Warburg effect. Energy Production In Cancer Cell. How Does it Benefit Cancer Cells?
ฝัง
- เผยแพร่เมื่อ 14 ต.ค. 2024
- 0:01 What is it Warburg Effect
MECHANISM EXPLAINED
1:14 Normal Glycolysis
6:37 Glycolysis in Cancer cell
6:58 Why Lactate cause acidosis
3:33 Metabolic properties of Warburg effect.
WHY?
8:28 Enegy benefit
11:03 Acid-mediated invasion hypothesis
Why patients with cancer lose weight.
#usmle #step1 #step2 #medicine #pathology #physiology #education #medicalschool #pharmacology #biochemistry #highyield #lab
Liberti MV, Locasale JW. The Warburg Effect: How Does it Benefit Cancer Cells? [published correction appears in Trends Biochem Sci. 2016 Mar;41(3):287] [published correction appears in Trends Biochem Sci. 2016 Mar;41(3):287]. Trends Biochem Sci. 2016;41(3):211-218. doi:10.1016/j.tibs.2015.12.001 Link - www.ncbi.nlm.n...
DeBerardinis, R. J., & Chandel, N. S. (2020). We need to talk about the Warburg effect. Nature metabolism, 2(2), 127-129. doi.org/10.103...
This video is a review of the Warburg effect in cancer cells. Warburg effect definition. Explained the mechanism of the Warburg effect for step 1 and step 2 pathology. How Warburg effect cause atp robbery. The Warburg hypothesis how neoplastic cells deprive normal cells of glucose. Why cancer cause weight loss and cachexia. How TCA cycle affects Warbug metabolism. The reason why cancer cells with sufficient amount of oxygen use anaerobic glycolysis and produce Lactate instead of aerobic glycolysis. The role of LDH ( Lactate dehydrogenase) in cancer cells and Warburg metabolism. How lactate cause polimerization of tissue-associated macrophages and promote cancer growth. Reverse warburg effect. Biochemical and biological approach to cancer metabolism.
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Easy to understand
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extraordinary!!!! congratulations for your content
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This is a phenomenal video with beautiful graphics! Will be returning to the channel in the future :)
Thank you very much 😉
Aerobic respiration in normal cells generates much more energy than anaerobic respiration in cancer cells. Some portion of this energy is converted into heat which is a waste product. However, this waste product is very essential for normal functioning of the cells,either normal or cancerous. Because cancer cells generate much less energy and concurrent heat, they resort to aerobic glycolysis and consume glucose on a large scale to produce energy and heat to sustain themselves. Cancer is a disease caused by gene mutation and this mutation forces cancer cells to resort to aerobic glycolysis,an inefficient pathway to generate energy and heat. In other words, cancer cells maintain low heat profile which assists them to grow and proliferate uncontrollably. The cure for cancer may probably lie in raising the temperature of the cancer site by half a degree or one degree C as in human embryo development where the temperature of the mother is raised by half a degree C throughout pregnancy. The idea is to provide sustaining heat to cancer cells which are obviously heat starved, and cause in them expression of right genes for normal functioning.
Anaerobic glycolysis generates more energy per time than aerobic. But aerobic glycolysis brings more energy per 1 glucose molecule. Do you have any reliable articles where this mechanism (about heat) is described?
@@Foxterrier I have written two Articles on cancer subject and sent to cancer research centres in America including the Harvard Medical School for testing my hypothesis. My Articles are elaborate and are based on proven facts with logical inferences drawn by me. I am a cancer research enthusiast and have studied a lot concerning cancer and its cure. My research concentrates on the close relationship between heat and cancer and it is a new approach to treat cancer by heat application. It is different from hyperthermia treatment which has already been tried.
Thank you so much!
This is the best video on warburg effect on TH-cam.
subbed 👍🏿
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Such precise and beautiful explanation !
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more people should see this !
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fantastic
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fantastic explanation, thank you
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best video on warburg effect out here, thank you so much
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Please l need answere. !!!
Does gloucose inter cancer cells by insulin, like normal cells?
Most of cancer cells have insulin receptors and their glucose uptake can be stimulated by insulin . But at the same time cancer cells can take up glucose efficiently even in the absence of insulin .
@@Foxterrier
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Great video! Thanks for putting it out.
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This is why ketogenic diets and fasting should be encouraged in cancer patients. But there is no money to be made from that, so it’s discouraged. 😢
There is still a debates about keto in cancer, probably it can provide some benefits, but i doubt that it can be applied, simply due to cachexia.
@@Foxterrier You would want to stick with keto, in late stages. It’s got everything the body needs. Fasting is tougher if you aren’t fat adapted yet, but honestly after two days it’s easy, still you may not want to fast during late stages. I feel like it’s a good way to prevent, but would definitely not consider as the only treatment.
Newer research is indicating that, decreasing sugar (for example Keto) stops the direct fueling of cancer (glycolysis) and decreases inflammation. However, the cancer cells are getting fuel (atp) possibly by fermentation of glutamine. It looks like Fenbendazole may stop glutamine conversion. Thus, Keto with intermittant fasting and Fenbendazole. This is early research but thought provoking
Can someone kindly dumb this down for me please?
Simply speaking Cancer cells can produce energy by aerobic way ( with Mitochondria) and by anaerobic way. Usually cells prefer aerobic, but cancer cells prefer anaerobic - because it's the fastest way to produce energy.