing acids and bacteria in the mouth, helping to protect teeth. A lack of saliva allows harmful bacteria to thrive, leading to increased tooth decay and gum disease. Poor Oral Hygiene: Individuals using methamphetamine may neglect oral hygiene practices such as regular tooth brushing, flossing, and dental check-ups. Poor oral hygiene contributes to the accumulation of plaque and bacteria, leading to tooth decay and gum problems. Dietary Habits: Methamphetamine use can suppress appetite, leading to poor nutrition and unhealthy dietary habits. A diet lacking essential nutrients can weaken the teeth and gums, making them more susceptible to decay and infection. Bruxism (Teeth Grinding): Methamphetamine use is often associated with bruxism, or teeth grinding and clenching. This habit can lead to the wearing down of tooth enamel, chipping, and fractures, making teeth more prone to decay and damage. Vasoconstriction: Methamphetamine is known to cause vasoconstriction, narrowing blood vessels and reducing blood flow to oral tissues. This can compromise the health of the gums and surrounding structures. Chemical Properties: The acidic nature of methamphetamine can contribute to enamel erosion and weaken the overall structure of the teeth, making them more vulnerable to decay and other dental problems. It's important to note that "meth mouth" is not solely attributed to a single factor but is likely a combination of the effects mentioned above. The severity of dental issues may vary among individuals based on factors such as the duration and intensity of methamphetamine use, overall oral hygiene practices, and individual susceptibility to dental problems. Seeking professional dental care and addressing substance abuse issues are crucial steps in preventing and managing meth-related dental problems." That seems to cover it!
I had gastric bypass. I come from a long line of big people, and having that surgery changed my life. But here’s the thing, you need to do so much work for the surgery to work. A lot of people think it’s cheating or a quick fix, but it’s the exact opposite. The failure rate is still insanely high. My doctor got on my an amazing program, and I worked with a great team, and I’m keeping off almost 300 lbs. I love working out. Which I never thought I’d ever say. Granted, I never hit my ‘goal’ weight or size(I’m 5’9 and stupidly wanted to be under 150). If I did, I would look so sickly. Haha but I am all for these shots and pills - if you do the work, to make sure you don’t gain everything back immediately. Like Remi Bader(?) was on it, and bitched about putting more weight on after getting off it. Well, she also has B.E.D., and she doesn’t sound like she was taking care of that or getting any type of treatment for it, while she was doing Ozempic. Which, I’m sorry - that’s stupid. Just because you fix one thing, doesn’t mean you fixed everything. The lack of education is irresponsible, and does more harm than good. IMO. Sorry if that comes off Kareny.
@@Daniel-vc1oc what a shame that a silly meme has devolved into demonizing women for speaking their minds so they abstain lest they be deemed a 'Karen'
@@DasGoodSoup id imagine it takes a mix of things. The heaviest I got was 240 @ 5'5 when I was 13. I was fat af and unathletic but didn't have any organ or hormone issues, I just had no discipline or education about nutrition and ate to make myself feel better because my family life sucked. I got into lifting in highschool and learned better eating habits which helped me get back to a healthier and athletic weight. Now as a 25yr old, I'm 6'0 225lbs and pretty muscular. So I'd think you'd have to have that going on plus maybe hypothyroidism and other metabolic issues to get to 400+
Glad to see more conversation on this. I feel like half the people I know are on it now and they all seemingly believe it’s nothing but positives with no possible side affects.
I did semaglutide. Derek hit the nail on the head. I ended up losing weight. The weight lost was significant, and it was more proportionally muscle loss. I discontinued use after the negative sides outweighed the results. My sides were mainly lethargy and I couldn’t force myself to eat enough protein. It did completely remove alcohol cravings, which is good. Now being off for a few months. I can’t say it was bad. Overall good experience w it, but it’s not a long term candidate for me.
I specialize in eating disorders and disordered eating patterns. Your eloquent assessment about reinforcing counter productive eating behaviors are helpful for sufferers if they heed your warnings. Well done
Issue of muscle loss is probably due to not getting adequate protein, due to eating less. That can happen with weight loss on any diet/exercise regime that doesn't prioritize protein.
Would be curious to see studies on individuals who take semaglutide for weight loss in conjunction with a high protein/ketogenic-like diet compared to a standard diet and compare the levels of muscle preservation of the two groups
ive been using semaglutide with 400 mg a week test and 50 mg anavar daily . I eat 250 grams minimum daily of protein (chicken breast and rice 3x a day) Over 6 weeks i've lost 4 pounds. Have not lost any strength in terms of PR lift capacity.
Coming in strong with another great topic and video Derek, thank you. I know a person who is currently using a GLP-1 agonist as basically a general weight loss aid when they are no where near morbidly obese and could stand to improve diet and exercise as a beginning. I thought it was an extreme measure, especially when there’s alternatives left on the table
I had two of my good friends try this. Everything was going well until they tried to get off of it. They said the cravings were 10x worse, and that feeling lasted for a month…until they decided to go back on them. Wild
That's gonna be the catch with the new weight loss drugs that are gonna be pushed out by big pharma, Their saying this is already a thing of the past ''Ozempic/Semiglutide'' so imagine the new and ''improved'' bullshit their gonna push.
That's probably a result of the weight loss increasing hunger, and the drugs completely numbing their natural hunger sensations. Imagine turning off your hunger for 3 months, and then suddenly turning it back on at the end of a 3 month cut. Recovering from the stress and fatigue of significant weight loss can take MONTHS. It's really just very slow starvation.
@@c6q3a24 I support this line of thought. Bodybuilders doing a bit of starvation naturally also experience the cravings and often enjoy a post competition meal that's pretty big. Nothing new here, just a starved person who got their apetite un-supressed
The drugs shouldnt be a replacement for diet and exercise. They can be a replacement for discipline, making it a hell of a lot easier to stick to a good diet and make the progress to stay excited about exercise
The heart rate thing is concerning. For me when I'm losing body fat my heart rate actually decreases by about five beats per minute when resting. I wonder what is causing the increase
my aunt went on it and it made it easier for her to build healthy habits, once she got off she had no issue keeping the weight off, cravings were higher BUT she was way more active than she was when she started (went from no gym to lifting/cardio 5x a week) and MAJORITY of her food she eats is healthy. been 6 months and has only gained 2lbs back and is eating at maintenance (for reference she was 250lbs and got to 165lbs) and now is 167lbs and staying there. End of the day rebound is easy cuz people go on these crazy diets get fit but dont change the habits that made them fat, what happens after that is they get fat again. Weight loss isnt about the scale going down its about building healthy habits that keep the scale down and only require small adjustments to keep u at ur base goal weight.
I agree. I'm on Mounjaro 5.0 mg and I'm doing resistance training, taking protein and creatine, and eating a rational diet. The result is that I've lost weight and I've gained muscles at the same time. It's a three-pronged approach. Of course, a well-informed doctor will advise their patients that these drugs should be taken with lifestyle changes (exercise and diet). Also, anyone who takes the time to read about these GLP / GIP drugs, or watches some You Tube videos about them, knows they have to do all three: injection, exercise, diet, injection, exercise, diet, and on and on. It's their own fault if they don't follow these guidelines. [BTW, from my experience, and from hearing from others, most people on these drugs do not eat fast food or rich, hight fat foods. Because we are no longer hungry, those foods no longer have any appeal. As those on the drug say, the food "noise" is gone. Also, because people know they still have to eat even though not hungry, they are more likely to eat a rational, healthy diet than a dirty diet. For that reason, I think your fears about bad eating on GLP/GIP drugs are not well founded. The real problem is when they discontinue these drugs; weight is regained. Also, the heart rate stuff is temporary and minor, and note that weekly doses are perfectly fine, not like TRT, plus, most people prefer the convenience of a weekly dose. Side effects are minor and temporary and mostly occur when starting on the drug or up-dosing to a new level.]
Thanks for pointing out the nuances of this Derek. Guys like Peter often look at a study and run with it without critical thinking. Just because something happened to the average person in a study doesn't mean that will happen to any particular individual in the future. They need to do a study where they control for all the variables; protein intake, weight training, rate of weight loss, etc. I bet you'd see very similar results if you compared those taking Wegovy( or similar) and those who didn't when equating the variables.
It's still important to learn what happens to "average" people. That information can be used to educate doctors, and patients, on how to safely use these drugs. e.g. "This can decrease your appetite, but it's very important you eat a lot of protein, and do some resistance training, or you will lose a LOT of muscle, and not much fat."
What's the point of training and adhering to a diet while on this drug to counteract it's negative effects when this is being marketed as a replacement to going to the gym and adhering to a diet for weight loss. It defeats the whole purpose and just proves that it's not viable on it's own.
@@SpongeBob5000_It’s not marketed as a replacement for the gym and diet though. The medication helps people with high ghrelin by controlling cravings and insane hunger. This helps you adhere to your diet regiment
I’m using Ozempic. I’m at the 6 weeks point and I’m pretty happy. Lost almost zero muscle. The drug (for me) make it really easy to follow a proper diet.
5-10 beats per minute doesn't seem crazy until you factor in the fact that these people are losing significant a amount of weight as well. Typically your heartrate would go down by a good margin when losing 30+ pounds.
I actually used ozempic in low dose but instead of bumping the single weekly dose, i slowly moved my dosing days closer to get to every other day. And never went up enough to make it hard to keep my maintenance calories. Just went up enough to where i had to make a small concious effort to maintain it. I kept increasing Skeletal muscle and lowering body fat. The biggest things for me is i never really wanted to binge eat or drink alcohol, which are my big downfalls in this regard. I also had no negative side effects with it, but did with other glp agonists like trulicity. Done reasonably, especially if binging food and alcohol is a big issue for you, i 100% recommend it if it doesn't give you big nausea and whatnot.
The no desire for alcohol is pretty interesting. I think they have found a direction at least that could possibly help lots of people on a multitude of issues, if done right of course.
I found fasting doing this without semiglutide, hunger feelings aren't there anymore and whilst eating i feel my body actually responds earlier and says you're full. Whilst if i was eating 4-6 times a day and start early cravings and hunger were topic of the day.
Bro I started listening to you about eight months ago after my surgery. I hadn't been in the gym in years and got fat as f. I started hitting the gym around 5 days a week. When I started I weigh 230 lb with very little muscle mass. 6 almost 7 months later I am at 205 but my muscle mass Leaps and Bounds Beyond where was in my thirties. First time in my life I have random people stopping and asking about my routine, saying crap like I hope I'm as jacked as you when I'm your age. My bench press went from 160 to where I'm at now which is 315 for 3. Planned on doing trt after watching a lot of your videos and learning way more than I thought I would I chose to hold off on that and I feel I'm way better for it. 43 years old I'll go on trt when I need it and fortunately right now it is not needed
That’s great to hear and it gives me hope that I can recover at my age (just realized today is my 36th bday) You sound like a cool dude. Thanks for sharing.
As someone who has been perscribed ADHD meds (which also make you lose weight because you don't want to eat) the increased heartrate is real. When I initially took them my resting heart rate became like 90 bpm.
That’s because adderall is amphetamine. It’s a methyl group away from being methamphetamine. No shit it makes your heart rate go up; it’s speed! And Ritalin, blocks reuptake of dopamine and norep which is same mechanism of action to how cocaine works
ADHD medications are usually stimulants. Things like methylphenidate, dextroamphetamine, lisdexamfetamine are CNS stimulants and quite powerful ones. That’s why they make your heart beat fast, don’t mix up the cause and the effect :)
They have to, bc Pfizer has a daily oral that is going to be coming out, too. They’re all pretty effective. Orals will be game-changing since most folks don’t like injecting
11:15 you're losing lean body mass because you aren't doing resistance training in addition to dieting. Same thing happens when you diet naturally and don't lift weights.
My experience. I've been on Mounjaro since last October. Lost 22% body weight - 52 lb fat mass and 6 lb muscle mass based on Withings + scale. My A1C went from 6.3 to 5.6 and all cholesterol numbers are in normal range now. No change in average heart rate (58 resting) - based on Apple watch.
Back in 2015 I lost about 100 lbs. It amazes me how far people will go to avoid the simple things in weight loss. You will be hungry, it is uncomfortable and always be mindful with your eating. Check in every bite or two and ask yourself "Am I full or just eating?". Literally people would take chemicals with poorly understood long term effects than use an ounce of discipline and endure any amount of discomfort. It's also not sustainable, you didn't learn to manage your life or eating any better, nothing has improved. It's so short sighted it's unreal.
That hasn't been my experience at all. Been on it or 3 months so far. I'm down from 265 to 225. Waist circumference from 44" to 39" at the bellybutton. I'm still squatting north of 400lbs for work sets, and pulling just under 500lbs for work sets.
Started semaglutide alongside my trt. Ran sem for something like 8 or 9 weeks before I needed to stop. Nausea was gnarly for me. I'd barely begin a meal and then I'd get repulsed by eating. Made it really tough to get enough protein.
Great video but we have to realize that people on these studies are not doing strength training and probably not eating a high protein diet, of course they’re gonna lose muscle too. I used semaglutide when I was 23% bf and got to 12% body fat and kept all of my muscle because I was strength training and eating enough protein. I would love to see studies done on weight training athletes who eat enough protein
I'm on a cut right now and taking 1mg semaglutide, split into .5mg 2x per week . It's like a cheat code. I tapered to from .25mg per week. Gets rid of the cravings and binge eating I'd inevitably spiral into after 4 weeks. I'm pretty muscular and my maintenance cals are 3300. Eating only 2700 calories would previously make me ravenous. Now I'm stuffed with the same amount. I've even had a week or two where I tried only 2200 cals, and still experienced good satiety. I bumped the cals back up though due to gym performance and muscle retention. Only side I've experienced is some heartburn in the evenings if i have mildly spicy food. Started at 240, down to 222 right now after 8 weeks. I obtained a mixable vial and use an insulin needle to inject. I'm on trt too so my muscle loss isn't really an issue compared to the average joe Derek talks about in the video. My resting heart rate has also stayed the same at 66-68bpm. I have been getting 10k steps per day for the last year though.
GLP-1 is an appetite hormone and . Can't find any peer reviewed journals talking about how there is a disproportionate amount of muscle loss due to semaglutide vs traditional means. Dr.Attia observes it from his clinical practice but not sure about any good data supporting him that he cites. In fact, I've seen studies find INCREASES in FFMI compared to baseline (although there are definitely conflicts of interest possibly)
@@VallavanatI’ve been on zepbound for 2 months and I’ve gotten stronger and retained muscle tissue by combining the medication with high protein and lifting
I am on 10 mg of tirzepatide every 10 days. I'm seventy-four years old. My battle against my eating addictions has taken its toll over the years. So as of last year, I had developed type 2 diabetes, coronary artery disease, peripheral artery disease, stage 3 chronic kidney disease, hypertension, non-alcoholic fatty liver disease, and hyperlipidemia. I was obviously losing the battle against my food addictions and was too tired to exercise. Mounjaro has totally turned my life and health around in 7 months. For example, my a1c is down from 6.5 to 5.6 and probably lower than that by now. EGFR went from 47 to 60, a degree of change that my doctor had never heard of. Virtually all of my critical health metrics are improved and I have even been able to cut back on my blood pressure medicine. The appetite suppression effects of Mounjaro have actually made it more possible for me to adopt a healthy diet, something that my food addictions would never allow me to do in the past. I'm just starting to get some energy in my life so now I am more able to exercise, both aerobics and resistance training. So for me, Mounjaro has not provided an excuse for me to continue my old bad habits, quite the opposite. I agree with Derrek's assessment, but don't let perfection be the enemy of the good. If you are you eating a crap diet, just eating less crap will improve your health. Then if you really care about your health, Mounjaro can free you from enslavement to your hunger hormones and help you adopt a much healthier diet. Once you lose some weight, there is a good chance that you will have the energy to start exercising. I have been blessed to have no gastrointestinal side effects. But the heart rate increase does concern me. It was not my choice to have a 10-day interval between doses. That was my doctor's directive and it was a bad idea. 10 mg increases my heart too much for about a week and then after a week I gain about 5 pounds before taking my next shot.
To be fair when i looked into this, a high protein diet and excersise was recommended, and my doctor had to send me to a nutritionist before he could even prescribe this to me, my insurance didn't cover it though lol
Read this is *'Smeagaltude'* & my brain immediately conjured images of Gollum-people, distorted & emaciated beyond recognition.... the reality not being nearly as grotesque, but thanks to some humorous lysdexia, I got a chuckle out of it.
I’ve completed three weeks of Semaglutide, 1 mg / week. I’ve lost 12 1/4 pounds. I’m resistance training 1 1/2 hours a day and consuming 2.4 grams / kg of lean body mass in protein. I consume 1500 calories a day. My electrical impedance scale, which I’ve used religiously for 12 years, indicates I’m losing 66% fat and 33% lean mass. I started at 32% body fat
Best appetite suppressant I ever had was a parasite cleanse. Broke out of my sugar addiction, restored my willpower around food, & eventually was able to fast with ease.
How many people in these studies are working out alongside taking semaglutide? Pretty much any calorie-restricted diet done without resistance training will cause lots of muscle loss too, it's not the semaglutide's fault...
Especially with the kind of of calorie and protein deficit many of the people on semaglutide are on. I bet if there was a controlled study with a placebo group with the same eating and exercise habits, muscle loss would be similar.
@@krste3000 aah, true, I was a bit hasty with the comment and made it before he got to the same point around 25:00... though now it feels too late to just delete
@Razvan Ciuca it's not too late lmao. Leaving it up will lead people to believe otherwise. Bc people like you will immediately go to the comments before actually watching the video
Just started semaglutide while maintaining protein intake and consistent resistance training. Also TRT to offset muscle loss. I’m one week in and did notice resting HR up 8 bpm 3 days after 250 mcg. Appetite suppression is immediate but focusing on hitting slight caloric deficit to cut under 10%.
Glp1 agonists make you lose more fat and less muscle than just dieting. All the studys show better body composition and higher lean mass proportion after trial. Wish you would've checked ncbi for lean mass loss like you did for rhr. The guy who said 2/3 is lean mass obviously pulled that number from his behind.
That's in extremely obese people. Obviously their body is going to lose fat over muscle if they have 100+ extra pounds of fat. A slightly overweight person is going to lose more muscle than fat.
People lost 4 kg fat and 3 kg muscle, so overall 7 kg of bodyweight. No it wasn't morbidly obese test subject, because they were not weight loss studies, they were body composition studys, were no test subject had more fat mass than muscle msss so the change in body weight is accounted for and we investigate body composition only! I think a buch of scientists are smart enough to know that, and even I was smart enough to not tell you what a weight loss study said, but what a ton of body composition studys say.
This is why I was surprised derek didn't say that guy is wrong, because he said that those weight loss fda trials didn't account for body composition, which is not only wrong, because these are diabetes medication and literally every diabetes medication needs to have a favorable impact on body composition, otherwise it's not a diabetes medication it's a short term hyperglycemia relief! How do you approve a medication that worsens your glycemic control in long run for diabetes? What he said was also irrelevant because there are literally more than dozens of studys investigating the glp1 agonist group on body composition.
I am on 1mg of semaglutide per week for Diabetes. After watching this video I will be monitoring my heartrate. Through diet and exercise I have gone off a few diabetic meds. I have also gained more weight (muscle) through weight lifting. I quit keto and went on carnivore. My Doctor said all my bloodwork was great. I will be monitoring my heart. Thanks for the info Derek.
Thank you for the insights! My wife used it for 2 months and lost the 12kg that she's been trying to loose for 5-6 years! It was fantastic, with almost no side effects. I'll tell her to start pumping to get some lean muscle mass on 💪
Ozempic completely ruined my life 6 months ago. I was taking it for weight loss to increase my testosterone. My endocrinologist said i needed to lose weight because im a 24 Male with 215 ng/dl testosterone . I was on my 3rd week of ozempic and got gastroparesis and then was diagnosed with cdiff. This was back in June... my stomach is almost back to normal. However taking anitbiotics in the future will be a pain.
I was type two diabetic and reversed it with mounjaro. Went from 195 to 155. I climb and work out 5-7 days a week. My climbing went from a 5.11 to a 5.13-. Shredded now. I did lose some muscle mass. Oh, and I was suffering from hypertension. That’s also gone now. I leveraged the drug to cut my junk food intake. Meat and veggies only now. Only time I have junk is if I need a quick something to increase my calories drastically for the day. About to lean bulk.
Kevin hall actually made a response to this in which he used a study to compare the lean body mass loss to weightloss without semaglutide. According to his calculations body composition improved in the people taking semaglutide however there was more lean bodymass loss compared to people not taking semaglutide. There are yet to be studies done confirming this hypothesis
Holy sheep sh*t. I’ve been on liraglutide which is a daily glp-1. Once I slowly ramped up to the full 3mgs a day the side effects became overwhelming. And no counter medication could combat them. Acid reflux, nausea, vomiting and diarrhea and all of those arrived in the middle of the night thus waking me up violently. But the medicine works……
Yes. But there also studies published that although semaglutide increases HR, but also lowers blood pressure. And It has shown benefit for patients with cardiorenal conditions.
Thanks for the info, Derek. I put on some weight a while ago due to massive mental health issues and the apathy that came with with, I've been having a hard time to be motivated getting back into the gym to be healthy like I used to be. Lately I've been thinking of trying one of these apetite suppressants to be a catalyst for me to start me getting back. I know it's looking for an easy way to start losing weight, I'm very aware of the long process it takes to get in and be in shape. Not sure if I will try a suppressant, but it's good to have the info in case I do.
The key to being successful with this stuff is immediately starting to lift. If you are too self conscious to go to the gym , grab a pull up bar, and a set of dumbbells. That’s all you’ll need in the beginning anyways. The difference between someone looking for the easy way and the right way is lifting. You can start with just 15-20 minutes a day see how you feel and work up to the hour.
You know very well that the reason going to the gym and losing weight is such a reliable way of crawling out of a mental health hole is not because you look a little bit better. It’s because you re-teach yourself discipline, you short term and long term selves start to work in harmony, you make good decisions and look after yourself. After a while of treating yourself like you’re worth being looked after, you start to believe it, and you’re well on the path to success and happiness. Don’t rob yourself of that my man
I usually skip some of the vids because they are so long, but Derek videos are in short supply now and have been missing them, so watching every second!
Hopefully, if these GLP-1 RAs potentially develop into several more generations with respect to decreasing cardiovascular risk, I could see it being super beneficial in the bodybuilding community that are considering a "weight-loss" drug in their stack that dont want to use sympathomimetics like Clenbuterol. Awesome video! I'd love to see a more in-depth video on the adverse effects in the future.
I really don't think we need more drugs for bodybuilders to kill/starve/whatever themselves with. Like...I hope they realise what a futile endeavor it is, so vain and unhealthy. Not that they get more or better drugs to do it more
@@dimitrijekrstic7567 You’re absolutely right. Bodybuilding can be incredibly unhealthy in my opinion. I just feel like it’s an inevitability at the highest level that the top guys are going to do whatever it takes to look the best as possible. But if people are more aware about taking the safest drugs at educated, moderated amounts, I still feel like that is a step in the right direction.
Damn it Derek. I put a calendar reminder to call my PCP next week to get this medication. I’m a 40 year old female, had 3 kids, workout 5x a week, powerlifting, legs are pretty muscular, 5’8, 225lbs, use Carbon app and struggling losing damn weight. It’s so frustrating. What do I do?!
Not Derek but I'll give this a crack. When something isn't working in your training program, do the complete opposite. Flip your program upside-down. Source is Precision Nutrition (PN). The Principal of PN did an interview with Stronger by Science. More information there. Her advice concerned a client with exactly the same problem as you. Female exercising a lot (and under a lot of stress) was struggling to lose the last bit of weight. Her program was turned upside-down. Training went from 5 x week to 2 x or 1 x weekly. Rest days went up. Her calories increased from a deficit to maintenance. Major changes within a few weeks. Give it a go and see what happens. Also nothing wrong with *using* drugs like GLP Agonists instead of *abusing* them. Obviously these drugs are made to do one thing and one thing only - modulate appetite. Dr. Mike Israetel did a great video on the subject on the Renaissance Periodisation channel. Good luck V C.
Muscle weighs more than fat. You've indicated you're powerlifting, are you eating for powerlifting, as powerlifters usually do? That's probably the place to start. Yes if you eat cleaner and deficit you're going to lose power output
As long as you are looking better and are progressing in weight, the fat is and will come off. Don’t focus so much on the scale. Remember muscle weighs more then fat. I recently put on 20 lbs but I actually look skinnier cause the muscles. So don’t worry so much day to day or week to week the weight as long as you are progressing in weight and reps and sets and eating a balanced diet the fat will come off. Remember, it’s not a race; sustainable fat loss is about .5-1lb a week. Give it time and you will be rewarded. Personally , I agree with the other commenter; that you need your calories to do these lifts and gain muscle and raise the metabolic rate. It’s the muscle gained that raises basal metabolic rate that will do most for weight loss especially long term. You start taking a drug that makes you not eat, you won’t lift as much, you’ll lose muscle, then basal metabolic rate will go down and it will make it harder longterm. You are already on the right path. This drug, it’s for people who aren’t lifting to lose weight(ie lazy people ie people doing it wrong). Try upping protein to 1g/lb. That will make you lose weight and help with muscle. It’s hard to overeat when you are really getting the required protein intake as protein is very satiating and it’s actually a good bit of protein. If you can’t get it all from diet, add protein shakes.
It's also likely perimenopause. Loss of estrogenus slow but it absolutely affects your metabolism. Try transdermal patch birth control. I dropped 15 pounds and got my waist back.
Ah man it's nice to have Derek back on my feed; you've been missed lord of delts
Stop forming weird internet relationships with people you’ve never met. Fandom is bs.
@@pierrea3094 stop watching videos of people who you dislike
@@pierrea3094 it's not nearly that serious
Lmaoooo, you sound more like a Nick BS fan. Stay away from these educative videos bud
@@pierrea3094 i'd walk a mile over broken glass just to hear daddy delts fart through a walkie talkie
Ah Derek 5 month after the "this year will be different video" finally delivering. Love it
He didn’t lie, disappearing for a few months was certainly new😂
@@IsaiahDC man’s building a supplement empire, LET HIM BUILD
@@LivermooreJesse965ud I’m cool with it, doesn’t mean I can’t laugh at the irony😉
I’m appreciating the return to information-dense content.
Yeah, Derek lost a lot of fans. The non-cucks like me know Derek didn't care, he just wants money. Cucks like you apologize for Derek all the time. So sad.
I've been on semaglutide for 5 months, it's been one year total of exercise, weight lifting and dietary changes, and as of today I'm down 105lbs! I've been obese since 5th grade, this is the first time (at 35) that I've been under 300lbs in 25 years... Can't tell you how much this shit changed my life. Hard work, weight training, and protein intake make sure you lose fat but not muscle. It's working for me! Good luck everyone!
If you have only been exercising for the last year. You added fitness, you cleaned your diet. Get off the drug. You have the rest of your life to keep exercising and maintaining a healthy lifestyle with good healthy habits. Exercise is the life time sentence, not this crappy drug. 💪💪#mindset
@@FitnessSheriff absolutely brother, this was about a lifestyle change that before I couldn't do on my own, I was 410lbs and was sure set for an early death, now under 300 I've made the changes Ive needed and dropped most of the weight I needed, so I'll drop the drug and continue on, I just needed that extra push in the beginning to help me fight the hunger that was so damn hard to fight as an obese person, so damn hard.
@@FitnessSheriff I doubt you've been morbidly obese ever in your life or struggled to stop eating. Please leave your bs for people that have just decided to start losing weight. For those that have struggled to keep the weight off and are still struggling to learn self-control when it comes to eating this could be saving lives if it works out.
@@dougroach88Good for you man 👍 Hope this inspires more people
Hell yeah brother
At my heaviest I weighed 605; I'm down to 540 since April.
I gained and lost the same 50 pounds for three years because I had become so insulin resistant; Ozempic has been key to my success.
I've had side-effects: you definitely have to "behave" when you're taking it. You can't eat fatty or sugary foods, nor can you overeat, or you WILL experience intestinal discomfort.
Before I found Ozempic, I was going to trying to get to 500 so I could have the gastric sleeve surgery. However, I've been so successful with Ozempic,I really don't see the need to surgically remove 80% of my stomach.
But I haven't been relying solely on Ozempic: I hired a personal trainer, and I've been building up my stamina to walk longer and longer distances.
I'll ask my doctor for that test.
Here's what it boils down to: I'd rather be "skinny fat" than dead.
As my personal trainer said, "You don't see too many old fat people."
Why no, no you don't.
Keep going that’s amazing progress
You are certainly the person Ozempic should be used on. I think the biggest problem is with people who are 20-50 pounds overweight and use Ozempic rather than exercise, let alone people who are already below the obese line using this drug.
Look at getting on TRT as well, it helps preserve and even build muscle mass while on GLP-1 agonists. You're old enough that it is likely applicable, and will make your later years a lot more enjoyable.
Derek was on Tirzepatide like 2 months (and might still be). I agree this stuff isn’t sunshine but a more interesting video would be on its dopaminergic effects and possible addiction-resistance effect. People have quit alcohol, cigs, drugs, etc. while on this by accident.
Hear hear, +1
My night binges are more or less gone, ditto gaming binges
Interesting question, like a low dose, combined with proper nutrition type of situation?
Damn, this is really interesting, we need to get this comment higher!
I need to hear more about this
up vote this, first time im even hearing about it and now i have ten tabs opened going down a rabbit hole.
You can modify the dosages in the pens by calculating "clicks". The spring mechanism works similarily in all the pens and each "click" corresponds to a certain dosage. For example, on a 1mg pen the full 1mg is 72 clicks while 36-37 is 0.5mg. Buying more needles allows you to customize how much you want to use as well as how often. I personally have had huge GI issues when going up to 1mg and will be testing splitting the dosages in two 0.5mg weekly doses to see if it works based on your recommendation.
I was luckily smart enough to extensively research the drug and have kept up with resistance training and a proper diet, had a BMI of almost 40 and am now down 10kg in the last 4 months. I have deliberately been taking it slow and the effectiveness for the drug has not been as massive for me as for some other people.
good work!
Do oral antidiabetics work for weight loss?
10kg weight lose is pretty good.
Thanks Derek for making this video. I just started on Wegovy 2 weeks ago, and have already noticed a crazy decrease in appetite. And you hit the nail on the head, your appetite can get suppressed in such a way that it's so easy to forget to eat quality, nutrition-rich foods. Seriously, thanks for sharing this very pertinent take 👍
Can I ask how much weight you’ve dropped? And if you’ve noticed a drop off in gym performance (assuming you’re still eating nutritional meals and with supplements like protein/multi vitamins to make up for decreased intake)
honestly - good luck - but I dont understand why would anyone touch this garbage...
There is a rebound effect btw, it’s called tolerance , you will gain the weight back after 6 months and even the max dose will not reduce appetite anymore,
@@dandylion968 If you properly lose weight at a safe rate and do a maintenance period you'll be fine. Stop spreading misinformation and start working on yourself.
@@ElAndresRodriguez i dispense this and take it , how about you take some yourself for a year then see what happens , not all info online is true especially when they want to make money off you
MD here with quite some experience prescribing GLP1s for some years now. Great video as usual but I wanted to provide 2 comments bc there are a couple of misleading messages here:
-I am not sure what was the whole answer from Attia, but what is shown in the bit here it’s just not what good data shows. From the 2 main cohorts (sub-studies from Phase 3 trials) with DXA data, it’s clear that patients lose more fat mass than lean mass. In all studies available, body composition IMPROVES in these patients. So it’s just not true that they get fatter. It’s the opposite (I would need to see Dr. Attia’s data: baseline metabolic status, what GLP1, what dose, for how long, etc. - but the data available so far with GLP1s is pretty solid). Agree in any case that results will be even better with the diet+exercise adjustments described here, but the net benefit on body composition is already there.
-Increase in HR: good discussion on a well-known adverse effect of this class of drugs. Agree that mechanism is still unclear (probably autonomous-mediated). But the most important thing I believe is there are a solid number of studies (and meta-analysis) with a huge number of patients showing that these drugs have a spectacular benefit on CV as well as all-cause survival. This means that despite the increase in HR, thr average patient on GLP1 should expect a 20-30% reduction in risk of CV mortality rather than be concerned by this well-known AE.
Please do not overlook that the main benefit of GLP1s is that they are able to improve SURVIVAL in the populations tested so far, beyond the obvious and much hyped results on WL.
And that’s probably why Elon made a good decision to get on them…
2 minor comments:
-The problem of the limitation of just one Wegovy 2.4 mg dose is right on point, but the company also relies on the use of lower doses of ozempic already on the market…
-tolerability remains the biggest point of improvement of this drug class. We all feel this is just the beginning, and the upcoming new treatments will be even better wrt to these issues (nausea, sarcopenia, etc.). But I doubt they’ll be able to improve the already great benefit on survival/CV outcomes…
its nice to see dr's who actually know what theyre talking about with respect to research/data. Most drs suck at this. Here in the UK most GPs dont even know anything about semaglutide and how important it is (its not even available on the NHS to most people even if they are extremely obese and have a history of CVD)
Semaglutide makes me feel like a normal person at the dinner table. I actually feel full in the middle of my meal and can easily stop, and when I am stressed and want gorge I eat a little bit of something that makes me feel better and stop after a normal amount.
Is this something a person can safely be on for their whole life?
@@anonmouse956no
But-and this is no hate, really-if you served yourself an appropriate portion you should be able to eat all of it and feel full. If it’s an appropriate portion, then you’re under eating, if it’s not an appropriate portion and you feel full midway, why serve yourself that much?
Again no hate, just confused
Also eating cause you’re stressed-while I do it myself and is something I’m aware of and working on-even if you only eat a little bit to take the edge off is not necessarily reinforcing good eating patterns.
I do get it though, I do the same; eat only a few potato chips (always have done this though, I’m not on semiglutide, so I can see how it could help w true binging)
americans always look for an easy way. just train and dont eat all day, its very easy
Eat enough protein
Dont be in too much of a deficit
Hit your micronutrients
Train hard
Tren* hard
@@tehcarnagetest your limits
Finally a good old fashioned long video from Derek! Today's gonna be a good day
I’m just excited to have these long mpmd videos. I was so excited yesterday that I actually used the affiliate link to place my first magic spoon order.😅
Guaranteed we’ll see major effects emerging over the next 2-3 years. The sheer volume of people taking these drugs vs. 12 months ago is stunning. Much like surgery if we’re talking about people who are 100lbs overweight who simply refuse to lose weight on other ways then it’s a net positive. In everyone else it’s more complex.
I mean it's like using cocaine to lose weight... I'm obviously no scientist but it's completely the wrong way to do it. I don't think we'll discover anything we didn't already know
Semiglutide has been used for literally decades. It's not a new drug. It's only "new" when being used for fat loss. Not saying there won't be newer side effects discovered but one of the benefits is that it's been around for a long time
Its very well known and safe for most people
@@somethingginterestingg4275 xanax has been out for a long time. Still causes a lot of problems
@@dimitrijekrstic7567 right. But we already know about the side effects.
Make a video about Bryan Johnson and his anti aging regime, especially about the hair loss part !
I’ve had a raging clue since Derek has been uploading more again 🕵️♂️🤙🏾🖤
I’ve got such a raging clew rioght neow
@@louistaylor8808 my clew is pointing over there
@whiteshaq0172 let's follow your raging clew 😂
I think we can all thank Chael Sonnen for this, put another W on that man's record!
Ooooh show me your raging clew
The Delt God posts 2 in 1 week? We are blessed
I tried it before and it was a trip. Won’t stop stress eating/your grocery shopping. But it absolutely makes eating less super easy. Probably won’t use it again, because I don’t need it but it absolutely makes you not hungry lol.
This stuff was a miracle for me. Years of zigzag dieting and I decided to hop on ozempic. Lost 110lbs of mostly fat from what I can tell and 2 years off the drug it’s still gone. Basically zero side effects and I took between 0.25-0.5mg most of the time.
So you learned healthy habits to live a better life?
But. Can you really speak for side effects long term? It's just life doesn't do short cuts
@@TheFaro2011 lol, I’d wager to say losing 110lbs and keeping it off naturally after is WAY healthier in the long run. The medicine was made with the intention of longterm use from the beginning, people using it short-term to literally get their life back on track and learn healthy habits aren’t going to be in anymore danger than anyone who watches Dericks vids and takes supplements and is a gym rat. What Derick has done has more risk associated than people taking this drug properly.
What advice to get best results
@@mikel6090 Have a big genetic predisposition to obesity. I was well aware of what a healthy lifestyle looked like but the drug gave me breathing room to be able to control those calories. I learned how to count calories while on it yes, but the drug was invaluable for me. Weight loss is simple but not easy and we shouldn’t dismiss anything that could help fight the obesity epidemic.
Isn't the lean body mass loss just the result of drastic weight loss with no resistance training? Would love to see a study where calorie deficit and exercise is equated between semaglutide and non semaglutide groups
No, lean body mass is everything that isn’t fat. Doesn’t matter if you’re a ultra muscular roidhead or ultramarathon malnourished runner.
@@LumemDH he didn’t ask “what is lean mass” he asked if the lean mass loss was as a result of a lack of resistance training. In other terms, if you’re training and have enough protein intake, will you still have this loss of lean mass?
@@lastactionhero7541 unlikely, but the point is that the people who are using this drug are clearly not doing that, otherwise they wouldn’t need this drug
Good point, wonder if there are studies of lean mass loss post gastric bypass, where there is also fast weight loss without resistance training
@@dabofiron.itzsimplicity this lmao. this is for people with rare medical conditions and idiots who want magic pill fixes.
I’m a pharmacist and Derek did a great job explaining all the injectable GLP1/GIP medications. I have personally managed diabetic patients on these injectables too and it’s about 50/50 for tolerability. Usually the worse side effects occur in the first 2-3 days after injection and they have a long half life so it takes about a month before reaching steady state (side effects become most tolerable at this point). Another thing is this medication has been responsible for causing pancreatitis and we will see an uptick or these cases as the years go on and more individuals are on them. Some studies are showing long-term side effects relating to metabolism, such as hair loss and an overall lower metabolism baseline.
What do you do as a pharmacists in the practice you work at to help these people that suffer from the side effects of GLP1- agonists and still continue taking the drugs to lose weight?
@@zikrullahkafa7132 with a collaborative practice agreement, I have authority to work with specific patients on their disease states. Most commonly hypertension and diabetes. I’ve also dealt with patient needing pain relief with chronic opiate use and manage their dosing on that. Essentially I see patients and can change/prescribe the medications I have a collaborative practice for.
If they’re suffering from side effects, it’s most commonly nausea and that is mainly due to the delay gastric emptying. They are overeating usually.
I am scared shitless of this semaglutide shit i just got talked into taking with my testosterone shots weekly....
I have about 15 lbs of fat on lower stomach and the formation of manboobs coming..which is main reason i agreed to it and already paid for the month for it....but stupid ole me , i should have done research first...but anyway.
I hear this stuff has addiction and compulsion benefits as well...for people who smoke, drink etc
I also am currently weaning down on suboxone for the tenth time and am almost off...but when i dont take it, i have no energy at all!!!
I currently do HIT 3 times a week and its been a nice change from constantly having tendonitis from trying to outrun/outwork my diet in the gym,..
Also i sometimes have GERD and i will sometimes wake up unable to breath from reflux...
Its like this inability to breathe for about 5-10 seconds that feels like hours...its very frightening.
I literally am having an anxiety attack thinking about it...fuck.
I wish i could get a straight answer from anyone.
Hair loss can be explained by people unintentionally going into too large of a caloric deficit for a prolonged time while using this drug. It's easy for this to happen when you don’t feel hunger.
I didn’t use this drug but lost 30kg over the course of 8 months, lost practically all my hairline and hair on the front of my head, fully regrown once I went into a surplus for my bulk.
that is so interesting. I need to make more friends in Pharmacy
Since I started taking Meth for weight loss I also lost my teeth, job and family. But I’m thinner.
What is about meth and losing teeth? Why does it happen? Ah, I ask ChatGPT, here's the response. "Methamphetamine abuse is associated with a phenomenon commonly referred to as "meth mouth," which involves severe dental problems, including tooth decay, gum disease, and tooth loss. There are several reasons why methamphetamine use is linked to dental issues:
Dry Mouth (Xerostomia): Methamphetamine use often leads to a decrease in saliva production, resulting in dry mouth. Saliva plays a crucial role in neutralizing acids and bacteria in the mouth, helping to protect teeth. A lack of saliva allows harmful bacteria to thrive, leading to increased tooth decay and gum disease.
Poor Oral Hygiene: Individuals using methamphetamine may neglect oral hygiene practices such as regular tooth brushing, flossing, and dental check-ups. Poor oral hygiene contributes to the accumulation of plaque and bacteria, leading to tooth decay and gum problems.
Dietary Habits: Methamphetamine use can suppress appetite, leading to poor nutrition and unhealthy dietary habits. A diet lacking essential nutrients can weaken the teeth and gums, making them more susceptible to decay and infection.
Bruxism (Teeth Grinding): Methamphetamine use is often associated with bruxism, or teeth grinding and clenching. This habit can lead to the wearing down of tooth enamel, chipping, and fractures, making teeth more prone to decay and damage.
Vasoconstriction: Methamphetamine is known to cause vasoconstriction, narrowing blood vessels and reducing blood flow to oral tissues. This can compromise the health of the gums and surrounding structures.
Chemical Properties: The acidic nature of methamphetamine can contribute to enamel erosion and weaken the overall structure of the teeth, making them more vulnerable to decay and other dental problems.
It's important to note that "meth mouth" is not solely attributed to a single factor but is likely a combination of the effects mentioned above. The severity of dental issues may vary among individuals based on factors such as the duration and intensity of methamphetamine use, overall oral hygiene practices, and individual susceptibility to dental problems. Seeking professional dental care and addressing substance abuse issues are crucial steps in preventing and managing meth-related dental problems." That seems to cover it!
I had gastric bypass. I come from a long line of big people, and having that surgery changed my life. But here’s the thing, you need to do so much work for the surgery to work. A lot of people think it’s cheating or a quick fix, but it’s the exact opposite. The failure rate is still insanely high. My doctor got on my an amazing program, and I worked with a great team, and I’m keeping off almost 300 lbs. I love working out. Which I never thought I’d ever say. Granted, I never hit my ‘goal’ weight or size(I’m 5’9 and stupidly wanted to be under 150). If I did, I would look so sickly. Haha but I am all for these shots and pills - if you do the work, to make sure you don’t gain everything back immediately. Like Remi Bader(?) was on it, and bitched about putting more weight on after getting off it. Well, she also has B.E.D., and she doesn’t sound like she was taking care of that or getting any type of treatment for it, while she was doing Ozempic. Which, I’m sorry - that’s stupid. Just because you fix one thing, doesn’t mean you fixed everything. The lack of education is irresponsible, and does more harm than good. IMO. Sorry if that comes off Kareny.
How do you get to be 400+ lbs i cant even imagine wolfing down quadstack burgers with a gallon of coke
Not Kareny at all, more people should hear experiences like this, without "sugar coating" it lol
@@Daniel-vc1oc what a shame that a silly meme has devolved into demonizing women for speaking their minds so they abstain lest they be deemed a 'Karen'
@@DasGoodSoup id imagine it takes a mix of things. The heaviest I got was 240 @ 5'5 when I was 13. I was fat af and unathletic but didn't have any organ or hormone issues, I just had no discipline or education about nutrition and ate to make myself feel better because my family life sucked. I got into lifting in highschool and learned better eating habits which helped me get back to a healthier and athletic weight. Now as a 25yr old, I'm 6'0 225lbs and pretty muscular. So I'd think you'd have to have that going on plus maybe hypothyroidism and other metabolic issues to get to 400+
@@DasGoodSoup bad genes, and poor mental state. I came from a family who either coped with food or booze, and I did both.
Lots of subjects to rip into in these crazy ridiculous times, hope you make a few more more often.
Glad to see more conversation on this. I feel like half the people I know are on it now and they all seemingly believe it’s nothing but positives with no possible side affects.
I did semaglutide. Derek hit the nail on the head. I ended up losing weight. The weight lost was significant, and it was more proportionally muscle loss. I discontinued use after the negative sides outweighed the results. My sides were mainly lethargy and I couldn’t force myself to eat enough protein. It did completely remove alcohol cravings, which is good.
Now being off for a few months. I can’t say it was bad. Overall good experience w it, but it’s not a long term candidate for me.
I specialize in eating disorders and disordered eating patterns. Your eloquent assessment about reinforcing counter productive eating behaviors are helpful for sufferers if they heed your warnings. Well done
Issue of muscle loss is probably due to not getting adequate protein, due to eating less. That can happen with weight loss on any diet/exercise regime that doesn't prioritize protein.
Would be curious to see studies on individuals who take semaglutide for weight loss in conjunction with a high protein/ketogenic-like diet compared to a standard diet and compare the levels of muscle preservation of the two groups
or stacking it with a SARM lol
@@rustysausage69or test
Just look on steroid forums, many people stack Sema with PEDs lol
Have a friend who does it, he started 1 week ago, he is on trt
ive been using semaglutide with 400 mg a week test and 50 mg anavar daily . I eat 250 grams minimum daily of protein (chicken breast and rice 3x a day) Over 6 weeks i've lost 4 pounds. Have not lost any strength in terms of PR lift capacity.
Coming in strong with another great topic and video Derek, thank you. I know a person who is currently using a GLP-1 agonist as basically a general weight loss aid when they are no where near morbidly obese and could stand to improve diet and exercise as a beginning. I thought it was an extreme measure, especially when there’s alternatives left on the table
Your friend is not a “they”
@@Deport_All_nonWhites Jesus Christ seriously. Lol. Get a hobby.
@@KevinJDildonikthey have a hobby. It's hating anything that even slightly resembles something that makes them uncomfortable.
@@KevinJDildonikno tranny i wont
@@kmax1189 my hobby is putting freaks in their place, i'm not a they, but we will make you was/were
I had two of my good friends try this. Everything was going well until they tried to get off of it. They said the cravings were 10x worse, and that feeling lasted for a month…until they decided to go back on them.
Wild
Most research doesn’t show that. Dr. Mike talked about it briefly and didn’t mention that either. Does anyone have a reference for this side effect?
My father is on this. I want more data on what you are referring to.
That's gonna be the catch with the new weight loss drugs that are gonna be pushed out by big pharma, Their saying this is already a thing of the past ''Ozempic/Semiglutide'' so imagine the new and ''improved'' bullshit their gonna push.
That's probably a result of the weight loss increasing hunger, and the drugs completely numbing their natural hunger sensations.
Imagine turning off your hunger for 3 months, and then suddenly turning it back on at the end of a 3 month cut.
Recovering from the stress and fatigue of significant weight loss can take MONTHS. It's really just very slow starvation.
@@c6q3a24 I support this line of thought. Bodybuilders doing a bit of starvation naturally also experience the cravings and often enjoy a post competition meal that's pretty big. Nothing new here, just a starved person who got their apetite un-supressed
Dude I'd love a podcast with Derek and Peter. Would be very interesting
Derek when are we going to get your view on Pyrilutamide? Give us an update on the hair routine at least!
Durk
His hair is looking stellar these days. Lots of volume and character. Norwood reaper is busy dealing with some of us other guys tho
@@WisdomEDM yeah the reapers currently at me... I really should try get some shit to sort it out before its too late.
The drugs shouldnt be a replacement for diet and exercise. They can be a replacement for discipline, making it a hell of a lot easier to stick to a good diet and make the progress to stay excited about exercise
The heart rate thing is concerning. For me when I'm losing body fat my heart rate actually decreases by about five beats per minute when resting. I wonder what is causing the increase
Yea and 5-10 beats is freaking massive
Yeah your heart rate will increase from Dereks fat burners as well
my aunt went on it and it made it easier for her to build healthy habits, once she got off she had no issue keeping the weight off, cravings were higher BUT she was way more active than she was when she started (went from no gym to lifting/cardio 5x a week) and MAJORITY of her food she eats is healthy. been 6 months and has only gained 2lbs back and is eating at maintenance (for reference she was 250lbs and got to 165lbs) and now is 167lbs and staying there. End of the day rebound is easy cuz people go on these crazy diets get fit but dont change the habits that made them fat, what happens after that is they get fat again. Weight loss isnt about the scale going down its about building healthy habits that keep the scale down and only require small adjustments to keep u at ur base goal weight.
Congrats to your aunt! That’s a big change & isn’t easy, no matter how you do it! ❤
That’s how you do it right: as a tool and not as the cure.
I agree. I'm on Mounjaro 5.0 mg and I'm doing resistance training, taking protein and creatine, and eating a rational diet. The result is that I've lost weight and I've gained muscles at the same time. It's a three-pronged approach. Of course, a well-informed doctor will advise their patients that these drugs should be taken with lifestyle changes (exercise and diet). Also, anyone who takes the time to read about these GLP / GIP drugs, or watches some You Tube videos about them, knows they have to do all three: injection, exercise, diet, injection, exercise, diet, and on and on. It's their own fault if they don't follow these guidelines. [BTW, from my experience, and from hearing from others, most people on these drugs do not eat fast food or rich, hight fat foods. Because we are no longer hungry, those foods no longer have any appeal. As those on the drug say, the food "noise" is gone. Also, because people know they still have to eat even though not hungry, they are more likely to eat a rational, healthy diet than a dirty diet. For that reason, I think your fears about bad eating on GLP/GIP drugs are not well founded. The real problem is when they discontinue these drugs; weight is regained. Also, the heart rate stuff is temporary and minor, and note that weekly doses are perfectly fine, not like TRT, plus, most people prefer the convenience of a weekly dose. Side effects are minor and temporary and mostly occur when starting on the drug or up-dosing to a new level.]
Thanks for pointing out the nuances of this Derek. Guys like Peter often look at a study and run with it without critical thinking. Just because something happened to the average person in a study doesn't mean that will happen to any particular individual in the future. They need to do a study where they control for all the variables; protein intake, weight training, rate of weight loss, etc. I bet you'd see very similar results if you compared those taking Wegovy( or similar) and those who didn't when equating the variables.
It's still important to learn what happens to "average" people. That information can be used to educate doctors, and patients, on how to safely use these drugs.
e.g. "This can decrease your appetite, but it's very important you eat a lot of protein, and do some resistance training, or you will lose a LOT of muscle, and not much fat."
What's the point of training and adhering to a diet while on this drug to counteract it's negative effects when this is being marketed as a replacement to going to the gym and adhering to a diet for weight loss. It defeats the whole purpose and just proves that it's not viable on it's own.
@@SpongeBob5000_It’s not marketed as a replacement for the gym and diet though. The medication helps people with high ghrelin by controlling cravings and insane hunger. This helps you adhere to your diet regiment
I’m using Ozempic. I’m at the 6 weeks point and I’m pretty happy. Lost almost zero muscle. The drug (for me) make it really easy to follow a proper diet.
5-10 beats per minute doesn't seem crazy until you factor in the fact that these people are losing significant a amount of weight as well. Typically your heartrate would go down by a good margin when losing 30+ pounds.
I actually used ozempic in low dose but instead of bumping the single weekly dose, i slowly moved my dosing days closer to get to every other day. And never went up enough to make it hard to keep my maintenance calories. Just went up enough to where i had to make a small concious effort to maintain it. I kept increasing Skeletal muscle and lowering body fat. The biggest things for me is i never really wanted to binge eat or drink alcohol, which are my big downfalls in this regard. I also had no negative side effects with it, but did with other glp agonists like trulicity.
Done reasonably, especially if binging food and alcohol is a big issue for you, i 100% recommend it if it doesn't give you big nausea and whatnot.
What dose? And how long
What negative effects did u have from Trulicity?
The no desire for alcohol is pretty interesting. I think they have found a direction at least that could possibly help lots of people on a multitude of issues, if done right of course.
I found fasting doing this without semiglutide, hunger feelings aren't there anymore and whilst eating i feel my body actually responds earlier and says you're full. Whilst if i was eating 4-6 times a day and start early cravings and hunger were topic of the day.
Love it man. Shit is crazy. Lost 50 but chicken legged it. It isn't just suppression. You eat the energy that would otherwise go to muscle.
Sounds bad to me.. Walking about with chicken legs sounds like bad body composition
That makes no sense at all.
Bro I started listening to you about eight months ago after my surgery. I hadn't been in the gym in years and got fat as f. I started hitting the gym around 5 days a week. When I started I weigh 230 lb with very little muscle mass. 6 almost 7 months later I am at 205 but my muscle mass Leaps and Bounds Beyond where was in my thirties. First time in my life I have random people stopping and asking about my routine, saying crap like I hope I'm as jacked as you when I'm your age. My bench press went from 160 to where I'm at now which is 315 for 3. Planned on doing trt after watching a lot of your videos and learning way more than I thought I would I chose to hold off on that and I feel I'm way better for it. 43 years old I'll go on trt when I need it and fortunately right now it is not needed
That’s great to hear and it gives me hope that I can recover at my age (just realized today is my 36th bday) You sound like a cool dude. Thanks for sharing.
As someone who has been perscribed ADHD meds (which also make you lose weight because you don't want to eat) the increased heartrate is real. When I initially took them my resting heart rate became like 90 bpm.
That’s because adderall is amphetamine. It’s a methyl group away from being methamphetamine. No shit it makes your heart rate go up; it’s speed!
And Ritalin, blocks reuptake of dopamine and norep which is same mechanism of action to how cocaine works
@@cat-le1hf thats a myth, you can just keep taking your meds year after year.
Speed meth
@@Bromidias no, it’s not a myth. Tolerance isn’t a myth.
ADHD medications are usually stimulants. Things like methylphenidate, dextroamphetamine, lisdexamfetamine are CNS stimulants and quite powerful ones. That’s why they make your heart beat fast, don’t mix up the cause and the effect :)
Just this week Novo Nordisk released details on their phase III trial of a daily oral Wegovy. Still shows 15-17% weight loss
They have to, bc Pfizer has a daily oral that is going to be coming out, too. They’re all pretty effective. Orals will be game-changing since most folks don’t like injecting
We get Derek videos two days in a row? Too good to be true, we eating good boys
11:15 you're losing lean body mass because you aren't doing resistance training in addition to dieting. Same thing happens when you diet naturally and don't lift weights.
Doctor "To lose weight you can either exercise and eat less, or take a drug that will slowly destroy your body"
Patient "Drug please."
I’m a recently retired physician. That statement is so accurate.
Of course for the target demographic it's likely other weight loss mechanism have failed. I see these drugs as potential very useful if well managed
Vintage Derek. One of your best. Welcome back bro
My experience. I've been on Mounjaro since last October. Lost 22% body weight - 52 lb fat mass and 6 lb muscle mass based on Withings + scale. My A1C went from 6.3 to 5.6 and all cholesterol numbers are in normal range now. No change in average heart rate (58 resting) - based on Apple watch.
What a time to be alive. Ai gonn do everything and getting and staying in shape has never been easier. Nothing requires work anymore.
Back in 2015 I lost about 100 lbs. It amazes me how far people will go to avoid the simple things in weight loss. You will be hungry, it is uncomfortable and always be mindful with your eating. Check in every bite or two and ask yourself "Am I full or just eating?". Literally people would take chemicals with poorly understood long term effects than use an ounce of discipline and endure any amount of discomfort. It's also not sustainable, you didn't learn to manage your life or eating any better, nothing has improved. It's so short sighted it's unreal.
Congratulations on your weight loss, you seem to have a good mindset about it.
The auto-generated subtitles are having a field day with this one when Derek comes blasting out the gate like this!
That hasn't been my experience at all. Been on it or 3 months so far. I'm down from 265 to 225. Waist circumference from 44" to 39" at the bellybutton. I'm still squatting north of 400lbs for work sets, and pulling just under 500lbs for work sets.
Ozempic pens allow you to control the dose. You could have a 1mg pen but turn it 37 clicks and it would release a .5mg dose
Started semaglutide alongside my trt. Ran sem for something like 8 or 9 weeks before I needed to stop. Nausea was gnarly for me. I'd barely begin a meal and then I'd get repulsed by eating. Made it really tough to get enough protein.
Daddy Derek has delivered us another video praise
Great video but we have to realize that people on these studies are not doing strength training and probably not eating a high protein diet, of course they’re gonna lose muscle too. I used semaglutide when I was 23% bf and got to 12% body fat and kept all of my muscle because I was strength training and eating enough protein. I would love to see studies done on weight training athletes who eat enough protein
Does weight lifting while on Wegovy counteract the effects of muscle loss? I'm thinking about getting a prescription to help manage my obesity.
I'm on a cut right now and taking 1mg semaglutide, split into .5mg 2x per week . It's like a cheat code. I tapered to from .25mg per week. Gets rid of the cravings and binge eating I'd inevitably spiral into after 4 weeks. I'm pretty muscular and my maintenance cals are 3300. Eating only 2700 calories would previously make me ravenous. Now I'm stuffed with the same amount. I've even had a week or two where I tried only 2200 cals, and still experienced good satiety. I bumped the cals back up though due to gym performance and muscle retention. Only side I've experienced is some heartburn in the evenings if i have mildly spicy food.
Started at 240, down to 222 right now after 8 weeks.
I obtained a mixable vial and use an insulin needle to inject.
I'm on trt too so my muscle loss isn't really an issue compared to the average joe Derek talks about in the video. My resting heart rate has also stayed the same at 66-68bpm. I have been getting 10k steps per day for the last year though.
GLP-1 is an appetite hormone and . Can't find any peer reviewed journals talking about how there is a disproportionate amount of muscle loss due to semaglutide vs traditional means. Dr.Attia observes it from his clinical practice but not sure about any good data supporting him that he cites. In fact, I've seen studies find INCREASES in FFMI compared to baseline (although there are definitely conflicts of interest possibly)
High Protien, heavy lifting , heaps of cardio low dose semiglutide.
Works like a charm.
You noticed no muscle loss when doing this strategy?
I haven't @@Vallavanat
@@VallavanatI’ve been on zepbound for 2 months and I’ve gotten stronger and retained muscle tissue by combining the medication with high protein and lifting
@@Nightmaresfromthemetaverse that was my biggest worry thanks man!!
Father Derek delivers another platinum plus video.... thanks for your work.
Derek throwing the Team America distress signal for 38 min straight. 🙌
I am on 10 mg of tirzepatide every 10 days. I'm seventy-four years old. My battle against my eating addictions has taken its toll over the years. So as of last year, I had developed type 2 diabetes, coronary artery disease, peripheral artery disease, stage 3 chronic kidney disease, hypertension, non-alcoholic fatty liver disease, and hyperlipidemia. I was obviously losing the battle against my food addictions and was too tired to exercise.
Mounjaro has totally turned my life and health around in 7 months. For example, my a1c is down from 6.5 to 5.6 and probably lower than that by now. EGFR went from 47 to 60, a degree of change that my doctor had never heard of. Virtually all of my critical health metrics are improved and I have even been able to cut back on my blood pressure medicine.
The appetite suppression effects of Mounjaro have actually made it more possible for me to adopt a healthy diet, something that my food addictions would never allow me to do in the past. I'm just starting to get some energy in my life so now I am more able to exercise, both aerobics and resistance training. So for me, Mounjaro has not provided an excuse for me to continue my old bad habits, quite the opposite.
I agree with Derrek's assessment, but don't let perfection be the enemy of the good. If you are you eating a crap diet, just eating less crap will improve your health. Then if you really care about your health, Mounjaro can free you from enslavement to your hunger hormones and help you adopt a much healthier diet. Once you lose some weight, there is a good chance that you will have the energy to start exercising.
I have been blessed to have no gastrointestinal side effects. But the heart rate increase does concern me.
It was not my choice to have a 10-day interval between doses. That was my doctor's directive and it was a bad idea. 10 mg increases my heart too much for about a week and then after a week I gain about 5 pounds before taking my next shot.
We need studies on high protein, resistance trained subjects.
How can you get enough protein if your appetite is suppressed so much that you don’t want to eat enough of anything.
@@workingmanaudio2754 force feed. Shakes, if nothing else. Just gotta get it in.
So glad you're back. TH-cam hasn't been recommending ANY of your videos to me.
I lost 115 pounds in 4 months. Went from 45% to 15% body fat. I lost 6 pounds of mucle in the process. I also took mk-677 and trained.
How the fuck....!? Of fat?
Holy moly
Wtf when he says "dual" in the beginning of the video it sounds like one of those distorted helium YTP voices.
To be fair when i looked into this, a high protein diet and excersise was recommended, and my doctor had to send me to a nutritionist before he could even prescribe this to me, my insurance didn't cover it though lol
2 videos? In a day? God thank for this!
Derek summoning the sauna demon with that intro
Read this is *'Smeagaltude'* & my brain immediately conjured images of Gollum-people, distorted & emaciated beyond recognition.... the reality not being nearly as grotesque, but thanks to some humorous lysdexia, I got a chuckle out of it.
I trust Derek more than my doctor.
I’ve completed three weeks of Semaglutide, 1 mg / week. I’ve lost 12 1/4 pounds. I’m resistance training 1 1/2 hours a day and consuming 2.4 grams / kg of lean body mass in protein. I consume 1500 calories a day. My electrical impedance scale, which I’ve used religiously for 12 years, indicates I’m losing 66% fat and 33% lean mass. I started at 32% body fat
Hope Derek can start posting again🙏. TH-cam's been a little stale lately.
Best appetite suppressant I ever had was a parasite cleanse. Broke out of my sugar addiction, restored my willpower around food, & eventually was able to fast with ease.
How many people in these studies are working out alongside taking semaglutide? Pretty much any calorie-restricted diet done without resistance training will cause lots of muscle loss too, it's not the semaglutide's fault...
true you need to keep protein high and training intensity high to get lean
Especially with the kind of of calorie and protein deficit many of the people on semaglutide are on. I bet if there was a controlled study with a placebo group with the same eating and exercise habits, muscle loss would be similar.
He literally made the same point in the video. You should watch it, it's a good video.
@@krste3000 aah, true, I was a bit hasty with the comment and made it before he got to the same point around 25:00... though now it feels too late to just delete
@Razvan Ciuca it's not too late lmao. Leaving it up will lead people to believe otherwise. Bc people like you will immediately go to the comments before actually watching the video
I like your pharmacology related videos. Keep em coming!
Just started semaglutide while maintaining protein intake and consistent resistance training. Also TRT to offset muscle loss.
I’m one week in and did notice resting HR up 8 bpm 3 days after 250 mcg.
Appetite suppression is immediate but focusing on hitting slight caloric deficit to cut under 10%.
Agree, I'm on the same, only 1mg a week, it works perfect, no issues.. A1C going down
Thanks :) . Denifinitelly heavy enough to consider it ... added your video to my list of resources about semaglutide.
Glp1 agonists make you lose more fat and less muscle than just dieting. All the studys show better body composition and higher lean mass proportion after trial. Wish you would've checked ncbi for lean mass loss like you did for rhr. The guy who said 2/3 is lean mass obviously pulled that number from his behind.
This is absolutely false
That's in extremely obese people. Obviously their body is going to lose fat over muscle if they have 100+ extra pounds of fat. A slightly overweight person is going to lose more muscle than fat.
People lost 4 kg fat and 3 kg muscle, so overall 7 kg of bodyweight. No it wasn't morbidly obese test subject, because they were not weight loss studies, they were body composition studys, were no test subject had more fat mass than muscle msss so the change in body weight is accounted for and we investigate body composition only! I think a buch of scientists are smart enough to know that, and even I was smart enough to not tell you what a weight loss study said, but what a ton of body composition studys say.
This is why I was surprised derek didn't say that guy is wrong, because he said that those weight loss fda trials didn't account for body composition, which is not only wrong, because these are diabetes medication and literally every diabetes medication needs to have a favorable impact on body composition, otherwise it's not a diabetes medication it's a short term hyperglycemia relief! How do you approve a medication that worsens your glycemic control in long run for diabetes? What he said was also irrelevant because there are literally more than dozens of studys investigating the glp1 agonist group on body composition.
I am on 1mg of semaglutide per week for Diabetes. After watching this video I will be monitoring my heartrate. Through diet and exercise I have gone off a few diabetic meds. I have also gained more weight (muscle) through weight lifting. I quit keto and went on carnivore. My Doctor said all my bloodwork was great. I will be monitoring my heart. Thanks for the info Derek.
With just the carnivore diet I have seen patients reverse diabetes.
Thank you for the insights! My wife used it for 2 months and lost the 12kg that she's been trying to loose for 5-6 years! It was fantastic, with almost no side effects. I'll tell her to start pumping to get some lean muscle mass on 💪
Oh I’m sure there’s side effects….you’re just not aware
@@bradbaker4679yeah with numbers like those, I'd bet
Ozempic completely ruined my life 6 months ago. I was taking it for weight loss to increase my testosterone. My endocrinologist said i needed to lose weight because im a 24 Male with 215 ng/dl testosterone . I was on my 3rd week of ozempic and got gastroparesis and then was diagnosed with cdiff. This was back in June... my stomach is almost back to normal. However taking anitbiotics in the future will be a pain.
Most intense stomach pain I've ever experienced as well as uncontrollable vomiting and diarrhea. And I couldn't tolerate most foods for a long time!
Theres a class action forming now in the us. You're far from alone in this
Durk just posted guys
I was type two diabetic and reversed it with mounjaro. Went from 195 to 155. I climb and work out 5-7 days a week. My climbing went from a 5.11 to a 5.13-. Shredded now. I did lose some muscle mass. Oh, and I was suffering from hypertension. That’s also gone now. I leveraged the drug to cut my junk food intake. Meat and veggies only now. Only time I have junk is if I need a quick something to increase my calories drastically for the day. About to lean bulk.
All shortcuts come with consequences
Kevin hall actually made a response to this in which he used a study to compare the lean body mass loss to weightloss without semaglutide. According to his calculations body composition improved in the people taking semaglutide however there was more lean bodymass loss compared to people not taking semaglutide. There are yet to be studies done confirming this hypothesis
Holy sheep sh*t. I’ve been on liraglutide which is a daily glp-1. Once I slowly ramped up to the full 3mgs a day the side effects became overwhelming. And no counter medication could combat them. Acid reflux, nausea, vomiting and diarrhea and all of those arrived in the middle of the night thus waking me up violently. But the medicine works……
Yes. But there also studies published that although semaglutide increases HR, but also lowers blood pressure. And It has shown benefit for patients with cardiorenal conditions.
Thanks for the info, Derek. I put on some weight a while ago due to massive mental health issues and the apathy that came with with, I've been having a hard time to be motivated getting back into the gym to be healthy like I used to be. Lately I've been thinking of trying one of these apetite suppressants to be a catalyst for me to start me getting back. I know it's looking for an easy way to start losing weight, I'm very aware of the long process it takes to get in and be in shape. Not sure if I will try a suppressant, but it's good to have the info in case I do.
The key to being successful with this stuff is immediately starting to lift. If you are too self conscious to go to the gym , grab a pull up bar, and a set of dumbbells. That’s all you’ll need in the beginning anyways. The difference between someone looking for the easy way and the right way is lifting.
You can start with just 15-20 minutes a day see how you feel and work up to the hour.
You know very well that the reason going to the gym and losing weight is such a reliable way of crawling out of a mental health hole is not because you look a little bit better. It’s because you re-teach yourself discipline, you short term and long term selves start to work in harmony, you make good decisions and look after yourself. After a while of treating yourself like you’re worth being looked after, you start to believe it, and you’re well on the path to success and happiness. Don’t rob yourself of that my man
@@sticklebacketiennebeautifully put
I usually skip some of the vids because they are so long, but Derek videos are in short supply now and have been missing them, so watching every second!
A topic very much in the zeitgeist, nice
great reminder that it's not just about the number on a scale, it's about healthier choices
Hopefully, if these GLP-1 RAs potentially develop into several more generations with respect to decreasing cardiovascular risk, I could see it being super beneficial in the bodybuilding community that are considering a "weight-loss" drug in their stack that dont want to use sympathomimetics like Clenbuterol. Awesome video! I'd love to see a more in-depth video on the adverse effects in the future.
I really don't think we need more drugs for bodybuilders to kill/starve/whatever themselves with. Like...I hope they realise what a futile endeavor it is, so vain and unhealthy. Not that they get more or better drugs to do it more
@@dimitrijekrstic7567 You’re absolutely right. Bodybuilding can be incredibly unhealthy in my opinion. I just feel like it’s an inevitability at the highest level that the top guys are going to do whatever it takes to look the best as possible. But if people are more aware about taking the safest drugs at educated, moderated amounts, I still feel like that is a step in the right direction.
@@seejay4185 I say cut the drugs and go back to healthy looking bodies lol
I went from 220 to 190 and RHR went from mid 50s average to upper 40s and that was before strengthening my cardio
Damn it Derek. I put a calendar reminder to call my PCP next week to get this medication. I’m a 40 year old female, had 3 kids, workout 5x a week, powerlifting, legs are pretty muscular, 5’8, 225lbs, use Carbon app and struggling losing damn weight. It’s so frustrating. What do I do?!
Not Derek but I'll give this a crack.
When something isn't working in your training program, do the complete opposite. Flip your program upside-down. Source is Precision Nutrition (PN). The Principal of PN did an interview with Stronger by Science. More information there.
Her advice concerned a client with exactly the same problem as you. Female exercising a lot (and under a lot of stress) was struggling to lose the last bit of weight. Her program was turned upside-down. Training went from 5 x week to 2 x or 1 x weekly. Rest days went up. Her calories increased from a deficit to maintenance. Major changes within a few weeks. Give it a go and see what happens.
Also nothing wrong with *using* drugs like GLP Agonists instead of *abusing* them. Obviously these drugs are made to do one thing and one thing only - modulate appetite. Dr. Mike Israetel did a great video on the subject on the Renaissance Periodisation channel.
Good luck V C.
Muscle weighs more than fat. You've indicated you're powerlifting, are you eating for powerlifting, as powerlifters usually do? That's probably the place to start. Yes if you eat cleaner and deficit you're going to lose power output
Eat less/eat more volumenous foods that are low cal so you are satiated. Add cardio or more cardio to your routine.
As long as you are looking better and are progressing in weight, the fat is and will come off. Don’t focus so much on the scale. Remember muscle weighs more then fat.
I recently put on 20 lbs but I actually look skinnier cause the muscles. So don’t worry so much day to day or week to week the weight as long as you are progressing in weight and reps and sets and eating a balanced diet the fat will come off.
Remember, it’s not a race; sustainable fat loss is about .5-1lb a week. Give it time and you will be rewarded.
Personally , I agree with the other commenter; that you need your calories to do these lifts and gain muscle and raise the metabolic rate.
It’s the muscle gained that raises basal metabolic rate that will do most for weight loss especially long term.
You start taking a drug that makes you not eat, you won’t lift as much, you’ll lose muscle, then basal metabolic rate will go down and it will make it harder longterm.
You are already on the right path.
This drug, it’s for people who aren’t lifting to lose weight(ie lazy people ie people doing it wrong).
Try upping protein to 1g/lb. That will make you lose weight and help with muscle. It’s hard to overeat when you are really getting the required protein intake as protein is very satiating and it’s actually a good bit of protein. If you can’t get it all from diet, add protein shakes.
It's also likely perimenopause. Loss of estrogenus slow but it absolutely affects your metabolism. Try transdermal patch birth control. I dropped 15 pounds and got my waist back.
Not even interested in this topic but I will watch any Derek video